Effects of 3 months' neoadjuvant hormonal treatment with a GnRH analogue (triptorelin) prior to radical retropubic prostatectomy on prostate-specific antigen and tumour volume in prostate cancer.

Abstract:

:In this retrospective study the relationship between serum prostate-specific antigen (PSA) and tumour volume (assessed by the planimetric method on whole mount section) was analysed in 56 patients subjected to radical prostatectomy, of whom 28 received 3 months of neoadjuvant GnRH analogue (triptorelin) treatment. Serum PSA in the control group was strongly correlated to the tumour volume while no such correlation was found after hormonal pretreatment (r = 0.84 vs. 0.18), indicating that serum PSA is unreliable as a tumour marker after hormonal deprivation. When the pretreatment PSA (before hormonal deprivation) per tumour volume ratio was calculated, a group of 10 patients (36%) showed considerably higher values, suggesting true tumour volume reduction in those patients as a result of the neoadjuvant hormonal treatment.

journal_name

Eur Urol

journal_title

European urology

authors

Aus G,Brändstedt S,Häggman M,Pedersen K,de la Torre M,Hugosson J

doi

10.1159/000475337

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

22-8

issue

1

eissn

0302-2838

issn

1873-7560

journal_volume

26

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章

    doi:

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  • The Incremental Role of Magnetic Resonance Imaging for Prostate Cancer Staging before Radical Prostatectomy.

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  • Paratesticular rhabdomyosarcoma in adolescents.

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    pub_type: 杂志文章,评审

    doi:

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    更新日期:1988-01-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    pub_type: 杂志文章

    doi:

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  • The impact of androgen deprivation therapy on health related quality of life in asymptomatic men with lymph node positive prostate cancer.

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    pub_type: 临床试验,杂志文章,随机对照试验

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