Abstract:
INTRODUCTION:Odontoblasts produce dentin throughout life and in response to trauma. The purpose of this study was to identify the roles of endogenous Wnt signaling in regulating the rate of dentin accumulation. METHODS:Histology, immunohistochemistry, vital dye labeling, and histomorphometric assays were used to quantify the rate of dentin accumulation as a function of age. Two strains of Wnt reporter mice were used to identify and follow the distribution and number of Wnt-responsive odontoblasts as a function of age. To show a causal relationship between dentin secretion and Wnt signaling, dentin accumulation was monitored in a strain of mice in which Wnt signaling was aberrantly elevated. RESULTS:Dentin deposition occurs throughout life, but the rate of accumulation slows with age. This decline in dentin secretion correlates with a decrease in endogenous Wnt signaling. In a genetically modified strain of mice, instead of tubular dentin, aberrantly elevated Wnt signaling resulted in accumulation of reparative dentin or osteodentin secreted from predontoblasts. CONCLUSIONS:Wnt signaling regulates dentin secretion by odontoblasts, and the formation of reparative or osteodentin is the direct consequence of elevated Wnt signaling. These preclinical data have therapeutic implications for the development of a biologically based pulp capping medicant.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Zhao Y,Yuan X,Bellido T,Helms JAdoi
10.1016/j.joen.2019.07.014subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1357-1364.e1issue
11eissn
0099-2399issn
1878-3554pii
S0099-2399(19)30548-5journal_volume
45pub_type
杂志文章abstract::A molar-incisor malformation (MIM) is a newly reported type of dental anomaly that involves a characteristic root malformation in permanent first molars and deciduous second molars and a crown defect in permanent central incisors. This case report describes a nonsurgical root canal treatment of a MIM-affected molar by...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.11.004
更新日期:2016-04-01 00:00:00
abstract::Previous studies have indicated that vertical root fracture tends to occur in a buccolingual direction, where dentin thickness is greatest. Factors potentially influencing the location and direction of root fracture include root canal shape, external root morphology, and dentin thickness. In this finite-element study,...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200308000-00008
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:Revascularization is a valuable treatment in immature necrotic teeth that allows the continuation of root development. In this article we describe successful revascularization treatment of 2 necrotic immature first mandibular molars. METHODS:The clinical and radiographic examinations showed extensive coro...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2011.01.011
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:The choice of single- versus multiple-visit root canal treatment for infected teeth is in dispute. The purpose of this systematic review was to compare the healing rate and post-obturation pain of single- versus multiple-visit root canal treatment for teeth with infected root canals. METHODS:An exhaustive...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2010.09.005
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:The root canal treatment of a mandibular molar with aberrant canal configuration can be diagnostically and technically challenging. METHODS:This case report presents the clinical management of a mandibular first molar with three separate mesial canals including middle mesial canal, which was confirmed by ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.11.008
更新日期:2010-03-01 00:00:00
abstract::Studies of endodontic outcomes suggest that fracture of the tooth after endodontic therapy may be a greater problem than endodontic reinfection. Immediate full coverage with or without a post and core is the best way to prevent fracture. Unfortunately, in many population areas, due predominantly to cost, this restorat...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2019.12.012
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the push-out bond strengths of different obturating materials. METHODS:Forty single-rooted human extracted teeth were used in this study. The teeth were instrumented and irrigated by using 5.25% NaOCl, 15% ethylenediaminetetraacetic acid, and sterile water. The te...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.10.026
更新日期:2010-02-01 00:00:00
abstract:INTRODUCTION:Experimental studies show that dental pulp cells respond unfavorably to contact with resin composite restorative material. Hypothetically, in a random population, the frequency of apical periodontitis should be higher for teeth restored with resin composite than with amalgam. Therefore, the aim was to comp...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.05.002
更新日期:2014-09-01 00:00:00
abstract::The putative hazardous nature of chloroform and xylene implies that safer substitutes should be considered. Standard cylindrical gutta-percha samples were immersed in Hemo-De, a xylene substitute, for 60 s at 37 degrees C. Weight loss of a sample, after drying, was used as a measure of its solubility. Master and acces...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200007000-00001
更新日期:2000-07-01 00:00:00
abstract::It is known that many factors participate in the process of inflammation and pain transmission. Recently, various neuropeptides have been demonstrated in the intrapulpal nerve fibers immunobiohistochemically. These neuropeptides may play some role in the process of inflammation and transmission of pain sensation. In t...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81566-9
更新日期:1990-02-01 00:00:00
abstract::The purpose of this study was to evaluate the effect of occlusal load on the integrity of root canal obturation. Maxillary anterior teeth were cleaned, shaped, and obturated with either gutta-percha (GP)/AH Plus or Resilon/Epiphany. Afterwards, teeth were placed under 100 N force at 2 Hz for 22 hours in a 37 degrees C...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.01.022
更新日期:2008-04-01 00:00:00
abstract:INTRODUCTION:This retrospective study assessed the effects of microsurgical treatment of post-treatment endodontic disease using SuperEBA (Bosworth, Skokie, IL) as the root-end filling material and evaluated the potential prognostic factors in relation to outcome. METHODS:Data were collected from patients diagnosed wi...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.11.001
更新日期:2014-03-01 00:00:00
abstract::Twenty volunteers with first molars free of restorations and caries were recruited. One molar from each arch was selected, and rubber dam was applied. Seven sites on each crown were electric pulp tested 4 times with an Elements Diagnostic Unit, and lowest threshold responses were recorded. Data were analyzed with one-...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2007.08.006
更新日期:2007-11-01 00:00:00
abstract::The aim of this laboratory based study was to determine the shaping ability of Lightspeed nickel-titanium rotary instruments in simulated root canals. A total of 40 canals with four different shapes in terms of angle and position of curve were prepared with Lightspeed instruments using the stepback technique recommend...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(97)80347-0
更新日期:1997-12-01 00:00:00
abstract::The objective of this study was to assess and compare canal blockages and apical extrusion of dentin debris during canal shaping with eight preparation techniques. A total of 208 canals in extracted human teeth were prepared by one operator using one type of file. The techniques included were standardized, stepback wi...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/s0099-2399(06)80443-7
更新日期:1995-03-01 00:00:00
abstract::This study compared a tapered, calibrated spreader/plugger instrument (M-series) to noncalibrated spreaders and pluggers in achieving apical condensation of gutta-percha in 20 single-rooted human teeth. The distances between the tip of the instruments and the tip of the master gutta-percha were measured. Results showe...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)80680-1
更新日期:1993-04-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to determine the variations in root canal length (RCL) occurring during endodontic treatment stages (initial, preflared, and concluded) and correlate them with the accuracy of Root ZX II (RZX). METHODS:After coronal access, 26 mandibular molars had the apical foramen of the 52 me...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.07.022
更新日期:2016-11-01 00:00:00
abstract::The purpose of this study was to evaluate the effect of different irrigating solutions on smear layer removal and dentinal tubule opening on root canal surfaces after post space preparation and to study whether additional ultrasonic irrigation has any effect on smear layer removal. Forty-eight anterior teeth were trea...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.01.006
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:This study evaluated the cyclic fatigue resistance (CFR) of Reciproc (R25 and R40; VDW, Munich, Germany) and Reciproc Blue (R25 and R40, VDW) instruments used in an artificial S-shaped canal. METHODS:A total of 80 files were tested in an S-shaped canal (n = 20 for each file, Reciproc R25 and R40 and Recip...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.04.009
更新日期:2017-10-01 00:00:00
abstract::A polydimethylsiloxane-based sealer (GuttaFlow) was used for filling single-rooted teeth with four obturation techniques. Prefitted gutta-percha master-cones were employed in groups 1 to 3 with backfilling of the sealer. Apical third of the roots were first filled with GuttaFlow, and sealer-coated master cones were se...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2006.07.009
更新日期:2006-12-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to visualize the stresses and strain distribution patterns in ProTaper Universal F2 files (Dentsply Maillefer, Ballaigues, Switzerland) and to establish the stress- and strain-curvature relationship for this instrument under various conditions by using a dynamic, three-dimensi...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.06.003
更新日期:2011-10-01 00:00:00
abstract::The purpose of this study was to compare the wicking propensity of multifilament sutures. Dexon II, Vicryl, and black silk suture (BSS) were dipped in saline or soaked for 48 h, then suspended on a microscope slide. Fluorescein isothiocyanate-dextran (FITC-D) was placed at the suture mid points, and its movement was o...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000121617.67923.05
更新日期:2004-09-01 00:00:00
abstract:INTRODUCTION:Speed of injection may affect the solution spread in the pterygomandibular space. It was hypothesized that speed of injection will affect the anesthetic efficacy of inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis. METHODS:Fifty-nine adult volunteers who were activel...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2012.08.006
更新日期:2012-12-01 00:00:00
abstract::The endodontic endosseous implant (EEI) enjoyed wide use in the United States after it was introduced in the 1960's. For various reasons including incorrect case selection, improper use of the materials, and poor preparation for the implant a high number of failures resulted. Following opposition by some members of th...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81496-2
更新日期:1993-10-01 00:00:00
abstract:INTRODUCTION:The study was designed as a randomized double-blind trial to evaluate the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine in inferior alveolar nerve block (IANB) and infiltration anesthetic techniques to anesthetize mandibular molars with irreversible pulpitis. METHODS:The study was compose...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2011.09.009
更新日期:2011-12-01 00:00:00
abstract::The purpose of this study was to evaluate the effect of citric acid and EDTA solutions on the microhardness and the roughness of human root canal dentin. Forty-five human teeth sectioned longitudinally were used. Specimens were randomly divided into three groups of 30 teeth each and were treated as follows: (a) one mo...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000136212.53475.ad
更新日期:2005-02-01 00:00:00
abstract::The oral region comprises 1% of the total body area, yet it accounts for 5% of all bodily injuries. In preschool children, oral injuries make up as much as 17% of all bodily injuries. The incidence of traumatic dental injuries is 1%-3%, and the prevalence is steady at 20%-30%. The annual cost of treatment is US $2-$5 ...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2012.11.021
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:The management of endodontic emergencies has been particularly challenging during the coronavirus disease 2019 (COVID-19) outbreak because of the possible generation of airborne particles and aerosols. The aim of this report was to contribute to the practice of endodontics by proposing a general protocol f...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2020.09.018
更新日期:2021-01-01 00:00:00
abstract::Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusua...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.09.006
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:Apical surgery is frequently indicated in maxillary first molars. Occasionally, a vascular anastomosis in the lateral maxillary sinus wall can be observed during surgery. The aim of this study was to examine the distance between the vascular bone channel (VBC) and the root apices of maxillary first molars ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.09.004
更新日期:2019-12-01 00:00:00