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Intercellular adhesion induced by anti-alpha 3 integrin (VLA-3) antibodies.

Abstract：

:We generated four monoclonal antibodies (mAbs) specific for human alpha 3 integrin (VLA-3 alpha subunit). All of them were found to induce homotypic cell aggregation of HT1080 fibrosarcoma and SN12C renal carcinoma cells, both of which express high levels of alpha 3 integrin. The antibodies also induced the cell aggregation of K562 erythroleukemic cells transfected with alpha 3 integrin cDNA, but not the parental K562 cells. The aggregation was observed in a temperature-dependent manner and was not inhibited by the addition of EDTA. Immunofluorescence microscopic observation showed that alpha 3 integrin on HT1080 cells was translocated into the contact regions after the mAb treatment. The intercellular adhesion between cells expressing alpha 3 integrin and cells without alpha 3 integrin was also induced by the anti-alpha 3 antibody treatment.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Takeuchi K,Tsuji T,Hakomori S,Irimura T

doi

10.1006/excr.1994.1069

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

133-41

issue

1

eissn

0014-4827

issn

1090-2422

pii

S001448278471069X

journal_volume

211

pub_type

杂志文章

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