Pulpal and periapical tissue reactions after experimental pulpal exposure in rats.

Abstract:

:The purpose of this study was to investigate histologically and histometrically the changes in pulpal and periapical tissues after pulpal exposure in rats. All animals received a pulpal exposure in the left mandibular first molar. Animals were killed at 1 to 56 days after pulpal exposure, and their mandibles were evaluated histologically and histometrically. Histologically, pulpal necrosis extended gradually from the upper part of the pulpal tissue to the apex, with inflammation starting in the periapical tissue at an early stage. As the periapical lesion developed, alveolar bone and cementum resorption was also found. Histometrically, the length of pulpal necrosis increased gradually from 1 to 28 days. The vertical length of the periapical lesion after 14 days was significantly increased, while the horizontal length and the overall area after 7 days were also significantly increased. The periapical lesion extended in a mesiodistal direction at first and then in a vertical direction before expansion ceased.

journal_name

J Endod

journal_title

Journal of endodontics

authors

Yamasaki M,Kumazawa M,Kohsaka T,Nakamura H,Kameyama Y

doi

10.1016/s0099-2399(06)80020-8

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

13-7

issue

1

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(06)80020-8

journal_volume

20

pub_type

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