Prognostic factors in metastatic non-seminomatous germ cell tumours: an interim analysis of the EORTC GU-Group experience.

Abstract:

:Univariate and multivariate analyses were performed in 632 patients treated with cisplatin combination chemotherapy for metastatic non-seminomatous testicular germ cell tumours. Multivariately, the most important poor prognosis factors for the prediction of survival were: HCG > or = 10,000 IU/l, lung metastases > or = 10, abdominal metastases with a horizontal diameter of > or = 5 cm and the presence of supraclavicular metastases. If patients had 2 or more of these factors the death rates increased from 30% for patients with 2 factors to 65% for patients with 3 or 4 factors. The patients studied here are not a random sample of the metastatic testicular cancer patients in general, as the population studied comprised a large proportion of low volume metastatic disease patients. Therefore, the final analysis will include patients from all the recently completed trials.

journal_name

Eur Urol

journal_title

European urology

authors

Stoter G,Sleijfer D,Kaye SB,Jones WG,ten Bokkel Huinink WW,de Pauw M,Sylvester R

doi

10.1159/000474594

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

202-6

issue

1

eissn

0302-2838

issn

1873-7560

journal_volume

23

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2018-10-01 00:00:00

  • Comparison of transperitoneal and extraperitoneal laparoscopic radical prostatectomy using match-pair analysis.

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    doi:10.1016/j.eururo.2004.05.004

    authors: Erdogru T,Teber D,Frede T,Marrero R,Hammady A,Seemann O,Rassweiler J

    更新日期:2004-09-01 00:00:00

  • Renal cell carcinoma guideline.

    abstract:OBJECTIVES:The European Association of Urology (EAU) Guideline Group for renal cell carcinoma (RCC) prepared this guideline to help urologists assess the evidence-based management of RCC and to incorporate the guideline recommendations into their clinical practice. METHODS:The recommendations provided in the current g...

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    doi:10.1016/j.eururo.2007.03.035

    authors: Ljungberg B,Hanbury DC,Kuczyk MA,Merseburger AS,Mulders PF,Patard JJ,Sinescu IC,European Association of Urology Guideline Group for renal cell carcinoma.

    更新日期:2007-06-01 00:00:00

  • Urothelial lined colocystoplasty in a sheep model.

    abstract::Nineteen lambs underwent colocystoplasty using a segment of demucosalised sigmoid colon, and were compared to 14 control animals. Nine animals had a procedure which included the addition of the muscle patch to an autoaugmented bladder, and 10 had a clam cystoplasty with the denuded colon. Six months after the procedur...

    journal_title:European urology

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    doi:10.1159/000475387

    authors: Dewan PA,Lorenz C,Stefanek W,Byard RW

    更新日期:1994-01-01 00:00:00

  • Upregulation of penile brain-derived neurotrophic factor (BDNF) and activation of the JAK/STAT signalling pathway in the major pelvic ganglion of the rat after cavernous nerve transection.

    abstract:OBJECTIVES:Increasing attention is being focused on identifying novel approaches to recover cavernous nerve (CN) function after injury or secondary to disease states such as diabetes mellitus. We examined penile brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) expression, and activation of the Janus k...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.10.043

    authors: Bella AJ,Lin G,Garcia MM,Tantiwongse K,Brant WO,Lin CS,Lue TF

    更新日期:2007-08-01 00:00:00

  • Innovative approaches to the hormonal treatment of advanced prostate cancer.

    abstract::Androgen ablation therapy is the treatment of choice for the palliation of patients with advanced prostate cancer. In addition to palliation, maximal androgen ablation (MAA), with a combination of medical or surgical castration and an antiandrogen, has been shown to increase the survival of patients with metastatic pr...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:

    authors: Trachtenberg J

    更新日期:1997-01-01 00:00:00

  • Postchemotherapy retroperitoneal lymph node dissection in advanced germ cell tumours of the testis.

    abstract:OBJECTIVES:To review the role of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) in patients with advanced testicular germ cell tumours (TGCT) with special attention towards the indication, surgical technique, and oncological outcome. METHODS:A structured review of the literature until May 2007 using...

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    authors: Heidenreich A,Thüer D,Polyakov S

    更新日期:2008-02-01 00:00:00

  • Radical nephrectomy with and without lymph node dissection: preliminary results of the EORTC randomized phase III protocol 30881. EORTC Genitourinary Group.

    abstract:OBJECTIVE:The authors present demographic and surgical data from a randomized phase III trial, instituted by the EORTC Genitourinary Group in 1988, the aim of which was to assess whether complete lymph node dissection in conjunction with radical nephrectomy for renal cell cancer is more effective than radical nephrecto...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000020050

    authors: Blom JH,van Poppel H,Marechal JM,Jacqmin D,Sylvester R,Schröder FH,de Prijck L

    更新日期:1999-12-01 00:00:00

  • Genomic Characterization of Renal Cell Carcinoma with Sarcomatoid Dedifferentiation Pinpoints Recurrent Genomic Alterations.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2016.01.051

    authors: Malouf GG,Ali SM,Wang K,Balasubramanian S,Ross JS,Miller VA,Stephens PJ,Khayat D,Pal SK,Su X,Sircar K,Tamboli P,Jonasch E,Tannir NM,Wood CG,Karam JA

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  • Skeletal morbidity in men with prostate cancer: quality-of-life considerations throughout the continuum of care.

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    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2004.08.016

    authors: Saad F,Olsson C,Schulman CC

    更新日期:2004-12-01 00:00:00

  • Wolf Piezolith 2200 versus the modified Dornier HM3. Efficacy and range of indications.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471518

    authors: Rassweiler J,Gumpinger R,Bub P,Kohl H,Mayer A,Eisenberger F

    更新日期:1989-01-01 00:00:00

  • Characterizing the impact of lymph node metastases on the survival outcome for metastatic renal cell carcinoma patients treated with targeted therapies.

    abstract:BACKGROUND:It is unknown whether lymph node metastases (LNM) and their localization negatively affect clinical outcome in metastatic renal cell carcinoma (mRCC) patients. OBJECTIVE:To evaluate the clinicopathological features, survival outcome, and treatment response in mRCC patients with LNM versus those without LNM ...

    journal_title:European urology

    pub_type: 杂志文章

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  • Genomic Predictors of Outcome in Prostate Cancer.

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    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2015.04.008

    authors: Boström PJ,Bjartell AS,Catto JW,Eggener SE,Lilja H,Loeb S,Schalken J,Schlomm T,Cooperberg MR

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  • Predictive value of pathological features for progression after radical prostatectomy.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475379

    authors: Ravery V,Boccon-Gibod LA,Meulemans A,Dauge-Geffroy MC,Toublanc M,Boccon-Gibod L

    更新日期:1994-01-01 00:00:00

  • A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment.

    abstract:CONTEXT:Current literature suggests that several pathophysiological factors and mechanisms might be responsible for the nonspecific symptom complex of overactive bladder (OAB). OBJECTIVE:To provide a comprehensive analysis of the potential pathophysiology underlying detrusor overactivity (DO) and OAB. EVIDENCE ACQUIS...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2019.02.038

    authors: Peyronnet B,Mironska E,Chapple C,Cardozo L,Oelke M,Dmochowski R,Amarenco G,Gamé X,Kirby R,Van Der Aa F,Cornu JN

    更新日期:2019-06-01 00:00:00

  • Delaying/reducing the risk of clinical tumour progression after primary curative procedures.

    abstract::The advent of prostate-specific antigen (PSA) testing and increased patient awareness has led to patients being diagnosed with prostate cancer at an earlier stage and a younger age than previously. Adjuvant hormonal therapy to radiotherapy or prostatectomy has been shown to reduce the risk of tumour progression, and i...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000049880

    authors: Wirth M

    更新日期:2001-01-01 00:00:00

  • Tissue adhesives: their use in urology.

    abstract::Tissue adhesives have certain advantages and should be used only for nephropexy and urethropexy but not for orchiopexy. Because of possible incrustation it should be avoided in the urinary collecting system. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471999

    authors: Kelâmi A

    更新日期:1976-01-01 00:00:00

  • Late complications of ureteral stents.

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    journal_title:European urology

    pub_type: 杂志文章

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  • Mechanisms of prostate atrophy after glandular botulinum neurotoxin type a injection: an experimental study in the rat.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2008.07.003

    authors: Silva J,Pinto R,Carvallho T,Coelho A,Avelino A,Dinis P,Cruz F

    更新日期:2009-07-01 00:00:00

  • Current status of cytotoxic chemotherapy in hormone refractory prostate cancer.

    abstract::Adenocarcinoma of the prostate is the most prevalent neoplastic disease in men and continues to be a major cause of morbidity and mortality. Death from prostate cancer is associated with objective and biochemical progression following hormonal manipulations often described as hormone refractory prostate cancer (HRPCA)...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000052426

    authors: Heidenreich A,von Knobloch R,Hofmann R

    更新日期:2001-02-01 00:00:00

  • EAU guidelines on renal cell carcinoma: 2014 update.

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    pub_type: 杂志文章,meta分析,评审

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    更新日期:2015-05-01 00:00:00

  • The role of ESWL in the treatment of calculi with anomalous kidneys.

    abstract:OBJECTIVE:To evaluate the efficacy of Extracorporeal shock wave lithotripsy (ESWL) in renal anomalies. MATERIAL AND METHODS:From 1991 to May 1995. 53 patients with calculi in anomalous kidneys presented to our clinic for treatment with ESWL. Average patient age was 39 years, a range of 6-66 years. These patients (32 m...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474472

    authors: Semerci B,Verit A,Nazli O,Ilbey O,Ozyurt C,Cikili N

    更新日期:1997-01-01 00:00:00

  • Myelolipoma of the adrenal gland.

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    pub_type: 杂志文章

    doi:10.1159/000473191

    authors: Hanafy HM

    更新日期:1981-01-01 00:00:00

  • Trastuzumab (Herceptin) in metastatic transitional cell carcinoma of the urinary tract: report on six patients.

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    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.eururo.2005.07.015

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    更新日期:2005-11-01 00:00:00

  • Blind-ending bifid ureter with an intravesical ectopic orifice.

    abstract::Blind-ending bifid ureters, as one type of duplications, are a rare congenital anomaly of the urinary tract. Occasionally they present with unspecific symptoms and require surgical intervention. This case of a blind-ending bifid ureter was associated with an intravesical ectopic orifice. Recurrent urinary tract infect...

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    pub_type: 杂志文章

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  • EAU guidelines for the management of urogenital schistosomiasis.

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    pub_type: 杂志文章,实务指引

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  • European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章,随机对照试验

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