Cyproterone acetate lead-in prevents initial rise of serum testosterone induced by luteinizing hormone-releasing hormone analogs in the treatment of metastatic carcinoma of the prostate.

Abstract:

:Luteinizing hormone-releasing hormone (LH-RH) analogs are an effective treatment of metastatic carcinoma of the prostate. However, they induce an initial rise in serum testosterone responsible for 10-30% of diseases flares. The efficacy of the antiandrogen cyproterone acetate (CPA) was tested in 15 patients with metastatic carcinoma of the prostate. 10 patients were given 100 mg CPA t.i.d. from day 1 to 14 in association with the LH-RH analog Buserelin, 500 micrograms t.i.d., from day 7 to 14.5 patients were given CPA and Buserelin at the same doses from day 1 to 7. Serum testosterone determinations were obtained on days 1-7, 8, 11 and 14, at 08.00 h, and on days 8, 11, 1 h after each analog injection in group 1, and on days 1, 4 and 7 at 08.00 h and 1 h after each analog injection in group 2. All the patients were then treated by orchidectomy. Pretreatment with CPA blunted the initial rise of testosterone which never rose above pretreatment levels. Simultaneous treatment had no demonstrable effects on the rise of serum testosterone. It is concluded that pretreatment with CPA allows a safer use of LH-RH analogs in the treatment of metastatic carcinoma of the prostate.

journal_name

Eur Urol

journal_title

European urology

authors

Boccon-Gibod L,Laudat MH,Dugue MA,Steg A

doi

10.1159/000472667

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

400-2

issue

6

eissn

0302-2838

issn

1873-7560

journal_volume

12

pub_type

杂志文章
  • Association between HLA antigens and bladder tumors.

    abstract::HLA antigen type was studied in 55 patients with transitional cell carcinoma of the bladder. The results showed high HLA-B5 and low HLA-BW35 frequencies. Histological grade, stage, and recurrence rate of tumors were also evaluated separately. The results were more significant in recurrent tumors. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472775

    authors: Tokuç R,Akdaş A,Ozerkan K,Remzi D

    更新日期:1987-01-01 00:00:00

  • Ultrastructural changes of bladder cancer cells following methylene blue-sensitized photodynamic treatment.

    abstract::The cytotoxic efficacy of methylene blue-sensitized photoinactivation of bladder cancer cells has been proved in vitro and in vivo in our previous work. The ultrastructural changes of MBT-2 murine bladder cancer cells following methylene blue-sensitized phototherapy have been evaluated by scanning and transmission ele...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473652

    authors: Yu DS,Chang SY,Ma CP

    更新日期:1991-01-01 00:00:00

  • Image analysis in the determination of ploidy and prognosis in renal cell carcinoma.

    abstract::The usefulness of ploidy determination by flow cytometry in renal cell carcinoma is disputed. An alternative technique for DNA quantitation, computerised static image analysis, has several advantages over flow methods. Tissue from 90 cases of primary renal cell carcinoma was analysed by image analysis. Cases were assi...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474761

    authors: Lanigan DJ,McLean PA,Murphy DM,Donovan MG,Leader M

    更新日期:1992-01-01 00:00:00

  • Brainstem neural mechanisms of sleep and wakefulness.

    abstract::The three diffuse projection systems arising in the brainstem, that is, noradrenergic projection originating in the locus coeruleus, serotonergic projection from the dorsal raphe nucleus, and cholinergic projection from neurons gathering in the laterodorsal tegmental nucleus and scattering in the pedunculopontine tegm...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000052235

    authors: Kayama Y,Koyama Y

    更新日期:1998-01-01 00:00:00

  • Perioperative morbidity of the extended radical perineal prostatectomy.

    abstract:PURPOSE:Perioperative morbidity is an essential indicator for the quality of an operative technique. This fact is especially important in radical prostatectomy since different treatment modalities may provide similar outcome in terms of local tumor control. MATERIALS AND METHODS:The conventional type of radical perine...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000049764

    authors: Brehmer B,Borchers H,Kirschner-Hermanns R,Biesterfeld S,Jakse G

    更新日期:2001-08-01 00:00:00

  • Mucosal host responses to bacteriuria in colonic and ileal neobladders.

    abstract:OBJECTIVE:To study the local host response in patients with colonic and ileal neobladders, with or without bacteriuria. METHODS:Twenty-three patients with colonic neobladders and 19 with ileal neobladders were included. Eleven radical prostatectomy patients and seven healthy male volunteers were used as controls. Six ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.02.012

    authors: Wullt B,Bergsten G,Carstensen J,Gustafsson E,Gebratsedik N,Holst E,Månsson W

    更新日期:2006-11-01 00:00:00

  • Comparison of transperitoneal and extraperitoneal laparoscopic radical prostatectomy using match-pair analysis.

    abstract:PURPOSE:Based on the experience of 1000 cases of laparoscopic radical prostatectomy, we compared the operative parameters of transperitoneal and extraperitoneal approaches in match-paired patient groups. PATIENTS AND METHODS:We reviewed the charts of 53 consecutive patients who underwent selectively extraperitoneal la...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.05.004

    authors: Erdogru T,Teber D,Frede T,Marrero R,Hammady A,Seemann O,Rassweiler J

    更新日期:2004-09-01 00:00:00

  • Survival and Functional Stability in Chronic Kidney Disease Due to Surgical Removal of Nephrons: Importance of the New Baseline Glomerular Filtration Rate.

    abstract:BACKGROUND:Chronic kidney disease (CKD) can be associated with a higher risk of progression to end-stage renal disease and mortality, but the etiology of nephron loss may modify this. Previous studies suggested that CKD primarily due to surgical removal of nephrons (CKD-S) may be more stable and associated with better ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2015.04.043

    authors: Lane BR,Demirjian S,Derweesh IH,Takagi T,Zhang Z,Velet L,Ercole CE,Fergany AF,Campbell SC

    更新日期:2015-12-01 00:00:00

  • Sleep polygraphic studies using cystomanometry in twenty patients with enuresis.

    abstract::Polygraphic exploration during sleep using cystomanometry was performed in 20 patients aged 7-17 years with primary (17) or secondary (3) enuresis. In this group of patients, 9 presented with isolated nocturnal enuresis while 11 patients had associated diurnal micturition troubles. During this study we documented 24 e...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474272

    authors: Robert M,Averous M,Besset A,Carlander B,Billiard M,Guiter J,Grasset D

    更新日期:1993-01-01 00:00:00

  • Preferential preservation of bone mineralisation by LHRH agonists in the treatment of metastatic prostate cancer.

    abstract::Histomorphometric measurements of tumour-free bone have been undertaken in a closely matched group of patients with metastatic prostate cancer treated either by subcapsular orchidectomy (SCO) or luteinising hormone-releasing hormone (LHRH) agonists. Age, fasting morning urine hydroxyproline/creatinine ratios, alkaline...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473597

    authors: Clarke NW,McClure J,George NJ

    更新日期:1991-01-01 00:00:00

  • Neuroendocrine differentiation in hormone refractory prostate cancer following androgen deprivation therapy.

    abstract:OBJECTIVE:To evaluate the relationship between neuroendocrine differentiation (NED) status and hormone refractory prostate cancer (HRPC) following hormone therapy based on immunohistochemical study. METHODS:Seventy-two prostate cancer specimens obtained at radical prostatectomy and 21 prostate cancer autopsy specimens...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2003.11.032

    authors: Hirano D,Okada Y,Minei S,Takimoto Y,Nemoto N

    更新日期:2004-05-01 00:00:00

  • Laparo-endoscopic single-site left transperitoneal adrenalectomy.

    abstract::A 53-yr-old woman presented with abdominal pain. Ultrasonography, computed tomography, and an endocrinologic work-up revealed a 4-cm nonfunctional left adrenal mass. A TriPort laparoscopic adrenalectomy was performed. The TriPort was inserted through a 3-cm subcostal incision. Using 5-mm instruments, a left adrenalect...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2009.07.001

    authors: Cindolo L,Gidaro S,Tamburro FR,Schips L

    更新日期:2010-05-01 00:00:00

  • Patterns of stromal elements in an implanted ureteric transitional cell carcinoma. An immunohistochemical and ultrastructural study.

    abstract::The results of the study of three implanted ureteric tumors from a primary transitional cell carcinoma of the renal pelvis are reported. Using both light microscopic immunohistochemistry and transmission electron microscopy, the stroma of the tumor showed consistent evidence for the production of at least its collagen...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472741

    authors: Al-Zuhair AG,Al-Adnani MS,Al-Bader AA,Ek AG,Sabha M

    更新日期:1987-01-01 00:00:00

  • Exploring Variation in the Use of Conservative Management for Low-risk Prostate Cancer in the Veterans Affairs Healthcare System.

    abstract::Current guidelines recommend conservative management as the preferred option for most low-risk prostate cancer cases, with certain possible exceptions (age <55yr, African Americans, and high-volume grade group 1). Although previous studies have documented substantial heterogeneity in the uptake of conservative managem...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2020.02.004

    authors: Loeb S,Byrne NK,Wang B,Makarov DV,Becker D,Wise DR,Lepor H,Walter D

    更新日期:2020-06-01 00:00:00

  • alpha1- and alpha2-adrenoceptors in BPH.

    abstract::The dynamic obstruction of the bladder outlet secondary to benign prostatic hyperplasia (BPH), and the contractile properties of the human prostate are mediated primarily by alpha1-adrenoceptors. There are now at least three subtypes (A, B, and D) of alpha1-adrenoceptors, and recent work revealed that alpha1A-adrenoce...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000052315

    authors: Takeda M,Hatano A,Arai K,Obara K,Tsutsui T,Takahashi K

    更新日期:1999-01-01 00:00:00

  • Urinary hydroxyproline concentration in primary hyperparathyroidism with and without renal stones.

    abstract::Eleven cases with histologically confirmed primary hyperparathyroidism have been studied. Although histologically, bone turnover increased in all but 1 patient, urinary hydroxyproline excretion and serum alkaline phosphatase in patients with renal stones were within the upper normal limits of slightly elevated (27.5 m...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472103

    authors: Sommer-Tsilenis E

    更新日期:1977-01-01 00:00:00

  • Use of immunohistochemically demonstrated c-erb B-2 oncoprotein expression as a prognostic factor in transitional cell carcinoma of the urinary bladder.

    abstract::Formalin-fixed, paraffin-embedded specimens from 91 primary transitional cell cancers (TCC) of the urinary bladder were stained with a monoclonal antibody to c-erb B-2 oncoprotein. Twelve percent (11/91) of the TCC stained for c-erb b-2 oncoprotein, and in 4% (4/91) of cases, the expression was graded as moderate or h...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471706

    authors: Lipponen P,Eskelinen M,Syrjänen S,Tervahauta A,Syrjänen K

    更新日期:1991-01-01 00:00:00

  • Prevalence of and Risk Factors for Urinary Incontinence in Home Hospice Patients.

    abstract::Urinary incontinence (UI) is a debilitating and embarrassing condition that is prevalent among aging males and females. Little is known about UI in the home hospice setting. We sought to determine UI prevalence and risk factors in a cohort of 15432 home hospice patients over 4yr. Most of the study patients were female...

    journal_title:European urology

    pub_type: 信件

    doi:10.1016/j.eururo.2018.10.027

    authors: Chughtai B,Thomas D,Russell D,Bowles K,Prigerson H

    更新日期:2019-02-01 00:00:00

  • Total androgen blockade: the United States experience.

    abstract::Maximal androgen blockade may improve the effectiveness of treatment of prostate cancer. To test this hypothesis we conducted a randomized, double-blind trial in patients with disseminated and previously untreated prostate cancer (stage D2). All patients (n = 603) received leuprolide, 1 mg/day s.c. in combination with...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000474395

    authors: Benson RC

    更新日期:1993-01-01 00:00:00

  • Influence of photoselective vaporization of the prostate on sexual function: results of a prospective analysis of 149 patients with long-term follow-up.

    abstract:BACKGROUND:Even though transurethral resection of the prostate remains the gold standard treatment for lower urinary tract symptoms (LUTS) refractory to medical therapy, photoselective vaporization of the prostate (PVP) has become a popular alternative. Early PVP studies seem encouraging, but few data exist regarding t...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2010.04.027

    authors: Bruyère F,Puichaud A,Pereira H,Faivre d'Arcier B,Rouanet A,Floc'h AP,Bodin T,Brichart N

    更新日期:2010-08-01 00:00:00

  • Systematic review of adrenalectomy and lymph node dissection in locally advanced renal cell carcinoma.

    abstract:CONTEXT:Controversy remains over whether adrenalectomy and lymph node dissection (LND) should be performed concomitantly with radical nephrectomy (RN) for locally advanced renal cell carcinoma (RCC) cT3-T4N0M0. OBJECTIVE:To systematically review all relevant literature comparing oncologic, perioperative, and quality-o...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2013.04.033

    authors: Bekema HJ,MacLennan S,Imamura M,Lam TB,Stewart F,Scott N,MacLennan G,McClinton S,Griffiths TR,Skolarikos A,MacLennan SJ,Sylvester R,Ljungberg B,N'Dow J

    更新日期:2013-11-01 00:00:00

  • Two-year follow-up of a prospective randomised trial of electrovaporization versus resection of prostate.

    abstract:OBJECTIVES:Transurethral electrovaporization of the prostate (TUVP) has become a popular, minimally invasive procedure to treat BPH with promising initial results. This study was conducted to compare the efficacy, safety and durability of TUVP with standard TURP. We report the 2-year follow-up. METHODS:104 consecutive...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000019710

    authors: Hammadeh MY,Madaan S,Singh M,Philp T

    更新日期:1998-09-01 00:00:00

  • Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial.

    abstract:BACKGROUND:The extent of lymph node dissection (LND) in bladder cancer (BCa) patients at the time of radical cystectomy may affect oncologic outcome. OBJECTIVE:To evaluate whether extended versus limited LND prolongs recurrence-free survival (RFS). DESIGN, SETTING, AND PARTICIPANTS:Prospective, multicenter, phase-III...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.eururo.2018.09.047

    authors: Gschwend JE,Heck MM,Lehmann J,Rübben H,Albers P,Wolff JM,Frohneberg D,de Geeter P,Heidenreich A,Kälble T,Stöckle M,Schnöller T,Stenzl A,Müller M,Truss M,Roth S,Liehr UB,Leißner J,Bregenzer T,Retz M

    更新日期:2019-04-01 00:00:00

  • Prognostic value of Ki-67 expression in renal cell carcinomas.

    abstract:OBJECTIVE:The aim of the study was to determine the prognostic power of Ki-67 immunostaining in renal cell carcinomas (RCC). METHODS:Clinical follow-up data were reviewed in 111 RCC and the results of Ki-67 immunolabelling were correlated to standard prognostic factors and survival data of the patients. RESULTS:Ki-67...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474482

    authors: Aaltomaa S,Lipponen P,Ala-Opas M,Eskelinen M,Syrjänen K

    更新日期:1997-01-01 00:00:00

  • Evidence for eosinophil activation in eosinophilic cystitis.

    abstract::Eosinophilic cystitis (EC) is a rare condition. Recent studies have shown that activated eosinophils release cytotoxic cationic proteins which can induce tissue damage. Moreover, in vitro studies have shown that interleukin-5 (IL-5) is a cytokine able to attract and activate eosinophils. The goal of this study was to ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475293

    authors: Dubucquoi S,Janin A,Desreumaux P,Rigot JM,Copin MC,François M,Torpier G,Capron M,Gosselin B

    更新日期:1994-01-01 00:00:00

  • Functional evaluation of bladder neck disease.

    abstract::22 patients diagnosed as having bladder neck disease were evaluated retrospectively point of view. Urodynamic study including intravesical pressure, rectal pressure, intrinsic detrusor pressure and urine flow was performed in every case. A relation was established between the findings and the definite etiology. Two ur...

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Romero-Maroto J,Tallada-Buñuel M,Verdú-Tartajo F,Perales-Cabanas L,Escudero-Barrilero A,Romero-Aguirre C

    更新日期:1982-01-01 00:00:00

  • Describing the Grade of Prostate Cancer: Consistent Use of Contemporary Terminology Is Now Required.

    abstract::Editors of the major urological literature advocate the use of the recent Gleason Grade groupings when reporting analyses of prostate cancer. ...

    journal_title:European urology

    pub_type: 社论

    doi:10.1016/j.eururo.2016.03.007

    authors: Zietman A,Smith J,Klein E,Droller M,Dasgupta P,Catto J

    更新日期:2016-07-01 00:00:00

  • Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades.

    abstract:BACKGROUND:Prior studies assessing the correlation of Gleason score (GS) at needle biopsy and corresponding radical prostatectomy (RP) predated the use of the modified Gleason scoring system and did not factor in tertiary grade patterns. OBJECTIVE:To assess the relation of biopsy and RP grade in the largest study to d...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2012.01.050

    authors: Epstein JI,Feng Z,Trock BJ,Pierorazio PM

    更新日期:2012-05-01 00:00:00

  • Randomized Trial Comparing Open Radical Cystectomy and Robot-assisted Laparoscopic Radical Cystectomy: Oncologic Outcomes.

    abstract:BACKGROUND:Open radical cystectomy (ORC) has proven to be an important component in the treatment of high-risk bladder cancer (BCa). ORC surgical morbidity remains high; therefore, minimally invasive surgical techniques have been introduced in an attempt to improve patient outcomes. OBJECTIVE:To compare cancer outcome...

    journal_title:European urology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.eururo.2018.04.030

    authors: Bochner BH,Dalbagni G,Marzouk KH,Sjoberg DD,Lee J,Donat SM,Coleman JA,Vickers A,Herr HW,Laudone VP

    更新日期:2018-10-01 00:00:00

  • Clinical experience with the N-shaped ileal neobladder: assessment of complications, voiding patterns, and quality of life in our series of 58 patients.

    abstract:PURPOSE:The purpose of this retrospective study was to assess complications, voiding patterns, and quality of life in patients with an orthotopic bladder substitution, using an N-shaped ileal neobladder. MATERIALS AND METHODS:Between May 1996 and December 2002, 58 patients (52 men and 6 women) underwent an orthotopic ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.12.006

    authors: Joniau S,Benijts J,Van Kampen M,De Waele M,Ooms J,Van Cleynenbreugel B,Van Poppel H

    更新日期:2005-05-01 00:00:00