Mutant frequencies in workers at the Sellafield installation.

Abstract:

:The frequency of hypoxanthine-guanine phosphoribosyltransferase (hprt) mutations has been determined in the peripheral T-lymphocytes of 18 workers at the Sellafield nuclear reprocessing installation with cumulative recorded radiation doses of about 500 mSv or more in comparison with a matched control group of 18 workers with doses less than 50 mSv. The mean dose of the exposed group was 663 mSv (range 449.3-880.8), and of the unexposed group 10.9 mSv (range 0-46.5). During the most recent 6 y the mean doses were 40.1 mSv (range 1.9-93.9) and 2.3 mSv (range 0-8.7), respectively. The logarithmic mean mutant frequency of the exposed group (9.3 x 10(-6)) was lower than that of the unexposed group (12.4 x 10(-6)). The apparent inverse association of mutant frequency and exposure varied in statistical significance tests from borderline to p < 0.01 depending on how the analysis was performed and whether recent or total exposure was considered.

journal_name

Health Phys

journal_title

Health physics

authors

Cole J,Arlett CF,Green MH,Holdsworth D,Tawn EJ,Bridges BA

doi

10.1097/00004032-199503000-00011

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

388-93

issue

3

eissn

0017-9078

issn

1538-5159

journal_volume

68

pub_type

临床试验,杂志文章
  • A Comparison of Measurements and Calculations of the Effects of Scattered Radiation on Dosimeter Calibration in a Calibration Range.

    abstract::The method presented provides an alternative to the shadow shield method for experimentally measuring the contribution due to scattering radiation in a calibration range. Scattering of 0.6616 MeV photons from a Cs irradiator in a calibration range does not only occur due to the walls and floor of the range. It also oc...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318294453e

    authors: Rowan MS,Blue TE,Lahti E,Talnagi J,Herminghuysen K,Petrie CM

    更新日期:2013-09-01 00:00:00

  • Internal dose following a major nuclear war.

    abstract::The PATHWAY model results were used, in conjunction with a hypothetical major nuclear attack on the U.S., to arrive at the ratio of internal to external dose for humans from early (48 h) fallout. Considered were the four nuclides (137Cs, 89Sr, 90Sr, 131I) that account for most of the reconstructed whole-body committed...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199201000-00004

    authors: Peterson KR,Shapiro CS

    更新日期:1992-01-01 00:00:00

  • Compromise of Personal Protective Clothing from Liquid Exposure.

    abstract:INTRODUCTION:Following critiques of multiple personal contamination events from entries into the Oak Ridge National Laboratory's Spallation Neutron Source Transfer Bay, it was considered that the most likely causes for contamination were personal protective clothing doffing errors or moisture (sweat) allowing contamina...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001275

    authors: Schwahn SO,Foster ND

    更新日期:2020-08-01 00:00:00

  • Gas mixing for achieving suitable conditions for single point aerosol sampling in a straight tube: experimental and numerical results.

    abstract::Experimental measurements of velocity and tracer gas concentration are taken in a straight tube to evaluate the effectiveness of mixing in achieving conditions as required by ANSI N13.1-1999 for single point extractive sampling from stacks and ducts of nuclear facilities. Mixing is evaluated for inlet turbulent intens...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200301000-00007

    authors: Anand M,McFarland AR,Rajagopal KR

    更新日期:2003-01-01 00:00:00

  • Further studies of plutonium and americium at Thule, Greenland.

    abstract::Eleven years after the accidental loss of nuclear weapons in 1968, the fourth scientific expedition to Thule occurred. The estimated inventory of 1 TBq 239,240Pu in the marine sediments was unchanged when compared with the estimate based on the 1974 data. Plutonium from the accident had moved further away from the imp...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198401000-00001

    authors: Aarkrog A,Dahlgaard H,Nilsson K,Holm E

    更新日期:1984-01-01 00:00:00

  • A radiation protection approach to assessing population risk for threshold-type radiobiological effects.

    abstract::The potential harm to a population exposed to radiation from a nuclear accident, such as the one that recently occurred at the Chernobyl plant in the Soviet Union, is of concern to many individuals. The average dose to a population is a useful index of harm (IH) only for linear, nonthreshold-type, quantal (i.e., all-o...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198808000-00048

    authors: Scott BR

    更新日期:1988-08-01 00:00:00

  • Differences in lung cancer mortality trends from 1986-2012 by radon risk areas in British Columbia, Canada.

    abstract::Residential exposure to radon gas is associated with increased risk of lung cancer, especially in smokers. Most evidence about the health effects of radon has been derived from meta-analyses on global epidemiologic studies, but administrative data can help public health authorities to explore the local impacts. Eighty...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000005

    authors: Henderson SB,Rauch SA,Hystad P,Kosatsky T

    更新日期:2014-05-01 00:00:00

  • Use of alpha spectroscopy for conducting rapid surveys of transuranic activity on air sample filters and smears.

    abstract::This paper demonstrates the utility of a portable alpha Continuous Air Monitor (CAM) as a bench top scalar counter for multiple sample types. These include using the CAM to count fixed air sample filters and radiological smears. In counting radiological smears, the CAM is used very much like a gas flow proportional co...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000156959.35525.57

    authors: Hayes RB,Peña AM,Goff TE

    更新日期:2005-08-01 00:00:00

  • Radon and Thoron Measured in Petrol and Gas-oil Exhaust Fumes by Using CR-39 and LR-115 II Nuclear Track Detectors: Radiation Doses to the Respiratory Tract of Mechanic Workers.

    abstract::Mechanic workers are exposed to exhaust fumes when controlling vehicle engines in motion inside repair shops. To assess radiation doses due to radon short-lived progeny from the inhalation of exhaust fumes by mechanic workers, concentrations of these radionuclides were measured in petrol (gasoline) and gas-oil exhaust...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000285

    authors: Misdaq MA,Chaouqi A,Ouguidi J,Touti R,Mortassim A

    更新日期:2015-06-01 00:00:00

  • High 222Rn levels, enhanced surface deposition, increased diffusion coefficient, humidity, and air change effects.

    abstract::Measurements have been made of surface deposition rates for 218Po radon decay products in a small (0.283m3) aluminum test chamber for 222Rn levels from 1 to 1,600 kBq m-3. an increase in macroscopic surface deposition rate has been found to be induced by the high 222Rn concentrations. A distinct 222Rn level threshold ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199603000-00008

    authors: Leonard BE

    更新日期:1996-03-01 00:00:00

  • A multi-functional electronic program for the management of radioisotopes.

    abstract::Everyone will agree that specialized computer programs have done away with the many tedious tasks associated with manually keeping track of radioisotopes. Enhanced electronic programs have virtually cut the time of managing radioisotopes. Agriculture and Agri-Food, Canada's (AAFC) program for the management of radiois...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000308501.32700.f1

    authors: Ritchot N,Santary W

    更新日期:2008-05-01 00:00:00

  • Concentration factors used in the assessment of radiation dose to consumers of fish: a review of 27 radionuclides.

    abstract::Concentration factors (CFs) for 27 radionuclides in marine and freshwater fish were reviewed, as were factors that may influence the dose commitment to man resulting from the consumption of fish. These factors include environmental partitioning, ecological trophic level discrimination and specific tissue accumulation ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198811000-00004

    authors: Poston TM,Klopfer DC

    更新日期:1988-11-01 00:00:00

  • Evaluation of a technique for separating organic material from mineral bone in individuals occupationally exposed to Pu.

    abstract::The shaft portion of the left femur from an individual occupationally exposed to Pu was used to investigate the suitability of an ethylenediamine extraction technique to separate mineral bone from organic material. Marrow in the lumen was removed before the extraction technique was used and was analyzed separately for...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198706000-00006

    authors: Miglio JJ,Willis LC

    更新日期:1987-06-01 00:00:00

  • Radiation accident dosimetry on plastics by EPR spectrometry.

    abstract::In case of acute exposure to ionizing radiation, the dose absorbed by the victims has to be rapidly and accurately assessed in order to choose an appropriate medical treatment. Tooth enamel and bone biopsies measured by EPR spectrometry are often used as dose indicators, due to the good radiation sensitivity and the s...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000346334.78268.31

    authors: Trompier F,Bassinet C,Clairand I

    更新日期:2010-02-01 00:00:00

  • An analytically based model for the simultaneous leaching-chain decay of radionuclides from contaminated ground surface soil layers.

    abstract::This paper describes an analytically based method for modeling the time-dependent radionuclide areal densities of contaminated soil surface layers when the soil experiences simultaneous leaching, surface erosion and chain radioactive decay. The model is used to predict time-dependent radionuclide areal densities in a ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199712000-00006

    authors: Jarzemba MS,Manteufel RD

    更新日期:1997-12-01 00:00:00

  • Actinides concentrations in human tissues.

    abstract::Fallout 239,240Pu concentrations in some autopsy tissues from the general population in Japan are described. Body burden and relative distribution among tissues of plutonium were obtained by extrapolating using the mass of relevant tissues of the normal Japanese adult. 239,240Pu-to-90Sr body burden ratio was obtained....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198306001-00043

    authors: Kawamura H,Tanaka G

    更新日期:1983-01-01 00:00:00

  • Estimating internal dose due to ingestion of radionuclides from Nevada Test Site fallout.

    abstract::The U.S. Department of Energy initiated the Radiation Exposure Review Project to provide a critical reexamination of radiation doses to people resulting from testing nuclear devices at the Nevada Test Site. One part of this effort focused on the dose resulting from the ingestion of contaminated food. The PATHWAY radio...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199610000-00007

    authors: Kirchner TB,Whicker FW,Anspaugh LR,Ng YC

    更新日期:1996-10-01 00:00:00

  • Radiological effluents released by U.S. commercial nuclear power plants from 1995-2005.

    abstract::Commercial nuclear power plants release gaseous and liquid radiological effluents into the environment as by-products of electrical generation. In the U.S. these releases are monitored by the Nuclear Regulatory Commission (U.S. NRC) and Environmental Protection Agency (U.S. EPA). Traditionally these releases have alwa...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000324201.89669.30

    authors: Harris JT,Miller DW

    更新日期:2008-12-01 00:00:00

  • Use of epidemiological data and direct bioassay for prioritization of affected populations in a large-scale radiation emergency.

    abstract::Following a radiation emergency, evacuated, sheltered or other members of the public would require monitoring for external and/or internal contamination and, if indicated, decontamination. In addition, the potentially-impacted population would be identified for biodosimetry/bioassay or needed medical treatment (chelat...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31821dd9a2

    authors: Miller CW,Ansari A,Martin C,Chang A,Buzzell J,Whitcomb RC Jr

    更新日期:2011-08-01 00:00:00

  • Lauriston S. Taylor lecture: Radiation Protection and Public Policy in an Uncertain World.

    abstract::Ionizing radiation is a known, well-documented, and reasonably well-quantified human cancer risk factor based on a remarkably consistent body of dose-response information from epidemiological studies of exposed populations supported by experimental studies using animal and cellular models. This fact is largely ascriba...

    journal_title:Health physics

    pub_type:

    doi:10.1097/HP.0b013e318227e822

    authors: Land CE

    更新日期:2011-11-01 00:00:00

  • Sensitivity of effective radiating area measurement for therapeutic ultrasound transducers to variations in hydrophone scanning technique.

    abstract::Clinical efficacy and safety may be compromised if output from ultrasonic therapy transducers differs significantly from the indicated value. Space-averaged effective intensities selected for treatment are a ratio of the emitted ultrasonic power to the effective radiating area (ERA). In this study, ERA measurements fo...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198910000-00017

    authors: Bly SH,Hussey RG,Kingsley JP,Dickson AW

    更新日期:1989-10-01 00:00:00

  • Operational radiation safety for PET-CT, SPECT-CT, and cyclotron facilities.

    abstract::Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are well- established and indispensable imaging modalities in modern medicine. State-of-the-art computed tomography (CT) scanners have now been integrated into multi-modality PET-CT and SPECT-CT devices, and these devices, partic...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000327651.15794.f7

    authors: Zanzonico P,Dauer L,St Germain J

    更新日期:2008-11-01 00:00:00

  • Behavior of 222Rn and its progeny in high-rise buildings.

    abstract::Unlike detached or semi-detached houses, the main source of indoor radon in high-rise buildings is the building material. Radon released from the building material will be removed by ventilation, either forced or natural, so that its concentration, its progeny's concentration, and the equilibrium between the two will ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199809000-00010

    authors: Leung JK,Tso MY,Ho CW

    更新日期:1998-09-01 00:00:00

  • Radiation exposure of German aircraft crews under the impact of solar cycle 23 and airline business factors.

    abstract::The exposure of German aircraft crews to cosmic radiation varies both with solar activity and operational factors of airline business. Data come from the German central dose registry and cover monthly exposures of up to 37,000 German aircraft crewmembers that were under official monitoring. During the years 2004 to 20...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000150

    authors: Frasch G,Kammerer L,Karofsky R,Schlosser A,Stegemann R

    更新日期:2014-12-01 00:00:00

  • Determining 222Rn diffusion lengths in soils and sediments.

    abstract::Radon-222 diffusion length has been measured for 28 Danish soils and sediments. Samples were placed in a diffusion column connected to a 222Rn reservoir and the transport of 222Rn through the column was measured. The diffusion length was found by comparing the measured data to time-dependent diffusion theory. Dry silt...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198711000-00002

    authors: Søgaard-Hansen J,Damkjaer A

    更新日期:1987-11-01 00:00:00

  • Mitigating radiation-induced toxicity: an overview of new approaches developed at the French Military Biomedical Research Institute.

    abstract::Acute radiation syndrome represents the clinical response of radiation-sensitive key tissues (i.e., hematopoietic, gastrointestinal and neurovascular) following exposure to high doses of ionizing radiation. In this context, the hematopoietic syndrome remains the first therapeutic challenge. Today, identifying new drug...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/HP.0000000000000039

    authors: Drouet M,Hérodin F

    更新日期:2014-06-01 00:00:00

  • A contribution to optimizing radiological protection in a U mine.

    abstract::This article presents an optimization study for radiological protection in a U mine. The mathematical model of the alpha contamination associated with short-lived Rn daughters allows the comparison of various protection strategies through a cost-effectiveness analysis. Determining the optimal protection strategy is ca...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198604000-00004

    authors: Lombard J,Oudiz A,Zettwoog P

    更新日期:1986-04-01 00:00:00

  • Effect of Residential Radon Decay Product Dose Factor Variability on Reporting of Dose.

    abstract::Guidelines for occupational exposure to radiation are based on annual absorbed or effective dose. Guidelines for Rn exposure are currently based on air concentrations of Rn or decay products. Models of bronchial dose from decay product exposure are based on calculations that have five major parameters with parameter v...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000828

    authors: Harley NH

    更新日期:2018-04-01 00:00:00

  • Sorption of tin on human teeth.

    abstract::The sorption of tin ions on human teeth from water and other drinks has been studied by the radioactive tracer technique using the isotope 113Sn (T(1/2) = 115.1 d) as a tracer. The tooth holds a minimum amount of tin from coffee and a maximum amount is held from water and from tea with sugar. The same technique was al...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200201000-00014

    authors: Helal AA,Alian GA,Madbouly HA

    更新日期:2002-01-01 00:00:00

  • Dose-reduction Effects of Vehicles against Gamma Radiation in the Case of a Nuclear Accident.

    abstract::Self-evacuation by a private vehicle is one of the most commonly used methods of public evacuation in the case of a nuclear accident. The aim of this paper is to evaluate the dose-reduction effects of vehicles. To achieve this aim, a model for calculating the dose reduction factor was developed based on the actual sha...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000729

    authors: Takahara S,Watanabe M,Hirouchi J,Iijima M,Munakata M

    更新日期:2018-01-01 00:00:00