Abstract:
:Stereotactic biopsies represent a routine neurosurgical procedure for the diagnosis of intracranial lymphomas and selected diffusely infiltrating gliomas. Acquisition of tissue samples that do not allow correct tumor typing and grading is, however, not uncommon. Five-aminolevulinic acid (5-ALA) has been shown to accumulate in malignant tumor tissue. The aim of this study was to prospectively investigate the clinical usability of 5-ALA for intraoperative detection of representative tissue in stereotactic tumor biopsies. Fifty consecutive patients underwent frameless stereotactic biopsy for a suspected brain tumor. 5-ALA was administered 4 h before anesthesia. Serial biopsy samples were obtained and intraoperatively checked for 5-ALA fluorescence (strong, vague, or none) using a modified neurosurgical microscope. All samples were examined for the presence of representative tumor tissue according to neuroimaging (MRI, positron emission tomography, and/or chemical shift imaging) and histopathological parameters. Visible 5-ALA fluorescence was observed in 43/50 patients (strong in 39 and vague fluorescence in four cases). At biopsy target, 52/53 samples of glioblastomas, 9/10 samples of gliomas grade III, and 14/16 samples of lymphomas revealed strong 5-ALA fluorescence. Samples with strong 5-ALA fluorescence were only observed at, but not outside the biopsy target. All tissue samples with strong 5-ALA fluorescence were representative according to our neuroimaging and histopathological criteria (positive predictive value of 100%). Our data indicate that strong 5-ALA fluorescence is a reliable and immediately available intraoperative marker of representative tumor tissue of malignant gliomas and intracranial lymphomas in stereotactic biopsies. Thereby, the application of 5-ALA in stereotactic brain tumor biopsies may in future reduce costs for operating room and neuropathology and may decrease procedure-related morbidity.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Widhalm G,Minchev G,Woehrer A,Preusser M,Kiesel B,Furtner J,Mert A,Di Ieva A,Tomanek B,Prayer D,Marosi C,Hainfellner JA,Knosp E,Wolfsberger Sdoi
10.1007/s10143-012-0374-5subject
Has Abstractpub_date
2012-07-01 00:00:00pages
381-91; discussion 391issue
3eissn
0344-5607issn
1437-2320journal_volume
35pub_type
杂志文章abstract::Idiopathic normal pressure hydrocephalus is a hydrodynamic disorder whose etiology remains unclear. The diagnosis is mainly clinical and the traditional treatment is cerebrospinal fluid shunt diversion. With the introduction of modern management strategies, endoscopic third ventriculostomy has become a viable alternat...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-015-0685-4
更新日期:2016-10-01 00:00:00
abstract::Torticollis is either congenital or acquired in childhood. Acquired torticollis is not a diagnosis but rather a sign of an underlying disorder. The causes of acquired torticollis include ligamentous, muscular, osseous, ocular, psychiatric, and neurologic disorders and may be a symptom of significant abnormalities of t...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-006-0034-8
更新日期:2006-10-01 00:00:00
abstract::Whereas previously the dissection of arteries leading to the brain was thought to be a rare occurrence, this diagnosis has been found more frequently in the last years as a result of newer imaging methods. Furthermore, in contrast to earlier opinions, there is a rather good prognosis for the recanalisation of the vess...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF02352070
更新日期:1992-01-01 00:00:00
abstract::To achieve local control of malignant glioma, we designed a postoperative stereotactic radiotherapy using a micro-multileaf collimator (micro-MLC). The purpose of this study was to clarify the feasibility of this treatment. The treatment was performed in six patients who met the following eligibility criteria: (1) sup...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章
doi:10.1007/s101430100185
更新日期:2002-06-01 00:00:00
abstract::In a study the results recorded in 34 surgically treated patients with specific or unspecific spondylodiscitis after dorsoventral one-stage instrumentation with CDI and anterior grafting (group 1) were compared with those obtained in a group of 38 patients treated with anterior CDH instrumentation in combination with ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01105775
更新日期:1998-01-01 00:00:00
abstract::The early identification and optimized treatment of wound dehiscence are a complex issue, with implications on the patient's clinical and psychological postoperative recovery and on healthcare system costs. The most widely accepted treatment is surgical debridement (also called "wash out"), performed in theater under ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-1022-5
更新日期:2020-02-01 00:00:00
abstract::Traumatic bifrontal contusions (TBC) form a recognised clinical entity among patients with traumatic brain injury (TBI). This study aims to systematically review current literature on demographics, management, and predictors of outcomes of patients with TBC. A multi-database literature search (PubMed, Cochrane, OVID M...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01098-0
更新日期:2020-06-01 00:00:00
abstract::The transformation of sensory information to movement patterns in spinal interneuronal systems is far from just being a stereotyped reflex pattern. Information from the different sensory modalities (skin-, muscle, and joint receptors) is integrated at the interneuronal level and transformed into patterns of coordinate...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF00313016
更新日期:1990-01-01 00:00:00
abstract::Vasospasm is a major contributor to morbidity and mortality in aneurysmal subarachnoid hemorrhage (SAH), with inflammation playing a key role in its pathophysiology. Myeloperoxidase (MPO), an inflammatory marker, was examined as a potential marker of vasospasm in patients with SAH. Daily serum samples from patients wi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0375-4
更新日期:2012-07-01 00:00:00
abstract::Ethmoidal dural arteriovenous fistulae are rare vascular malformations associated with a high risk of bleeding. We present a multicenter contemporary series of patients treated with microsurgical and endovascular techniques. Sixteen consecutive patients were evaluated and/or treated between 2008 and 2015 at four cente...
journal_title:Neurosurgical review
pub_type: 杂志文章,多中心研究,评审
doi:10.1007/s10143-016-0764-1
更新日期:2018-04-01 00:00:00
abstract::Acute intracranial subdural hematoma (ASDH) is commonly associated with a grave prognosis citing a high incidence of morbidity and mortality. The parameters to decide on surgical evacuation of the hematoma are sometimes controversial. In this study, we theorized that the ratio between maximal hematoma thickness and mi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0873-5
更新日期:2018-04-01 00:00:00
abstract::It was suggested that D, L-Methadone might improve the clinical course of glioma patients. Owing to massive press coverage, patients demand the prescription of D, L-Methadone, but regarding its adjunctive use in glioma therapy there is no standard medication plan. Furthermore, it is not known which side effects the ad...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01250-1
更新日期:2020-02-14 00:00:00
abstract::Hemorrhagic complication is one of the notable surgical complications of the revascularization surgery for moyamoya disease (MMD). Cerebral hyperperfusion (CHP) has been considered as the underlying cause of this complication. It mostly occurs several days after surgery, but the intra-operative hemorrhage immediately ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0868-2
更新日期:2017-10-01 00:00:00
abstract::A primary xanthomatous tumor is very rare in the central nervous system (CNS). Here we report the case of a fibroxanthoma arising from the dura mater of the cerebrum that demonstrated no systemic disease or metabolic abnormalities. A 19-month-old, otherwise healthy boy was found to have an enlarged head. Magnetic reso...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050019
更新日期:1999-12-01 00:00:00
abstract::Surgical access to deep intracranial lesions causing the least amount of iatrogenic trauma to the surrounding brain tissue remains a challenging task. In this article, we evaluate the use of a set of sequential tubes that dilate and provide retraction of the overlying brain tissue acting as a surgical corridor for dee...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0442-x
更新日期:2013-04-01 00:00:00
abstract::In order to study the clinical characteristics of intraventricular meningiomas, we analyzed retrospectively 25 patients and reviewed the literature with regard to incidence, clinical manifestation, imaging features, preoperative diagnosis, surgical findings, and histopathological results. Intraventricular meningiomas ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-005-0418-1
更新日期:2006-01-01 00:00:00
abstract::The pathophysiology of syringomyelia development is not fully understood. Current prevailing theories suggest that increased pulse pressure in the subarachnoid space forces cerebrospinal fluid (CSF) through the spinal cord into the syrinx. It is generally accepted that the syrinx consists of CSF. The here-proposed int...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-006-0029-5
更新日期:2006-10-01 00:00:00
abstract::A retrospective study was conducted on 67 patients undergoing posterior cervical foraminotomy (PCF) for unilateral intraforaminal soft and hard disc disease. Neurologic impairment, employment, and severity of associated signs were assessed preoperatively and at a 3.1-year average follow-up (range, 1.5-7 years). Diminu...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/pl00011957
更新日期:2000-12-01 00:00:00
abstract::Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is a safe and effective treatment for moyamoya disease, although recent evidence suggests its substantial risk for symptomatic cerebral hyperperfusion. The diagnostic value of single-photon emission computed tomography (SPECT) for postoperative h...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0147-3
更新日期:2008-10-01 00:00:00
abstract::The endoscopic third ventriculostomy (ETV) success score (ETVSS) was developed to predict the success rate of ETV at 6 months. In this study, the authors assessed the performance of this score for > 6 months, i.e., at 12 months, and provided external validation in Brazilian children. All children undergoing first ETV ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01461-6
更新日期:2021-01-03 00:00:00
abstract::Post-radiotherapy carotid blowout syndrome (CBS) of the skull base is a rare but often catastrophic complication of head and neck malignancies. The existing literature on the treatment of this condition with flow-diverting devices (FDD) is extremely limited and disappointing. We present a case of impending CBS in a pa...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0875-3
更新日期:2017-10-01 00:00:00
abstract::The purpose of this study is to describe our series of nine unclippable and uncoilable ruptured aneurysms in eight patients treated by microsurgical wrapping with autologous muscle. Records were retrospectively reviewed for rebleeding rate, morbidity and mortality, changes in size or the aneurysm's configurations, and...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0408-z
更新日期:2013-01-01 00:00:00
abstract::This study was carried out to evaluate the early results and the prognostic factors affecting the outcome during the in-hospital stay of 110 patients with civilian gunshot wounds to the head admitted at the Hospital of Restauração, Recife, Brazil. Penetrating injury (66%) was the most prevalent type of wound encounter...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0377-2
更新日期:2012-07-01 00:00:00
abstract::Papillary meningioma (PM) is a rare central nervous system tumor. We aimed to analyze the characteristics and outcomes of patients with PM (WHO grade III) and identify risk factors that influence survival using the Surveillance, Epidemiology, and End Results (SEER) database. Clinical characteristics, tumor features, a...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01449-2
更新日期:2021-01-08 00:00:00
abstract::Epidermoid cysts constitute less than 1% of intracranial tumors with the majority of them involving cerebellopontine angle (CPA). Although several mechanisms for cranial nerve dysfunction due to these tumors have been proposed, no direct evaluation for hyper- or hypoactive dysfunction has been done. In this case serie...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0684-5
更新日期:2016-04-01 00:00:00
abstract::Forty-four adult acromegalic patients carrying growth hormone-producing pituitary macroadenomas were investigated with neuroradiological and endocrinological techniques. Plasma growth hormone and somatomedin-C levels were repeatedly measured before surgical removal of tumors and during the follow-up period. Twenty-fiv...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01105562
更新日期:1997-01-01 00:00:00
abstract::A new technique for interbody lumbar spondylodesis using a new cancellous metal, plug-shaped construct was performed in 35 cases with spondylolisthesis or lumbar instability. All of these patients have had severe low-back pain for years, some with radicular symptoms and had been treated unsuccessfully for years. In a ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00638889
更新日期:1990-01-01 00:00:00
abstract::Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-016-0775-y
更新日期:2018-04-01 00:00:00
abstract::Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 te...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0118-0
更新日期:2008-04-01 00:00:00
abstract::In view of the high incidence of late instability during conservative treatment of cervical spine fractures, operative stabilization should be performed as soon as possible. Besides immediate decompression of the spinal cord, rapid mobilisation of the patient without external fixation is possible. We report on the res...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00304331
更新日期:1993-01-01 00:00:00