Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.

abstract：:Small RNAs (sRNAs) are hypothesized to contribute to hybrid vigor because they maintain genome integrity, contribute to genetic diversity, and control gene expression. We used Illumina sequencing to assess how sRNA populations vary between two maize inbred lines (B73 and Mo17) and their hybrid. We sampled sRNAs from t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber WT,Zhang W,Win H,Varala KK,Dorweiler JE,Hudson ME,Moose SP

更新日期：2012-06-26 00:00:00

abstract：:The T-cell antigen receptor alpha-chain genes of an alloreactive, H-2Db-specific cytotoxic T-cell clone (3F9) are described. This study and our work on the 3F9 beta-chain genes reveal that the variable region gene segments for the alpha and beta chains expressed in 3F9 are identical to the ones used by a chicken eryth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rupp F,Brecher J,Giedlin MA,Mosmann T,Zinkernagel RM,Hengartner H,Joho RH

更新日期：1987-01-01 00:00:00

abstract：:Serum provides growth factors that regulate and limit the growth of normal cells in tissue culture. Animal cells that are malignantly transformed usually exhibit diminished serum requirements for growth in culture. We have used a defined, serum-free medium to determine which of these growth factors becomes dispensable...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherington PV,Smith BL,Pardee AB

更新日期：1979-08-01 00:00:00

abstract：:Hybridomas producing human monoclonal IgM antibodies (mAbs) against bacterial lipopolysaccharide (LPS) were generated by fusion of B lymphocytes from sensitized human spleen with heteromyeloma cells. The splenocytes were from patients undergoing splenectomy during staging for Hodgkin disease after vaccination with the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng NN,Kaplan HS,Hebert JM,Moore C,Douglas H,Wunderlich A,Braude AI

更新日期：1985-03-01 00:00:00

abstract：:The primate visual motion system performs numerous functions essential for survival in a dynamic visual world. Prominent among these functions is the ability to recover and represent the trajectories of objects in a form that facilitates behavioral responses to those movements. The first step toward this goal, which c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albright TD,Stoner GR

更新日期：1995-03-28 00:00:00

abstract：:The genetic code in a eukaryotic system has been expanded by the engineering of Escherichia coli tyrosyl-tRNA synthetase (TyrRS) with the Y37V and Q195C mutations (37V195C), which specifically recognize 3-iodo-L-tyrosine rather than L-tyrosine. In the present study, we determined the 3-iodo-L-tyrosine- and L-tyrosine-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi T,Sakamoto K,Takimura T,Sekine R,Kelly VP,Kamata K,Nishimura S,Yokoyama S

更新日期：2005-02-01 00:00:00

abstract：:Intracellular transport is based on molecular motors that pull cargos along cytoskeletal filaments. One motor species always moves in one direction, e.g., conventional kinesin moves to the microtubule plus end, whereas cytoplasmic dynein moves to the microtubule minus end. However, many cellular cargoes are observed t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller MJ,Klumpp S,Lipowsky R

更新日期：2008-03-25 00:00:00

abstract：:Analysis of commercial catches reveals a serial depletion of some oceanic fish stocks over time, resulting in fisheries focusing on increasingly smaller species closer to the base of the food chain. This effect, described as fishing down the marine food web, is observed when the trophic level of the catch declines ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunlop ES,Goto D,Jackson DA

更新日期：2019-10-01 00:00:00

abstract：:A recombinant vaccinia virus that directs the synthesis of bacteriophage T7 RNA polymerase provides the basis for the expression of genes that are regulated by T7 promoters in mammalian cells. The T7 transcripts, which account for as much as 30% of the total cytoplasmic RNA at 24 hr after infection, are largely uncapp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elroy-Stein O,Fuerst TR,Moss B

更新日期：1989-08-01 00:00:00

abstract：:Previous experiments have demonstrated that the human beta-globin gene is correctly regulated in transgenic mice. The beta-globin gene is not expressed in yolk sac-derived erythroid cells in early embryonic development but is expressed concomitantly with the adult mouse beta-globin genes in 14- to 16-day fetal liver a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Behringer RR,Hammer RE,Brinster RL,Palmiter RD,Townes TM

更新日期：1987-10-01 00:00:00

abstract：:Myosin I, an actin-dependent force-generating enzyme, has been purified from three mammalian sources: bovine adrenal medulla, adrenal cortex, and brain. The purification procedure includes extraction of tissue with ATP at low ionic strength and coprecipitation with actin, followed by gel filtration on Sepharose 4B, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barylko B,Wagner MC,Reizes O,Albanesi JP

更新日期：1992-01-15 00:00:00

abstract：:We have cloned a member of the nuclear receptor superfamily. The cDNA was isolated from a rat liver library and encodes a protein of 446 aa with a predicted mass of 50 kDa. This clone (OR-1) shows no striking homology to any known member of the steroid/thyroid hormone receptor superfamily. The most related receptor is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teboul M,Enmark E,Li Q,Wikström AC,Pelto-Huikko M,Gustafsson JA

更新日期：1995-03-14 00:00:00

abstract：:The human Bernard-Soulier syndrome is an autosomal recessive disorder of platelet dysfunction presenting with mild thrombocytopenia, circulating "giant" platelets and a bleeding phenotype. The bleeding in patients with the Bernard-Soulier syndrome is disproportionately more severe than suggested by the reduced platele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ware J,Russell S,Ruggeri ZM

更新日期：2000-03-14 00:00:00

abstract：:A hitherto unknown Neoproterozoic orogenic system, the Saharides, is described in North Africa. It formed during the 900-500-Ma interval. The Saharides involved large subduction accretion complexes occupying almost the entire Arabian Shield and much of Egypt and parts of the small Precambrian inliers in the Sahara inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Şengör AMC,Lom N,Zabcı C,Sunal G,Öner T

更新日期：2020-12-22 00:00:00

abstract：:We showed previously that rrn P1 promoters require unusually high concentrations of the initiating nucleoside triphosphates (ATP or GTP, depending on the promoter) for maximal transcription in vitro. We proposed that this requirement for high initiating NTP concentrations contributes to control of the rrn P1 promoters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider DA,Gaal T,Gourse RL

更新日期：2002-06-25 00:00:00

abstract：:A cell line has been developed from the imaginal wing discs of the lepidopteran insect Trichoplusia ni (Hübner). The cells grow in suspension as fluid-filled, multicellular vesicles. The cell line has been designated IAL-TND1. Two-dimensional electrophoresis (isoelectric focusing and sodium dodecyl sulfate/polyacrylam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynn DE,Miller SG,Oberlander H

更新日期：1982-04-01 00:00:00

abstract：:Poly(A)-containing RNA was isolated from ovaries of Xenopus laevis laevis and Triturus cristatus carnifex and used as a template for the synthesis of radioactive complementary DNA with RNA-dependent DNA polymerase. When annealed with an excess of homologous DNA, the complementary DNA is rendered double-stranded with k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosbash M,Ford PJ,Bishop JO

更新日期：1974-09-01 00:00:00

abstract：:Proper synaptic function requires the spatial and temporal compartmentalization of RNA metabolism via transacting RNA-binding proteins (RBPs). Loss of RBP activity leads to abnormal posttranscriptional regulation and results in diverse neurological disorders with underlying deficits in synaptic morphology and transmis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klein ME,Younts TJ,Castillo PE,Jordan BA

更新日期：2013-02-19 00:00:00

abstract：:How colloidal particles interact with each other is one of the key issues that determines our ability to interpret experimental results for phase transitions in colloidal dispersions and our ability to apply colloid science to various industrial processes. The long-accepted theories for answering this question have be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Bratko D,Prausnitz JM

更新日期：1998-12-22 00:00:00

abstract：:Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 positions). We recently described a halide-catalyzed pathway that preferentially generates cis adducts and now report that the trans chlorohydrin of anti-BPDE (trans-BP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meehan T,Wolfe AR,Negrete GR,Song Q

更新日期：1997-03-04 00:00:00

abstract：:The elongated three-helix bundle domains spectrin R16 and R17 fold some two to three orders of magnitude more slowly than their homologue R15. We have shown that this slow folding is due, at least in part, to roughness in the free-energy landscape of R16 and R17. We have proposed that this roughness is due to a frustr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wensley BG,Kwa LG,Shammas SL,Rogers JM,Browning S,Yang Z,Clarke J

更新日期：2012-10-30 00:00:00

abstract：:Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibility to colorectal cancer tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fearnhead NS,Wilding JL,Winney B,Tonks S,Bartlett S,Bicknell DC,Tomlinson IP,Mortensen NJ,Bodmer WF

更新日期：2004-11-09 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are trimeric cation-selective ion channels activated by protons in the physiological range. Recent reports have revealed that postsynaptically localized ASICs contribute to the excitatory postsynaptic current by responding to the transient acidification of the synaptic cleft that acco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacLean DM,Jayaraman V

更新日期：2017-03-21 00:00:00

abstract：:The cationic conductances of purified bovine retinal rod membranes were studied by incorporation of vesicles into planar lipid bilayers. When the membranes were stripped of all peripheral proteins [guanine nucleotide-binding protein (G protein) and cGMP phosphodiesterase (3',5'-cyclic-GMP 5'-nucleotidohydrolase), EC 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett N,Ildefonse M,Crouzy S,Chapron Y,Clerc A

更新日期：1989-05-01 00:00:00

abstract：:When the content of cyclic AMP (cAMP) was compared in livers of a series of congenic mouse strains differing at the H-2 locus, significant variation in concentration of cAMP per unit wet weight was found among strains, and also for animals of a given strain with increasing age. For a given age, from 8 to 22 weeks, cAM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meruelo D,Edidin M

更新日期：1975-07-01 00:00:00

abstract：:Small molecules that specifically bind with high affinity to any designated DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have been developed to rationally alter the sequence specificity of minor groove-binding polyamides containing N-methyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho J,Parks ME,Dervan PB

更新日期：1995-10-24 00:00:00

abstract：:We describe a Xenopus mRNA, Xrel1, that is related to the avian protooncogene c-rel, the embryonic pattern gene dorsal of Drosophila, and the mammalian transcription factor NK-kappa B/KBF1. The sequence of Xrel1 is homologous to the other rel-related proteins in the large amino-terminal region that defines this class ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kao KR,Hopwood ND

更新日期：1991-04-01 00:00:00

abstract：:The Mars Organic Analyzer (MOA), a microfabricated capillary electrophoresis (CE) instrument for sensitive amino acid biomarker analysis, has been developed and evaluated. The microdevice consists of a four-wafer sandwich combining glass CE separation channels, microfabricated pneumatic membrane valves and pumps, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skelley AM,Scherer JR,Aubrey AD,Grover WH,Ivester RH,Ehrenfreund P,Grunthaner FJ,Bada JL,Mathies RA

更新日期：2005-01-25 00:00:00

abstract：:Most human tumors are clonal in origin, although the cells may be diverse in their properties. Since the tumors evolve through progressive stages over decades of time, it is possible that the conditions that induced the tumor transform many cells, but that selective overgrowth of the fastest growing lead to a clonal p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao A,Rubin H

更新日期：1993-11-15 00:00:00

abstract：:The one-sided multipliers of an operator space X are a key to "latent operator algebraic structure" in X. We begin with a survey of these multipliers, together with several of the applications that they have had to operator algebras. We then describe several new results on one-sided multipliers, and new applications, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blecher DP,Zarikian V

更新日期：2004-01-20 00:00:00