Abstract:
:Glial tumors are the most common tumors of the nervous system, affecting individuals at any age. Since understanding of the molecular pathologies underlying human gliomas is still very poor, the treatment and therefore prognosis of this malignancy could not yet be improved. In order to determine whether different glioblastoma-associated genomic aberrations may serve as prognostic markers in combination with histopathological findings, 20 primary glioblastoma multiforme tumors were screened by comparative genomic hybridization, and the results were compared with histopathological and clinical features. All tumors showed genomic copy aberrations detected by comparative genomic hybridization. Regional and numerical increases in chromosome 7 copy number were the most frequently seen abnormality (10/20 tumors), followed by loss of chromosome 10 (8/20). Both of these aberrations were associated with shorter surveillance time. Chromosome 12q amplification was detected in seven tumors. Loss of 17p, 1p, and 19q in combination was seen in three cases. One of them was a giant cell GBM, whereas the remaining two cases were still alive. Combination of chromosome 1p and 19q deletions was also seen in a case with long surveillance. According to the preliminary findings of this study, in addition to the EGFR gene, amplification of other genes on chromosome 7 and the deletion of PTEN gene and other cancer-related genes on chromosome 10 appeared important to the development of glioblastoma multiforme and were associated with poor prognosis, whereas the combination of chromosome 1p and 19q deletions seems to be an informative molecular marker for better prognosis. The clinical features and genetic alterations of primary and secondary glioblastoma multiforme should be compared in large series to clarify the effective prognostic markers; and further molecular analyses focused on chromosomes 7 and 10 will be very helpful for understanding the molecular mechanisms underlying the progression of glioblastoma.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Arslantas A,Artan S,Oner U,Müslümanoğlu H,Durmaz R,Cosan E,Atasoy MA,Başaran N,Tel Edoi
10.1007/s10143-003-0279-4keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
58-64issue
1eissn
0344-5607issn
1437-2320journal_volume
27pub_type
杂志文章abstract::A large variety of vertebral tumours undergoes transarterial embolisation (TAE) prior to surgery. However, the subsequent intra-operative blood loss is unpredictable. This retrospective analysis, aims to determine the impact of various factors that may potentially influence the estimated intra-operative blood loss (EB...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-1003-8
更新日期:2019-12-01 00:00:00
abstract::Chemotherapy of malignant glioma has been discussed in relation to recent advances in experimental and clinical studies. It is now obvious that chemotherapy is of increasing importance in the multidisciplinary treatment of malignant gliomas. Survival time of patients was prolonged by intensive and prolonged chemothera...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF01743285
更新日期:1984-01-01 00:00:00
abstract::Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is a safe and effective treatment for moyamoya disease, although recent evidence suggests its substantial risk for symptomatic cerebral hyperperfusion. The diagnostic value of single-photon emission computed tomography (SPECT) for postoperative h...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0147-3
更新日期:2008-10-01 00:00:00
abstract::Gamma knife radiosurgery (GKRS) has emerged as a possible treatment option for metastasis brain tumor (MBTs) originated from breast cancer. However, the intermediate or long-term outcome of GKRS on MBTs originated from breast carcinoma is not well defined. The outcome of GKRS on MBTs derived from breast carcinoma was ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0624-4
更新日期:2015-07-01 00:00:00
abstract::There are still different descriptions of the segmentation of the posterior cerebral artery, although there is a radiological and anatomical consensus on the segmentation of the anterior and the middle cerebral artery. This study aims to define the most appropriate localization for origin and end points of the segment...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-0972-y
更新日期:2019-03-01 00:00:00
abstract::Experimental brain tumours were produced in cats by stereotactic implantation of 4 million suspended cells of a rat glioma clone into the internal capsule. Three weeks after implantation a spherical tumour developed with a diameter of up to 10 mm which was surrounded by vasogenic white matter oedema. In untreated anim...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01743708
更新日期:1981-01-01 00:00:00
abstract::Injury to the internal carotid artery (ICA) is a life-threatening complication of endoscopic endonasal approaches. The objective of this study is to illustrate the detail anatomy of the parapharyngeal segment of the ICA (PPICA) to safe endoscopic endonasal surgery. The anatomical dissection was performed in 10 cadaver...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01176-3
更新日期:2020-10-01 00:00:00
abstract::Chiari I malformation (CI) continues to raise great interest among physicians due to the larger and larger number of newly diagnosed cases. The clinical and radiological picture and the management options of such a chronic disease are well acknowledged as well as those of the associated syringomyelia. Little is known,...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-012-0391-4
更新日期:2012-07-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01790685
更新日期:1989-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-009-0201-9
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01336-w
更新日期:2020-06-30 00:00:00
abstract::This study reviewed the surgical management of cirsoid aneurysms of the scalp, which are rarely encountered in the neurosurgical practice, and compares the results with embolization. 21 patients with cirsoid aneurysm underwent surgery. There were 1 female and 20 male patients. Trauma was present in four patients. Sele...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-006-0023-y
更新日期:2006-07-01 00:00:00
abstract::80-90% of individuals suffering from aneurysmal bone cyst (ABC) are children or adolescents. Primary ABC is a non-neoplastic lesion. Diagnostic assessment and detection of recurrence demands repeated plain x-rays or CT scans. These repeated radiographic examinations expose these young patients to large doses of ionizi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00383659
更新日期:1990-01-01 00:00:00
abstract::Proximally located posterior communicating artery (PCoA) aneurysms, projecting postero-laterally in proximity to the tentorium, may pose a technical challenge for microsurgical clipping due to obscuration of the proximal aneurysmal neck by the anterior petroclinoid fold. We describe an efficacious technique utilizing ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0554-6
更新日期:2014-10-01 00:00:00
abstract::Craniotomy surgical site infections are an inherent risk and dreaded complication for the elective brain tumor patient. Sequelae can include delays in resumption in adjuvant treatments for multiple surgeries if staged cranioplasty is pursued. Here, the authors review their experience in operative debridement of surgic...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-0955-z
更新日期:2018-10-01 00:00:00
abstract::To achieve local control of malignant glioma, we designed a postoperative stereotactic radiotherapy using a micro-multileaf collimator (micro-MLC). The purpose of this study was to clarify the feasibility of this treatment. The treatment was performed in six patients who met the following eligibility criteria: (1) sup...
journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章
doi:10.1007/s101430100185
更新日期:2002-06-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/pl00011947
更新日期:2000-09-01 00:00:00
abstract::In 112 comatose patients somatosensory, visual and auditory evoked potentials were registered within 36 hours after the onset of coma or admission. Main causes of coma were head injury, and intracerebral and subarachnoid haemorrhage. The initial bilateral loss of any evoked potential was associated with a mortality of...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF00383655
更新日期:1990-01-01 00:00:00
abstract::The device is constructed for intra-operative angiographic studies. The main features of the unit are: semi-automatic positioning of the tube into preset coordinates, TV camera serving as receptor, reproduction of the videosignal with twice the number of lines compared with that used normally, retrieval technique perm...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01780706
更新日期:1984-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-019-01187-0
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abstract::We evaluate the current literature regarding treatment of intracranial atherosclerotic disease, with particular emphasis on emerging medical, surgical, and endovascular trials. A MEDLINE and PubMed search of the literature related to intracranial atherosclerotic disease was performed. Articles which discussed medical,...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-008-0172-2
更新日期:2009-01-01 00:00:00
abstract::The posteroinferior region of the thalamus is formed by the pulvinar, and it is surgically accessed through the infratentorial supracerebellar approach, between the midline and the retromastoid region. This study aimed to compare the paramedian, lateral, extreme lateral, and contralateral paramedian corridors with the...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01405-0
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abstract::A primary xanthomatous tumor is very rare in the central nervous system (CNS). Here we report the case of a fibroxanthoma arising from the dura mater of the cerebrum that demonstrated no systemic disease or metabolic abnormalities. A 19-month-old, otherwise healthy boy was found to have an enlarged head. Magnetic reso...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050019
更新日期:1999-12-01 00:00:00
abstract::The purpose of this study is to compare intervertebral bone fusion and clinical outcomes in L4-5 posterior lumbar interbody fusion (PLIF) using the same posterior instrumentation with four combinations of one of three types of interbody cage with one of two bone grafts, iliac and local or only local. In 67 patients wh...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0610-x
更新日期:2015-07-01 00:00:00
abstract::This study was carried out to evaluate the early results and the prognostic factors affecting the outcome during the in-hospital stay of 110 patients with civilian gunshot wounds to the head admitted at the Hospital of Restauração, Recife, Brazil. Penetrating injury (66%) was the most prevalent type of wound encounter...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0377-2
更新日期:2012-07-01 00:00:00
abstract::Optic pathway glioma (OPG) encompasses a spectrum of findings ranging from lesions confined to the optic nerve only, lesions affecting the optic chiasm and hypothalamus, and lesions with diffuse involvement of a large part of the optic pathway and neighboring structures. The majority of pediatric low-grade astrocytoma...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-016-0747-2
更新日期:2017-01-01 00:00:00
abstract::A remote cerebellar hemorrhage (RCH) is a spontaneous bleeding in the posterior fossa, which can be rarely observed as a complication of spine surgery. As well as for RCH reported after supratentorial procedures, it shows a characteristic bleeding pattern defined "zebra sign". Nowadays, RCH pathophysiology still remai...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-015-0673-8
更新日期:2016-07-01 00:00:00
abstract::The authors describe a case of hemifacial spasm associated with Marfan's syndrome. A 24-year-old-woman suffered from left hemifacial spasm for 6 years. She had undergone surgical treatments for bilateral ectopia lentis and kyphoscoliosis in the second decade of life. She also had unusually long and slim limbs with ara...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF02389321
更新日期:1998-01-01 00:00:00
abstract::Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-016-0775-y
更新日期:2018-04-01 00:00:00
abstract::We report here on congenital sphenoorbital encephalocele which could not be disclosed by computed tomography including contrast medium application or by orbital sonography. Surgery and histological examination were necessary to establish correct the diagnosis. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01794689
更新日期:1988-01-01 00:00:00