Abstract：
:It was suggested that D, L-Methadone might improve the clinical course of glioma patients. Owing to massive press coverage, patients demand the prescription of D, L-Methadone, but regarding its adjunctive use in glioma therapy there is no standard medication plan. Furthermore, it is not known which side effects the administration of D, L-Methadone might harbor, especially if the patients are opioid-naïve and if D, L-Methadone therapy was managed by the patients themselves or their general practitioners. Opioid-naïve patients with high-grade glioma (new diagnosis or recurrent) receiving D, L-Methadone were included in this retrospective observational analysis. Side effects were assigned if the condition deteriorated in conjunction with the initiation of D, L-Methadone and resolved/ ameliorated after cessation of the intake/reduction of the dosage. Side effects were categorized according to the common toxicity criteria (CTC). Twenty-four patients were included. All patients were opioid-naïve and received D, L-Methadone from their general practitioners. Sixteen patients experienced side effects. The median dosage when side effects began to occur was 15.8 mg/ 24 h. Fatigue and mood changes were reported most frequently (14 of 24 patients). Five patients had severe side effects related to relatively high doses. In all cases, symptoms resolved after cessation or dose reduction. Our results show that D/L M intake lead to frequent occurrence of side effects in opioid-naïve patients especially when not handled with caution and close supervision. Patients, their relatives, their GPs and neuro-oncologists need to be informed about the broad spectrum of side effects in order to thoroughly counsel glioma patients.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
von der Brelie C,Schatlo B,Bettag C,Rohde Vdoi
10.1007/s10143-020-01250-1subject
Has Abstractpub_date
2020-02-14 00:00:00eissn
0344-5607issn
1437-2320pii
10.1007/s10143-020-01250-1pub_type
杂志文章abstract：:Patients with craniocervical disorders (CCD) show a wide variety of symptoms and signs suggesting cerebellar and/or high cervical lesion. The anatomic localization of respiratory centers and their possible injury may explain the presence of respiratory disturbances in these diseases. The aim of this preliminary study ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/pl00011947
更新日期：2000-09-01 00:00:00
abstract：:Unruptured intracranial aneurysms represent a decisional challenge. Treatment risks have to be balanced against an unknown probability of rupture. A better understanding of the physiopathology is the basis for a better prediction of the natural history of an individual patient. Knowledge about the possible determining...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-013-0501-y
更新日期：2014-01-01 00:00:00
abstract：:A review of a series of 56 patients with a giant intracranial aneurysm showed that 28 presented with signs related to the mass effect and 19 with subarachnoid hemorrhage (SAH). Additional clinical signs observed were seizures, ischemia, and endocrinological disturbances. Fourty-five aneurysms involved the carotid arte...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00383260
更新日期：1991-01-01 00:00:00
abstract：:As a result of their presumed benign natural history, cerebral capillary telangiectasias (CCTs) are infrequently addressed in the neurosurgical literature. We performed a comprehensive review of CCTs via the PubMed database to synthesize overall epidemiological, radiographic, natural history, and treatment results. Ac...
journal_title：Neurosurgical review
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10143-012-0435-9
更新日期：2013-04-01 00:00:00
abstract：:Sinus pericranii is a rare vascular abnormality characterised by abnormal connections between the intra- and extracranial venous systems and is usually found in children. In most instances, a sinus pericranii presents as a soft scalp swelling that appears with the patient in the recumbent position and disappears in th...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-011-0325-6
更新日期：2012-01-01 00:00:00
abstract：:Multilevel discectomy and inter-vertebral body fusion combined with anterior plate-screw fixation is the common procedure in cervical spine surgery. The correct placement of the screws is an important factor for the outcome of these operations. Yet no systematic approach has been undertaken to optimize the geometry of...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-005-0386-5
更新日期：2005-10-01 00:00:00
abstract：:Pediatric cortical ependymomas (CEs) are rare; the clinical features and optimal treatment remain ill-defined. We aimed to clarify the clinical characteristics and outcome of pediatric CEs based on institutional series and literature review. Thirteen children with CEs from our department were included in the present s...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01336-w
更新日期：2020-06-30 00:00:00
abstract：:Von Hippel-Lindau disease (VHL) is a hereditary cancer syndrome caused by germline mutations of the VHL tumor suppressor gene. Major progress has been made in the last decade in both clinical and fundamental aspects of VHL. The VHL gene product, pVHL, has major and multiple functions: pVHL regulates not only first ang...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s101430050024
更新日期：2000-03-01 00:00:00
abstract：:Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 te...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-007-0118-0
更新日期：2008-04-01 00:00:00
abstract：:Optic pathway glioma (OPG) encompasses a spectrum of findings ranging from lesions confined to the optic nerve only, lesions affecting the optic chiasm and hypothalamus, and lesions with diffuse involvement of a large part of the optic pathway and neighboring structures. The majority of pediatric low-grade astrocytoma...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-016-0747-2
更新日期：2017-01-01 00:00:00
abstract：:We previously introduced a novel noninvasive technique of intracranial pressure (ICP) monitoring in children with open fontanelles. Within this study, we describe the first clinical implementation and results of this new technique in management of children with hydrocephalus caused by intraventricular hemorrhage (IVH)...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-019-01105-4
更新日期：2020-04-01 00:00:00
abstract：:A large variety of vertebral tumours undergoes transarterial embolisation (TAE) prior to surgery. However, the subsequent intra-operative blood loss is unpredictable. This retrospective analysis, aims to determine the impact of various factors that may potentially influence the estimated intra-operative blood loss (EB...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-1003-8
更新日期：2019-12-01 00:00:00
abstract：:The introduction of computed tomography (CT) and magnetic resonance (MR) imaging has resulted in the detection of increasing numbers of asymptomatic intraventricular tumors. Establishing the correct preoperative diagnosis is important to prevent unnecessary surgical intervention. Our study includes nine cases of benig...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-004-0353-6
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Trigeminal neuralgia (TN) is characterized by jolts of pain along the distribution of the trigeminal nerve. If patients fail conservative management, microvascular decompression (MVD) is the next step in treatment. MVD is largely done by placing implant pads between the nerve and compressing vessels. We cond...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-019-01187-0
更新日期：2020-02-01 00:00:00
abstract：:Forty-four adult acromegalic patients carrying growth hormone-producing pituitary macroadenomas were investigated with neuroradiological and endocrinological techniques. Plasma growth hormone and somatomedin-C levels were repeatedly measured before surgical removal of tumors and during the follow-up period. Twenty-fiv...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01105562
更新日期：1997-01-01 00:00:00
abstract：:Direct delivery of antibiotics to the ventricular system offers an alternative for the management of nosocomial meningitis. However, the available literature frequently results in controversial findings regarding its safety. The present meta-analysis aimed at summarizing the risk of local complications after the admin...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-019-01226-w
更新日期：2019-12-24 00:00:00
abstract：:Surgical approaches for medically refractory mesial temporal lobe epilepsy (MTLE) that previously have been reported include anterior temporal lobectomy (ATL), transcortical selective amygdalohippocampectomy, transsylvian amygdalohippocampectomy, and subtemporal amygdalohippocampectomy. Each approach has its advantage...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-015-0657-8
更新日期：2016-01-01 00:00:00
abstract：:Radical excision of meningioma is suggested to provide for the best tumor control rates. However, aggressive surgery for meningiomas located at the posterior cranial fossa may lead to elevated postoperative morbidity of adjacent cranial nerves which in turn worsens patients' postoperative quality of life. Therefore, w...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01275-6
更新日期：2020-02-27 00:00:00
abstract：:Fifteen cases of chronic vegetative state (CVS), following severe head injury and lasting for two years or more, are reported. Vegetative state, in most instances after a period of coma, consists of a return of wakefulness accompanied by an apparent total lack of higher mental activity. A protracted period of vegetati...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01790694
更新日期：1989-01-01 00:00:00
abstract：:The orbitotomy has a central importance in craniofacial surgery. It is indicated for premature craniosynostoses, malformations and tumor surgery. The aim of the treatment is to correct functional disturbances and aesthetic impairments. Anatomical structures must be respected. Functional and anatomical aspects of the o...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01787121
更新日期：1989-01-01 00:00:00
abstract：:There is growing evidence that the nervous system influences spinal cord vasculature. However, most descriptions of the spinal cord have paid little attention to this important aspect. We reviewed the literature on the innervation of spinal cord vessels with an emphasis on findings that may be applicable to human medi...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-016-0788-6
更新日期：2018-07-01 00:00:00
abstract：:The vasodilatory calcitonin gene-related peptide (CGRP) is excessively released after spontaneous subarachnoid hemorrhage (sSAH) and modulates psycho-behavioral function. In this pilot study, we prospectively analyzed the treatment-specific differences in the secretion of endogenous CGRP into cerebrospinal fluid (CSF)...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01333-z
更新日期：2020-06-22 00:00:00
abstract：:The objective of this study was to ascertain if stereotactic neurosurgical biopsy (SNB) optimizes the therapy of undefined CNS masses. The design was of retrospective treatment and outcome analysis and the setting was a large general hospital. We studied a total of 141 patients with undefined, space-occupying CNS lesi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s101430050043
更新日期：1999-10-01 00:00:00
abstract：:Direct electrical stimulation (DES) of the optic radiation (OR) during an awake tumor resection has been repeatedly reported. In all cases, visual function monitoring was performed in patients with open eyes which were looking at a picture. We report a new modification of the standard method, OR stimulation in patient...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0535-9
更新日期：2014-07-01 00:00:00
abstract：:This retrospective study included eight consecutive cases with C2 vertebral body neoplastic lesions. The anterior retropharyngeal approach was used to remove the lesions and decompress the spinal cord. Spinal stabilization with occipitocervical plating in a second-stage operation makes the treatment more tolerable for...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-003-0319-0
更新日期：2004-07-01 00:00:00
abstract：:The authors describe a case of hemifacial spasm associated with Marfan's syndrome. A 24-year-old-woman suffered from left hemifacial spasm for 6 years. She had undergone surgical treatments for bilateral ectopia lentis and kyphoscoliosis in the second decade of life. She also had unusually long and slim limbs with ara...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF02389321
更新日期：1998-01-01 00:00:00
abstract：:We report here on congenital sphenoorbital encephalocele which could not be disclosed by computed tomography including contrast medium application or by orbital sonography. Surgery and histological examination were necessary to establish correct the diagnosis. ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01794689
更新日期：1988-01-01 00:00:00
abstract：:Massive hemorrhage is a very uncommon event among hemangioblastomas. Forty-four cases have been reported before this review. Thorough analysis of all reported cases on literature was accomplished. The majority presented as parenchymatous or subarachnoid bleedings. Subarachnoid hemorrhage was only associated with spina...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-009-0217-1
更新日期：2010-01-01 00:00:00
abstract：:The purpose of the present study is to analyze the impact of intraoperative resection control modalities on overall survival (OS) and progression-free survival (PFS) following gross total resection (GTR) of glioblastoma. We analyzed data of 76 glioblastoma patients (30f, mean age 57.4 ± 11.6 years) operated at our ins...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-015-0698-z
更新日期：2016-07-01 00:00:00
abstract：:Recently, a bioactive glass ceramic (BGC) has been developed for use as intervertebral cages for anterior cervical discectomy and fusion (ACDF). However, the effectiveness and safety of BGC cages remain to be evaluated. We completed a retrospective comparison of the radiological and clinical outcomes of 36 patients (5...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-019-01225-x
更新日期：2020-10-01 00:00:00
