Abstract:
:The advantages and disadvantages of two different methods of analyzing the European Randomized Study of Screening for Prostate Cancer (ERSPC) trial with respect to the effect of prostate-specific antigen (PSA) screening on prostate cancer (PCa) mortality (ie, disease-specific mortality analysis and excess mortality analysis) are discussed in depth. The traditional disease-specific mortality is the best end point, but it could be biased by misclassification of causes of death, and it does not take into account the possible effect of the screening process on other causes of death. Excess mortality analysis overcomes these problems, but the results could be biased if the expected mortality is not corrected for attendance status. Both methods, when applied to the ERSPC trials, demonstrate that no increase in non-PCa mortality occurred in the screening group and confirm that PSA screening decreases PCa mortality.
journal_name
Eur Uroljournal_title
European urologyauthors
Zappa M,Puliti D,Hugosson J,Schröder FH,van Leeuwen PJ,Kranse R,Auvinen A,Carlsson S,Kwiatkowski M,Nelen V,Paez Borda A,Roobol MJ,Villers Adoi
10.1016/j.eururo.2013.12.055subject
Has Abstractpub_date
2014-09-01 00:00:00pages
401-3issue
3eissn
0302-2838issn
1873-7560pii
S0302-2838(13)01480-2journal_volume
66pub_type
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