Abstract:
:Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain. Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. These results indicate that different receptors are associated with specific neuronal systems and could be used as markers for these neuronal populations in different pathological studies. The possibility of visualizing receptors in the living human with non-invasive techniques such as PET could lead to the future use of receptor alterations as a diagnostic tool.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Palacios JM,Chinaglia G,Probst Adoi
10.1007/BF01787120subject
Has Abstractpub_date
1989-01-01 00:00:00pages
11-20issue
1eissn
0344-5607issn
1437-2320journal_volume
12pub_type
杂志文章abstract::Von Hippel-Lindau disease (VHL) is a hereditary cancer syndrome caused by germline mutations of the VHL tumor suppressor gene. Major progress has been made in the last decade in both clinical and fundamental aspects of VHL. The VHL gene product, pVHL, has major and multiple functions: pVHL regulates not only first ang...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s101430050024
更新日期:2000-03-01 00:00:00
abstract::Intracranial pseudoaneurysm formation due to ruptured non-traumatic saccular aneurysm is extremely rare. We experienced two cases of large pseudoaneurysm formation due to rupture of a saccular aneurysm. The neuroradiological ghost-like appearance of the aneurysms led to misdiagnoses as large partially thrombosed aneur...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-004-0336-7
更新日期:2004-10-01 00:00:00
abstract::Magnesium has neuroprotective and antivasospastic properties in the presence of subarachnoid hemorrhage (SAH). The present study investigated the effect of intracisternal administration of magnesium on cerebral vasospasm in the experimental SAH rat model. The rat double-SAH model (0.2 mL autologous blood injected twic...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0122-z
更新日期:2008-04-01 00:00:00
abstract::The present study aimed to determine the clinical presentation, the multimodal interdisciplinary treatment strategies and outcome of posterior fossa arterio-venous malformations (AVMs) in our neurovascular centre. Fifty-three patients with a posterior fossa AVM were seen between 1998 and 2012 and analysed retrospectiv...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0551-9
更新日期:2014-10-01 00:00:00
abstract::Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- an...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0880-6
更新日期:2018-04-01 00:00:00
abstract::Cerebral vasospasm is delayed narrowing of the large arteries of the circle of Willis occurring 4 to 14 days after aneurysmal subarachnoid hemorrhage (SAH). It is but one cause of delayed deterioration after SAH but, in general, is the most important potentially treatable cause of morbidity and mortality after SAH. De...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-005-0013-5
更新日期:2006-07-01 00:00:00
abstract::In the last decade, operative decompression of cord and cauda, internal fixation with rods, bony fusion and early ambulation, have become more popular in the management of thoracolumbar injuries with neurological deficit. Computer-tomography, CT myelography and peroperative ultrasonography provided direct evidence, th...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01743066
更新日期:1986-01-01 00:00:00
abstract::The unruptured intracranial aneurysm treatment score (UIATS) was published in April 2015 as a multidisciplinary consensus regarding treatment of unruptured intracranial aneurysms (UIA). As a tertiary center with focus on vascular neurosurgery, we aimed to investigate whether our treatment decision-making in patients w...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-0944-2
更新日期:2018-10-01 00:00:00
abstract::We report our experience with the anterior subtemporal approach for the posterior communicating artery aneurysm protruding posteriorly. Between 2000 and 2005, seven patients with posterior communicating artery aneurysm were operated on through the anterior subtemporal approach. The approach provided a better view than...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0083-7
更新日期:2007-07-01 00:00:00
abstract::Torticollis is either congenital or acquired in childhood. Acquired torticollis is not a diagnosis but rather a sign of an underlying disorder. The causes of acquired torticollis include ligamentous, muscular, osseous, ocular, psychiatric, and neurologic disorders and may be a symptom of significant abnormalities of t...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-006-0034-8
更新日期:2006-10-01 00:00:00
abstract::Concordance between the Unruptured Intracranial Aneurysm Treatment Score (UIATS), Earlier Subarachnoid Hemorrhage, Location, Age, Population, Size, Shape (ELAPSS) score, and Population, Hypertension, Age, Size, Earlier Subarachnoid Hemorrhage, Site (PHASES) score with real-world management decisions in unruptured intr...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01356-6
更新日期:2020-07-22 00:00:00
abstract::As a result of their presumed benign natural history, cerebral capillary telangiectasias (CCTs) are infrequently addressed in the neurosurgical literature. We performed a comprehensive review of CCTs via the PubMed database to synthesize overall epidemiological, radiographic, natural history, and treatment results. Ac...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-012-0435-9
更新日期:2013-04-01 00:00:00
abstract::Chemotherapy of malignant glioma has been discussed in relation to recent advances in experimental and clinical studies. It is now obvious that chemotherapy is of increasing importance in the multidisciplinary treatment of malignant gliomas. Survival time of patients was prolonged by intensive and prolonged chemothera...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF01743285
更新日期:1984-01-01 00:00:00
abstract::Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-018-01074-0
更新日期:2019-06-01 00:00:00
abstract::There are many satisfactory long-term outcomes after posterolateral fusion (PLF) for degenerative lumbar spondylolisthesis (DLS); nonunion cases have also achieved good clinical outcomes. Facet fusion (FF), a minimally invasive evolution of PLF, also resulted in good clinical outcomes. We aimed to assess the course of...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-021-01479-4
更新日期:2021-01-20 00:00:00
abstract::The endoscope has become an essential tool for transsphenoidal pituitary surgeries because of the panoramic view and the ability to visualize structures beyond the direct line of vision. However, the regular dedicated instruments for these surgeries sometimes do not reach the areas visualized by an angled endoscope, a...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0108-2
更新日期:2008-01-01 00:00:00
abstract::The purpose of this study is to compare intervertebral bone fusion and clinical outcomes in L4-5 posterior lumbar interbody fusion (PLIF) using the same posterior instrumentation with four combinations of one of three types of interbody cage with one of two bone grafts, iliac and local or only local. In 67 patients wh...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0610-x
更新日期:2015-07-01 00:00:00
abstract::Although endovascular or surgical treatment has been performed for preventing the rupture of saccular cerebral aneurysms (sCA), in some patients, the aneurysms may recur and require retreatment. We aimed to investigate the clinical and radiological outcomes of treating recurrent sCA. We retrospectively evaluated the d...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01259-6
更新日期:2020-02-21 00:00:00
abstract::Clinical and radiological features that help predict the growth potential of meningioma would be beneficial. The purpose of this study is to clarify the characteristics related to proliferating potential using the MIB-1 staining index. We analyzed the relationship of MIB-1 staining indices to characteristics of 342 co...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-006-0039-3
更新日期:2006-10-01 00:00:00
abstract::In spite of recent advancements in the management of ruptured aneurysm, there are still controversies as to how to threat the patients in serious conditions, one of these concerning whether to operate patients admitted with symptomatic vasospasm (vasospasm on admission) and when. While early surgery may protect patien...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00417662
更新日期:1995-01-01 00:00:00
abstract::Skull base chordomas represent very interesting neoplasms, due to their rarity, biological behavior, and resistance to treatment. Their management is very challenging. Recently, the use of a natural corridor, through the nose and the sphenoid sinus, improved morbidity and mortality allowing also for excellent removal ...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章
doi:10.1007/s10143-013-0503-9
更新日期:2014-04-01 00:00:00
abstract::Patients with craniocervical disorders (CCD) show a wide variety of symptoms and signs suggesting cerebellar and/or high cervical lesion. The anatomic localization of respiratory centers and their possible injury may explain the presence of respiratory disturbances in these diseases. The aim of this preliminary study ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/pl00011947
更新日期:2000-09-01 00:00:00
abstract::In a study the results recorded in 34 surgically treated patients with specific or unspecific spondylodiscitis after dorsoventral one-stage instrumentation with CDI and anterior grafting (group 1) were compared with those obtained in a group of 38 patients treated with anterior CDH instrumentation in combination with ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01105775
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Trigeminal neuralgia (TN) is characterized by jolts of pain along the distribution of the trigeminal nerve. If patients fail conservative management, microvascular decompression (MVD) is the next step in treatment. MVD is largely done by placing implant pads between the nerve and compressing vessels. We cond...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-019-01187-0
更新日期:2020-02-01 00:00:00
abstract::Direct electrical stimulation (DES) of the optic radiation (OR) during an awake tumor resection has been repeatedly reported. In all cases, visual function monitoring was performed in patients with open eyes which were looking at a picture. We report a new modification of the standard method, OR stimulation in patient...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0535-9
更新日期:2014-07-01 00:00:00
abstract::Microvascular decompression represents an effective treatment for hemifacial spasm. The use of lateral spread response (LSR) monitoring remains a useful intraoperative tool to ensure adequate decompression of the facial nerve. The aim of this study was to assess the value of LSRs intraoperative monitoring as a prognos...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-016-0708-9
更新日期:2016-07-01 00:00:00
abstract::A 22-year-old woman presented with acute onset of headache and vomiting. Computed tomography (CT) demonstrated hydrocephalus and a huge midline mass with heterogeneous density involving both lateral ventricles. A small amount of hematoma was detected at the bottom of the left trigone. On magnetic resonance imaging (MR...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/pl00011968
更新日期:2001-03-01 00:00:00
abstract::Idiopathic normal pressure hydrocephalus is a hydrodynamic disorder whose etiology remains unclear. The diagnosis is mainly clinical and the traditional treatment is cerebrospinal fluid shunt diversion. With the introduction of modern management strategies, endoscopic third ventriculostomy has become a viable alternat...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-015-0685-4
更新日期:2016-10-01 00:00:00
abstract::Human malignant gliomas arise from neural progenitor cells and/or dedifferentiated astrocytes. By now, they are genetically so well characterized that several murine glioma models have emerged that faithfully reiterate the typical histological features of the disease. In experimental animals, only one or two elements ...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-003-0267-8
更新日期:2003-07-01 00:00:00
abstract::Proximally located posterior communicating artery (PCoA) aneurysms, projecting postero-laterally in proximity to the tentorium, may pose a technical challenge for microsurgical clipping due to obscuration of the proximal aneurysmal neck by the anterior petroclinoid fold. We describe an efficacious technique utilizing ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0554-6
更新日期:2014-10-01 00:00:00