Abstract：
:Despite decades of study, the etiology of brain cancer remains elusive. However, extensive molecular characterization of primary brain tumors has been accomplished, outlining recurrent features that are proving useful for devising targeted therapies. There are far too few patients available for comparing the efficacy of therapeutic combinations, especially when variations in dosing, frequency, and sequencing are taken into account. Consequently, there is a substantial need for increasing preclinical testing throughput using clinically relevant models. We review luminescent optical imaging for its potential in facilitating in vivo assessment of intracranial tumor growth and response to therapy in rodent orthotopic xenograft models of primary brain malignancies. We review the rationale behind the need of an in vivo model, why orthotopic tumor models displaying an invasive phenotype may be a superior choice when compared to flank-implanted tumors, and what advantages may be drawn from the use of modified cells, suitable for sequential monitoring by in vivo optical imaging. Studies show that luminescent signal correlates highly both with tumor burden and Kaplan-Meier survival curves of rodents bearing intracranial xenografts. We conclude that bioluminescent imaging is a highly sensitive technique for assessment of tumor burden, response to therapy, tumor recurrence, and behavior to salvage therapy, making it a superior option for longitudinal monitoring in intracranial rodent models of primary brain tumors.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Dinca EB,Voicu RV,Ciurea AVdoi
10.1007/s10143-010-0275-4subject
Has Abstractpub_date
2010-10-01 00:00:00pages
385-94issue
4eissn
0344-5607issn
1437-2320journal_volume
33pub_type
杂志文章abstract：:Proximally located posterior communicating artery (PCoA) aneurysms, projecting postero-laterally in proximity to the tentorium, may pose a technical challenge for microsurgical clipping due to obscuration of the proximal aneurysmal neck by the anterior petroclinoid fold. We describe an efficacious technique utilizing ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0554-6
更新日期：2014-10-01 00:00:00
abstract：:Idiopathic normal pressure hydrocephalus is a hydrodynamic disorder whose etiology remains unclear. The diagnosis is mainly clinical and the traditional treatment is cerebrospinal fluid shunt diversion. With the introduction of modern management strategies, endoscopic third ventriculostomy has become a viable alternat...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-015-0685-4
更新日期：2016-10-01 00:00:00
abstract：:Desmoplastic gangliogliomas (DIG) are rare primary neoplasms that comprise 0.5-1.0% of all intracranial tumors. Clinically, there are two forms of DIG, the infantile and the non-infantile. These tumors invariably arise in the supratentorial region and commonly involve more than one lobe, preferentially the temporal an...
journal_title：Neurosurgical review
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10143-010-0303-4
更新日期：2010-04-01 00:00:00
abstract：:Papillary meningioma (PM) is a rare central nervous system tumor. We aimed to analyze the characteristics and outcomes of patients with PM (WHO grade III) and identify risk factors that influence survival using the Surveillance, Epidemiology, and End Results (SEER) database. Clinical characteristics, tumor features, a...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01449-2
更新日期：2021-01-08 00:00:00
abstract：:In neurosurgical operations, proper craniotomy using retractors is necessary. Various surgical instruments are used for this purpose, including standard retractors and multipurpose head frame retractor systems. However, the conventional multipurpose head frame system is often not optimal for use in some craniotomies a...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01237-y
更新日期：2020-01-11 00:00:00
abstract：:Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identi...
journal_title：Neurosurgical review
pub_type： 杂志文章,meta分析
doi：10.1007/s10143-018-0965-x
更新日期：2020-02-01 00:00:00
abstract：:The authors describe 3 cases of cerebral pleomorphic xanthoastrocytoma, one of which has an unusual neuroradiological appearance, and review the clinical and prognostic features of the 96 cases reported in the literature. Pleomorphic xanthoastrocytoma is a neuroectodermal tumor that affects young patients, in a superf...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF00346603
更新日期：1996-01-01 00:00:00
abstract：:In spite of recent advancements in the management of ruptured aneurysm, there are still controversies as to how to threat the patients in serious conditions, one of these concerning whether to operate patients admitted with symptomatic vasospasm (vasospasm on admission) and when. While early surgery may protect patien...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00417662
更新日期：1995-01-01 00:00:00
abstract：:Hemangioblastoma is a rare benign tumor that consists of neoplastic vacuolated stromal cells and highly developed capillary blood vessels. These tumors are almost exclusively found in the central nervous system, but in extremely rare cases, it can arise in peripheral nerves. In the majority of cases, it occurs sporadi...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-014-0587-x
更新日期：2015-01-01 00:00:00
abstract：:In 63 specimens, 74 aneurysms, and five other lesions, postmortem microsurgical and endoscopic inspection (PMI) was done. This work not only allowed for safe pathoanatomic findings, but moreover showed characteristics of a training method developed according to a model with clear standards. PMI gives training in: 1. U...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s101430100155
更新日期：2002-03-01 00:00:00
abstract：:The aim of this study was to determine the efficacy and safety of intrathecal baclofen therapy delivered by a programmable pump for the chronic treatment of spinal spasticity. Twelve patients with intractable spasticity caused by spinal cord injuries underwent implantation of a programmable continuous infusion pump af...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-002-0221-1
更新日期：2002-08-01 00:00:00
abstract：:A retrospective study was conducted on 67 patients undergoing posterior cervical foraminotomy (PCF) for unilateral intraforaminal soft and hard disc disease. Neurologic impairment, employment, and severity of associated signs were assessed preoperatively and at a 3.1-year average follow-up (range, 1.5-7 years). Diminu...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/pl00011957
更新日期：2000-12-01 00:00:00
abstract：:A multidimensional concept of diagnosis and treatment of mental disorders is presented. Major contributions to basic research come from pharmacological experiments. Clinical outcome in treatment of endogenous depression can be assessed by rating scales and psychophysiological tests and correlated with the serum level ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01650030
更新日期：1980-01-01 00:00:00
abstract：:Glial tumors are the most common tumors of the nervous system, affecting individuals at any age. Since understanding of the molecular pathologies underlying human gliomas is still very poor, the treatment and therefore prognosis of this malignancy could not yet be improved. In order to determine whether different glio...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-003-0279-4
更新日期：2004-01-01 00:00:00
abstract：:Although approximately 30% of facial nerve schwannoma cases present with no facial palsy, a large facial nerve schwannoma extending to the middle and posterior cranial fossa quite rarely presents without facial palsy. The authors encountered two patients with large facial nerve schwannoma who presented with only heari...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-005-0381-x
更新日期：2005-07-01 00:00:00
abstract：:With the increasing number of endovascular interventions during the last years, the number of procedure-related complications has risen accordingly. Despite sophisticated and effective endovascular treatments for acute thromboembolic events during intervention, vessel occlusion can remain refractory to medical and end...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0283-4
更新日期：2011-01-01 00:00:00
abstract：:Epidermoid cysts constitute less than 1% of intracranial tumors with the majority of them involving cerebellopontine angle (CPA). Although several mechanisms for cranial nerve dysfunction due to these tumors have been proposed, no direct evaluation for hyper- or hypoactive dysfunction has been done. In this case serie...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-015-0684-5
更新日期：2016-04-01 00:00:00
abstract：:The patterns of regional cerebral blood flow (rCBF) in patients with dementia caused by Alzheimer's disease is compared with that of patients with dementia caused by multiple cerebral infarctions. A total of 47 patients were examined with 133Xenon SPECT. The results show that the global CBF correlates with the severit...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01741445
更新日期：1987-01-01 00:00:00
abstract：:Traumatic bifrontal contusions (TBC) form a recognised clinical entity among patients with traumatic brain injury (TBI). This study aims to systematically review current literature on demographics, management, and predictors of outcomes of patients with TBC. A multi-database literature search (PubMed, Cochrane, OVID M...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-019-01098-0
更新日期：2020-06-01 00:00:00
abstract：:The purpose of this study is to describe our series of nine unclippable and uncoilable ruptured aneurysms in eight patients treated by microsurgical wrapping with autologous muscle. Records were retrospectively reviewed for rebleeding rate, morbidity and mortality, changes in size or the aneurysm's configurations, and...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-012-0408-z
更新日期：2013-01-01 00:00:00
abstract：:Acute intracranial subdural hematoma (ASDH) is commonly associated with a grave prognosis citing a high incidence of morbidity and mortality. The parameters to decide on surgical evacuation of the hematoma are sometimes controversial. In this study, we theorized that the ratio between maximal hematoma thickness and mi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-017-0873-5
更新日期：2018-04-01 00:00:00
abstract：:Long-term patency of superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery for atherosclerotic disease and associated risk factors for loss of patency have rarely been discussed. We retrospectively analyzed long-term patency following STA-MCA bypass and evaluated various demographic and clinic...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-016-0736-5
更新日期：2016-10-01 00:00:00
abstract：:Intradiploic epidermoid tumor of the occipital bone was presented. There were neither intracranial extensions nor neurologic deficits. The lesion started as a painless mass under the scalp. The total removal of the tumor was associated with a good prognosis. ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00418080
更新日期：1996-01-01 00:00:00
abstract：:Cavernous hemangiomas are the most frequently found primary tumors in the orbital region. They normally appear in adults. Diagnostic features in the majority of cases include protrusio bulbi and orbital enlargement. B-Scan and computed tomography/MRI are the prime diagnostic aids. We recommend surgical removal of thes...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF01794679
更新日期：1988-01-01 00:00:00
abstract：:Clinical and radiological features that help predict the growth potential of meningioma would be beneficial. The purpose of this study is to clarify the characteristics related to proliferating potential using the MIB-1 staining index. We analyzed the relationship of MIB-1 staining indices to characteristics of 342 co...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-006-0039-3
更新日期：2006-10-01 00:00:00
abstract：:The rupture of an intracranial aneurysm leads to subarachnoid hemorrhage (SAH). To prevent SAH, unruptured lesions can be treated by either endovascular or microsurgical approach. Due to their complex anatomy, middle cerebral artery (MCA) aneurysms represent a unique subgroup of intracranial aneurysms. Primary objecti...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0563-5
更新日期：2014-10-01 00:00:00
abstract：:The measurement of cerebral blood flow (CBF) in addition to cerebral computerized tomography (CT) and angiography is most reliable in cases of transient ischemic attacks (TIA) and prolonged reversible ischemic neurologic deficits (PRIND). Alterations of CBF can be detected in symptom-free intervals. The cerebrovascula...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01781948
更新日期：1987-01-01 00:00:00
abstract：:Based on extensive personal experiences during the past three decades, a review is given on infections and infestations of the central nervous system, which are found in India and in other tropical and subtropical areas. Besides the main disease such as tuberculosis, pyogenic infections and parasitic infestations, rar...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF01742760
更新日期：1983-01-01 00:00:00
abstract：:Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 te...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-007-0118-0
更新日期：2008-04-01 00:00:00
abstract：:Colloid cysts of the third ventricle are considered as benign lesions. The clinical manifestations are not clear in most of cases. Many treatment options are available and endoscopic removal of the cysts proves to be a very successful method especially if the lateral ventricles are moderately or severely dilated. Some...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-0956-y
更新日期：2019-03-01 00:00:00
