Improved Reporting of Randomized Controlled Trials in the Urologic Literature.

Abstract:

BACKGROUND:Well-designed randomized controlled trials (RCTs) have the potential to provide high-quality evidence to inform questions of therapy and prevention, but this potential is contingent on the use of appropriate methods and transparent reporting. OBJECTIVE:To systematically assess the quality of urology RCT reporting and identify trends over time. DESIGN, SETTING, AND PARTICIPANTS:All RCTs published in four leading urology journals in 2013 were identified and compared to a prior analysis of studies from 1996 and 2004. Two reviewers abstracted data based on the Consolidated Standards of Reporting Trials (CONSORT) checklist. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:A summary reporting score (range: 0-22) for each study was determined. Mean overall scores for 1996, 2004, and 2013 were compared using analysis of variance. We used χ2 to compare the reporting frequency of individual criteria. RESULTS AND LIMITATIONS:Mean CONSORT scores for RCTs were 15.6±2.0 in 2013 (n=82), 12.0±0.3 in 2004 (n=87), and 10.2±0.3 in 1996 (n=65); p<0.01. Key deficiencies remain in reporting methods of allocation concealment and group assignment (selection bias), and blinding of participants, personnel, and outcome assessors (performance and detection bias). Study limitations are potential reviewer bias resulting from lack of journal deidentification and the relatively low number of studies reviewed. CONCLUSIONS:There has been a substantial improvement in reporting quality of RCTs in urology since CONSORT. Some methodological criteria remain underreported, and increased efforts are necessary to further this improvement. PATIENT SUMMARY:Treatment decisions are often based on data from randomized controlled trials. We looked at whether these trials in urology are transparent in reporting their design and conduct using a framework known as the CONSORT criteria and found significant improvements over time. Some areas of deficiency remain, and our paper aimed to highlight these drawbacks to promote continued high-quality research.

journal_name

Eur Urol

journal_title

European urology

authors

Narayan VM,Cone EB,Smith D,Scales CD Jr,Dahm P

doi

10.1016/j.eururo.2016.07.042

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1044-1049

issue

6

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(16)30447-X

journal_volume

70

pub_type

杂志文章
  • Value of ultrasound-guided systematic sextant biopsies in prostate tumor mapping.

    abstract:OBJECTIVE:To determine the value of positive sextant biopsies in assessing the location of prostate tumors within radical prostatectomy specimens and to determine if prostate weight influences the results. METHODS:From 1988 to 1996, 166 radical prostatectomies were performed for localized prostate cancer diagnosed by ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019863

    authors: Salomon L,Colombel M,Patard JJ,Lefrère-Belda MA,Bellot J,Chopin D,Abbou CC

    更新日期:1999-04-01 00:00:00

  • The alteration of urine composition due to stone material present in the urinary tract.

    abstract:OBJECTIVES:Based on a recently introduced mathematical model approach we show that uroliths located in the urinary tract (UT) can substantially deplete the urinary concentrations of lithogenic constituents by continuous growth. METHODS:To illustrate the influence of the urinary depletion effect on urinalysis, a "typic...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(03)00365-8

    authors: Laube N,Pullmann M,Hergarten S,Schmidt M,Hesse A

    更新日期:2003-11-01 00:00:00

  • Upper tract tumours in patients with vesico-ureteral reflux and recurrent bladder tumours.

    abstract::27 patients with recurrent low-grade, low-stage transitional cell carcinoma (TCC) of the bladder and uni- or bilateral vesico-ureteral reflux were followed for up to 18 years in order to study a possible higher incidence of TCC of the upper tract. None of the patients developed tumours of the upper collecting system d...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472439

    authors: Mukamel E,Nissenkorn I,Glanz I,Vilcovsky E,Servadio C

    更新日期:1985-01-01 00:00:00

  • Prevention and management of postprostatectomy sexual dysfunctions part 2: recovery and preservation of erectile function, sexual desire, and orgasmic function.

    abstract:CONTEXT:Sexual dysfunction is common in patients who undergo radical prostatectomy (RP) for prostate cancer (PCa). OBJECTIVE:Review the available literature concerning prevention of, and management strategies for, post-RP sexual dysfunction in terms of postoperative treatments for erectile function (EF), sexual desire...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2012.04.047

    authors: Salonia A,Burnett AL,Graefen M,Hatzimouratidis K,Montorsi F,Mulhall JP,Stief C

    更新日期:2012-08-01 00:00:00

  • Antiandrogens as monotherapy for prostate cancer.

    abstract::Castration or antiandrogen monotherapies remain options for prostate cancer treatment as only marginal benefits have been demonstrated with combined androgen blockade, although it may be that certain subgroups of patient may benefit. Of the nonsteroidal antiandrogens, bicalutamide 150 mg was as effective as castration...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000052291

    authors: Schröder FH

    更新日期:1998-01-01 00:00:00

  • Diagnostic value of computerised isotopic section renal scanning.

    abstract::Isotope section renal scanning in the diagnosis of kidney disease has been compared with ultrasonic examination adn specialised radiological techniques. The computerised isotope tomographic section technique developed in Aberdeen has increased the accuracy and differential diagnosis of renal lesions especially cysts a...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472118

    authors: MacDonald AF,Keyes WI,Mallard JR,Steyn JH

    更新日期:1977-01-01 00:00:00

  • Inflammation in prostate biopsies of men without prostatic malignancy or clinical prostatitis: correlation with total serum PSA and PSA density.

    abstract:OBJECTIVE:Inflammation is a frequent histological finding in prostate biopsies, performed on men without prostatic malignancy or clinical prostatitis. We investigated the relationship between morphological parameters of inflammation in prostatic tissue and total serum prostate-specific antigen (PSA) and prostate-specif...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000020161

    authors: Schatteman PH,Hoekx L,Wyndaele JJ,Jeuris W,Van Marck E

    更新日期:2000-04-01 00:00:00

  • Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer.

    abstract:BACKGROUND:Metastatic castration-resistant prostate cancer (mCRPC) is the lethal form of the disease. Several recent studies have identified genomic alterations in mCRPC, but the clinical implications of these genomic alterations have not been fully elucidated. OBJECTIVE:To use whole-genome sequencing (WGS) to assess ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2019.03.020

    authors: Chen WS,Aggarwal R,Zhang L,Zhao SG,Thomas GV,Beer TM,Quigley DA,Foye A,Playdle D,Huang J,Lloyd P,Lu E,Sun D,Guan X,Rettig M,Gleave M,Evans CP,Youngren J,True L,Lara P,Kothari V,Xia Z,Chi KN,Reiter RE,Maher

    更新日期:2019-11-01 00:00:00

  • Pathologic Outcomes in Favorable-risk Prostate Cancer: Comparative Analysis of Men Electing Active Surveillance and Immediate Surgery.

    abstract:BACKGROUND:It remains unclear whether men selecting active surveillance (AS) are at increased risk of unfavorable longer term outcomes as compared with men who undergo immediate treatment. OBJECTIVE:To compare adverse pathologic outcomes in men with favorable-risk prostate cancer who underwent delayed prostatectomy af...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2015.09.032

    authors: Tosoian JJ,Sundi D,Trock BJ,Landis P,Epstein JI,Schaeffer EM,Carter HB,Mamawala M

    更新日期:2016-04-01 00:00:00

  • Modified pubovaginal sling and Martius graft for repair of the recurrent vesicovaginal fistula involving the internal urinary sphincter.

    abstract::A modified Martius graft interposition flap was used in conjunction with the modified pubovaginal sling bladder suspension to treat a recurrent vesicovaginal fistula involving the proximal urethra and bladder neck. The patient recovered with no incontinence, voiding dysfunction or dyspareunia. Incontinence should be a...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475169

    authors: Ghoniem GM,Monga M

    更新日期:1995-01-01 00:00:00

  • Laparoscopic surgery versus antegrade scrotal sclerotherapy: Retrospective comparison of two different approaches for varicocele treatment.

    abstract:OBJECTIVE:Both laparoscopic surgery and antegrade sclerotherapy are effective treatment options in the management of varicoceles. However, very limited data comparing these two approaches are available in the literature. We present our experience regarding outcome and complications with each treatment modality. PATIEN...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.10.023

    authors: May M,Johannsen M,Beutner S,Helke C,Braun KP,Lein M,Roigas J,Hoschke B

    更新日期:2006-02-01 00:00:00

  • Guidelines on erectile dysfunction.

    abstract::The introduction of new oral therapies has completely changed the diagnostic and therapeutic approach to erectile dysfunction. A panel of experts in this field have developed guidelines for clinical evaluation and treatment based on the review of available scientific information. ...

    journal_title:European urology

    pub_type: 指南,杂志文章,实务指引

    doi:10.1016/s0302-2838(01)00008-2

    authors: Wespes E,Amar E,Hatzichristou D,Montorsi F,Pryor J,Vardi Y,European Association of Urology.

    更新日期:2002-01-01 00:00:00

  • Long-term outcomes of patients with lymph node metastasis treated with radical prostatectomy without adjuvant androgen-deprivation therapy.

    abstract:BACKGROUND:The presence of lymph node metastasis (LNM) at radical prostatectomy (RP) is associated with poor outcome, and optimal treatment remains undefined. An understanding of the natural history of node-positive prostate cancer (PCa) and identifying prognostic factors is needed. OBJECTIVE:To assess outcomes for pa...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2013.03.053

    authors: Touijer KA,Mazzola CR,Sjoberg DD,Scardino PT,Eastham JA

    更新日期:2014-01-01 00:00:00

  • Treatment of anterior vaginal wall prolapse with porcine skin collagen implant by the transobturator route: preliminary results.

    abstract:OBJECTIVE:To assess the feasibility and efficacy of porcine skin collagen (Pelvicol) implant by the transobturator route for the treatment of anterior vaginal wall prolapse. PATIENTS AND METHODS:Twenty-seven women with stage III or IV prolapse underwent anterior vaginal wall repair with porcine skin collagen implantat...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2003.09.005

    authors: Salomon LJ,Detchev R,Barranger E,Cortez A,Callard P,Darai E

    更新日期:2004-02-01 00:00:00

  • Long-term Outcomes After Bladder-preserving Tri-modality Therapy for Patients with Muscle-invasive Bladder Cancer: An Updated Analysis of the Massachusetts General Hospital Experience.

    abstract:BACKGROUND:Tri-modality therapy (TMT) is a recognized treatment strategy for selected patients with muscle-invasive bladder cancer (MIBC). OBJECTIVE:Report long-term outcomes of patients with MIBC treated by TMT. DESIGN, SETTING, AND PARTICIPANTS:Four hundred and seventy-five patients with cT2-T4a MIBC were enrolled ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2016.12.020

    authors: Giacalone NJ,Shipley WU,Clayman RH,Niemierko A,Drumm M,Heney NM,Michaelson MD,Lee RJ,Saylor PJ,Wszolek MF,Feldman AS,Dahl DM,Zietman AL,Efstathiou JA

    更新日期:2017-06-01 00:00:00

  • Multiorgan failure 17 years after initial stone therapy: forgotten ureteral stent in a horseshoe kidney.

    abstract::We report on the case of a 44-yr-old white man who was referred as an emergency from a local hospital to the medical intensive care unit (ICU) at our institution for progressive multiorgan failure of unknown cause. The CT scan of the abdomen showed a horseshoe kidney with extensive stone formation in both kidneys and ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.01.040

    authors: Pühse G,Piechota H,Scheffold C,Kloska S,Hertle L,Wülfing C

    更新日期:2007-12-01 00:00:00

  • Tumour-associated antibodies against renal cell carcinomas detected by immunofluorescence.

    abstract::Serum from 39 of 288 (13.5%) cancer patients contained antibodies detectable by immunofluorescence which reacted with frozen tumour sections from kidneys, prostate glands and ovaries. The serum did not react against areas of normal kidney taken from the same diseased organ. In comparison, 0.7% of normal persons and 3....

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Ackermann R

    更新日期:1975-01-01 00:00:00

  • The relationships among filling, voiding subscores from International Prostate Symptom Score and quality of life in Japanese elderly men and women.

    abstract:OBJECTIVES:Lower urinary tract symptoms (LUTS) are reported to influence the quality of life (QoL) of the elderly. The aim of this study was to elucidate the relationships among filling problems, voiding problems and QoL in elderly men and women. METHODS:A total of 450 males and 228 females, aged 50 years or older res...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00438-4

    authors: Okamura K,Usami T,Nagahama K,Maruyama S,Mizuta E

    更新日期:2002-11-01 00:00:00

  • Identification of androgen receptors in the motoneurons of the external urethral sphincter in the spinal cord of female rats.

    abstract:OBJECTIVES:In women, aging is associated with profound hormonal changes. Menopause has been implicated in the etiology of urinary tract complaints including incontinence, urgency and recurrent urinary tract infections. However, the use of hormone replacement therapy for these conditions has given conflicting and disapp...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.07.004

    authors: Blanchet P,Yaici el-D,Cayzergues L,Giuliano F,Jardin A,Benoit G,Droupy S

    更新日期:2005-01-01 00:00:00

  • Clinical Outcomes of Castration-resistant Prostate Cancer Treatments Administered as Third or Fourth Line Following Failure of Docetaxel and Other Second-line Treatment: Results of an Italian Multicentre Study.

    abstract:BACKGROUND:The availability of new agents (NAs) active in patients with metastatic castration-resistant prostate cancer (mCRPC) progressing after docetaxel treatment (abiraterone acetate, cabazitaxel, and enzalutamide) has led to the possibility of using them sequentially to obtain a cumulative survival benefit. OBJEC...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2014.10.014

    authors: Caffo O,De Giorgi U,Fratino L,Alesini D,Zagonel V,Facchini G,Gasparro D,Ortega C,Tucci M,Verderame F,Campadelli E,Lo Re G,Procopio G,Sabbatini R,Donini M,Morelli F,Sartori D,Zucali P,Carrozza F,D'Angelo A,Vicario

    更新日期:2015-07-01 00:00:00

  • Two-year follow-up of a prospective randomised trial of electrovaporization versus resection of prostate.

    abstract:OBJECTIVES:Transurethral electrovaporization of the prostate (TUVP) has become a popular, minimally invasive procedure to treat BPH with promising initial results. This study was conducted to compare the efficacy, safety and durability of TUVP with standard TURP. We report the 2-year follow-up. METHODS:104 consecutive...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000019710

    authors: Hammadeh MY,Madaan S,Singh M,Philp T

    更新日期:1998-09-01 00:00:00

  • Treatment of uretero-intestinal and ureterovesical strictures by Acucise balloon catheter.

    abstract:OBJECTIVE:Acucise balloon catheter has been proposed as an alternative to open surgery for the treatment of strictures of the ureteropelvic junction because of its low morbidity and the short hospital stay following the endoscopic procedure. The objective of this study was to evaluate the results of this technique appl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00070-2

    authors: Touiti D,Gelet A,Deligne E,Fassi-Fehri H,Benrais H,Martin X,Dubernard JM

    更新日期:2002-07-01 00:00:00

  • Immunologic aspect of testicular torsion: detection of antisperm antibodies in contralateral testicle.

    abstract:OBJECTIVE:To evaluate the immunologic etiology in unilateral testicular torsion, an experimental study in rats was carried out. MATERIALS AND METHODS:75 adult Wistar rats included in the study program were divided into six different groups according to a torsion-detorsion procedure. Torsion degree was kept constant fo...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000020060

    authors: Koşar A,Küpeli B,Alçigir G,Ataoglu H,Sarica K,Küpeli S

    更新日期:1999-12-01 00:00:00

  • A preoperative prognostic model for patients treated with nephrectomy for renal cell carcinoma.

    abstract:BACKGROUND:Currently two pretreatment prognostic models with limited accuracy (65-67%) can be used to predict survival in patients with localized renal cell carcinoma (RCC). OBJECTIVE:We set out to develop a more accurate pretreatment model for predicting RCC-specific mortality after nephrectomy for all stages of RCC....

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2008.07.037

    authors: Karakiewicz PI,Suardi N,Capitanio U,Jeldres C,Ficarra V,Cindolo L,de la Taille A,Tostain J,Mulders PF,Bensalah K,Artibani W,Salomon L,Zigeuner R,Valéri A,Descotes JL,Rambeaud JJ,Méjean A,Montorsi F,Bertini R,Patard

    更新日期:2009-02-01 00:00:00

  • Active surveillance of small renal masses: progression patterns of early stage kidney cancer.

    abstract:BACKGROUND:Most early stage kidney cancers are renal cell carcinomas (RCCs), and most are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence suggests that most small RCCs grow slowly and rarely metastasize. OBJECTIVE:To determine the progression and growth rates for newly diagnosed SRMs ...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2011.03.030

    authors: Jewett MA,Mattar K,Basiuk J,Morash CG,Pautler SE,Siemens DR,Tanguay S,Rendon RA,Gleave ME,Drachenberg DE,Chow R,Chung H,Chin JL,Fleshner NE,Evans AJ,Gallie BL,Haider MA,Kachura JR,Kurban G,Fernandes K,Finelli A

    更新日期:2011-07-01 00:00:00

  • Frequency analysis of the electromyographic activity in striated pelvic floor muscles: a preliminary report.

    abstract::A power spectrum of the electromyographic signals in urethral and anal sphincters has been analyzed in 25 patients. Different spectra are observed in each muscle, with higher frequencies in the urethral sphincter. The high frequencies are manifest at short brisk contractions (e.g. cough) and disappear quicly during a ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472130

    authors: Vereecken RL,Ketelaer P,Joossens J,Leruitte A

    更新日期:1977-01-01 00:00:00

  • A Systematic Review of Virtual Reality Simulators for Robot-assisted Surgery.

    abstract:CONTEXT:No single large published randomized controlled trial (RCT) has confirmed the efficacy of virtual simulators in the acquisition of skills to the standard required for safe clinical robotic surgery. This remains the main obstacle for the adoption of these virtual simulators in surgical residency curricula. OBJE...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2015.09.021

    authors: Moglia A,Ferrari V,Morelli L,Ferrari M,Mosca F,Cuschieri A

    更新日期:2016-06-01 00:00:00

  • ETS gene fusions in prostate cancer: from discovery to daily clinical practice.

    abstract:CONTEXT:In 2005, fusions between the androgen-regulated transmembrane protease serine 2 gene, TMPRSS2, and E twenty-six (ETS) transcription factors were discovered in prostate cancer. OBJECTIVE:To review advances in our understanding of ETS gene fusions, focusing on challenges affecting translation to clinical applica...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2009.04.036

    authors: Tomlins SA,Bjartell A,Chinnaiyan AM,Jenster G,Nam RK,Rubin MA,Schalken JA

    更新日期:2009-08-01 00:00:00

  • Retinoids in chemoprevention.

    abstract::Over several decades, in vitro experimental studies have demonstrated that retinoids effect the process of carcinogenesis and tend towards the alteration of cells back to more normal differentiation. This hypothesis has formed the basis of several chemopreventive studies in breast cancer, cervical cancer, head and nec...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000019874

    authors: Whelan P

    更新日期:1999-01-01 00:00:00

  • Two-year results of transurethral resection of the prostate versus four 'less invasive' treatment options.

    abstract:OBJECTIVE:The aim of this study was to compare the efficacy or transurethral resection of the prostate (TURP) versus four less invasive treatment options during a 2-year follow-up. MATERIAL AND METHODS:95 elderly men with lower urinary tract symptoms due to benign prostatic hyperplasia (BPH) were assigned prospectivel...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000020220

    authors: Schatzl G,Madersbacher S,Djavan B,Lang T,Marberger M

    更新日期:2000-06-01 00:00:00