Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced brain and retinal damages.

Abstract:

:Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 teletherapy machine. Groups 3, 4, and 5 received irradiation plus 40 kg(-1) day(-1) Vitamin E or 200 mg kg(-1)day(-1) L-carnitine alone or in combination. Brain and retinal damages were histopathologically evaluated by two independent pathologists. Antioxidant enzyme levels were also measured. Radiation significantly increased brain and retinal damages. A significant increase in malondialdehyde levels as well as a decrease in superoxide dismutase and catalase enzymes in brain was found in group 2. Separate administration of Vitamin E+RT and L-carnitine+RT significantly reduced the severity of brain and retinal damages and decreased the malondialdehyde levels and increased the activity of superoxide dismutase and catalase enzymes in the brain. The findings of current study support the antioxidant and radioprotective roles of vitamin E and L-carnitine. However, the combined use of Vitamin E and L-carnitine plus irradiation interestingly did not exhibit an additive radioprotective effect.

journal_name

Neurosurg Rev

journal_title

Neurosurgical review

authors

Sezen O,Ertekin MV,Demircan B,Karslioğlu I,Erdoğan F,Koçer I,Calik I,Gepdiremen A

doi

10.1007/s10143-007-0118-0

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

205-13; discussion 213

issue

2

eissn

0344-5607

issn

1437-2320

journal_volume

31

pub_type

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