Abstract:
:Virulence of hantavirus strain of SR-11 Seoul virus and Hantaan 76-118 (HTN) of Hantaan virus were compared. Infections of both strains were lethal in newborn mice. However, inoculum required to cause lethal infection was about 4,000 times higher for strain HTN (1.65 x 10(3) PFU/mouse/LD50) than for strain SR-11 (0.36 PFU). Thus, both strains were considered pathogenic to newborn mice but they possessed different levels of virulence. The assay system used for these strains in newborn mice proved to be useful in the study of hantavirus virulence. Growth curves of the two strains in CV-7 cell cultures were compared. Strain SR-11 was shown to have higher activity of virus replication and virus release into the culture fluids than strain HTN. The possibility of a relationship between replication activity and high levels of virulence in mice was suggested.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Yoo YC,Yoshimatsu K,Yoshida R,Tamura M,Azuma I,Arikawa Jdoi
10.1111/j.1348-0421.1993.tb01677.xsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
557-62issue
7eissn
0385-5600issn
1348-0421journal_volume
37pub_type
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