Factors predicting pituitary adenoma invasiveness in acromegalic patients.

Abstract:

:Forty-four adult acromegalic patients carrying growth hormone-producing pituitary macroadenomas were investigated with neuroradiological and endocrinological techniques. Plasma growth hormone and somatomedin-C levels were repeatedly measured before surgical removal of tumors and during the follow-up period. Twenty-five patients presented preoperatively with an invasive adenoma that involved the cavernous sinus (CS). Diagnosis of tumor invasivity was made according to distinct neuroradiological criteria and was confirmed or rejected during surgery Significantly higher basal growth hormone levels were found in patients with CS invasion than in cases without tumor growth in the CS. Evidence is presented that plasma growth hormone level in acromegalics is a more sensitive indicator for predicting tumor invasiveness than somatomedin-C. Growth hormone basal values before surgery and the extent of their decrease after removal of tumor correlate with adenoma growth in the parasellar compartments and should be used as a prognostic factor to aid in planing adjuvant tumor treatment.

journal_name

Neurosurg Rev

journal_title

Neurosurgical review

authors

Rieger A,Rainov NG,Ebel H,Sanchin L,Shibib K,Helfrich C,Hoffmann O,Burkert W

doi

10.1007/BF01105562

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

182-7

issue

3

eissn

0344-5607

issn

1437-2320

journal_volume

20

pub_type

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