Abstract：
:Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- and gender-matched controls. Plasma levels of tHcy were measured at admission using direct immunoassay. All the variables were analyzed with respect to tHcy levels and outcome according to Glasgow Outcome Score (GOS) at 3 months. Univariate and multivariate analyses were performed using SPSS 21. There were a total of 72 patients in the study. tHcy levels were significantly higher after head injury (mean 24.03[SD ± 16.0] μmol/L), compared to matched controls (mean 16.62 [SD ± 10.4] μmol/L) (p = 0.05). Patients with severe head injury, acute SDH, or diffuse higher radiological grades had greater levels of tHcy compared to others. There was a significant relationship between tHcy level and neurological outcome. tHcy levels were significantly higher in patients who had unfavorable GOS (mean 36.22[±25.3] μmol/L), compared to those with favorable GOS (mean 22.71[±14.3] μmol/L) (P = 0.03). In multivariate analysis, tHcy level (adj. odds ratio [OR] 1.17, P = 0.05) and Glasgow Coma Scale (adj. OR 5.17, P = 0.01) had significant association with neurological outcome at 3 months independent of age, dietary habit, radiological grading and of each other. tHcy level has significant independent impact on neurological outcome and may be useful as a prognostic marker following head injury.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Dhandapani S,Bajaj A,Gendle C,Saini I,Kaur I,Chaudhary I,Jasandeep,Kaur J,Kalyan G,Dhandapani M,Gupta SKdoi
10.1007/s10143-017-0880-6subject
Has Abstractpub_date
2018-04-01 00:00:00pages
513-517issue
2eissn
0344-5607issn
1437-2320pii
10.1007/s10143-017-0880-6journal_volume
41pub_type
杂志文章abstract：:Magnesium has neuroprotective and antivasospastic properties in the presence of subarachnoid hemorrhage (SAH). The present study investigated the effect of intracisternal administration of magnesium on cerebral vasospasm in the experimental SAH rat model. The rat double-SAH model (0.2 mL autologous blood injected twic...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-008-0122-z
更新日期：2008-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0554-6
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pub_type： 杂志文章
doi：10.1007/s10143-005-0418-1
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pub_type： 杂志文章
doi：10.1007/s10143-018-0982-9
更新日期：2019-06-01 00:00:00
abstract：:Acute intracranial subdural hematoma (ASDH) is commonly associated with a grave prognosis citing a high incidence of morbidity and mortality. The parameters to decide on surgical evacuation of the hematoma are sometimes controversial. In this study, we theorized that the ratio between maximal hematoma thickness and mi...
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pub_type： 杂志文章
doi：10.1007/s10143-017-0873-5
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journal_title：Neurosurgical review
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doi：10.1007/s10143-014-0555-5
更新日期：2014-10-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-0972-y
更新日期：2019-03-01 00:00:00
abstract：:Concordance between the Unruptured Intracranial Aneurysm Treatment Score (UIATS), Earlier Subarachnoid Hemorrhage, Location, Age, Population, Size, Shape (ELAPSS) score, and Population, Hypertension, Age, Size, Earlier Subarachnoid Hemorrhage, Site (PHASES) score with real-world management decisions in unruptured intr...
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doi：10.1007/s10143-020-01356-6
更新日期：2020-07-22 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0563-5
更新日期：2014-10-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章,评审
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0300-7
更新日期：2010-04-01 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章,评审
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01743105
更新日期：1983-01-01 00:00:00
abstract：:Radical excision of meningioma is suggested to provide for the best tumor control rates. However, aggressive surgery for meningiomas located at the posterior cranial fossa may lead to elevated postoperative morbidity of adjacent cranial nerves which in turn worsens patients' postoperative quality of life. Therefore, w...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01275-6
更新日期：2020-02-27 00:00:00
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journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-1011-8
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journal_title：Neurosurgical review
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pub_type： 杂志文章,评审
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journal_title：Neurosurgical review
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journal_title：Neurosurgical review
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journal_title：Neurosurgical review
pub_type： 杂志文章
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journal_title：Neurosurgical review
pub_type： 杂志文章,评审
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journal_title：Neurosurgical review
pub_type： 杂志文章,meta分析,评审
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journal_title：Neurosurgical review
pub_type： 杂志文章
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