Abstract：
:Plasminogen activator converts plasminogen to plasmin, and plasmin activates the latent matrix metalloproteinases. Tissue plasminogen activator (t-PA) is one of the important proteolysis factors present in human inflamed tissues. However, few studies reported on the mechanisms of tissue destruction via a t-PA proteolysis pathway in pulpal and periapical diseases. The subsequent reactions leading to pulpal and periapical injury after the induction of proinflammatory cytokines remains to be elucidated. The aim of this study was to investigate the effects of interleukin-1alpha and tumor necrosis factor-alpha on the expression of t-PA mRNA gene in cultured human pulp and gingival fibroblasts. The mRNAs for t-PA were measured by reverse transcription-polymerase chain reaction at 2, 6, and 24 h. The results show that both cytokines induced significantly high levels of t-PA mRNA gene expression in human pulp fibroblasts. The peak of t-PA mRNA levels induced by both proinflammatory cytokines was at the 6-h incubation period. Interleukin-1alpha was found to be more effective in induction of t-PA gene expression than tumor necrosis factor-alpha. In addition, a similar induction pattern was also found in human gingival fibroblasts. These results indicate that proinflammatory cytokines can induce t-PA gene expression and such an effect may partially contribute to the destruction of pulpal and periapical tissues through dysregulated pericellular proteolysis. An understanding of the mechanism could not only further define the role of immune events in pulpal and periapical diseases but also have important implication for pharmacological intervention.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Chang YC,Yang SF,Huang FM,Tai KW,Hsieh YSdoi
10.1097/00004770-200302000-00007keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
114-7issue
2eissn
0099-2399issn
1878-3554pii
S0099-2399(05)60546-8journal_volume
29pub_type
杂志文章abstract：INTRODUCTION:Lipopolysaccharide (LPS) has been shown to regulate the function of odontoblasts. However, the molecular mechanisms of the effect of LPS on odontoblasts are poorly understood. Decorin (DCN), one of the major matrix proteoglycans, is known to affect the mineralization of teeth. In this study, we investigate...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2011.12.021
更新日期：2012-04-01 00:00:00
abstract：:This study highlighted the characteristics and distribution of cracked tooth syndrome (CTS) and the associated factors in adult attendees in the University of Nigeria Teaching Hospital. Three hundred seventy patients aged 18 years to 77 years with CTS-like conditions were included and studied over 12 months. The follo...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2008.12.011
更新日期：2009-03-01 00:00:00
abstract：INTRODUCTION:In this study, we investigated if apical periodontitis (AP) associated with diabetes influenced the levels of endogenous antioxidants, the total antioxidant capacity (TAC), and the oxidant parameter in the serum of Wistar rats. METHODS:Forty male rats were divided into 4 equal groups: normal rats (N), rat...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2017.05.014
更新日期：2017-10-01 00:00:00
abstract：INTRODUCTION:Teeth undergoing initial endodontic therapy have a very high survival rate. Some teeth that continue to show signs of pathosis after the initial therapy will require nonsurgical (orthograde) retreatment. Outcome assessment of endodontic retreatment is crucial for appropriate case selection and treatment pl...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2010.02.009
更新日期：2010-05-01 00:00:00
abstract：INTRODUCTION:The goal of replantation after dental avulsion is to maintain the tooth in its socket. Presence of vital periodontal ligament cells on the root surface of the replanted tooth and the immunologic status of the patient are factors that protect against root resorption. It is known that dental constituents pla...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.09.020
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to establish a stable experimental mice pulpal inflammatory model and to evaluate inflammatory reactions of pulpal tissue after pulpal exposure. METHODS:Pulpal inflammation was induced in 80 C57BL/6 mice by occlusal exposure of the pulp of the maxillary first molar. The mice ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.09.003
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess 2 cone-beam computed tomographic systems on the detection of artificially induced vertical root fractures (VRFs) and artifact intensity using birooted teeth restored with different intracanal materials. METHODS:The sample consisted of 20 extracted birooted premolars. Ro...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2019.10.028
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:This in vitro study compared the cyclic fatigue resistance of ProFile Vortex rotary instruments (DENTSPLY Tulsa Dental, Tulsa, OK) made of two different raw materials: M-Wire and regular superelastic wire (SE-wire) at two different rotational speeds. Two rotary-based Profile Vortex instruments with taper 0...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2010.02.015
更新日期：2010-07-01 00:00:00
abstract：:The purpose of this study was to evaluate the ultramorphological and chemical changes in Er,Cr:YSGG laser-treated radicular dentin in comparison with two different irrigation regimes. Extracted human premolars were assigned into three experimental groups. Group 1: After each file size, root canals were irrigated with ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2005.08.005
更新日期：2006-05-01 00:00:00
abstract：INTRODUCTION:Platelet-rich plasma (PRP) has been widely used in regenerative dentistry for over 2 decades. Nevertheless, previous studies have shown that its growth factor content is released over a short time period, and the application of anticoagulants limits its regenerative potential. Therefore, a second-generatio...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2019.04.002
更新日期：2019-08-01 00:00:00
abstract：INTRODUCTION:Root canal therapy is a highly successful in-office treatment and preventive measure against periapical abscesses. Left untreated, periapical abscesses can have serious consequences that can lead to hospitalization. This study observes the trends of hospitalizations attributed to periapical abscesses. MET...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.04.042
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:Porphyromonas gingivalis and Tannerella forsythia are anaerobic bacteria commonly involved in root canal infections. Although previous investigations have assessed these species by strictly qualitative approaches, accurate determination of their cell levels by a sensitive quantitative technique may contrib...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2009.08.005
更新日期：2009-11-01 00:00:00
abstract：:A comparison of the microleakage of mineral trioxide aggregate (MTA) and a high copper admix amalgam (Valiant PhD) in root-end preparations was made using a fluid conductive device. Thirty-three bilaterally matched pairs of extracted, single-rooted teeth were prepared and obturated using lateral compaction of gutta-pe...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(98)80160-X
更新日期：1998-11-01 00:00:00
abstract：INTRODUCTION:Information on the nerve fibers innervating the dental pulp is crucial for understanding dental pain and hypersensitivity. This study investigated the morphologic differences of parvalbumin (PV)-positive (+) myelinated fibers in 3 different regions of the human dental pulp. METHODS:Light and electron micr...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2017.01.010
更新日期：2017-06-01 00:00:00
abstract：:A degree of uncertainty exists about the use of cotton pellets in the pulp chamber after canal obturation. The purpose of this study was to poll practicing endodontists and generalists regarding their preference. Forty-six endodontists and an equal number of general dentists were polled in a mail survey regarding thei...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200209000-00007
更新日期：2002-09-01 00:00:00
abstract：:A technique using K files with modified tips has been developed for the penetration of constricted canals. The tip of a #10 K file was sliced diagonally to make it thinner. Because this modified K file has an especially fine tip and an appropriate stiffness, it followed constricted or sharply curved canals well and ha...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(97)80190-2
更新日期：1997-06-01 00:00:00
abstract：:Unlike most cases of combined orthodontic and endodontic therapy that have been reported, in this case endodontic treatment with calcium hydroxide-induced calcification was utilized prior to orthodontic treatment. A 14-yr-old female required orthodontic therapy due to anterior crowding. Preoperative periapical radiogr...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(06)80290-6
更新日期：1994-05-01 00:00:00
abstract：INTRODUCTION:This ex vivo study compared the disinfection and shaping abilities of 2 preparation protocols in C-shaped canals. METHODS:Mandibular second molars with type I C-shaped canals were pair matched based on micro-computed tomographic (micro-CT) analysis and distributed into 2 groups. The canals were contaminat...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2020.11.007
更新日期：2020-11-18 00:00:00
abstract：:The purpose of this study was to compare clinical, radiographic, and histopathologic effects of Nd:YAG laser pulpotomy to formocresol pulpotomy on human primary teeth. Patients with at least two vital primary molar teeth that required pulpotomy, because of pulpal exposure to caries, were selected for this study. After...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2006.12.013
更新日期：2007-04-01 00:00:00
abstract：:A case study is presented that described an acute flare-up of a tooth following a vital bleaching procedure. The case illustrates (a) the importance of assessing the pulpal and periradicular status of a tooth prior to any vital bleaching procedure; and (b) the alteration of the local adaptation syndrome by the bleachi...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(06)80488-7
更新日期：1992-07-01 00:00:00
abstract：:A comparison was made of the apical leakage of three sealers. Fifty single-root human teeth were randomly divided into 5 groups (n = 10; 3 experimental and 2 control). The teeth of the positive-control and experimental groups were instrumented with K-type files to size 45. The experimental groups were obturated by lat...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200206000-00001
更新日期：2002-06-01 00:00:00
abstract：INTRODUCTION:The pulpal anesthetic success rates for an inferior alveolar nerve block (IANB) alone in patients presenting with symptomatic irreversible pulpitis are less than adequate. Nitrous oxide and clonidine have shown increases in IANB success when administered individually, but their success has not been evaluat...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2020.12.014
更新日期：2020-12-30 00:00:00
abstract：:The Editorial Board of the Journal of Endodontics has developed a literature-based study guide of topical areas related to endodontics. This study guide is intended to give the reader a focused review of the essential endodontic literature and does not cite all possible articles related to each topic. Although citing ...
journal_title：Journal of endodontics
pub_type： 杂志文章,评审
doi：10.1016/j.joen.2007.08.012
更新日期：2008-05-01 00:00:00
abstract：:An examination of 5616 endodontically treated and retreated maxillary first and second molars was made in an attempt to determine the percentage of MB2 canals that could be located routinely, and evaluate if there were any significant differences between initial treatments and retreatments. The teeth examined were 357...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/01.don.0000140581.38492.8b
更新日期：2005-04-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to analyze the features of lesions obtained from biopsies at the periapical area of teeth with a radiographic or clinical initial diagnosis of apical periodontitis. METHODS:A retrospective study was conducted on biopsies obtained from 1953-2018 at 3 Brazilian oral and maxillo...
journal_title：Journal of endodontics
pub_type： 杂志文章,多中心研究
doi：10.1016/j.joen.2020.01.003
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to investigate the potential of autologous mesenchymal bone marrow stem cells (BMSCs) to promote hard-tissue formation after direct pulp capping procedures. MATERIALS AND METHODS:Bone marrow was aspirated from the iliac crest of healthy dogs of nonspecific race. Mononuclear cells...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.12.012
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:Irrigation dynamics and antibacterial activity determine the efficacy of root canal disinfection. Sonic or ultrasonic agitation of irrigants is expected to improve irrigation dynamics. This study examined the effects of microbubble emulsion (ME) combined with sonic or ultrasonic agitation on irrigation dyn...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.07.007
更新日期：2012-11-01 00:00:00
abstract：:In the present study, we used Fos expression as an index of nociceptive input to the spinal trigeminal nucleus after exposure of the coronal pulp tissue of maxillary right first molars and examined the effects of pretreatment with an opioid, a nonsteroidal anti-inflammatory drug or a local anesthetic before pulp expos...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/01.don.0000153844.61709.64
更新日期：2005-08-01 00:00:00
abstract：INTRODUCTION:Odontoblasts produce dentin throughout life and in response to trauma. The purpose of this study was to identify the roles of endogenous Wnt signaling in regulating the rate of dentin accumulation. METHODS:Histology, immunohistochemistry, vital dye labeling, and histomorphometric assays were used to quant...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2019.07.014
更新日期：2019-11-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to investigate if nickel-titanium instruments with similar designs manufactured by different thermal treatments would exhibit significantly different in vitro behavior. METHODS:Thirty-six instruments each of ProTaper Universal (PTU F1; Dentsply Maillefer, Ballaigues, Switzerl...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.06.005
更新日期：2015-01-01 00:00:00
