Abstract：
:The purpose of this study was to study the acute phase effects of adenosine triphosphate (ATP)-MgCl2 on experimental spinal cord clip compression injury. Spinal cord clip compression injury was performed on 36 albino Wistar rats. The rats were divided into five groups. T4-T8 total laminectomy was performed on all rats. Group 1: sham-operated group. Group 2: clip compression group. In group 3, ATP-MgCl2 (100 micro mol/kg) was given 2 min before the "clip compression injury." In group 4, ATP-MgCl2 (100 micro mol/kg) was given 5 min after the clip compression injury. In group 5, ATP MgCl2 (100 micro mol/kg) was administered 8 h after the injury. The spinal cords were excised for a length of 2 cm and deep frozen at -76 degrees C. Tissue malondialdehyde (MDA) levels were used to determine the effects of ATP-MgCl2 on spinal cord lipid peroxidation. In the groups in which ATP MgCl2 was administered after the clip compression injury (groups 4 and 5), the decrease in spinal cord MDA levels was statistically significant when compared with those of the injury group (group 2). Although MDA levels of group 4 were lower than those of group 5, this difference was not statistically significant. Administration of the ATP-MgCl2 before the clip compression injury (in group 3) did not have a statistically significant effect on lipid peroxidation when compared with the injury group (group 2). In this study, we found that ATP-MgCl2 has decreased lipid peroxidation in spinal cord injury and protected the spinal cord from secondary injury after the trauma. We concluded that ATP-MgCl2 may be used in the treatment of spinal cord injuries in conjunction with the other treatment modalities, but further investigations are mandatory.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Cakir E,Baykal S,Karahan SC,Kuzeyli K,Uydu Hdoi
10.1007/s10143-002-0233-xkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
67-70issue
1eissn
0344-5607issn
1437-2320journal_volume
26pub_type
杂志文章abstract：:The unruptured intracranial aneurysm treatment score (UIATS) was published in April 2015 as a multidisciplinary consensus regarding treatment of unruptured intracranial aneurysms (UIA). As a tertiary center with focus on vascular neurosurgery, we aimed to investigate whether our treatment decision-making in patients w...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-0944-2
更新日期：2018-10-01 00:00:00
abstract：:Overcoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1alpha and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression profiles of the U-2...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-007-0070-z
更新日期：2007-07-01 00:00:00
abstract：:Three of 30 human cerebral cortex biopsies from infants treated for hydrocephalus by shunt operation are described. The descriptions include an account of their case history, the clinical methods, and the operational procedures. The biopsy specimens were studied in semithin and ultrathin sections. Attention is drawn t...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01741422
更新日期：1988-01-01 00:00:00
abstract：:Dissecting aneurysms in the anterior cerebral artery (ACA), although rare, can cause ischemic and/or hemorrhagic stroke. Hemorrhagic dissecting aneurysms in the A1 portion of the ACA are often associated with a poor prognosis. We retrospectively investigated three rare cases of hemorrhagic dissecting aneurysms in the ...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-017-0841-0
更新日期：2018-04-01 00:00:00
abstract：:Between 1987 and 1991 we performed a unilateral or bilateral frontoorbital advancement to correct trigono- or plagiocephaly in 10 children: Three-dimensional CT provides an exact basis for operation planning. Titanium miniplates allow an already primarily rather stable osteosynthesis. The best time for this interventi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00345936
更新日期：1992-01-01 00:00:00
abstract：:Spinal instability neoplastic score (SINS) classification evaluates spinal stability by adding together six radiographic and clinical components. The objective of this study was to verify the association between SINS and Tokuhashi scoring system (TSS) score. Fifty-eight patients with vertebral metastases were admitted...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-016-0706-y
更新日期：2016-07-01 00:00:00
abstract：:The endoscope has become an essential tool for transsphenoidal pituitary surgeries because of the panoramic view and the ability to visualize structures beyond the direct line of vision. However, the regular dedicated instruments for these surgeries sometimes do not reach the areas visualized by an angled endoscope, a...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-007-0108-2
更新日期：2008-01-01 00:00:00
abstract：:This study aimed to find the factors that may affect the surgical outcomes of congenital tethered cord syndrome (TCS) in adults by evaluating the long-term surgical outcomes of 25 consecutive cases. Medical records of 79 TCS cases which underwent surgery in Bakırköy Research and Training Hospital for Neurology, Neuros...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-017-0842-z
更新日期：2018-01-01 00:00:00
abstract：:Cavernous hemangiomas are the most frequently found primary tumors in the orbital region. They normally appear in adults. Diagnostic features in the majority of cases include protrusio bulbi and orbital enlargement. B-Scan and computed tomography/MRI are the prime diagnostic aids. We recommend surgical removal of thes...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF01794679
更新日期：1988-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative disease of the nervous system. It affects adults in all age groups and leads to death few years after the diagnosis. The etiology is unknown, and there no convincing medical or surgical therapy Some diseases can mimic ALS. If diagnosed early these may ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01105785
更新日期：1998-01-01 00:00:00
abstract：:The vasodilatory calcitonin gene-related peptide (CGRP) is excessively released after spontaneous subarachnoid hemorrhage (sSAH) and modulates psycho-behavioral function. In this pilot study, we prospectively analyzed the treatment-specific differences in the secretion of endogenous CGRP into cerebrospinal fluid (CSF)...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01333-z
更新日期：2020-06-22 00:00:00
abstract：:Cerebral vasospasm is delayed narrowing of the large arteries of the circle of Willis occurring 4 to 14 days after aneurysmal subarachnoid hemorrhage (SAH). It is but one cause of delayed deterioration after SAH but, in general, is the most important potentially treatable cause of morbidity and mortality after SAH. De...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-005-0013-5
更新日期：2006-07-01 00:00:00
abstract：:The objective of this study was to ascertain if stereotactic neurosurgical biopsy (SNB) optimizes the therapy of undefined CNS masses. The design was of retrospective treatment and outcome analysis and the setting was a large general hospital. We studied a total of 141 patients with undefined, space-occupying CNS lesi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s101430050043
更新日期：1999-10-01 00:00:00
abstract：:This study sought to describe and evaluate any relationship between D-dimer values and progressive hemorrhagic injury (PHI) after traumatic brain injury (TBI). In patients with TBI, plasma D-dimer was measured while a computed tomography (CT) scan was conducted as soon as the patient was admitted to the emergency depa...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0251-z
更新日期：2010-07-01 00:00:00
abstract：:This study reviewed the surgical management of cirsoid aneurysms of the scalp, which are rarely encountered in the neurosurgical practice, and compares the results with embolization. 21 patients with cirsoid aneurysm underwent surgery. There were 1 female and 20 male patients. Trauma was present in four patients. Sele...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-006-0023-y
更新日期：2006-07-01 00:00:00
abstract：:During surgeries in the upper cerebellopontine angle (CPA), the superior petrosal veins (SPVs) often act as obstacles; and their sectioning sometimes causes serious complications. In this study, we introduced a classification system for the SPVs wherein their tributaries were classified into four groups on the basis o...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-014-0548-4
更新日期：2014-10-01 00:00:00
abstract：:Direct delivery of antibiotics to the ventricular system offers an alternative for the management of nosocomial meningitis. However, the available literature frequently results in controversial findings regarding its safety. The present meta-analysis aimed at summarizing the risk of local complications after the admin...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-019-01226-w
更新日期：2019-12-24 00:00:00
abstract：:Hemangiopericytomas represent rare intracranial tumors that have a tendency to recur locally and have the unique characteristic of giving extracranial metastases. Our current communication reviews a series of patients diagnosed with hemangiopericytoma who were treated in our facility. Eleven patients with a mean age o...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-005-0001-9
更新日期：2006-04-01 00:00:00
abstract：:Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is a safe and effective treatment for moyamoya disease, although recent evidence suggests its substantial risk for symptomatic cerebral hyperperfusion. The diagnostic value of single-photon emission computed tomography (SPECT) for postoperative h...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-008-0147-3
更新日期：2008-10-01 00:00:00
abstract：:Acute management of deep-seated hematomas remains controversial. Since patients with these hematoma later tend to develop severe edema and necrosis around the lesion, when surgery is indicated it should be done as early as possible. The purpose of this study was to compare whether early surgical removal and conservati...
journal_title：Neurosurgical review
pub_type： 临床试验,杂志文章
doi：10.1007/pl00012391
更新日期：2001-07-01 00:00:00
abstract：:Glial tumors are the most common tumors of the nervous system, affecting individuals at any age. Since understanding of the molecular pathologies underlying human gliomas is still very poor, the treatment and therefore prognosis of this malignancy could not yet be improved. In order to determine whether different glio...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-003-0279-4
更新日期：2004-01-01 00:00:00
abstract：:Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecu...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-0978-5
更新日期：2020-02-01 00:00:00
abstract：:Three patients suffering from hematogenous destructive spondylodiscitis were treated with one-session spondylectomy, bone graft-fusion and halo-device stabilization. A stable osseous fusion was achieved after three months with additional antibiotic therapy. ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00338196
更新日期：1991-01-01 00:00:00
abstract：:Excision of a circumscribed spongioblastoma with intrapontine-intramesencephalic extension was performed via the floor of the fourth ventricle in two girls 14 and 5 years of age. The preoperative neurological deficits (severe hemiparesis, cerebellar, and sixth and seventh cranial nerve disturbances) showed slow but co...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01743035
更新日期：1983-01-01 00:00:00
abstract：:Skull base chordomas represent very interesting neoplasms, due to their rarity, biological behavior, and resistance to treatment. Their management is very challenging. Recently, the use of a natural corridor, through the nose and the sphenoid sinus, improved morbidity and mortality allowing also for excellent removal ...
journal_title：Neurosurgical review
pub_type： 临床试验,杂志文章
doi：10.1007/s10143-013-0503-9
更新日期：2014-04-01 00:00:00
abstract：:The orbitotomy has a central importance in craniofacial surgery. It is indicated for premature craniosynostoses, malformations and tumor surgery. The aim of the treatment is to correct functional disturbances and aesthetic impairments. Anatomical structures must be respected. Functional and anatomical aspects of the o...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01787121
更新日期：1989-01-01 00:00:00
abstract：:The spinal nerve can be pinched between the transverse process of the fifth lumbar vertebra and the sacral ala. The patients are divided into two types: elderly persons with degenerative scoliosis and somewhat younger adults with isthmic spondylolisthesis. For the first time, we describe extraforaminal impingement of ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0300-7
更新日期：2010-04-01 00:00:00
abstract：:Intraoperative magnetic resonance imaging (iopMRI) actually has an important role in the surgery of brain tumors, especially gliomas and pituitary adenomas. The aim of our work was to describe the advantages and drawbacks of this tool for the surgical treatment of cervical intramedullary gliomas. We describe two expli...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-013-0510-x
更新日期：2013-11-15 00:00:00
abstract：:The authors describe 3 cases of cerebral pleomorphic xanthoastrocytoma, one of which has an unusual neuroradiological appearance, and review the clinical and prognostic features of the 96 cases reported in the literature. Pleomorphic xanthoastrocytoma is a neuroectodermal tumor that affects young patients, in a superf...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF00346603
更新日期：1996-01-01 00:00:00
abstract：:The aim of this study was to analyze the long-term clinical and radiological outcomes of craniocervical decompression for patients affected by Chiari I-related syringomyelia. We performed a retrospective analysis of a group of patients affected by Chiari I-associated syringomyelia treated by craniocervical decompressi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0260-y
更新日期：2010-07-01 00:00:00
