Abstract:
:The purpose of the present study is to analyze the impact of intraoperative resection control modalities on overall survival (OS) and progression-free survival (PFS) following gross total resection (GTR) of glioblastoma. We analyzed data of 76 glioblastoma patients (30f, mean age 57.4 ± 11.6 years) operated at our institution between 2009 and 2012. Patients were only included if GTR was achieved as judged by early postoperative high-field MRI. Intraoperative technical resection control modalities comprised intraoperative ultrasound (ioUS, n = 48), intraoperative low-field MRI (ioMRI, n = 22), and a control group without either modality (n = 11). The primary endpoint of our study was OS, and the secondary endpoint was PFS-both analyzed in Kaplan-Meier plots and Cox proportional hazards models. Median OS in all 76 glioblastoma patients after GTR was 20.4 months (95 % confidence interval (CI) 18.5-29.0)-median OS in patients where GTR was achieved using ioUS was prolonged (21.9 months) compared to those without ioUS usage (18.8 months). A multiple Cox model adjusting for age, preop Karnofsky performance status, tumor volume, and the use of 5-aminolevulinic acid showed a beneficial effect of ioUS use, and the estimated hazard ratio was 0.63 (95 % CI 0.31-1.2, p = 0.18) in favor of ioUS, however not reaching statistical significance. A similar effect was found for PFS (hazard ratio 0.59, p = 0.072). GTR of glioblastoma performed with ioUS guidance was associated with prolonged OS and PFS. IoUS should be compared to other resection control devices in larger patient cohorts.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Neidert MC,Hostettler IC,Burkhardt JK,Mohme M,Held U,Kofmehl R,Eisele G,Woernle CM,Regli L,Bozinov Odoi
10.1007/s10143-015-0698-zsubject
Has Abstractpub_date
2016-07-01 00:00:00pages
401-9issue
3eissn
0344-5607issn
1437-2320pii
10.1007/s10143-015-0698-zjournal_volume
39pub_type
杂志文章abstract::Between 1986 and 1988 100 patients in whom MRI had been used to diagnose prolapses of lumbar intervertebral discs were admitted to the neurosurgical department of the Munich Technical University. MRI proved to be a valuable diagnostic technique, even if one has to concede certain limitations to the usefulness of the r...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00383835
更新日期:1993-01-01 00:00:00
abstract::Generally speaking, the term "ophthalmic aneurysms" refers to carotid-ophthalmic aneurysms, which arise from the internal carotid artery (ICA) wall at or around the origin of the ophthalmic artery (OA). In contrast, aneurysms arising from the OA stem or its branches, separate from the ICA are called peripheral OA aneu...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-010-0290-5
更新日期:2011-01-01 00:00:00
abstract::Surgery of the infratemporal fossa (ITF) and parapharyngeal area presents a formidable challenge to the surgeon due to its anatomical complexity and limited access. Conventional surgical approaches to these regions were often too invasive and necessitate sacrifice of normal function and anatomy. To describe a less inv...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0655-x
更新日期:2016-01-01 00:00:00
abstract::Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecu...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-0978-5
更新日期:2020-02-01 00:00:00
abstract::This aimed to evaluate the effect of surgery for overall survival (OS) and progression-free survival (PFS) in intracranial primary CNS lymphoma (PCNSL) of all patients diagnosed at a single center. A prospective database at Oslo University Hospital of PCNSL was reviewed over a 12-year period (2003-2014). Seventy-nine ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-0946-0
更新日期:2018-10-01 00:00:00
abstract::As a result of their presumed benign natural history, cerebral capillary telangiectasias (CCTs) are infrequently addressed in the neurosurgical literature. We performed a comprehensive review of CCTs via the PubMed database to synthesize overall epidemiological, radiographic, natural history, and treatment results. Ac...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-012-0435-9
更新日期:2013-04-01 00:00:00
abstract::Magnesium has neuroprotective and antivasospastic properties in the presence of subarachnoid hemorrhage (SAH). The present study investigated the effect of intracisternal administration of magnesium on cerebral vasospasm in the experimental SAH rat model. The rat double-SAH model (0.2 mL autologous blood injected twic...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0122-z
更新日期:2008-04-01 00:00:00
abstract::Cerebral cysticercosis is the result of infestation of the brain with the larval stage of the intestinal tape worm Taenia Solium. The disease, endemic in some parts of the world, especially Mexico, South America, India, Eastern Europe, is still encountered practically all over the world. There appear to be distinct ge...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF01742763
更新日期:1983-01-01 00:00:00
abstract::Preoperative prediction of molecular information of lower-grade gliomas (LrGGs) helps to determine the overall treatment strategy as well as the initial surgical strategy. This study aimed to detect magnetic resonance imaging (MRI) texture parameters to predict the molecular signature of LrGGs using a commercially ava...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01157-6
更新日期:2020-08-01 00:00:00
abstract::Three of 30 human cerebral cortex biopsies from infants treated for hydrocephalus by shunt operation are described. The descriptions include an account of their case history, the clinical methods, and the operational procedures. The biopsy specimens were studied in semithin and ultrathin sections. Attention is drawn t...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01741422
更新日期:1988-01-01 00:00:00
abstract::Although several studies have suggested that aneurysmal wall inflammation and laminar thrombus are associated with the rupture of saccular aneurysms, the mechanisms leading to the rupture remain obscure. We performed full exposure of aneurysms before clip application and attempted to keep the fibrin cap on the rupture...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0628-0
更新日期:2015-07-01 00:00:00
abstract::Human malignant gliomas arise from neural progenitor cells and/or dedifferentiated astrocytes. By now, they are genetically so well characterized that several murine glioma models have emerged that faithfully reiterate the typical histological features of the disease. In experimental animals, only one or two elements ...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-003-0267-8
更新日期:2003-07-01 00:00:00
abstract::A large variety of vertebral tumours undergoes transarterial embolisation (TAE) prior to surgery. However, the subsequent intra-operative blood loss is unpredictable. This retrospective analysis, aims to determine the impact of various factors that may potentially influence the estimated intra-operative blood loss (EB...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-1003-8
更新日期:2019-12-01 00:00:00
abstract::Teflon is utilized in neurosurgery as well as in plastic, vascular and heart surgery. Although the effect of Teflon on different types of cells and tissues has been previously studied, we are not aware of any study in which the effect of Teflon was tested on cells of the central nervous system. We have therefore exami...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00346368
更新日期:1990-01-01 00:00:00
abstract::The results of percutaneous radiofrequency rhizotomy of lumbar spinal facets in 46 patients followed at least three months (mean 15 months) are reported and compared with those reported previously. Satisfactory pain relief three months after the procedure was achieved in 36.4 percent of patients without operations and...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01138194
更新日期:1997-01-01 00:00:00
abstract::Experimental brain tumours were produced in cats by stereotactic implantation of 4 million suspended cells of a rat glioma clone into the internal capsule. Three weeks after implantation a spherical tumour developed with a diameter of up to 10 mm which was surrounded by vasogenic white matter oedema. In untreated anim...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01743708
更新日期:1981-01-01 00:00:00
abstract::The management of posterior cranial fossa meningioma [PCFM] is challenging and many neurosurgeons advise gamma knife radiosurgery [GKRS] as a modality for its upfront or adjuvant treatment. Due to the varying radiosurgical response based on lesion location, tumor biology, and radiation dosage, we performed a pioneer a...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01144-x
更新日期:2020-08-01 00:00:00
abstract::Hemangioblastoma is a rare benign tumor that consists of neoplastic vacuolated stromal cells and highly developed capillary blood vessels. These tumors are almost exclusively found in the central nervous system, but in extremely rare cases, it can arise in peripheral nerves. In the majority of cases, it occurs sporadi...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-014-0587-x
更新日期:2015-01-01 00:00:00
abstract::The authors describe a case of hemifacial spasm associated with Marfan's syndrome. A 24-year-old-woman suffered from left hemifacial spasm for 6 years. She had undergone surgical treatments for bilateral ectopia lentis and kyphoscoliosis in the second decade of life. She also had unusually long and slim limbs with ara...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF02389321
更新日期:1998-01-01 00:00:00
abstract::The spatial complexity of highly vulnerable structures makes surgical resection of brainstem cavernomas (BSC) a challenging procedure. Diffusion tensor imaging (DTI) allows for the visualization of white matter tracts and enables a better understanding of the anatomical location of corticospinal and sensory tracts bef...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0550-x
更新日期:2014-07-01 00:00:00
abstract::Vasospasm is a major contributor to morbidity and mortality in aneurysmal subarachnoid hemorrhage (SAH), with inflammation playing a key role in its pathophysiology. Myeloperoxidase (MPO), an inflammatory marker, was examined as a potential marker of vasospasm in patients with SAH. Daily serum samples from patients wi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0375-4
更新日期:2012-07-01 00:00:00
abstract::Twenty patients with severe head injury were analysed as to whether they developed a humoral immunodeficiency syndrome. In spite of the fact that 75% developed pyogenic complications all patients showed a polyclonal humoral activation of their immune system with an increase in IgG, IgA, IgM and the complement factors....
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01790685
更新日期:1989-01-01 00:00:00
abstract::The transformation of sensory information to movement patterns in spinal interneuronal systems is far from just being a stereotyped reflex pattern. Information from the different sensory modalities (skin-, muscle, and joint receptors) is integrated at the interneuronal level and transformed into patterns of coordinate...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF00313016
更新日期:1990-01-01 00:00:00
abstract::The prognosis after evacuation of a chronic subdural hematoma is generally good, yet occasionally post-operative complications do occur. Intracerebral hematoma following such evacuation is rare and two cases are reported. It is suggested that this complication could be due to the disturbances of intracerebral vascular...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01790653
更新日期:1989-01-01 00:00:00
abstract::The unruptured intracranial aneurysm treatment score (UIATS) was published in April 2015 as a multidisciplinary consensus regarding treatment of unruptured intracranial aneurysms (UIA). As a tertiary center with focus on vascular neurosurgery, we aimed to investigate whether our treatment decision-making in patients w...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-0944-2
更新日期:2018-10-01 00:00:00
abstract::Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-018-01074-0
更新日期:2019-06-01 00:00:00
abstract::The apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) plays an important role in diagnosing intracranial tumors and predicting the histopathological grade of the tumor. However, the differences in the ADC values between craniopharyngiomas and germ cell tumors (GCTs) have not been clarified. We t...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0660-0
更新日期:2016-04-01 00:00:00
abstract::Microvascular decompression represents an effective treatment for hemifacial spasm. The use of lateral spread response (LSR) monitoring remains a useful intraoperative tool to ensure adequate decompression of the facial nerve. The aim of this study was to assess the value of LSRs intraoperative monitoring as a prognos...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-016-0708-9
更新日期:2016-07-01 00:00:00
abstract::Massive hemorrhage is a very uncommon event among hemangioblastomas. Forty-four cases have been reported before this review. Thorough analysis of all reported cases on literature was accomplished. The majority presented as parenchymatous or subarachnoid bleedings. Subarachnoid hemorrhage was only associated with spina...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-009-0217-1
更新日期:2010-01-01 00:00:00
abstract::There are still different descriptions of the segmentation of the posterior cerebral artery, although there is a radiological and anatomical consensus on the segmentation of the anterior and the middle cerebral artery. This study aims to define the most appropriate localization for origin and end points of the segment...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-0972-y
更新日期:2019-03-01 00:00:00