Abstract:
:Our primary aim in this study has been to evaluate selected conditions thought to influence the entry of injecting drug users (IDU) into detoxification and methadone maintenance programs, making use of a prospective study design to strengthen a cross-sectional investigation of these conditions. To begin our investigation, we analyzed cross-sectionally gathered data on 2879 IDUs who had been recruited through extensive community outreach efforts and who were interviewed at the time of recruitment. We then tested our hypotheses about suspected determinants of entry into treatment by analyzing prospectively gathered data on 1039 active drug users who had no recent history of being treated for drug problems. Among these 1039 IDUs (a subset of the initial cross-sectional sample), 144 entered a detoxification program between their recruitment interview and their next follow-up interview, conducted about six months after recruitment (range: 3.5-9.5 months) and 64 entered a methadone maintenance program during that observation interval. Using multiple logistic regression analyses, we found that a recent drug overdose, relatively higher frequency of injecting drugs, and a history of prior arrest or treatment were independent predictors of entry into detoxification. Being married or living with a partner, being female, a lengthy duration of drug use (> 10 years), and a history of prior treatment were independent predictors of entry into methadone maintenance. These findings shed light on what appears to be a different profile of suspected determinants of entry into a detoxification treatment versus methadone maintenance treatment, and help to clarify some potential differences between treated and untreated drug users that ought to be considered when evaluating results of investigations with IDU participants recruited solely from treatment settings.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Schütz CG,Rapiti E,Vlahov D,Anthony JCdoi
10.1016/0376-8716(94)90095-7subject
Has Abstractpub_date
1994-10-01 00:00:00pages
129-38issue
2eissn
0376-8716issn
1879-0046pii
0376-8716(94)90095-7journal_volume
36pub_type
杂志文章abstract::Cerebral spinal fluid (CSF) levels of methadone were measured in nine methadone maintenance patients requiring lumbar punctures for medical or surgical treatment. Concurrent serum methadone levels were also determined. The CSF concentration of methadone in all cases was a fraction of the corresponding serum level--ran...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(78)90022-4
更新日期:1978-03-01 00:00:00
abstract:BACKGROUND:Clinical trials reveal posttraumatic stress disorder (PTSD) improvement leads to decreased substance use among patients with comorbid substance use disorder (SUD). Using administrative medical record data, we determined whether clinically meaningful PTSD Checklist (PCL) (≥20 points) score decreases were posi...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108365
更新日期:2021-01-01 00:00:00
abstract:AIMS:To present the prevalence and correlates of hallucinogen use disorders (HUDs: abuse or dependence) and subthreshold dependence. METHODS:The study sample included adolescents aged 12-17 years (N=55,286) who participated in the National Survey on Drug Use and Health (2004-2006). Data were collected with a combinati...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2009.04.014
更新日期:2009-09-01 00:00:00
abstract::This paper provides a detailed analysis of the 2-year outcomes for 351 drug misusers allocated on an intention-to-treat basis to methadone maintenance or methadone reduction treatments. Both groups showed substantial reductions in their use of illicit drugs and in other outcome areas. However, whereas most methadone m...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(00)00211-8
更新日期:2001-05-01 00:00:00
abstract::Harm reduction refers to the use of strategies to prevent or reduce harmful consequences associated with illicit drug use. There is a paucity of research concerning the harm reduction practices employed by ecstasy users. This study aimed to explore the prevalence, nature and factors associated with harm reduction prac...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2005.09.009
更新日期:2006-04-28 00:00:00
abstract:OBJECTIVES:This study assesses the independent and combined effects of (1) perceived peer norms, (2) best friend use, and (3) being in the presence of others who use on middle school adolescents' consumption of marijuana and alcohol, and how the effects of these sources of social influence evolve over time as youth pro...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.08.012
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:This paper presents a systematic review and meta-analysis of available evidence on remission rates for substance use disorders (SUDs), providing weighted mean estimates of SUD remission rates. The review also explores study-level characteristics that may explain variations in remission rates across studies. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.drugalcdep.2016.08.625
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Previous studies have examined associations between alcohol use in pregnancy and offspring birth size but evidence on whether associations persist during childhood is limited. METHODS:We examined the association between maternal drinking during pregnancy and trajectories of offspring weight and height from ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.02.035
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:We characterize cannabinoid disposition in oral fluid (OF) after dronabinol, synthetic oral Δ(9)-tetrahydrocannabinol (THC), and Sativex, a cannabis-extract oromucosal spray, and evaluate whether smoked cannabis relapse or Sativex compliance can be identified with OF cannabinoid monitoring. METHODS:5 and 15...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2012.10.011
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:This study used a case-control female sample to test psychiatric mediators and genetic moderators of the effect of sexual abuse on later alcohol dependence. The study also tested differences between alcohol dependent women with or without a history of sexual abuse on variables that might affect tre...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.10.024
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Methadone maintenance therapy (MMT) is an efficacious form of medication assisted treatment for opioid use disorder (OUD), yet many individuals on MMT relapse. Chronic pain and deficits in positive affective response to natural rewards may result in dysphoria that fuels opioid craving and promotes relapse. A...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2019.07.007
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:This study evaluated plasma buprenorphine concentrations 24-72 h following sublingual administration of a dose of buprenorphine solution, ranging from 16 mg/70 kg to 44 mg/70 kg, administered on a daily or thrice-weekly schedule. Additionally, this study evaluated the effects of different thrice-weekly bupre...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0376-8716(98)00192-6
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Functional neuroimaging studies have shown that specific brain areas are associated with alcohol craving including the dorsolateral prefrontal cortex (DLPFC). We tested whether modulation of DLPFC using transcranial direct current stimulation (tDCS) could alter alcohol craving in patients with alcohol depend...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2007.06.011
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Despite the relatively high prevalence of marijuana use among college students, little information exists regarding health outcomes associated with different use patterns or trajectories. METHODS:Seven annual personal interviews (years 1-7) were administered to 1253 individuals, beginning in their first yea...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.02.022
更新日期:2012-10-01 00:00:00
abstract::Previous studies have demonstrated that administration of nonspecific opioid antagonists such as naltrexone or naloxone reduces ethanol-induced locomotor activity in mice. However, because of their broad pharmacological profile, it remains unclear through which opioid receptor this antagonism is achieved. Therefore, t...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2004.11.007
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Physical pain is considered a potential predictor of relapse in alcohol-dependent individuals after treatment. The aim of this study was to evaluate whether reductions in pain level during the follow-up period after treatment were associated with lower relapse risk. METHOD:A sample of 366 participants was re...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.11.020
更新日期:2016-01-01 00:00:00
abstract::A prospective double-blind placebo-controlled trial of intramuscular Naftidrofuryl was carried out on 32 randomly selected hospitalized male alcoholic patients with clinical, biochemical and histological evidence of hepatic damage. Seventeen patients received the drug (40 mg in 5 ml i.m. three times daily for 6 days) ...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0376-8716(82)90004-7
更新日期:1982-10-01 00:00:00
abstract:AIMS:We aimed to assess the prevalence of sleep disturbance in early alcohol recovery and its association with psychiatric comorbidity, cravings, propensity and severity of alcohol consumption. DESIGN:The sample consisted of 18-80 year old patients (n = 303) receiving treatment for alcohol dependence. Sleep disturbanc...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.107655
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Cannabis is the most widely used illicit drug in developed countries, and has a significant impact on mental and physical health in the general population. However, the validity of common diagnostic schemes and their applicability to cannabis abuse and dependence is poorly understood. This paper describes a ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(02)00223-5
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To characterize patterns and correlates of inhalant use among incarcerated youth. METHOD:Residents (N=723) of 27 Missouri Division of Youth Services facilities completed interviews assessing substance use, psychiatric symptoms, antisocial traits, trauma, suicidality, and criminality. RESULTS:Participants av...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.08.023
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Cocaine addiction continues to be a significant healthcare issue, yet there are no FDA approved medications for the treatment of cocaine use disorder within the United States. METHODS:This 12-week, prospective, double-blind, randomized, placebo-controlled study examined the effectiveness of quetiapine (Sero...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2014.12.037
更新日期:2015-04-01 00:00:00
abstract::We examine the association between education and smoking by women in the population, including smoking during pregnancy, and identify risk factors for smoking and the consequences of smoking in pregnancy for children's smoking and behavioral problems. Secondary analyses of four national data sets were implemented: The...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2008.12.005
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:The association between betel quid (BQ) chewing and oral cancer is well established. However, evidence regarding the relationship between BQ chewing and cardiovascular disease (CVD) is still insufficient. METHODS:This cross-sectional study included 2002 men and 1175 women aged 50 and older in a city-level h...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.05.020
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Recent changes in the legality of cannabis have prompted evaluation of whether blood levels of Δ(9)-tetrahydrocannabinol (THC) or its metabolites could be used to substantiate impairment, particularly related to behavioral tasks such as driving. However, because marked tolerance develops to behavioral effect...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.02.696
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Sexual minority adolescents are more likely than their heterosexual peers to use substances. This study tested factors that contribute to sexual orientation disparities in substance use among racially and ethnically diverse adolescents. Specifically, we examined how both minority stress (i.e., homophobic bul...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.04.013
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:This study examined factors associated with marijuana use initiation among never users, prior-to-past year user who return to use, and users who continue use over a 12-month follow-up period. METHODS:Two waves (W1 and W2) of the Population Assessment of Tobacco and Health (PATH) Study provided data (N=26,20...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.10.006
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Adherence to nicotine patches relates to cessation. This is the first study to examine the validity of self-reported nicotine patch adherence relative to saliva cotinine. METHODS:We used data from 198 clinical trial participants who received 11 weeks of nicotine patches, self-reported patch use, had saliva ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107967
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Although recreational gambling is prevalent and co-occurs with substance abuse/dependence, few studies have investigated the relationship between the two. METHODS:Logistic regression analyses were performed on data from a nationally representative sample from the Gambling Impact and Behavior Study. RESULTS...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2008.09.011
更新日期:2009-02-01 00:00:00
abstract::Individuals with co-occurring substance use and psychiatric disorders have a more severe clinical course and poorer outcomes than do individuals with one disorder. In an attempt to find intervening variables that may contribute to improvement in treatment outcomes among individuals with co-occurring disorders, we inve...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.01.009
更新日期:2007-07-10 00:00:00
abstract:OBJECTIVES:Medical marijuana use may substitute prescription opioid use, whereas nonmedical marijuana use may be a risk factor of prescription opioid misuse. This study examined the associations between recreational marijuana legalization and prescription opioids received by Medicaid enrollees. METHODS:State-level qua...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.09.016
更新日期:2019-01-01 00:00:00