Abstract:
:Direct delivery of antibiotics to the ventricular system offers an alternative for the management of nosocomial meningitis. However, the available literature frequently results in controversial findings regarding its safety. The present meta-analysis aimed at summarizing the risk of local complications after the administration of intraventricular/intrathecal (IVT/IT) antibiotics for the treatment of ventriculitis/meningitis (VM) associated with gram-negative pathogens. We systematically searched the medical literature from 1964 until July 2018, for clinical studies reporting on complications after the index treatment. The quality of the eligible studies was classified as "high," "moderated," and "low" for randomized controlled trials, observational studies, and case series, respectively. The results were summarized as pooled frequencies, estimated by the random- or fixed-effects models, according to the inter-study heterogeneity. The publication bias was visualized in trim-and-fill funnel plots. Τhe analysis included twenty-three primary studies with 229 patients. The overall complication rate was as high as 0.13 (95% CI 0.08; 0.19, I2 = 9%); chemical meningitis and seizures represented the majority of the complications, with an occurrence rate of 0.11 (95% CI 0.07; 0.17, I2 = 0%) and 0.07 (95% CI 0.04; 0.12; I2 = 0%), respectively. The meta-analysis was based on studies of "moderate" and "low" reporting quality, while the publication bias after inspecting of the funnel plots revealed significant asymmetry. The present review denotes the absence of large, high-quality studies in the field. Nevertheless, IVT/IT was associated with moderate morbidity, mainly attributed to chemical meningitis and seizures. Further high-quality studies are still required before this therapeutic modality becomes broadly established.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Brotis AG,Churis I,Karvouniaris Mdoi
10.1007/s10143-019-01226-wsubject
Has Abstractpub_date
2019-12-24 00:00:00eissn
0344-5607issn
1437-2320pii
10.1007/s10143-019-01226-wpub_type
杂志文章,评审abstract::Surgery of the infratemporal fossa (ITF) and parapharyngeal area presents a formidable challenge to the surgeon due to its anatomical complexity and limited access. Conventional surgical approaches to these regions were often too invasive and necessitate sacrifice of normal function and anatomy. To describe a less inv...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0655-x
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abstract::A primary xanthomatous tumor is very rare in the central nervous system (CNS). Here we report the case of a fibroxanthoma arising from the dura mater of the cerebrum that demonstrated no systemic disease or metabolic abnormalities. A 19-month-old, otherwise healthy boy was found to have an enlarged head. Magnetic reso...
journal_title:Neurosurgical review
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abstract::Intermediate nerve schwannomas (INS) are extremely rare lesions in literature. They have been described mimicking facial nerve schwannomas, but not vestibular schwannomas (VS). We aimed to review the previously published cases, as well as the evidence to believe that they are far more common, though usually misdiagnos...
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journal_title:Neurosurgical review
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journal_title:Neurosurgical review
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abstract::Human malignant gliomas arise from neural progenitor cells and/or dedifferentiated astrocytes. By now, they are genetically so well characterized that several murine glioma models have emerged that faithfully reiterate the typical histological features of the disease. In experimental animals, only one or two elements ...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
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abstract::Stereotactic biopsies represent a routine neurosurgical procedure for the diagnosis of intracranial lymphomas and selected diffusely infiltrating gliomas. Acquisition of tissue samples that do not allow correct tumor typing and grading is, however, not uncommon. Five-aminolevulinic acid (5-ALA) has been shown to accum...
journal_title:Neurosurgical review
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pub_type: 临床试验,杂志文章
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journal_title:Neurosurgical review
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0257-x
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journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-004-0354-5
更新日期:2005-04-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01449-2
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01647129
更新日期:1980-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章,评审
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journal_title:Neurosurgical review
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0279-4
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01259-6
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journal_title:Neurosurgical review
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doi:10.1007/s10143-003-0259-8
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journal_title:Neurosurgical review
pub_type: 杂志文章
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journal_title:Neurosurgical review
pub_type: 杂志文章,评审
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journal_title:Neurosurgical review
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:Neurosurgical review
pub_type: 杂志文章
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01157-6
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abstract::Cavernous hemangiomas are the most frequently found primary tumors in the orbital region. They normally appear in adults. Diagnostic features in the majority of cases include protrusio bulbi and orbital enlargement. B-Scan and computed tomography/MRI are the prime diagnostic aids. We recommend surgical removal of thes...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
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journal_title:Neurosurgical review
pub_type: 杂志文章
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