Abstract:
:Changing demography and expectations about maintaining quality of life mean that an increasing number of men will require treatment for benign prostatic hyperplasia (BPH). Many growth factors have a role in the development of BPH. Consequently growth factor antagonists offer an attractive therapeutic option. In double-blind randomised trials Tadenan, a drug known to have growth factor antagonist activity, conferred significant improvement of urinary symptoms, maximum flow rate and residual volume, with no serious side-effects. Therapeutic outcome could be enhanced in a number of ways including matching patients with particular cell type overgrowth for treatment with a growth factor antagonist specific for that cell type. Full exploitation of this approach awaits the development of less invasive means of determining the cell type affected.
journal_name
Eur Uroljournal_title
European urologyauthors
Desgrandchamps Fsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
28-31eissn
0302-2838issn
1873-7560journal_volume
32 Suppl 1pub_type
杂志文章,评审相关文献
EUROPEAN UROLOGY文献大全abstract::Despite the high cure rate in men with testicular cancer, efforts should be made to diagnose the disease at the preinvasive stage. The disease, which affects young males, is potentially lethal. Furthermore, testicular neoplasia diagnosed at the stage of CIS can be cured without the negative impact on the life-quality ...
journal_title:European urology
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::Urinary organic acids were determined by gradual titration of portioned urine samples of moderately and severely recurrent stone patients and compared to those found in healthy controls. An essential deficit of organic acids was found in patients with a high recurrence rate. According to the results, the lack of organ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000463803
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The presence of lymph node metastasis (LNM) at radical prostatectomy (RP) is associated with poor outcome, and optimal treatment remains undefined. An understanding of the natural history of node-positive prostate cancer (PCa) and identifying prognostic factors is needed. OBJECTIVE:To assess outcomes for pa...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2013.03.053
更新日期:2014-01-01 00:00:00
abstract::In making treatment decisions for patients with benign prostatic hyperplasia (BPH), physicians have to rely on the efficacy data published in the literature and adapt this to individual patient's needs. Criticism can be made, however, of the randomised clinical trials (RCTs) that are performed, as the patients enrolle...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000049884
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Active surveillance (AS) has been proposed as an effective strategy to reduce overtreatment among men with lower risk prostate cancers. However, historical rates of initial surveillance are low (4-20%), and little is known about its application among community-based urology practices. OBJECTIVE:To describe ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2014.08.024
更新日期:2015-01-01 00:00:00
abstract::The authors present their experience (24 children) with the endoscopic subureteral injection of Teflon paste in the correction of secondary vesicoureteral reflux: reimplantation failure; ureterocele; obstructive bladder; exstrophy; postchemocystitis, and Hutch's diverticulum. Of these 24 cases (31 refluxing ureters), ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000464067
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Standard management in the UK for high-risk stage 1 nonseminoma germ cell tumours of the testis (NSGCTT) is two cycles of adjuvant bleomycin, etoposide (360 mg/m2), and cisplatin (BE360P) chemotherapy, or surveillance. OBJECTIVE:To test whether one cycle of BE500P achieves similar recurrence rates to two cy...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2019.11.022
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Use of an augmented reality (AR)-based soft tissue navigation system in urologic laparoscopic surgery is an evolving technique. OBJECTIVE:To evaluate a novel soft tissue navigation system developed to enhance the surgeon's perception and to provide decision-making guidance directly before initiation of kidn...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2009.05.017
更新日期:2009-08-01 00:00:00
abstract::The foundations of the generally accepted principles underlying the surgical management of renal cell carcinoma (RCC) were best annunciated in 1969 by Robson in his classic description of the radical nephrectomy [J Urol 1969;101;297]. Since then, much has changed in our understanding of the basic biology and genetics ...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2004.02.002
更新日期:2004-06-01 00:00:00
abstract::An alternative to conventional laparoscopy when looking for virtually scarless surgery is mini-laparoscopy, a reproducible technique that preserves the triangulation concept. A drawback of this approach is the poor image quality provided by mini-scopes. The introduction of the SPIEs technology, a novel endoscopic came...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2014.06.001
更新日期:2014-10-01 00:00:00
abstract::Abscesses of the psoas muscle are due to a hematogenous dissemination, to the spread of infection from adjacent intestinal structures, to osteomyelitis of the spine or to tuberculous infection of a disc space. In contrast, psoas abscesses related to the urological tract have only been described on exception. The prese...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000475274
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVES:We performed a retrospective analysis of first relapses after cisplatin-based chemotherapy in patients with advanced germ-cell tumors, in order to better define the appropriate follow-up. METHODS:These patients were treated between 1986 and 1998 in two institutions. They were either followed after first-lin...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2005.06.018
更新日期:2005-12-01 00:00:00
abstract::The advantages and disadvantages of two different methods of analyzing the European Randomized Study of Screening for Prostate Cancer (ERSPC) trial with respect to the effect of prostate-specific antigen (PSA) screening on prostate cancer (PCa) mortality (ie, disease-specific mortality analysis and excess mortality an...
journal_title:European urology
pub_type: 信件
doi:10.1016/j.eururo.2013.12.055
更新日期:2014-09-01 00:00:00
abstract::Calcium metabolism was studied in 37 patients with "idiopathic hypercalciuria" on a home diet and after 10 days of low calcium dietary intake (less than 400 mg/24h). After low calcium intake, urinary calcium excretion returned to within normal limits in 70% of the cases. In the group of patients which failed to respon...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473258
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:We compared the BTA (bladder tumor antigen) stat test with the BTA TRAK assay in patients highly suspicious of bladder cancer. METHODS:The BTA stat and the BTA TRAK tests are two immunoassays that detect human complement factor H related protein in urine, employing the same antibody pair. The BTA stat is a q...
journal_title:European urology
pub_type: 临床试验,杂志文章
doi:10.1159/000019824
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:High-intensity focused ultrasound (HIFU) permits targeted homogeneous ablation of tissue. The objective of this phase 1 study was to evaluate the feasibility of HIFU ablation of small renal tumours under laparoscopic control. PATIENTS AND METHODS:Ten kidneys with solitary renal tumours were treated with a ne...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2007.11.020
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Macroscopic landmarks are lacking to identify the cavernosal nerves (CNs) during radical prostatectomy. The prostatic and capsular arteries run along the lateral border of the prostate and could help identify the location of the CNs during robot-assisted radical prostatectomy (RARP). OBJECTIVE:Describe the ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2011.12.047
更新日期:2012-03-01 00:00:00
abstract::Forty-eight patients with large renal staghorn calculi of more than 35 mm in maximum length on plain X-rays were treated by extracorporeal shock wave lithotripsy (ESWL) monotherapy for a period of 2 years. Thirty patients, with a follow-up of more than 6 months after the last treatment, were included in this study. Th...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000475262
更新日期:1994-01-01 00:00:00
abstract::A 62-yr-old woman with a 2-cm enhancing renal mass in the right moiety of a horseshoe kidney was treated via a four-port transperitoneal laparoscopic approach. The tumour was excised by cold scissors, and the parenchyma was sutured with Vicryl 1 sutures with Surgicel bolster and by using pledgets of Hem-o-lok((R)) cli...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2006.10.052
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:We evaluated the reliability of sonographic criteria in selecting solid renal masses for percutaneous fine-needle biopsy. METHODS:In study 1 (intraoperative ultrasound study), we prospectively examined 100 consecutive patients scheduled for partial/radical nephrectomy by using two different high-resolution ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2007.01.078
更新日期:2007-11-01 00:00:00
abstract::Prostate cancer is the most common malignancy found in males; however, little is as yet known regarding what initiates the disease. The incidence is highest among American Blacks and lowest in the East Asian population. Subtypes of the disease include familial clustering and a hereditary form (9%) supporting genetic e...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000019910
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Using videourodynamics (VUDS) we prospectively investigated the etiologies of lower urinary tract symptoms (LUTS) and low uroflow in young men and correlated the results with clinical symptoms and noninvasive exams. METHODS:From 1999 to 2001, 90 men 18-50 years old with LUTS and low uroflow were enrolled. P...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(03)00060-5
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:This prospective, multicenter study was initiated to evaluate the diagnostic performance of PSA, free/total PSA (f/tPSA) and complexed PSA (cPSA) with volume-based parameters for early detection of prostate cancer in patients with PSA between 2.5 and 20 ng/ml. MATERIALS AND METHODS:408 subjects with serum PSA ...
journal_title:European urology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.eururo.2004.10.009
更新日期:2005-03-01 00:00:00
abstract::A histological study, by means of bilateral biopsy, on 44 cryptorchid patients (26 of whom are monolateral and 18 bilateral), comparing them with the response obtained for the HCG gonadal stimulation test, is presented. A direct, although not always exact, relation is established between the testicular histology and t...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473085
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To investigate possible changes in the expression of the transient receptor potential vanilloid type 1 (TRPV1) from normal urothelium to transitional cell carcinoma (TCC) of human bladder. METHODS:Specimens from normal bladder (n=13, mean age 62 yrs), superficial TCC (n=16, mean age 62,4 yrs) and muscle inva...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2005.05.018
更新日期:2005-10-01 00:00:00
abstract::In the examination of >3000 radical prostatectomy specimens and their seminal vesicles (SVs), we came across a unique case of an intraepithelial abnormality in preexisting ducts and acini in the left SV of a 73-yr-old patient with prostatic adenocarcinoma. At low magnification, the epithelial lining was thicker than t...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2014.02.054
更新日期:2014-10-01 00:00:00
abstract::HLA antigen type was studied in 55 patients with transitional cell carcinoma of the bladder. The results showed high HLA-B5 and low HLA-BW35 frequencies. Histological grade, stage, and recurrence rate of tumors were also evaluated separately. The results were more significant in recurrent tumors. ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472775
更新日期:1987-01-01 00:00:00
abstract::To investigate the feasibility of chronic stimulation of the sacral nerves for control of sphincter and bladder function, we implanted bipolar electrodes in 10 dogs. These electrodes, of conventional cuff (4 dogs), as well as innovative spiral designs (6 dogs) were placed around the S2 roots of the 10 dogs and in 3 of...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474058
更新日期:1983-01-01 00:00:00
abstract::The question is addressed whether cisplatin-based chemotherapy for germ cell cancer has the same efficacy in intratesticular and in extragonadal sites. For this purpose, 7 patients with germ cell cancer, aged 16-35 years were analysed. Four of the patients had palpable testicular tumors, 3 had occult testicular tumors...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000475015
更新日期:1995-01-01 00:00:00
abstract::In this retrospective study the relationship between serum prostate-specific antigen (PSA) and tumour volume (assessed by the planimetric method on whole mount section) was analysed in 56 patients subjected to radical prostatectomy, of whom 28 received 3 months of neoadjuvant GnRH analogue (triptorelin) treatment. Ser...
journal_title:European urology
pub_type: 临床试验,杂志文章
doi:10.1159/000475337
更新日期:1994-01-01 00:00:00