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Intramuscular diclofenac versus intravenous indomethacin in the treatment of acute renal colic.

Abstract：

OBJECTIVE:We have conducted a clinical trial to compare the pain-relieving effect and safety of diclofenac administered intramuscularly to indomethacin given intravenously. METHODS:The study was designed as a randomized single-blind trial. It was carried out at Oslo Emergency Hospital (outpatient setting or stay < 24 h). 41 patients with a mean age of 41.6 years received 75 mg diclofenac and 42 patients with a mean age of 45.2 years were given 50 mg indomethacin. The two groups were similar in regard to baseline characteristics except gender distribution. RESULTS:Statistically significant reduction in pain intensity was achieved after 5 min in the diclofenac group (p < 0.01), and after 10 min in the indomethacin group (p < 0.01). The probability of having pain after 1 h was 52% in the indomethacin group and 37% in the diclofenac group (p = 0.11). Rescue medication with pethidine after 2 h was given in 9 and 5 patients, respectively. Four patients in the diclofenac group reported one occurrence of adverse effect each, while 9 patients on indomethacin experienced 14 occurrences, mainly dizziness and nausea. CONCLUSION:These findings together with a simpler mode of administration indicate that diclofenac may be preferred in the analgesic treatment of renal colic.

journal_name

Eur Urol

journal_title

European urology

authors

Laerum E,Ommundsen OE,Grønseth JE,Christiansen A,Fagertun HE

doi

10.1159/000474196

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

358-62

issue

3

eissn

0302-2838

issn

1873-7560

journal_volume

30

pub_type

临床试验,杂志文章,随机对照试验

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