Mitigating radiation-induced toxicity: an overview of new approaches developed at the French Military Biomedical Research Institute.

Abstract:

:Acute radiation syndrome represents the clinical response of radiation-sensitive key tissues (i.e., hematopoietic, gastrointestinal and neurovascular) following exposure to high doses of ionizing radiation. In this context, the hematopoietic syndrome remains the first therapeutic challenge. Today, identifying new drugs and developing new strategies to cope with acute radiation syndrome remain a priority, especially to prevent/cure the radiation-induced multiple organ dysfunction syndrome then failure. Cytokine, non-cytokine drugs, and cell/gene therapy represent a pattern of sophisticated approaches developed by this group and others to achieve this goal.

journal_name

Health Phys

journal_title

Health physics

authors

Drouet M,Hérodin F

doi

10.1097/HP.0000000000000039

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

682-8

issue

6

eissn

0017-9078

issn

1538-5159

pii

00004032-201406000-00009

journal_volume

106

pub_type

杂志文章,评审
  • Rapid urinary output normalization method using specific gravity.

    abstract::Spot urine samples are often taken for emergency radiobioassay to provide a quick dose assessment for contaminated individuals. The subsequent dosimetric analysis requires a urinary output normalization method to adjust spot sampling to daily urine excretion. A rapid specific gravity method that was developed for 24-h...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318213be69

    authors: Dai X,Kutschke K,Priest N

    更新日期:2011-08-01 00:00:00

  • Immune Reconstitution and Thymic Involution in the Acute and Delayed Hematopoietic Radiation Syndromes.

    abstract::Lymphoid lineage recovery and involution after exposure to potentially lethal doses of ionizing radiation have not been well defined, especially the long-term effects in aged survivors and with regard to male/female differences. To examine these questions, male and female C57BL/6 mice were exposed to lethal radiation ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001352

    authors: Wu T,Plett PA,Chua HL,Jacobsen M,Sandusky GE,MacVittie TJ,Orschell CM

    更新日期:2020-11-01 00:00:00

  • Radon-222 levels in New York State homes.

    abstract::Results are presented from a statewide survey that measured annual 222Rn concentrations in over 2000 single-family, owner-occupied homes in New York state. The participants were selected by a random-digit-dialing telephone interview approach developed by Mitofsky-Waksberg which allows inferences to be made from the sa...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199002000-00001

    authors: Perritt RL,Hartwell TD,Sheldon LS,Cox BG,Clayton CA,Jones SM,Smith ML,Rizzuto JE

    更新日期:1990-02-01 00:00:00

  • Characterization of the world's first nuclear explosion, the Trinity test, as a source of public radiation exposure.

    abstract::The world's first atomic bomb was tested in New Mexico on 16 July 1945. From 1999 through 2008, scientists working for the Centers for Disease Control and Prevention gathered information relevant to past releases from Los Alamos activities, including the Trinity test. Detonation on a 30.5 m tower enhanced radioactive ...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/HP.0b013e3181c18168

    authors: Widner TE,Flack SM

    更新日期:2010-03-01 00:00:00

  • Modeling Tissue Heating From Exposure to Radiofrequency Energy and Relevance of Tissue Heating to Exposure Limits: Heating Factor.

    abstract::This review/commentary addresses recent thermal and electromagnetic modeling studies that use image-based anthropomorphic human models to establish the local absorption of radiofrequency energy and the resulting increase in temperature in the body. The frequency range of present interest is from 100 MHz through the tr...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000854

    authors: Foster KR,Ziskin MC,Balzano Q,Bit-Babik G

    更新日期:2018-08-01 00:00:00

  • On the escaping radioactivity from coal power plants (CPP).

    abstract::The escaping radioactivity from Greek coal power plants (CPP) was studied. For the case studied the radioactivity is due to the uranium series. The major part (99%) escapes as very fine particles, while the rest is fly ash. The total escaping 226Ra activity is of the order of 40 Ci/yr. The particulate dispersion of fl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198402000-00005

    authors: Papastefanou C,Charalambous S

    更新日期:1984-02-01 00:00:00

  • U.S. radiation protection: role of national and international recommendations and opportunities for collaboration (harmony, not dissonance).

    abstract::For much of the 20th century, U.S. radiation protection policies were similar to those elsewhere in the world, in large part because the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) were closely aligned. In the 1970s, several U.S. r...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000236

    authors: Boyd MA

    更新日期:2015-02-01 00:00:00

  • The Neglected Side of the Coin: Quantitative Benefit-risk Analyses in Medical Imaging.

    abstract::While it is implicitly recognized that the benefits of diagnostic imaging far outweigh any theoretical radiogenic risks, quantitative estimates of the benefits are rarely, if ever, juxtaposed with quantitative estimates of risk. This alone - expression of benefit in purely qualitative terms versus expression of risk i...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000416

    authors: Zanzonico PB

    更新日期:2016-03-01 00:00:00

  • A review of countermeasures to reduce radioiodine in milk of dairy animals.

    abstract::The most effective countermeasure for radioiodine contamination of milk is to provide dairy animals with uncontaminated feed, with the added advantage that it will be effective for other radionuclides in the fallout. Another effective response is to process the milk into storable dairy products for an appropriate leng...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199611000-00005

    authors: Howard BJ,Voigt G,Segal MG,Ward GM

    更新日期:1996-11-01 00:00:00

  • Geographical distribution of radiation risks in The Netherlands.

    abstract::Risk assessment of exposure to sources of radiation is an important tool for national governments in regulating radionuclide emissions and thus reducing radiation doses for the general public. For this reason radiation doses from sources throughout The Netherlands have been analyzed. For sources with well-defined loca...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199806000-00005

    authors: Janssen MP,Blaauboer RO,Pruppers MJ

    更新日期:1998-06-01 00:00:00

  • A proposed method to determine the decision level for radioactivity measurements.

    abstract::When measuring radioactivity, the problem rises of deciding whether or not a sample contains radioactivity in excess of background and above which value the result is meaningful. This decision process is why the notion of decision level was introduced. Whereas there is unanimity about its definition, this is not the c...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-200308000-00002

    authors: Rigaud D

    更新日期:2003-08-01 00:00:00

  • Power-frequency magnetic fields from electric blankets.

    abstract::Power-frequency (50/60 Hz) magnetic fields produced by electric blankets are estimated from data on blanket design using a three-dimensional computer model. Maximum, minimum, and volume-average fields within human forms are presented as a function of blanket type and a number of geometric factors including body size, ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199004000-00012

    authors: Florig HK,Hoburg JF

    更新日期:1990-04-01 00:00:00

  • The use of the dicentric assay for biological dosimetry for radiation accidents in Bulgaria.

    abstract::This paper details the construction of a 137Cs gamma calibration curve that has been established for dicentric assay and the testing and validation of the curve through biological dosimetry in three situations of suspected workplace overexposure that arose accidentally or through negligence or lack of appropriate safe...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181ab3ccf

    authors: Hadjidekova V,Hristova R,Ainsbury EA,Atanasova P,Popova L,Staynova A

    更新日期:2010-02-01 00:00:00

  • Decay Chain Deduction of Uranium Fission Products.

    abstract::Delayed gamma spectrum is the fingerprint of uranium materials in arms control verification technology. The decay chain is simplified into basic state linear chain and excitation state linear chain to calculate and analyze the delayed gamma spectra of fission products. Formulas of the changing rule for nuclide number ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000521

    authors: Guo H,Tian C,Wang X,Lv N,Ma M,Wei Y

    更新日期:2016-07-01 00:00:00

  • Ninth Annual Warren K. Sinclair Keynote Address: effects of childhood radiation exposure: an issue from computed tomography scans to Fukushima.

    abstract::The acute and chronic effects of radiation on children have been and will continue to be of great social, public health, scientific, and clinical importance. The focus of interest on ionizing radiation and children has been clear for over half a century and ranges from the effects of fallout from nuclear weapons testi...

    journal_title:Health physics

    pub_type:

    doi:10.1097/HP.0b013e31829c3548

    authors: Mettler FA Jr,Constine LS,Nosske D,Shore RE

    更新日期:2013-11-01 00:00:00

  • A simple approximation for estimating centerline gamma absorbed dose rates due to a continuous Gaussian plume.

    abstract::A simple approximation for estimating the centerline gamma absorbed dose rates due to a continuous Gaussian plume was developed. To simplify the integration of the dose integral, this approach makes use of the Gaussian cloud concentration distribution. The solution is expressed in terms of the I1 and I2 integrals whic...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198708000-00004

    authors: Overcamp TJ,Fjeld RA

    更新日期:1987-08-01 00:00:00

  • Alternative goals and policy mechanisms for radiation protection.

    abstract::For decades, radiation protection philosophy and practice have been the domain of professionals trained in the physical and medical sciences. Radiation protection policy was formulated and implemented largely without consultation with or participation by other professional disciplines or the general public. Although, ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200104000-00020

    authors: Florig HK

    更新日期:2001-04-01 00:00:00

  • Uses of therapeutic x rays in medicine.

    abstract::Treatment of diseases with x rays began within months of Roentgen's discovery, and within four years x rays were being used successfully for the treatment of skin cancers. Deep-seated cancers began to be treated successfully in the 1920's with the advent of "deep" x-ray units and, especially, once supervoltage therapy...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/00004032-199511000-00004

    authors: Orton CG

    更新日期:1995-11-01 00:00:00

  • An approach to radiation safety department benchmarking in academic and medical facilities.

    abstract::Based on anecdotal evidence and networking with colleagues at other facilities, it has become evident that some radiation safety departments are not adequately staffed and radiation safety professionals need to increase their staffing levels. Discussions with management regarding radiation safety department staffing o...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000212

    authors: Harvey RP

    更新日期:2015-02-01 00:00:00

  • Doses to patients from diagnostic radiology in France.

    abstract::Reported here are results of a 1982 national survey in France to establish the collective effective dose equivalent associated with the main types of radiological examinations practiced annually in this country (except nuclear medicine, C.T. scans, dental radiology and mass chest screening). This report describes the ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198804000-00002

    authors: Maccia C,Benedittini M,Lefaure C,Fagnani F

    更新日期:1988-04-01 00:00:00

  • Lauriston S. Taylor Lecture: Assuring the safety of medical diagnostic ultrasound.

    abstract::In 1980, the NCRP formed Scientific Committee 66 with an assignment to address the subject of "biological effects of ultrasound and exposure criteria." It was recognized that the primary source of exposure to ultrasound was through medical applications and, especially, through procedures employing diagnostic ultrasoun...

    journal_title:Health physics

    pub_type:

    doi:10.1097/00004032-200205000-00004

    authors: Nyborg WL

    更新日期:2002-05-01 00:00:00

  • Radon entry into houses: the importance of scale-dependent permeability.

    abstract::Soil permeability to air can increase substantially with measurement length scale. We tested the hypothesis that the scale effect could resolve large model underpredictions of radon and soil-gas entry into two experimental basement structures located in natural sandy-loam soil at a field site in Ben Lomond, CA. Previo...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199908000-00008

    authors: Garbesi K,Robinson AL,Sextro RG,Nazaroff WW

    更新日期:1999-08-01 00:00:00

  • An alternative method for the release criteria and calculation of the total dose equivalent to another individual from a patient treated with a therapeutic dose of 131I.

    abstract::The Nuclear Regulatory Commission's Regulatory Guide 8.39, "Release of Patients Administered Radioactive Materials," permits licensees to authorize the release of patients treated with 131I [(T 1/2)p = 8.04 d] if the total dose equivalent to another individual from the released individual is not likely to exceed 5 mil...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200107000-00004

    authors: DeSantis DM,Chabot GE

    更新日期:2001-07-01 00:00:00

  • Application of optically stimulated luminescence to the dosimetry of recent radiation events involving low total absorbed doses.

    abstract::We determined the suitability of optically stimulated recombination luminescence in quartz for low-level dosimetry of recent events such as radiation accidents. Minimum detectable doses were determined for both fired and unfired quartz. Using a single aliquot technique, good detection of doses on the order of 0.01 Gy ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199310000-00007

    authors: Godfrey-Smith DI,Haskell EH

    更新日期:1993-10-01 00:00:00

  • Management of mixed wastes from biomedical research.

    abstract::Mixed radioactive and chemical wastes generated by biomedical research were characterized, and various treatment methods for reducing their volume were evaluated. These wastes consist primarily of organic solvents used in the extraction and purification of radiolabeled biomolecules that are contaminated with low level...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199109000-00014

    authors: Linins I,Klein RC,Gershey EL

    更新日期:1991-09-01 00:00:00

  • The effects of Thorotrast and quartz on the induction of lung tumors in rats.

    abstract::In a long-term animal study, the combined and separate effects of Thorotrast (colloidal 232ThO2) and silica dust on the induction of lung tumors were investigated. Female Wistar rats were exposed for 29 d to aerosol concentrations of quartz of either 6 mg m-3, 30 mg m-3, or 0 mg m-3 (6 h d-1, 5 d wk-1). After inhalati...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199207000-00011

    authors: Spiethoff A,Wesch H,Wegener K,Klimisch HJ

    更新日期:1992-07-01 00:00:00

  • Weak electric field interactions in the central nervous system.

    abstract::Exposure to extremely low frequency electric and magnetic fields will induce electric fields and currents within the body, but these are almost always much lower than those that can stimulate peripheral nerve tissue. Guidance on exposure to such fields has been published by NRPB and ICNIRP, which is based on the avoid...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200209000-00006

    authors: Saunders RD,Jefferys JG

    更新日期:2002-09-01 00:00:00

  • Radiometry and laser safety standards.

    abstract::The application of occupational limits (ELs) in the outdoor laser environment requires an understanding of the radiometric methods required to evaluate field exposures with respect to the ELs. The limiting aperture required to adequately specify the EL must always be kept in mind. Since all exposure limits are defined...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198905000-00018

    authors: Sliney DH

    更新日期:1989-05-01 00:00:00

  • Radiation protection and medical practice with special reference to health physicists and the Health Physics Society.

    abstract::This paper broadly examines the historical development of radiation protection in medical practice through an examination of the interactions of those concerned with radiation protection and medical practice with emphasis on the last half century and on the role played by health physicists and the Health Physics Socie...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/00004032-199511000-00014

    authors: Stannard JN,Kathren RL

    更新日期:1995-11-01 00:00:00

  • Promotion of radiation-induced liver neoplasia by ethanol.

    abstract::The risk of americium-induced liver cancer in beagle dogs that received long-term dietary ethanol was two to three times that of their nonalcoholic cohorts, even though the radionuclide retention time in hepatic tissue was shortened by the alcohol treatment. Liver malignancies did not occur in the ethanol-treated, non...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199202000-00008

    authors: Taylor GN,Lloyd RD,Mays CW,Shabestari L,Miller SC

    更新日期:1992-02-01 00:00:00