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The role of heme oxygenase-1 in the proliferation and odontoblastic differentiation of human dental pulp cells.

Abstract：

INTRODUCTION:It was recently reported that heme oxygenase-1 (HO-1) activity is related to stem cell differentiation; however, the involvement of HO-1 in pulp cell growth and differentiation has not been well explored. The purpose of this study was to investigate the role of HO-1 in the growth and differentiation of human dental pulp cells (HDPCs). METHODS:We evaluated cell growth by MTT assay, mineralization by alizarin red staining, and differentiation marker mRNA expression by reverse transcriptase polymerase chain reaction. RESULTS:HO-1 induction by cobaltic protoporphyrin IX (CoPP) in HDPCs increased cell growth and mineralization and up-regulated the messenger RNA expression of such odontoblastic markers as alkaline phosphatase, osteopontin, bone sialoprotein, dentin matrix protein-1, and dentin sialophosphoprotein. Carbon monoxide scavenger, iron chelator, HO-1 inhibitor, and HO-1 small interfering RNA (siRNA) attenuated HDPC growth and differentiation. CONCLUSIONS:CoPP treatment results in dental pulp cell proliferation and odontoblast differentiation that appears partly mediated by HO-1. Our results suggest that odontoblastic differentiation and growth are positively regulated by HO-1 induction and negatively regulated by HO-1 inhibition. Thus, pharmacologic HO-1 induction might represent a potent therapeutic approach for pulp capping and the regeneration of HDPCs.

journal_name

J Endod

journal_title

Journal of endodontics

authors

Kim SJ,Min KS,Ryu HW,Lee HJ,Kim EC

doi

10.1016/j.joen.2010.04.011

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

1326-31

issue

8

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(10)00383-3

journal_volume

36

pub_type

杂志文章

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