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Radical nephrectomy with and without lymph node dissection: preliminary results of the EORTC randomized phase III protocol 30881. EORTC Genitourinary Group.

Abstract：

OBJECTIVE:The authors present demographic and surgical data from a randomized phase III trial, instituted by the EORTC Genitourinary Group in 1988, the aim of which was to assess whether complete lymph node dissection in conjunction with radical nephrectomy for renal cell cancer is more effective than radical nephrectomy alone. METHODS:Before surgery, the renal cell carcinoma was staged and judged to be nonmetastatic and resectable. The patients were randomized prior to surgery into those having radical nephrectomy combined with complete lymph node dissection or into those having radical nephrectomy alone. Postoperatively all patients were followed until progression of disease or death. RESULTS:Of the 772 randomized patients, 41 were not eligible. 383 had a complete lymph node dissection together with a radical nephrectomy. 389 had a radical nephrectomy alone. The complication rate did not differ significantly between the two groups. A complete lymph node dissection in 336 patients revealed absence of lymph node metastases in 325 of them. CONCLUSIONS:The present study shows that complete lymph node dissection does not add morbidity to the radical nephrectomy. After proper preoperative staging, the incidence of unsuspected lymph node metastases is low (3.3%).

journal_name

Eur Urol

journal_title

European urology

authors

Blom JH,van Poppel H,Marechal JM,Jacqmin D,Sylvester R,Schröder FH,de Prijck L

doi

10.1159/000020050

keywords:

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

570-5

issue

6

eissn

0302-2838

issn

1873-7560

pii

20050

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验

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