Clinical relevance of growth factor antagonists in the treatment of benign prostatic hyperplasia.

Abstract:

:Changing demography and expectations about maintaining quality of life mean that an increasing number of men will require treatment for benign prostatic hyperplasia (BPH). Many growth factors have a role in the development of BPH. Consequently growth factor antagonists offer an attractive therapeutic option. In double-blind randomised trials Tadenan, a drug known to have growth factor antagonist activity, conferred significant improvement of urinary symptoms, maximum flow rate and residual volume, with no serious side-effects. Therapeutic outcome could be enhanced in a number of ways including matching patients with particular cell type overgrowth for treatment with a growth factor antagonist specific for that cell type. Full exploitation of this approach awaits the development of less invasive means of determining the cell type affected.

journal_name

Eur Urol

journal_title

European urology

authors

Desgrandchamps F

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

28-31

eissn

0302-2838

issn

1873-7560

journal_volume

32 Suppl 1

pub_type

杂志文章,评审
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    更新日期:2020-03-01 00:00:00

  • Augmented reality: a new tool to improve surgical accuracy during laparoscopic partial nephrectomy? Preliminary in vitro and in vivo results.

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    doi:10.1016/j.eururo.2009.05.017

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    更新日期:2009-08-01 00:00:00

  • Changing concepts in the surgical management of renal cell carcinoma.

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  • BTA stat and BTA TRAK: A comparative evaluation of urine testing for the diagnosis of transitional cell carcinoma of the bladder.

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    pub_type: 临床试验,杂志文章

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    更新日期:1999-02-01 00:00:00

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    更新日期:2008-04-01 00:00:00

  • The role of the prostatic vasculature as a landmark for nerve sparing during robot-assisted radical prostatectomy.

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  • Extracorporeal shock wave lithotripsy monotherapy for staghorn calculi.

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    pub_type: 杂志文章

    doi:10.1159/000475262

    authors: Yamaguchi A

    更新日期:1994-01-01 00:00:00

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    authors: Reichelt O,Gajda M,Chyhrai A,Wunderlich H,Junker K,Schubert J

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  • Genetic and environmental factors in prostate cancer genesis: identifying high-risk cohorts.

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    pub_type: 杂志文章,评审

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    pub_type: 临床试验,杂志文章,多中心研究

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    doi:10.1159/000473085

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