Abstract:
INTRODUCTION:The pulpal anesthetic success rates for an inferior alveolar nerve block (IANB) alone in patients presenting with symptomatic irreversible pulpitis are less than adequate. Nitrous oxide and clonidine have shown increases in IANB success when administered individually, but their success has not been evaluated when used together. The purpose of this prospective, randomized, double-blind study was to determine the effect of nitrous oxide/oxygen plus an IANB using lidocaine/clonidine on the success of the IANB in patients with symptomatic irreversible pulpitis and to evaluate the effect of clonidine on blood pressure and pulse. METHODS:Sixty-two emergency patients experiencing moderate to severe pain and a diagnosis of symptomatic irreversible pulpitis were enrolled. Subjects were randomly divided into 2 groups and received nitrous oxide/oxygen and an IANB using 2% lidocaine with either 27 μg clonidine or 18 μg epinephrine as vasoconstrictors. Blood pressure and pulse were recorded before and during the emergency endodontic treatment. Anesthetic success was defined as no or mild pain upon access and instrumentation of the canals. RESULTS:The pulpal anesthetic success rate in both treatments was 58%, with no significant difference between the groups. There was no statistically significant difference in pulse or systolic blood pressure with the use of clonidine compared with epinephrine. Diastolic blood pressure was significant. CONCLUSIONS:The use of nitrous/oxide plus the addition of lidocaine/clonidine for the IANB in teeth with symptomatic irreversible pulpitis resulted in no statistically significant difference in anesthetic success of the IANB. There were no statistically significant differences in pulse or systolic blood pressure with the use of clonidine compared with epinephrine; diastolic blood pressure was significant.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
MacDonald E,Drum M,Nusstein J,Fowler S,Beck M,Reader Adoi
10.1016/j.joen.2020.12.014subject
Has Abstractpub_date
2020-12-30 00:00:00eissn
0099-2399issn
1878-3554pii
S0099-2399(20)30969-9pub_type
杂志文章abstract:INTRODUCTION:This study tested whether heat stress (42 degrees C for 30 minutes) induces reactive oxygen species (ROS), proinflammatory cytokines, Nrf2 activation, and Nrf2 target genes such as antioxidant enzymes in human dental pulp (HDP) cells. METHODS:ROS was evaluated by using flow cytometry. Proteins and messeng...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.06.005
更新日期:2009-09-01 00:00:00
abstract::The purpose of this study was to investigate histologically and histometrically the changes in pulpal and periapical tissues after pulpal exposure in rats. All animals received a pulpal exposure in the left mandibular first molar. Animals were killed at 1 to 56 days after pulpal exposure, and their mandibles were eval...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/s0099-2399(06)80020-8
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess the effect of nitrogen ion implantation on the flexibility of rotary nickel-titanium (NiTi) instruments as measured by the load required to bend implanted and nonimplanted instruments at a 30° angle. METHODS:Thirty K3 files, size #40, 0.02 taper and 25-mm length, were a...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.01.012
更新日期:2012-05-01 00:00:00
abstract::The influence of different obturation techniques (lateral condensation, Obtura, and Thermafil) on root strains was assessed in 27 upper central incisors using strain gauges mounted on the coronal and apical one-thirds of the root surface. The vertical load applied with each obturation technique was also measured. Comp...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81008-3
更新日期:1995-06-01 00:00:00
abstract::It is thought that externally applied bleaching agents may penetrate into the pulp chamber. This study was conducted to evaluate the diffusion of peroxide bleaching agents into the pulp chamber of teeth restored with various restorative materials. Sixty-five human extracted anterior maxillary teeth were separated into...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200002000-00008
更新日期:2000-02-01 00:00:00
abstract:INTRODUCTION:This study aimed to examine the dynamic recovery of established multispecies biofilms of oral bacteria after an initial treatment by D-enantiomeric peptide DJK-5, L-enantiomeric peptide 1018, or chlorhexidine digluconate (CHX). METHODS:Oral biofilms from 2 donors were grown on collagen-coated hydroxyapati...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2020.11.020
更新日期:2020-11-25 00:00:00
abstract:INTRODUCTION:In recent years, the inflammasome has been determined to play an important role in inflammatory diseases. However, the role of the inflammasome in pulpitis remains unclear. Absent in melanoma 2 (AIM2) is a type of inflammasome that recognizes cytosolic double stranded DNA and forms a caspase-1-activating i...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.07.003
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to investigate the effects of instrumentation and irrigation on the initial adherence of Enterococcus faecalis to root canal dentin and to explore initial microbial adhesion to root filling materials. METHODS:The following specimens were prepared: instrumented and uninstrumen...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.04.006
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess 2 cone-beam computed tomographic systems on the detection of artificially induced vertical root fractures (VRFs) and artifact intensity using birooted teeth restored with different intracanal materials. METHODS:The sample consisted of 20 extracted birooted premolars. Ro...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.10.028
更新日期:2020-02-01 00:00:00
abstract:INTRODUCTION:This in vitro study compared cone-beam computed tomography (CBCT) exam with different voxel sizes with digital periapical radiography in the detection of vertical root fractures in teeth with and without intracanal metallic posts. METHODS:Eighteen single-rooted human teeth were endodontically treated, pre...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.08.031
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The aim of this in vitro study was to evaluate the depth of penetration of 4 different endodontic resin sealers into the radicular dentinal tubules with the aid of confocal microscopy. METHODS:Eighty single-rooted teeth were instrumented and divided into 4 groups composed of 20 teeth each. The samples were ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.05.017
更新日期:2012-10-01 00:00:00
abstract::The Editorial Board of the Journal of Endodontics has developed a literature-based study guide of topical areas related to endodontics. This study guide is intended to give the reader a focused review of the essential endodontic literature and does not cite all possible articles related to each topic. Although citing ...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2007.07.002
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate the effect of a range of alkaline pH values on the push-out strength of white mineral trioxide aggregate (WMTA). METHODS:The standardized lumens of root slices prepared from extracted single-rooted human teeth were filled with white ProRoot MTA. The specimens were the...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2010.08.022
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:This study aimed to investigate the effects of 2 inorganic polyphosphates (poly[P]) are linear polymers of orthophosphate (Pi) residues linked by energy-rich phosphoanhydride poly(P) compounds, sodium triphosphate (STP, Na5P3O10) and sodium hexametaphosphate (SHMP, Na15P13O40 ∼ Na20P18O40) on the prolifera...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.01.038
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:The purpose of this in vivo study was to evaluate the accuracy of small-volume cone-beam computed tomographic (CBCT) imaging compared with conventional periapical radiography (CPR) in the diagnosis of vertical root fractures (VRFs) using exploratory surgery as the reference standard. METHODS:Eighty-two de...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2020.04.015
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:The purpose of this prospective, randomized controlled trial was to evaluate the healing outcomes of platelet-rich fibrin (PRF) in periapical surgeries involving apicomarginal defects and to compare these results with surgeries not using any guided tissue regeneration techniques. METHODS:Thirty patients w...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2015.04.004
更新日期:2015-07-01 00:00:00
abstract::Ultrasonic instruments are a valuable asset for removing intraradicular posts from root canals before nonsurgical endodontic therapy. The purpose of this study was to evaluate the relative efficacy of post removal by ultrasonic and sonic devices. Fifty extracted teeth were instrumented and obturated. The canals were p...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)80044-0
更新日期:1994-10-01 00:00:00
abstract:INTRODUCTION:The diagnosis and treatment planning of cracked teeth depend on the understanding of how cracks affect the surrounding tissues. This study evaluated the dentin and pulp conditions in teeth affected by cracks and attrition. METHODS:Specimens under investigation included 12 cracked posterior teeth and 8 tee...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.09.021
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to compare centering ability and apical canal transportation of K-files (KF), ProGlider (PG), and G-Files (GF) after glide path enlargement in curved canals by using micro-computed tomography. METHODS:Thirty canals each were randomly assigned to KF, GF, and PG. Teeth were sca...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.04.005
更新日期:2016-07-01 00:00:00
abstract:INTRODUCTION:Passive ultrasonic irrigation (PUI) is the most widespread method used to activate irrigation solutions. Concerns have been raised that PUI is less effective in curved root canals and is not passive at all. Our aim was to compare a novel passive sonic irrigation (PSI) device (6000 Hz) with PUI and manual i...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.08.024
更新日期:2016-12-01 00:00:00
abstract::Characteristics of cyclooxygenase-2 (COX-2) expressing cells in human dental pulp were immunohistologically studied. Extirpated pulpal tissues from extracted teeth were examined to elucidate the localization and distribution of COX-2. Pulpal tissues were examined by the labeled streptavidin biotin method using specifi...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200106000-00003
更新日期:2001-06-01 00:00:00
abstract::Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusua...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.09.006
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:The root canal treatment of a mandibular molar with aberrant canal configuration can be diagnostically and technically challenging. METHODS:This case report presents the clinical management of a mandibular first molar with three separate mesial canals including middle mesial canal, which was confirmed by ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.11.008
更新日期:2010-03-01 00:00:00
abstract::The purpose of this study was to compare the cleaning efficacy of passive ultrasonic activation with that of passive sonic activation after hand instrumentation. Sixty curved molar canals were hand-instrumented to size 35 and divided into three groups. Group 1 received no further treatment. Group 2 received 3 min of p...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(99)80120-4
更新日期:1999-11-01 00:00:00
abstract::The purpose of this in vitro study was to evaluate the accuracy of Root ZX apex locator to determine the working length in teeth with simulated apical root resorption. Fifty extracted, single-rooted, human teeth with mature apices were used in this study. An irregular cavity defect was drilled at the apex of each toot...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200206000-00011
更新日期:2002-06-01 00:00:00
abstract::The purpose of this study was to compare the degree of anesthesia obtained with 2% lidocaine with three different concentrations of epinephrine for inferior alveolar nerve block. Using a repeated measures design, 30 subjects randomly received an inferior alveolar injection using masked cartridges of each solution at t...
journal_title:Journal of endodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0099-2399(97)80271-3
更新日期:1997-03-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate the effects of pretreatment of gel chlorhexidine and ethanol on the bond strength and durability of the adhesion of the fiber post relined with resin composite to the root dentin. METHODS:Sixty bovine incisor roots were divided into four groups: irrigation with phy...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.01.007
更新日期:2011-05-01 00:00:00
abstract::This study compared the effectiveness of four different techniques used for obturation of single rooted-teeth: lateral condensation, low-temperature gutta-percha (Ultrafil), vertical condensation of gutta-percha softened by means of three different laser devices (argon, CO2, and Nd:YAG), or composite resin photopolyme...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81530-X
更新日期:1995-09-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to establish a stable experimental mice pulpal inflammatory model and to evaluate inflammatory reactions of pulpal tissue after pulpal exposure. METHODS:Pulpal inflammation was induced in 80 C57BL/6 mice by occlusal exposure of the pulp of the maxillary first molar. The mice ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.09.003
更新日期:2017-01-01 00:00:00
abstract::In this retrospective study with limited cone-beam computed tomography (limited CBCT), we investigated the anatomic characteristics of the accessory mental foramina and accessory branches of the mandibular canal. The CBCT records of approximately 150 patients were evaluated, and 17 accessory mental foramina were found...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.08.033
更新日期:2008-12-01 00:00:00