Abstract:
:Human malignant gliomas arise from neural progenitor cells and/or dedifferentiated astrocytes. By now, they are genetically so well characterized that several murine glioma models have emerged that faithfully reiterate the typical histological features of the disease. In experimental animals, only one or two elements of the growth factor/Ras, PI3K/PTEN/PKB, p53/ARF/HDM2, and p16/Rb/cyclinD/CDK4 pathways are targeted. In human gliomas, many additional genes and pathways are targeted due to a most severe mutator phenotype that leads to the accumulation of countless epigenetic and genetic alterations. Changes that convey a growth advantage are selected for, leading to overgrowth of precursor cell populations with increasingly malignant tumor cell clones. While murine models represent a powerful tool for elucidating the role of genetic pathways, mechanisms of response and resistance to new therapeutic agents might be fundamentally different due to the high degree of genomic instability in the human disease. In fact, little is known about the molecular causes of genomic instability involved in gliomas, except for the rare Turcot's syndrome, O(6)-methylguanine-DNA methyltransferase, and the apurinic/apyrimidinic endonuclease Ape-1. Novel approaches that selectively exploit fundamental metabolic differences between tumor and normal cells have to consider these fundamental differences between human disease and presently available, highly sophisticated animal models.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Merlo Adoi
10.1007/s10143-003-0267-8keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
145-58issue
3eissn
0344-5607issn
1437-2320journal_volume
26pub_type
杂志文章,评审abstract::A neuroendoscopic biopsy is a minimally invasive and useful procedure for the diagnosis and initial management of tumor-associated hydrocephalus. We describe the nationwide investigation of the current status of neuroendoscopic biopsy for intra- and paraventricular tumors in children, as well as the treatment of tumor...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0629-z
更新日期:2015-10-01 00:00:00
abstract::Experimental brain tumours were produced in cats by stereotactic implantation of 4 million suspended cells of a rat glioma clone into the internal capsule. Three weeks after implantation a spherical tumour developed with a diameter of up to 10 mm which was surrounded by vasogenic white matter oedema. In untreated anim...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01743708
更新日期:1981-01-01 00:00:00
abstract::The measurement of cerebral blood flow (CBF) in addition to cerebral computerized tomography (CT) and angiography is most reliable in cases of transient ischemic attacks (TIA) and prolonged reversible ischemic neurologic deficits (PRIND). Alterations of CBF can be detected in symptom-free intervals. The cerebrovascula...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01781948
更新日期:1987-01-01 00:00:00
abstract::A technique to reconstruct the posterior elements of the spinal canal in osteoplastic laminotomy is described. The use of titanium microplates allows a stable fixation of the laminar arch with optimal realignment of the lamina cut ends. The titanium implants are fully compatible with magnetic resonance imaging. The au...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF02389311
更新日期:1998-01-01 00:00:00
abstract::Damage which occurs following spinal traumas is often irreversible. During recent years free oxygen radicals formed due to the pathological changes following neural tissue ischemia have been identified as being responsible for the ethio-pathogenesis of such damage. In our experimental study, model lesions are formed i...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00308614
更新日期:1993-01-01 00:00:00
abstract::A primary xanthomatous tumor is very rare in the central nervous system (CNS). Here we report the case of a fibroxanthoma arising from the dura mater of the cerebrum that demonstrated no systemic disease or metabolic abnormalities. A 19-month-old, otherwise healthy boy was found to have an enlarged head. Magnetic reso...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050019
更新日期:1999-12-01 00:00:00
abstract::Stereotactic biopsies represent a routine neurosurgical procedure for the diagnosis of intracranial lymphomas and selected diffusely infiltrating gliomas. Acquisition of tissue samples that do not allow correct tumor typing and grading is, however, not uncommon. Five-aminolevulinic acid (5-ALA) has been shown to accum...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0374-5
更新日期:2012-07-01 00:00:00
abstract::In view of the high incidence of late instability during conservative treatment of cervical spine fractures, operative stabilization should be performed as soon as possible. Besides immediate decompression of the spinal cord, rapid mobilisation of the patient without external fixation is possible. We report on the res...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00304331
更新日期:1993-01-01 00:00:00
abstract::Clinical practice guidelines (CPGs) play an important role in healthcare. The guideline development process should be precise and rigorous to ensure that the results are reproducible and not vague. To determine the quality of guidelines, the Appraisal of Guidelines and Research and Evaluation (AGREE) instrument was de...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-014-0569-z
更新日期:2015-01-01 00:00:00
abstract::Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identi...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析
doi:10.1007/s10143-018-0965-x
更新日期:2020-02-01 00:00:00
abstract::Despite the introduction of new antiepileptic drugs and advances in the surgical treatment of epilepsy, an important group of patients still remains uncontrolled by any of these methods. The relatively recent introduction of vagus nerve stimulation is yet another possible treatment for refractory epilepsy. This safe, ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0555-5
更新日期:2014-10-01 00:00:00
abstract::There is growing evidence that the nervous system influences spinal cord vasculature. However, most descriptions of the spinal cord have paid little attention to this important aspect. We reviewed the literature on the innervation of spinal cord vessels with an emphasis on findings that may be applicable to human medi...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-016-0788-6
更新日期:2018-07-01 00:00:00
abstract::The authors describe 3 cases of cerebral pleomorphic xanthoastrocytoma, one of which has an unusual neuroradiological appearance, and review the clinical and prognostic features of the 96 cases reported in the literature. Pleomorphic xanthoastrocytoma is a neuroectodermal tumor that affects young patients, in a superf...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF00346603
更新日期:1996-01-01 00:00:00
abstract::Many immune responses are controlled by genes of the major histocompatibility complex (MHC). In humans these include the loci encoding the HLA-A, -B, -C, -DR, -DQ, and -DP antigens, and many diseases have been linked with these. However, little information is available about any connection between malignant tumors and...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00418435
更新日期:1994-01-01 00:00:00
abstract::We conducted a systematic review of the literature to evaluate the efficacy of various treatment modalities for intracranial aneurysms (IA) in patients with moyamoya disease (MMD) based on anatomical location of IA. A comprehensive review of studies documenting single cases or series of MMD patients with concomitant I...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01307-1
更新日期:2020-05-08 00:00:00
abstract::Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- an...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0880-6
更新日期:2018-04-01 00:00:00
abstract::Supplemental education is desirable for neurosurgical training, and the use of human cadaver specimen and virtual reality models is routine. An in vivo porcine training model for cranial neurosurgery was introduced in 2005, and our recent experience with this unique model is outlined here. For the first time, porcine ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0572-4
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study is to describe our series of nine unclippable and uncoilable ruptured aneurysms in eight patients treated by microsurgical wrapping with autologous muscle. Records were retrospectively reviewed for rebleeding rate, morbidity and mortality, changes in size or the aneurysm's configurations, and...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0408-z
更新日期:2013-01-01 00:00:00
abstract::Paraffin-embedded surgical specimens from 55 meningiomas were immunostained after microwave processing using the streptavidin/peroxidase method and the monoclonal antibody (moAb) MIB-1 to the Ki-67 antigen. The authors assessed proliferative labelling index (LI) from a series of surgically removed meningiomas using im...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0261-1
更新日期:2003-07-01 00:00:00
abstract::The spatial complexity of highly vulnerable structures makes surgical resection of brainstem cavernomas (BSC) a challenging procedure. Diffusion tensor imaging (DTI) allows for the visualization of white matter tracts and enables a better understanding of the anatomical location of corticospinal and sensory tracts bef...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0550-x
更新日期:2014-07-01 00:00:00
abstract::Twenty-six patients with oculomotor nerve palsy due to cerebral aneurysms were examined. There were six males and twenty females with a mean age of 55 years. 25 of the 26 aneurysms were located at the junction of the internal carotid and the posterior communicating artery and one was at the junction of the basilar art...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01741485
更新日期:1989-01-01 00:00:00
abstract::Based on extensive personal experiences during the past three decades, a review is given on infections and infestations of the central nervous system, which are found in India and in other tropical and subtropical areas. Besides the main disease such as tuberculosis, pyogenic infections and parasitic infestations, rar...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF01742760
更新日期:1983-01-01 00:00:00
abstract::Acute management of deep-seated hematomas remains controversial. Since patients with these hematoma later tend to develop severe edema and necrosis around the lesion, when surgery is indicated it should be done as early as possible. The purpose of this study was to compare whether early surgical removal and conservati...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章
doi:10.1007/pl00012391
更新日期:2001-07-01 00:00:00
abstract::Multilevel discectomy and inter-vertebral body fusion combined with anterior plate-screw fixation is the common procedure in cervical spine surgery. The correct placement of the screws is an important factor for the outcome of these operations. Yet no systematic approach has been undertaken to optimize the geometry of...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-005-0386-5
更新日期:2005-10-01 00:00:00
abstract::Different disorders may produce irreducible atlanto-axial dislocation with compression of the ventral spinal cord. Among the surgical approaches available for a such condition, the transoral resection of the odontoid process is the most often used. The aim of this anatomical study is to demonstrate the possibility of ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0084-6
更新日期:2007-07-01 00:00:00
abstract::The author reports a case of a histologically proven cavernous hemangioma of the cavernous sinus and middle fossa, which was treated by radiotherapy. This very rare lesion represents a formidable challenge to the neurosurgeon and its excision has been associated with a considerable mortality rate. The significant redu...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00314842
更新日期:1996-01-01 00:00:00
abstract::Rare tumors with anecdotal reportage, oculomotor schwannomas are most often seen in the oculomotor cistern close to the anterior clinoidal region. Adding to the small series of reported cases of this unusual lesion, we report two male patients in their second decade who presented with different degrees of oculomotor p...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-011-0344-3
更新日期:2012-01-01 00:00:00
abstract::Solitary brain affection is rare in echinococcosis. We report the case of a 35-year-old woman presenting with symptomatic grand-mal epilepsy due to a right frontal, partially cystic space-occupying lesion. Pre-operative computed tomography and magnetic resonance imaging (MRI) suggested a cystic astrocytoma. However, h...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050011
更新日期:1999-01-01 00:00:00
abstract::The basic principles of NMRI are explained. Examples are given of the current medical uses of imaging with protons and other nuclei as well. Further developments towards spectroscopic imaging are discussed. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01892908
更新日期:1984-01-01 00:00:00
abstract::A rare case of fourth ventricle meningioma with a combined intraventricular-intracerebellar localization, successfully removed by surgical treatment, is reported. The features of this type of meningioma as compared to the purely intra-ventricular variety are discussed. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00313514
更新日期:1992-01-01 00:00:00