Abstract:
:Many immune responses are controlled by genes of the major histocompatibility complex (MHC). In humans these include the loci encoding the HLA-A, -B, -C, -DR, -DQ, and -DP antigens, and many diseases have been linked with these. However, little information is available about any connection between malignant tumors and HLA. In this study the possible association of HLA-A, -B, -C and -DR specificities with susceptibilities to malignant glioma was investigated in 42 patients with malignant glioma and 42 controls with non-glial intracranial tumors using the Terasaki-NIH standard method. The data were also compared with those of the 11th International HLA Workshop. The result showed that a high frequency of HLA-24(9) was observed in patients with intracranial malignant gliomas, which was not common in other, non-glial patient groups. In animals the MHC acts in defense against virally induced tumors, but until now there has been no evidence that they do so in human gliomas. Our discovery of its association with an HLA antigen is important for understanding the immunogenetic basis of susceptibility to glioma.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Nitta T,Ebato M,Sato Kdoi
10.1007/BF00418435subject
Has Abstractpub_date
1994-01-01 00:00:00pages
211-5issue
3eissn
0344-5607issn
1437-2320journal_volume
17pub_type
杂志文章abstract::Acute hydrocephalus is a well-documented complication of subarachnoid hemorrhage. The insertion of external ventricular drainage (EVD) has been the standard of care in the management of this complication, aiming primarily at immediate improvement of the clinical condition of these patients, making them more suitable c...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-005-0423-4
更新日期:2006-01-01 00:00:00
abstract::The aim of this study was to determine the efficacy and safety of intrathecal baclofen therapy delivered by a programmable pump for the chronic treatment of spinal spasticity. Twelve patients with intractable spasticity caused by spinal cord injuries underwent implantation of a programmable continuous infusion pump af...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-002-0221-1
更新日期:2002-08-01 00:00:00
abstract::Surgical resections of meningiomas, the most common intracranial tumor in adults, can only be curative if radical resection is achieved. Potentially, the extent of resection could be improved, especially in complex and/or high-grade meningiomas by fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA), indocy...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-018-01062-4
更新日期:2019-12-01 00:00:00
abstract::Fifteen cases of chronic vegetative state (CVS), following severe head injury and lasting for two years or more, are reported. Vegetative state, in most instances after a period of coma, consists of a return of wakefulness accompanied by an apparent total lack of higher mental activity. A protracted period of vegetati...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01790694
更新日期:1989-01-01 00:00:00
abstract::Pediatric cortical ependymomas (CEs) are rare; the clinical features and optimal treatment remain ill-defined. We aimed to clarify the clinical characteristics and outcome of pediatric CEs based on institutional series and literature review. Thirteen children with CEs from our department were included in the present s...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01336-w
更新日期:2020-06-30 00:00:00
abstract::Topographic brain mapping of EEG and evoked potentials permits the display of spontaneous and event-related activity of the brain. This new method is superior to conventional polygraphy because of the topographic approach which delineates structural and functional brain lesions. Data from 16 to 20 scalp electrodes wer...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01781950
更新日期:1987-01-01 00:00:00
abstract::Postoperative wound healing can pose a problem in patients undergoing instrumented surgery for pyogenic spondylodiscitis. Robotic guidance allows the minimally invasive placement of pedicle screws in the thoracolumbar spine. We assessed whether using this technique to perform minimally invasive surgery had an impact o...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0877-1
更新日期:2018-04-01 00:00:00
abstract::The purpose of the present study is to analyze the impact of intraoperative resection control modalities on overall survival (OS) and progression-free survival (PFS) following gross total resection (GTR) of glioblastoma. We analyzed data of 76 glioblastoma patients (30f, mean age 57.4 ± 11.6 years) operated at our ins...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0698-z
更新日期:2016-07-01 00:00:00
abstract::Between 1986 and 1988 100 patients in whom MRI had been used to diagnose prolapses of lumbar intervertebral discs were admitted to the neurosurgical department of the Munich Technical University. MRI proved to be a valuable diagnostic technique, even if one has to concede certain limitations to the usefulness of the r...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00383835
更新日期:1993-01-01 00:00:00
abstract::Long-term patency of superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery for atherosclerotic disease and associated risk factors for loss of patency have rarely been discussed. We retrospectively analyzed long-term patency following STA-MCA bypass and evaluated various demographic and clinic...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-016-0736-5
更新日期:2016-10-01 00:00:00
abstract::Cerebral infarction (CI) associated with clipping of unruptured intracranial aneurysms (UIAs) has not been completely studied. The role of individual and operative characteristics is not known, and the risk of silent CI has not been well described. To determine the incidence, risk factors, and clinical outcome of post...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0913-1
更新日期:2018-04-01 00:00:00
abstract::The objective of this study was to ascertain if stereotactic neurosurgical biopsy (SNB) optimizes the therapy of undefined CNS masses. The design was of retrospective treatment and outcome analysis and the setting was a large general hospital. We studied a total of 141 patients with undefined, space-occupying CNS lesi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050043
更新日期:1999-10-01 00:00:00
abstract::Intracranial aneurysms usually occur at arterial bifurcations. However, in middle cerebral artery (MCA) aneurysms, we often find that the aneurysmal neck does not necessarily exist just on the arterial bifurcation. In this study, we have evaluated the relation among aneurysmal neck, parent artery, and daughter arterie...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章
doi:10.1007/s10143-005-0379-4
更新日期:2005-07-01 00:00:00
abstract::The pathophysiology of syringomyelia development is not fully understood. Current prevailing theories suggest that increased pulse pressure in the subarachnoid space forces cerebrospinal fluid (CSF) through the spinal cord into the syrinx. It is generally accepted that the syrinx consists of CSF. The here-proposed int...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-006-0029-5
更新日期:2006-10-01 00:00:00
abstract::The apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) plays an important role in diagnosing intracranial tumors and predicting the histopathological grade of the tumor. However, the differences in the ADC values between craniopharyngiomas and germ cell tumors (GCTs) have not been clarified. We t...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0660-0
更新日期:2016-04-01 00:00:00
abstract::Case reports and postmortem neuropathological findings of a wide spectrum of diseases affecting the vertebral arteries, in particular vasculitis, traumatic lesions, degenerative changes and congenital abnormalities, are discussed. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00638894
更新日期:1990-01-01 00:00:00
abstract::The number of patients undergoing surgical treatment for pharmacoresistant temporal lobe epilepsy is rapidly increasing. While there have been many clinicopathological studies concerning the medial structures of the temporal lobe in temporal lobe epilepsy, its lateral structures have received little attention. To exam...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/pl00021698
更新日期:2000-06-01 00:00:00
abstract::It was suggested that D, L-Methadone might improve the clinical course of glioma patients. Owing to massive press coverage, patients demand the prescription of D, L-Methadone, but regarding its adjunctive use in glioma therapy there is no standard medication plan. Furthermore, it is not known which side effects the ad...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01250-1
更新日期:2020-02-14 00:00:00
abstract::Despite the introduction of new antiepileptic drugs and advances in the surgical treatment of epilepsy, an important group of patients still remains uncontrolled by any of these methods. The relatively recent introduction of vagus nerve stimulation is yet another possible treatment for refractory epilepsy. This safe, ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0555-5
更新日期:2014-10-01 00:00:00
abstract::Epidermoid cysts constitute less than 1% of intracranial tumors with the majority of them involving cerebellopontine angle (CPA). Although several mechanisms for cranial nerve dysfunction due to these tumors have been proposed, no direct evaluation for hyper- or hypoactive dysfunction has been done. In this case serie...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0684-5
更新日期:2016-04-01 00:00:00
abstract::Hemangioblastoma is a rare benign tumor that consists of neoplastic vacuolated stromal cells and highly developed capillary blood vessels. These tumors are almost exclusively found in the central nervous system, but in extremely rare cases, it can arise in peripheral nerves. In the majority of cases, it occurs sporadi...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-014-0587-x
更新日期:2015-01-01 00:00:00
abstract::Preoperative prediction of molecular information of lower-grade gliomas (LrGGs) helps to determine the overall treatment strategy as well as the initial surgical strategy. This study aimed to detect magnetic resonance imaging (MRI) texture parameters to predict the molecular signature of LrGGs using a commercially ava...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01157-6
更新日期:2020-08-01 00:00:00
abstract::Hemangiopericytomas represent rare intracranial tumors that have a tendency to recur locally and have the unique characteristic of giving extracranial metastases. Our current communication reviews a series of patients diagnosed with hemangiopericytoma who were treated in our facility. Eleven patients with a mean age o...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-005-0001-9
更新日期:2006-04-01 00:00:00
abstract::Histological, immunocytochemical, and biological features of 38 giant cell gliomas were investigated. The invasion of these tumors and its giant cells by histiocytes, lymphocytes, plasma cells, and especially by eosinophilic granulocytes is viewed as an immune response, which may explain a favorable clinical course. F...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01782050
更新日期:1987-01-01 00:00:00
abstract::It is well known that radiation can induce meningiomas. These tumors usually arise in patients with a history of low-dose radiation to the scalp for treatment of tinea capitis or high-dose radiation for a previous brain tumor. Radiation-associated meningiomas (RAMs) morphologically resemble their spontaneously arising...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-004-0366-1
更新日期:2005-04-01 00:00:00
abstract::Otogenic brain abscesses are a significant cause of mortality and morbidity in developing countries. Usually they occur either by distant thrombophlebitis of cerebral veins or by direct extension in an unsafe type of chronic suppurative otitis media. This case of cerebellar abscess was prepared for surgical excision, ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01111489
更新日期:1998-01-01 00:00:00
abstract::Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. W...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01787120
更新日期:1989-01-01 00:00:00
abstract::The purpose of this study was to study the acute phase effects of adenosine triphosphate (ATP)-MgCl2 on experimental spinal cord clip compression injury. Spinal cord clip compression injury was performed on 36 albino Wistar rats. The rats were divided into five groups. T4-T8 total laminectomy was performed on all rats...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-002-0233-x
更新日期:2003-01-01 00:00:00
abstract::Supplemental education is desirable for neurosurgical training, and the use of human cadaver specimen and virtual reality models is routine. An in vivo porcine training model for cranial neurosurgery was introduced in 2005, and our recent experience with this unique model is outlined here. For the first time, porcine ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0572-4
更新日期:2015-01-01 00:00:00
abstract::Direct delivery of antibiotics to the ventricular system offers an alternative for the management of nosocomial meningitis. However, the available literature frequently results in controversial findings regarding its safety. The present meta-analysis aimed at summarizing the risk of local complications after the admin...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-019-01226-w
更新日期:2019-12-24 00:00:00