Abstract:
:Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 teletherapy machine. Groups 3, 4, and 5 received irradiation plus 40 kg(-1) day(-1) Vitamin E or 200 mg kg(-1)day(-1) L-carnitine alone or in combination. Brain and retinal damages were histopathologically evaluated by two independent pathologists. Antioxidant enzyme levels were also measured. Radiation significantly increased brain and retinal damages. A significant increase in malondialdehyde levels as well as a decrease in superoxide dismutase and catalase enzymes in brain was found in group 2. Separate administration of Vitamin E+RT and L-carnitine+RT significantly reduced the severity of brain and retinal damages and decreased the malondialdehyde levels and increased the activity of superoxide dismutase and catalase enzymes in the brain. The findings of current study support the antioxidant and radioprotective roles of vitamin E and L-carnitine. However, the combined use of Vitamin E and L-carnitine plus irradiation interestingly did not exhibit an additive radioprotective effect.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Sezen O,Ertekin MV,Demircan B,Karslioğlu I,Erdoğan F,Koçer I,Calik I,Gepdiremen Adoi
10.1007/s10143-007-0118-0subject
Has Abstractpub_date
2008-04-01 00:00:00pages
205-13; discussion 213issue
2eissn
0344-5607issn
1437-2320journal_volume
31pub_type
杂志文章abstract::Although approximately 30% of facial nerve schwannoma cases present with no facial palsy, a large facial nerve schwannoma extending to the middle and posterior cranial fossa quite rarely presents without facial palsy. The authors encountered two patients with large facial nerve schwannoma who presented with only heari...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-005-0381-x
更新日期:2005-07-01 00:00:00
abstract::The author reports a case of a histologically proven cavernous hemangioma of the cavernous sinus and middle fossa, which was treated by radiotherapy. This very rare lesion represents a formidable challenge to the neurosurgeon and its excision has been associated with a considerable mortality rate. The significant redu...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00314842
更新日期:1996-01-01 00:00:00
abstract::A neuroendoscopic biopsy is a minimally invasive and useful procedure for the diagnosis and initial management of tumor-associated hydrocephalus. We describe the nationwide investigation of the current status of neuroendoscopic biopsy for intra- and paraventricular tumors in children, as well as the treatment of tumor...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0629-z
更新日期:2015-10-01 00:00:00
abstract::During surgeries in the upper cerebellopontine angle (CPA), the superior petrosal veins (SPVs) often act as obstacles; and their sectioning sometimes causes serious complications. In this study, we introduced a classification system for the SPVs wherein their tributaries were classified into four groups on the basis o...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-014-0548-4
更新日期:2014-10-01 00:00:00
abstract::Twenty-six patients with oculomotor nerve palsy due to cerebral aneurysms were examined. There were six males and twenty females with a mean age of 55 years. 25 of the 26 aneurysms were located at the junction of the internal carotid and the posterior communicating artery and one was at the junction of the basilar art...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01741485
更新日期:1989-01-01 00:00:00
abstract::This short paper summarizes the basic concept and the technology of a new computed radiographic system which uses an energy-storage phosphorus panel called "Imaging Plate" as an image sensor. The "Imaging Plate" can be used to obtain radiographs in exactly the same way as the screen-film combination is used in convent...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01744878
更新日期:1985-01-01 00:00:00
abstract::Concordance between the Unruptured Intracranial Aneurysm Treatment Score (UIATS), Earlier Subarachnoid Hemorrhage, Location, Age, Population, Size, Shape (ELAPSS) score, and Population, Hypertension, Age, Size, Earlier Subarachnoid Hemorrhage, Site (PHASES) score with real-world management decisions in unruptured intr...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01356-6
更新日期:2020-07-22 00:00:00
abstract::The posteroinferior region of the thalamus is formed by the pulvinar, and it is surgically accessed through the infratentorial supracerebellar approach, between the midline and the retromastoid region. This study aimed to compare the paramedian, lateral, extreme lateral, and contralateral paramedian corridors with the...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01405-0
更新日期:2020-10-24 00:00:00
abstract::In 63 specimens, 74 aneurysms, and five other lesions, postmortem microsurgical and endoscopic inspection (PMI) was done. This work not only allowed for safe pathoanatomic findings, but moreover showed characteristics of a training method developed according to a model with clear standards. PMI gives training in: 1. U...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430100155
更新日期:2002-03-01 00:00:00
abstract::80-90% of individuals suffering from aneurysmal bone cyst (ABC) are children or adolescents. Primary ABC is a non-neoplastic lesion. Diagnostic assessment and detection of recurrence demands repeated plain x-rays or CT scans. These repeated radiographic examinations expose these young patients to large doses of ionizi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00383659
更新日期:1990-01-01 00:00:00
abstract::We present 78 patients with spinal cord injuries. Operation is not indicated in cord contusion, extended bleeding into the spinal canal or severe fracture dislocation. However, it would seem advisable to operate on patients with vertebral fractures, particularly at the lower thoracic and lumbar levels, if intraspinal ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01790702
更新日期:1989-01-01 00:00:00
abstract::Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identi...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析
doi:10.1007/s10143-018-0965-x
更新日期:2020-02-01 00:00:00
abstract::A remote cerebellar hemorrhage (RCH) is a spontaneous bleeding in the posterior fossa, which can be rarely observed as a complication of spine surgery. As well as for RCH reported after supratentorial procedures, it shows a characteristic bleeding pattern defined "zebra sign". Nowadays, RCH pathophysiology still remai...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-015-0673-8
更新日期:2016-07-01 00:00:00
abstract::Pediatric cortical ependymomas (CEs) are rare; the clinical features and optimal treatment remain ill-defined. We aimed to clarify the clinical characteristics and outcome of pediatric CEs based on institutional series and literature review. Thirteen children with CEs from our department were included in the present s...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01336-w
更新日期:2020-06-30 00:00:00
abstract::Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is a safe and effective treatment for moyamoya disease, although recent evidence suggests its substantial risk for symptomatic cerebral hyperperfusion. The diagnostic value of single-photon emission computed tomography (SPECT) for postoperative h...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0147-3
更新日期:2008-10-01 00:00:00
abstract::The patterns of regional cerebral blood flow (rCBF) in patients with dementia caused by Alzheimer's disease is compared with that of patients with dementia caused by multiple cerebral infarctions. A total of 47 patients were examined with 133Xenon SPECT. The results show that the global CBF correlates with the severit...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01741445
更新日期:1987-01-01 00:00:00
abstract::Arteriovenous malformation (AVM) may change the cerebral hemodynamics. The purpose of this study was to detect the effects of ionizing radiation (IR) on tissues surrounding AVM in a rat caroticojugular fistula model. Forty rats were divided into four groups. Eight weeks after caroticojugular fistulas and chronic hypop...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0316-3
更新日期:2004-04-01 00:00:00
abstract::The orbitotomy has a central importance in craniofacial surgery. It is indicated for premature craniosynostoses, malformations and tumor surgery. The aim of the treatment is to correct functional disturbances and aesthetic impairments. Anatomical structures must be respected. Functional and anatomical aspects of the o...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01787121
更新日期:1989-01-01 00:00:00
abstract::Topographic brain mapping of EEG and evoked potentials permits the display of spontaneous and event-related activity of the brain. This new method is superior to conventional polygraphy because of the topographic approach which delineates structural and functional brain lesions. Data from 16 to 20 scalp electrodes wer...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01781950
更新日期:1987-01-01 00:00:00
abstract::Among 1142 patients with head injuries hospitalized in the Neurosurgery Department of Gazi University Medical School during the period between 1979 and 1992, 583 had initial CT scans. A retrospective analysis of these initial CT images revealed intracranial air on admission in only 21 cases. These were classified as a...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章
doi:10.1007/BF01111479
更新日期:1998-01-01 00:00:00
abstract::The endoscope has become an essential tool for transsphenoidal pituitary surgeries because of the panoramic view and the ability to visualize structures beyond the direct line of vision. However, the regular dedicated instruments for these surgeries sometimes do not reach the areas visualized by an angled endoscope, a...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0108-2
更新日期:2008-01-01 00:00:00
abstract::Three patients suffering from hematogenous destructive spondylodiscitis were treated with one-session spondylectomy, bone graft-fusion and halo-device stabilization. A stable osseous fusion was achieved after three months with additional antibiotic therapy. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00338196
更新日期:1991-01-01 00:00:00
abstract::The objective of this systematic review is to create an overview of the literature on the comparison of navigated transcranial magnetic stimulation (nTMS) as a mapping tool to the current gold standard, which is (intraoperative) direct cortical stimulation (DCS) mapping. A search in the databases of PubMed, EMBASE, an...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01397-x
更新日期:2020-10-03 00:00:00
abstract::Multimodally evoked potentials were registered in 85 patients who fulfilled the criteria for brain death. While somatosensory and visual evoked potentials have been found to be of limited value for the diagnosis of brain death, the stepwise abolition of brain stem auditory evoked potentials (BAEP) confirmed brain deat...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00257800
更新日期:1992-01-01 00:00:00
abstract::Chiari I malformation (CI) continues to raise great interest among physicians due to the larger and larger number of newly diagnosed cases. The clinical and radiological picture and the management options of such a chronic disease are well acknowledged as well as those of the associated syringomyelia. Little is known,...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-012-0391-4
更新日期:2012-07-01 00:00:00
abstract::We aimed to evaluate whether bypass of the external carotid artery (ECA) to the middle cerebral artery (MCA) can be established by a short saphenous vein graft in order to increase the anastomosis patency. The method was performed to ten adult cadaver sides. We described a modified technique for bypass of the ECA to t...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0138-4
更新日期:2008-07-01 00:00:00
abstract::Sinus pericranii is a rare vascular abnormality characterised by abnormal connections between the intra- and extracranial venous systems and is usually found in children. In most instances, a sinus pericranii presents as a soft scalp swelling that appears with the patient in the recumbent position and disappears in th...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-011-0325-6
更新日期:2012-01-01 00:00:00
abstract::Postoperative wound healing can pose a problem in patients undergoing instrumented surgery for pyogenic spondylodiscitis. Robotic guidance allows the minimally invasive placement of pedicle screws in the thoracolumbar spine. We assessed whether using this technique to perform minimally invasive surgery had an impact o...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0877-1
更新日期:2018-04-01 00:00:00
abstract::Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-016-0775-y
更新日期:2018-04-01 00:00:00
abstract::Preoperative prediction of molecular information of lower-grade gliomas (LrGGs) helps to determine the overall treatment strategy as well as the initial surgical strategy. This study aimed to detect magnetic resonance imaging (MRI) texture parameters to predict the molecular signature of LrGGs using a commercially ava...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01157-6
更新日期:2020-08-01 00:00:00