Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series.


:It was suggested that D, L-Methadone might improve the clinical course of glioma patients. Owing to massive press coverage, patients demand the prescription of D, L-Methadone, but regarding its adjunctive use in glioma therapy there is no standard medication plan. Furthermore, it is not known which side effects the administration of D, L-Methadone might harbor, especially if the patients are opioid-naïve and if D, L-Methadone therapy was managed by the patients themselves or their general practitioners. Opioid-naïve patients with high-grade glioma (new diagnosis or recurrent) receiving D, L-Methadone were included in this retrospective observational analysis. Side effects were assigned if the condition deteriorated in conjunction with the initiation of D, L-Methadone and resolved/ ameliorated after cessation of the intake/reduction of the dosage. Side effects were categorized according to the common toxicity criteria (CTC). Twenty-four patients were included. All patients were opioid-naïve and received D, L-Methadone from their general practitioners. Sixteen patients experienced side effects. The median dosage when side effects began to occur was 15.8 mg/ 24 h. Fatigue and mood changes were reported most frequently (14 of 24 patients). Five patients had severe side effects related to relatively high doses. In all cases, symptoms resolved after cessation or dose reduction. Our results show that D/L M intake lead to frequent occurrence of side effects in opioid-naïve patients especially when not handled with caution and close supervision. Patients, their relatives, their GPs and neuro-oncologists need to be informed about the broad spectrum of side effects in order to thoroughly counsel glioma patients.


Neurosurg Rev


Neurosurgical review


von der Brelie C,Schatlo B,Bettag C,Rohde V




Has Abstract


2020-02-14 00:00:00








  • Morphometric analysis of untreated adult skulls in syndromic and nonsyndromic craniosynostosis.

    abstract::The aim of this study was to perform a morphometric analysis of untreated adult skulls displaying syndromic and nonsyndromic craniosynostosis. We analyzed, in detail, 42 adult craniosynostoses (18 scaphocephaly, 11 anterior plagiocephaly, 2 trigonocephaly, 9 oxycephaly, and 2 brachycephaly) from archeological (three s...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Weber J,Collmann H,Czarnetzki A,Spring A,Pusch CM

    更新日期:2008-04-01 00:00:00

  • Endoscopic management of third ventricular colloid cysts in mildly dilated lateral ventricles.

    abstract::Colloid cysts of the third ventricle are considered as benign lesions. The clinical manifestations are not clear in most of cases. Many treatment options are available and endoscopic removal of the cysts proves to be a very successful method especially if the lateral ventricles are moderately or severely dilated. Some...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Eshra MA

    更新日期:2019-03-01 00:00:00

  • Contribution to the problem of giant cell astrocytomas.

    abstract::Histological, immunocytochemical, and biological features of 38 giant cell gliomas were investigated. The invasion of these tumors and its giant cells by histiocytes, lymphocytes, plasma cells, and especially by eosinophilic granulocytes is viewed as an immune response, which may explain a favorable clinical course. F...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Müller W,Slowik F,Firsching R,Afra D,Sanker P

    更新日期:1987-01-01 00:00:00

  • Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection.

    abstract::5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue. Therefore, the use of 5-ALA in the surgical treatment of intracranial tumors, particularly gliomas, has gained popularity i...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Potapov AA,Goryaynov SA,Okhlopkov VA,Shishkina LV,Loschenov VB,Savelieva TA,Golbin DA,Chumakova AP,Goldberg MF,Varyukhina MD,Spallone A

    更新日期:2016-07-01 00:00:00

  • Fibroxanthoma arising from the cranial dura mater.

    abstract::A primary xanthomatous tumor is very rare in the central nervous system (CNS). Here we report the case of a fibroxanthoma arising from the dura mater of the cerebrum that demonstrated no systemic disease or metabolic abnormalities. A 19-month-old, otherwise healthy boy was found to have an enlarged head. Magnetic reso...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Miyazono M,Nishio S,Morioka T,Hamada Y,Fukui M,Yanai S

    更新日期:1999-12-01 00:00:00

  • Review of the literature regarding the relationship of rebleeding and external ventricular drainage in patients with subarachnoid hemorrhage of aneurysmal origin.

    abstract::Acute hydrocephalus is a well-documented complication of subarachnoid hemorrhage. The insertion of external ventricular drainage (EVD) has been the standard of care in the management of this complication, aiming primarily at immediate improvement of the clinical condition of these patients, making them more suitable c...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Fountas KN,Kapsalaki EZ,Machinis T,Karampelas I,Smisson HF,Robinson JS

    更新日期:2006-01-01 00:00:00

  • Hemodynamic changes in a middle cerebral artery aneurysm at follow-up times before and after its rupture: a case report and a review of the literature.

    abstract::Hemodynamic parameters play a significant role in the development of cerebral aneurysms. Parameters such as wall shear stress (WSS) or velocity could change in time and may contribute to aneurysm growth and rupture. However, the hemodynamic changes at the rupture location remain unclear because it is difficult to obta...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Sejkorová A,Dennis KD,Švihlová H,Petr O,Lanzino G,Hejčl A,Dragomir-Daescu D

    更新日期:2017-04-01 00:00:00

  • Familial gliomas. Analysis of six families with cerebral gliomas and without other inheritable syndromes.

    abstract::Although a familial tendency to develop brain tumors in the absence of well-recognized hereditary disorders is an important issue, it has been rarely reported. Studies of the familial occurrence of gliomas have yielded conflicting results. This phenomenon may be imputable to chance or environmental or hereditary facto...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Caroli E,Salvati M,Peruzzi P,Frati A,Giangaspero F

    更新日期:2003-10-01 00:00:00

  • Solid cerebral echinococcosis mimicking a primary brain tumor.

    abstract::Solitary brain affection is rare in echinococcosis. We report the case of a 35-year-old woman presenting with symptomatic grand-mal epilepsy due to a right frontal, partially cystic space-occupying lesion. Pre-operative computed tomography and magnetic resonance imaging (MRI) suggested a cystic astrocytoma. However, h...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Nanassis K,Alexiadou-Rudolf C,Tsitsopoulos P,Tzioufa V,Petsas G,Grigoriou K

    更新日期:1999-01-01 00:00:00

  • Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced brain and retinal damages.

    abstract::Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 te...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Sezen O,Ertekin MV,Demircan B,Karslioğlu I,Erdoğan F,Koçer I,Calik I,Gepdiremen A

    更新日期:2008-04-01 00:00:00

  • Demographics, presentation, and clinical outcomes after traumatic bifrontal contusions: a systematic review.

    abstract::Traumatic bifrontal contusions (TBC) form a recognised clinical entity among patients with traumatic brain injury (TBI). This study aims to systematically review current literature on demographics, management, and predictors of outcomes of patients with TBC. A multi-database literature search (PubMed, Cochrane, OVID M...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Van de Zande N,Manivannan S,Sharouf F,Shastin D,Abdulla M,Chumas PD,Zaben M

    更新日期:2020-06-01 00:00:00

  • Sinus pericranii: an overview and literature review of a rare cranial venous anomaly (a review of the existing literature with case examples).

    abstract::Sinus pericranii is a rare vascular abnormality characterised by abnormal connections between the intra- and extracranial venous systems and is usually found in children. In most instances, a sinus pericranii presents as a soft scalp swelling that appears with the patient in the recumbent position and disappears in th...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Akram H,Prezerakos G,Haliasos N,O'Donovan D,Low H

    更新日期:2012-01-01 00:00:00

  • Brain death: practicability of evoked potentials.

    abstract::Multimodally evoked potentials were registered in 85 patients who fulfilled the criteria for brain death. While somatosensory and visual evoked potentials have been found to be of limited value for the diagnosis of brain death, the stepwise abolition of brain stem auditory evoked potentials (BAEP) confirmed brain deat...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Firsching R,Frowein RA,Wilhelms S,Buchholz F

    更新日期:1992-01-01 00:00:00

  • Pure endoscopic endonasal odontoidectomy: anatomical study.

    abstract::Different disorders may produce irreducible atlanto-axial dislocation with compression of the ventral spinal cord. Among the surgical approaches available for a such condition, the transoral resection of the odontoid process is the most often used. The aim of this anatomical study is to demonstrate the possibility of ...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Messina A,Bruno MC,Decq P,Coste A,Cavallo LM,de Divittis E,Cappabianca P,Tschabitscher M

    更新日期:2007-07-01 00:00:00

  • In vivo porcine training model for cranial neurosurgery.

    abstract::Supplemental education is desirable for neurosurgical training, and the use of human cadaver specimen and virtual reality models is routine. An in vivo porcine training model for cranial neurosurgery was introduced in 2005, and our recent experience with this unique model is outlined here. For the first time, porcine ...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Regelsberger J,Eicker S,Siasios I,Hänggi D,Kirsch M,Horn P,Winkler P,Signoretti S,Fountas K,Dufour H,Barcia JA,Sakowitz O,Westermaier T,Sabel M,Heese O

    更新日期:2015-01-01 00:00:00

  • Cerebellopontine angle epidermoid cysts: clinical presentations and surgical outcome.

    abstract::Epidermoid cysts constitute less than 1% of intracranial tumors with the majority of them involving cerebellopontine angle (CPA). Although several mechanisms for cranial nerve dysfunction due to these tumors have been proposed, no direct evaluation for hyper- or hypoactive dysfunction has been done. In this case serie...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Hasegawa M,Nouri M,Nagahisa S,Yoshida K,Adachi K,Inamasu J,Hirose Y,Fujisawa H

    更新日期:2016-04-01 00:00:00

  • Surgical strategies for combined intraorbital and intracranial tumors.

    abstract::Three unusual cases of combined intraorbital-intracranial tumors of various types which were chosen from cases treated in the Clinic and Polyclinic of Neurosurgery of the University of Münster, to demonstrate the problems of surgical therapy. A list of indications for the various accesses to the orbita is worked out. ...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Szuwart U,Brandt M,Bennefeld H,Erlemann R

    更新日期:1988-01-01 00:00:00

  • Proliferation rate of intracranial meningiomas as defined by the monoclonal antibody MIB-1: correlation with peritumoural oedema and other clinicoradiological and histological characteristics.

    abstract::Paraffin-embedded surgical specimens from 55 meningiomas were immunostained after microwave processing using the streptavidin/peroxidase method and the monoclonal antibody (moAb) MIB-1 to the Ki-67 antigen. The authors assessed proliferative labelling index (LI) from a series of surgically removed meningiomas using im...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Aguiar PH,Tsanaclis AM,Tella OI Jr,Plese JP

    更新日期:2003-07-01 00:00:00

  • Cervical destructive spondylodiscitis: a report on three cases.

    abstract::Three patients suffering from hematogenous destructive spondylodiscitis were treated with one-session spondylectomy, bone graft-fusion and halo-device stabilization. A stable osseous fusion was achieved after three months with additional antibiotic therapy. ...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Brenner A,Donkersloot P

    更新日期:1991-01-01 00:00:00

  • Lipid peroxidation in experimental spinal cord injury: time-level relationship.

    abstract::Damage which occurs following spinal traumas is often irreversible. During recent years free oxygen radicals formed due to the pathological changes following neural tissue ischemia have been identified as being responsible for the ethio-pathogenesis of such damage. In our experimental study, model lesions are formed i...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Barut S,Canbolat A,Bilge T,Aydin Y,Cokneşeli B,Kaya U

    更新日期:1993-01-01 00:00:00

  • Polysomnographic respiratory findings in patients with Arnold-Chiari type I malformation and basilar invagination, with or without syringomyelia: preliminary report of a series of cases.

    abstract::Patients with craniocervical disorders (CCD) show a wide variety of symptoms and signs suggesting cerebellar and/or high cervical lesion. The anatomic localization of respiratory centers and their possible injury may explain the presence of respiratory disturbances in these diseases. The aim of this preliminary study ...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Botelho RV,Bittencourt LR,Rotta JM,Tufik S

    更新日期:2000-09-01 00:00:00

  • Cerebral capillary telangiectasias: a meta-analysis and review of the literature.

    abstract::As a result of their presumed benign natural history, cerebral capillary telangiectasias (CCTs) are infrequently addressed in the neurosurgical literature. We performed a comprehensive review of CCTs via the PubMed database to synthesize overall epidemiological, radiographic, natural history, and treatment results. Ac...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,meta分析,评审


    authors: Gross BA,Puri AS,Popp AJ,Du R

    更新日期:2013-04-01 00:00:00

  • Functional imaging of the brain in psychiatry--mapping of EEG and evoked potentials.

    abstract::Topographic brain mapping of EEG and evoked potentials permits the display of spontaneous and event-related activity of the brain. This new method is superior to conventional polygraphy because of the topographic approach which delineates structural and functional brain lesions. Data from 16 to 20 scalp electrodes wer...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Maurer K,Dierks T

    更新日期:1987-01-01 00:00:00

  • Keyhole epilepsy surgery: corticoamygdalohippocampectomy for mesial temporal sclerosis.

    abstract::Surgical approaches for medically refractory mesial temporal lobe epilepsy (MTLE) that previously have been reported include anterior temporal lobectomy (ATL), transcortical selective amygdalohippocampectomy, transsylvian amygdalohippocampectomy, and subtemporal amygdalohippocampectomy. Each approach has its advantage...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Yang PF,Zhang HJ,Pei JS,Lin Q,Mei Z,Chen ZQ,Jia YZ,Zhong ZH,Zheng ZY

    更新日期:2016-01-01 00:00:00

  • Osteoplastic laminotomy using titanium microplates for reconstruction of the laminar roof: a technical note.

    abstract::A technique to reconstruct the posterior elements of the spinal canal in osteoplastic laminotomy is described. The use of titanium microplates allows a stable fixation of the laminar arch with optimal realignment of the lamina cut ends. The titanium implants are fully compatible with magnetic resonance imaging. The au...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Wiedemayer H,Schoch B,Stolke D

    更新日期:1998-01-01 00:00:00

  • Rate of third nerve palsy recovery following endovascular management of cerebral aneurysms.

    abstract::Endovascular management of cerebral aneurysms resulting in third nerve palsies has been proposed as an alternative to microsurgical clip ligation. Third nerve function recovery following endovascular treatment in a large patient population has not been evaluated. A literature search of MEDLINE, PubMed, and Cochrane da...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Bulsara KR,Jackson D,Galvan GM

    更新日期:2007-10-01 00:00:00

  • Minimal access to deep intracranial lesions using a serial dilatation technique: case-series and review of brain tubular retractor systems.

    abstract::Surgical access to deep intracranial lesions causing the least amount of iatrogenic trauma to the surrounding brain tissue remains a challenging task. In this article, we evaluate the use of a set of sequential tubes that dilate and provide retraction of the overlying brain tissue acting as a surgical corridor for dee...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Almenawer SA,Crevier L,Murty N,Kassam A,Reddy K

    更新日期:2013-04-01 00:00:00

  • Clinical and radiological features related to the growth potential of meningioma.

    abstract::Clinical and radiological features that help predict the growth potential of meningioma would be beneficial. The purpose of this study is to clarify the characteristics related to proliferating potential using the MIB-1 staining index. We analyzed the relationship of MIB-1 staining indices to characteristics of 342 co...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Kasuya H,Kubo O,Tanaka M,Amano K,Kato K,Hori T

    更新日期:2006-10-01 00:00:00

  • Timing of cranial reconstruction after cranioplasty infections: are we ready for a re-thinking? A comparative analysis of delayed versus immediate cranioplasty after debridement in a series of 48 patients.

    abstract::The optimal management of cranioplasty infections remains a matter of debate. Most authors have suggested that the infected bone/implant removal is mandatory, combined with prolonged antibiotic therapy before reconstruction. However, failures can occur, even with 12-18-month intervals between the surgeries. Longer wai...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Di Rienzo A,Colasanti R,Gladi M,Dobran M,Della Costanza M,Capece M,Veccia S,Iacoangeli M

    更新日期:2020-06-26 00:00:00

  • Cerebral blood flow, computerized tomography and angiography in 562 cases of cerebrovascular insufficiency.

    abstract::The measurement of cerebral blood flow (CBF) in addition to cerebral computerized tomography (CT) and angiography is most reliable in cases of transient ischemic attacks (TIA) and prolonged reversible ischemic neurologic deficits (PRIND). Alterations of CBF can be detected in symptom-free intervals. The cerebrovascula...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Ulrich P,Heim C,Meinig G

    更新日期:1987-01-01 00:00:00