Abstract：
INTRODUCTION:The purpose of this study was to establish a stable experimental mice pulpal inflammatory model and to evaluate inflammatory reactions of pulpal tissue after pulpal exposure. METHODS:Pulpal inflammation was induced in 80 C57BL/6 mice by occlusal exposure of the pulp of the maxillary first molar. The mice were sacrificed randomly at 0, 1, 6, 12, 24, 48, and 72 hours after pulpal exposure. Mice without pulpal exposure served as controls. Maxillary teeth were obtained and prepared for histologic analyses and real-time polymerase chain reaction analyses. RESULTS:As the duration of pulpal exposure increases, the inflammatory reaction is exacerbated. Within 6 to 12 hours after pulpal exposure, pulp tissues experienced red blood cell extravasation to the destruction of the odontoblast layer. After 24 hours, necrosis was observed in the pulpal tissue; until 72 hours, necrosis spread to the whole coronal pulpal tissue, and a large number of inflammatory cells were found in the radicular pulpal tissue. The results of histomorphologic scores have the same trend; samples from the 72-hour group possessed the highest score followed by samples from other groups (P < .01). The expression levels of inflammatory cytokines increased over the 72 hours, and there was a high rate of inflammatory cytokine expression at 6 and 12 hours after pulpal exposure. CONCLUSIONS:Our study represents a stable mice model for studying pulpal inflammation in vivo. Mouse pupal inflammation progresses rapidly, with dramatic changes evident in just a few hours.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
He Y,Gan Y,Lu J,Feng Q,Wang H,Guan H,Jiang Qdoi
10.1016/j.joen.2016.09.003subject
Has Abstractpub_date
2017-01-01 00:00:00pages
90-95issue
1eissn
0099-2399issn
1878-3554pii
S0099-2399(16)30585-4journal_volume
43pub_type
杂志文章abstract：INTRODUCTION:Apical root resection is a biologically essential component in endodontic microsurgery. However, because it reduces the total root length and supported root surface, it changes the biomechanical response of the tooth. The purpose of this study was to analyze the biomechanical effect of apical root resectio...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.03.006
更新日期：2014-09-01 00:00:00
abstract：:Use of resin-based restorative materials recently has become widely accepted for treatment of endodontically treated teeth. However, some solutions routinely used during endodontic treatment procedures may have an effect on bond strengths of adhesive materials to root canal dentin. The purpose of this in vitro study w...
journal_title：Journal of endodontics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004770-200402000-00013
更新日期：2004-02-01 00:00:00
abstract：:Many root canal instruments with several different designs have been introduced during recent years. This article evaluates the machining properties of four such instruments: the Flex-R, K-Flex, Trio-Cut, and S file. There are large variations in the machining properties of these instruments. The results are comparabl...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/s0099-2399(07)80200-7
更新日期：1990-12-01 00:00:00
abstract：:Type IV matrix metalloproteinases (MMPs) are members of the family of MMPs and are thought to play an important role in degradation of extracellular components. Human pulp cells can secrete and produce these enzymes. Recent evidence shows that MMPs may play a role in pulpal inflammation. To date little is known regard...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200111000-00007
更新日期：2001-11-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to compare the efficacy of conventional syringe, ultrasonic, EndoVac (Discus Dental, Culver City, CA), and Self-Adjusting File (SAF) (Re-Dent-Nova, Ra'nana, Israel) irrigation systems in removing calcium hydroxide (Ca[OH]2) from simulated root canal irregularities. METHODS:The ro...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.10.019
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:This study examined the effect of a new bioactive dentin substitute material (Biodentine) on the viability of human gingival fibroblasts. METHODS:Biodentine, White ProRoot mineral trioxide aggregate (MTA), and glass ionomer cement were evaluated. Human gingival fibroblasts were incubated for 1, 3, and 7 d...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.11.026
更新日期：2013-04-01 00:00:00
abstract：INTRODUCTION:Revascularization treatment is rapidly becoming an accepted treatment alternative for the management of endodontic pathology in immature permanent teeth with necrotic dental pulps. However, the success and timing of clinical resolution of symptoms, and radiographic outcomes of interest, such as continued h...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.08.023
更新日期：2014-12-01 00:00:00
abstract：:Nickel-titanium engine-driven rotary instruments are used increasingly in endodontic practice. One frequently mentioned problem is fracture of an instrument in the root canal. Very few studies have been conducted on torsional characteristics of these instruments, and none has been done under dynamic conditions. The pu...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200003000-00007
更新日期：2000-03-01 00:00:00
abstract：INTRODUCTION:Patient preferences should be taken into account by clinicians when treatment planning. The purposes of this study were to describe the number of visits patients preferred when undergoing root canal therapy (RCT) and to assess whether their preferences were related to hypothetical treatment success rates. ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.06.038
更新日期：2012-10-01 00:00:00
abstract：:The cleaning capacity of manual and rotary instrumentation techniques in mesial-distal flattened canals was studied by morphometric analysis. Twenty human mandibular incisors were divided into two groups of 10 teeth each: group 1, crown-down technique with rotary instrumentation using ProFile .04; group 2, crown-down ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200205000-00004
更新日期：2002-05-01 00:00:00
abstract：INTRODUCTION:This retrospective cohort study aimed to observe the incidence of pulpitis and necrosis in teeth with cracks that were not endodontically treated. METHODS:One hundred eighty-four patients with 199 cracked teeth that were diagnosed with reversible pulpitis and were treated from January 2010 to December 201...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2019.02.003
更新日期：2019-05-01 00:00:00
abstract：:Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusua...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2015.09.006
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:This review aimed to find the most effective oral premedication in reducing pain in adults after nonsurgical root canal therapy (NSRCT) using network meta-analysis. METHODS:The review protocol was registered in the PROSPERO database (CRD42017071899). A literature search was performed in the MEDLINE and EB...
journal_title：Journal of endodontics
pub_type： 杂志文章,meta分析
doi：10.1016/j.joen.2018.10.016
更新日期：2019-04-01 00:00:00
abstract：:The aim of this study was to determine the effects of patient's age on the prevalence and depth of bacterial penetration inside dentinal tubules. Fifty-six single-rooted teeth were divided in two groups based on the patient's age: young (ages 18-25) and old (age >or=60). Teeth were instrumented and inoculated with a s...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2008.10.004
更新日期：2009-01-01 00:00:00
abstract：INTRODUCTION:This study aimed to investigate the effects of 2 inorganic polyphosphates (poly[P]) are linear polymers of orthophosphate (Pi) residues linked by energy-rich phosphoanhydride poly(P) compounds, sodium triphosphate (STP, Na5P3O10) and sodium hexametaphosphate (SHMP, Na15P13O40 ∼ Na20P18O40) on the prolifera...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2015.01.038
更新日期：2015-06-01 00:00:00
abstract：:Inflammation in the dental pulp is accompanied by release of a wide variety of highly oxidative molecules known as reactive oxygen species (ROS). ROS concentrations are controlled in vivo by an antioxidant enzyme scavenger system that may be overwhelmed by the increases in ROS production seen during inflammation. Supp...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200103000-00014
更新日期：2001-03-01 00:00:00
abstract：:The purpose of this study was to compare the antimicrobial efficacy of 1.3% NaOCl/BioPure MTAD to 5.25% NaOCl/15% EDTA for root canal irrigation. Twenty-six bilaterally matched pairs of human teeth were collected. The teeth were incubated with Enterococcus faecalis for 4 weeks. The teeth were divided into two experime...
journal_title：Journal of endodontics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.joen.2006.08.007
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate the effects of different curing units and 2 luting cements on the push-out bond strength of a translucent fiber post. METHODS:Thirty maxillary incisor roots were endodontically treated. Post spaces were prepared, and the smear layers were removed. Posts (FRC Postec Pl...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2010.04.026
更新日期：2010-09-01 00:00:00
abstract：:The purpose of this study was to evaluate the influence of Hero 642 rotary Ni-Ti instruments driven at 300, 400, or 600 rpm on root canal straightening, loss of working length, and instrument breakage. Sixty mesial root canals from extracted human mandibular molars were divided into 3 groups of 20 each and were instru...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200307000-00005
更新日期：2003-07-01 00:00:00
abstract：:Cells expressing interleukin-1 (IL-1) were examined in rat periapical lesions using immunohistochemical methods. During the acute phase, both IL-1 alpha- and IL-1 beta-expressing cells were observed adjacent to many osteoclasts that contained large cytoplasms, and consequently the periapical lesions tended to expand. ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(98)80008-3
更新日期：1998-12-01 00:00:00
abstract：INTRODUCTION:Various materials have been advocated for use as root-end filling materials. The purpose of the present in vitro study was to compare the cytotoxicity of 4 root-end filling materials: glass ionomer cement (GIC; Fuji II, GC Corp, Tokyo, Japan), reinforced zinc oxide-eugenol cement (IRM; Dentsply Tulsa Denta...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.09.004
更新日期：2012-12-01 00:00:00
abstract：:It has been shown that rotary nickel-titanium files cannot be used indefinitely. Researchers and clinicians have not been able to agree on how many times a file can be used before being discarded, except if a file has fractured or become visibly distorted. This study used ISO size 20 files of 0.04 taper in the curved ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200202000-00014
更新日期：2002-02-01 00:00:00
abstract：:This study evaluated the sealing ability of fast and regular set Super-EBA with different powder-to-liquid ratios as a root-end filling material. Fifty extracted maxillary central incisors were uniformly cleaned and shaped using a crown-down technique with Gates-Glidden drills and Profile series 29.04 taper rotary ins...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(99)80378-1
更新日期：1999-08-01 00:00:00
abstract：:Irreversibly inflamed pulp (IIP) constitutes both a pathophysiologic and a diagnostic challenge. Gingival crevicular fluid (GCF) samples were obtained with Periopaper strips from IIP and adjacent and contralateral teeth for interleukin-8 (CXCL8) and tumor necrosis factor-alpha (TNF-alpha) measurements. Pain intensity ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2007.10.022
更新日期：2008-02-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to compare the sensitivity and specificity of cone-beam computed tomography (CBCT) scans and digital periapical radiographs (PR) in detecting strip and root perforations after root canal treatment in mandibular molars. METHODS:Forty-five curved mesial roots were endodontically pr...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2010.12.003
更新日期：2011-04-01 00:00:00
abstract：:Two electronic apex locators based on the gradient (Apit) and absolute (Odontometer) impedance principles were evaluated. Distances of file tips to apical foramina were determined in vivo with the electronic apex locators and subsequently verified after extraction. Mean differences between file tips and apical foramin...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/s0099-2399(06)80145-7
更新日期：1996-05-01 00:00:00
abstract：INTRODUCTION:The aim of the present study was to compare sonic activation using EDDY (VDW, Munich, Germany), passive ultrasonic irrigation (PUI), and mechanical activation using the XPendo Finisher (FKG Dentaire, La Chaux-des-Fonds, Switzerland) for the removal of calcium hydroxide from artificial grooves in straight r...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2018.11.001
更新日期：2019-03-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to compare the amount of debris extruded from the apex during retreatment procedures with ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), Reciproc (RCP; VDW, Munich, Germany), and Twisted File Adaptive (TFA; SybronEndo, Orange, CA) files and the duration of these...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.12.003
更新日期：2017-04-01 00:00:00
abstract：:A descriptive, cross sectional survey was developed to determine the preferences of endodontists when prescribing analgesics. Eleven clinical scenarios describing common endodontic diagnoses or procedures with specified severity of pain were provided. A survey was sent to 310 AAE members and 63 responded, providing a ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2006.07.015
更新日期：2006-12-01 00:00:00
abstract：INTRODUCTION:This study assessed apical extrusion during treatment with GentleWave (GW; Sonendo Inc, Laguna Hills, CA), a conventional open-ended 30-G needle (CN), or Endovac (EV; SybronEndo, Orange, CA) in root canals enlarged to different dimensions with and without apical constriction. METHODS:Sixteen mandibular mo...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2015.04.009
更新日期：2016-01-01 00:00:00
