The role of brachytherapy in the treatment of glioblastoma multiforme.


:Brachytherapy (BT) for glioblastoma multiforme (GBM) involves the use of radioactive isotopes to deliver ionizing radiation directly into the tumor bed. Its application as a means to prolong survival in GBM patients over the past few decades has come with variable success. The objective of this review is to describe the utility of BT in GBM, and to report the outcomes and adverse events associated with its use in different multimodal treatment approaches. A search of the literature was conducted using the PubMed database. The most recent search was performed in September 2015. Thirty-two series involving 1571 patients were included in our review. The longest median overall survival (MOS) following BT for newly diagnosed GBM reached 28.5 months. Overall, 1-, 2-, and 3-year survival rates were 46-89 %, 20-57 %, and 14-27 %. For recurrent GBM, the longest reported MOS after BT was 15.9 months. One-, 2- and 3-year survival rates for recurrent GBM were 10-66 %, 3-23 %, and 9-15 %. Adverse events were reported in 27 % of patients. Reoperation for radiation necrosis occurred in 4 and 27 % of patients following low- and high-dose rate BT, respectively. BT is a feasible option for extending survival in carefully selected GBM patients. As patient outcomes and overall survival improve with more aggressive radiotherapy, so does the risk of radiation-related complications. The most effective use of BT is likely as a part of multimodal treatment with other novel therapies.


Neurosurg Rev


Neurosurgical review


Barbarite E,Sick JT,Berchmans E,Bregy A,Shah AH,Elsayyad N,Komotar RJ




Has Abstract


2017-04-01 00:00:00














  • Emergency embolectomy for embolic occlusion of the middle cerebral artery-review of the literature and two illustrative cases.

    abstract::With the increasing number of endovascular interventions during the last years, the number of procedure-related complications has risen accordingly. Despite sophisticated and effective endovascular treatments for acute thromboembolic events during intervention, vessel occlusion can remain refractory to medical and end...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Etminan N,Steiger HJ,Hänggi D

    更新日期:2011-01-01 00:00:00

  • Cerebellopontine angle epidermoid cysts: clinical presentations and surgical outcome.

    abstract::Epidermoid cysts constitute less than 1% of intracranial tumors with the majority of them involving cerebellopontine angle (CPA). Although several mechanisms for cranial nerve dysfunction due to these tumors have been proposed, no direct evaluation for hyper- or hypoactive dysfunction has been done. In this case serie...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Hasegawa M,Nouri M,Nagahisa S,Yoshida K,Adachi K,Inamasu J,Hirose Y,Fujisawa H

    更新日期:2016-04-01 00:00:00

  • Management of intracranial meningeal hemangiopericytomas: outcome and experience.

    abstract::Hemangiopericytomas represent rare intracranial tumors that have a tendency to recur locally and have the unique characteristic of giving extracranial metastases. Our current communication reviews a series of patients diagnosed with hemangiopericytoma who were treated in our facility. Eleven patients with a mean age o...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Fountas KN,Kapsalaki E,Kassam M,Feltes CH,Dimopoulos VG,Robinson JS,Smith JR

    更新日期:2006-04-01 00:00:00

  • Endoscopic third ventriculostomy in the treatment of idiopathic normal pressure hydrocephalus: a review study.

    abstract::Idiopathic normal pressure hydrocephalus is a hydrodynamic disorder whose etiology remains unclear. The diagnosis is mainly clinical and the traditional treatment is cerebrospinal fluid shunt diversion. With the introduction of modern management strategies, endoscopic third ventriculostomy has become a viable alternat...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Tasiou A,Brotis AG,Esposito F,Paterakis KN

    更新日期:2016-10-01 00:00:00

  • Acute phase effects of ATP-MgCl2 on experimental spinal cord injury.

    abstract::The purpose of this study was to study the acute phase effects of adenosine triphosphate (ATP)-MgCl2 on experimental spinal cord clip compression injury. Spinal cord clip compression injury was performed on 36 albino Wistar rats. The rats were divided into five groups. T4-T8 total laminectomy was performed on all rats...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Cakir E,Baykal S,Karahan SC,Kuzeyli K,Uydu H

    更新日期:2003-01-01 00:00:00

  • Supratentorial pediatric cortical ependymomas: a comprehensive retrospective study.

    abstract::Pediatric cortical ependymomas (CEs) are rare; the clinical features and optimal treatment remain ill-defined. We aimed to clarify the clinical characteristics and outcome of pediatric CEs based on institutional series and literature review. Thirteen children with CEs from our department were included in the present s...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Wang Q,Cheng J,Zhang S,Li Q,Hui X,Ju Y

    更新日期:2020-06-30 00:00:00

  • Innervation of the blood vessels of the spinal cord: a comprehensive review.

    abstract::There is growing evidence that the nervous system influences spinal cord vasculature. However, most descriptions of the spinal cord have paid little attention to this important aspect. We reviewed the literature on the innervation of spinal cord vessels with an emphasis on findings that may be applicable to human medi...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Montalbano MJ,Loukas M,Oskouian RJ,Tubbs RS

    更新日期:2018-07-01 00:00:00

  • Cerebral capillary telangiectasias: a meta-analysis and review of the literature.

    abstract::As a result of their presumed benign natural history, cerebral capillary telangiectasias (CCTs) are infrequently addressed in the neurosurgical literature. We performed a comprehensive review of CCTs via the PubMed database to synthesize overall epidemiological, radiographic, natural history, and treatment results. Ac...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,meta分析,评审


    authors: Gross BA,Puri AS,Popp AJ,Du R

    更新日期:2013-04-01 00:00:00

  • Solitary nonchordomatous lesions of the clival bone: differential diagnosis and current therapeutic strategies.

    abstract::A nonchordomatous solitary lesion of the clival bone is an exceptionally rare pathological entity, which represents a diagnostic and a therapeutic challenge. Many diseases with extremely different biological behavior, and requiring a dedicated treatment strategy, may result in similar clinical patterns. The approach t...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Gagliardi F,Boari N,Mortini P

    更新日期:2013-10-01 00:00:00

  • Novel method of intraoperative ocular movement monitoring using a piezoelectric device: experimental study of ocular motor nerve activating piezoelectric potentials (OMNAPP) and clinical application for skull base surgeries.

    abstract::Intraoperative monitoring systems that utilize various evoked potentials for the detection and/or preservation of cranial nerves have become increasingly common due to recent technical and commercial developments, particularly during skull base surgeries. We established a novel system for the intraoperative monitoring...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Sakata K,Suematsu K,Takeshige N,Nagata Y,Orito K,Miyagi N,Sakai N,Koseki T,Morioka M

    更新日期:2020-02-01 00:00:00

  • Visualizing receptors for neurotransmitters in the human brain with autoradiography.

    abstract::Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. W...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Palacios JM,Chinaglia G,Probst A

    更新日期:1989-01-01 00:00:00

  • Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies.

    abstract::Stereotactic biopsies represent a routine neurosurgical procedure for the diagnosis of intracranial lymphomas and selected diffusely infiltrating gliomas. Acquisition of tissue samples that do not allow correct tumor typing and grading is, however, not uncommon. Five-aminolevulinic acid (5-ALA) has been shown to accum...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Widhalm G,Minchev G,Woehrer A,Preusser M,Kiesel B,Furtner J,Mert A,Di Ieva A,Tomanek B,Prayer D,Marosi C,Hainfellner JA,Knosp E,Wolfsberger S

    更新日期:2012-07-01 00:00:00

  • The traumatic aneurysm of intracranial vessels.

    abstract::From our observations of two patients, the problems of traumatic intracranial aneurysm are discussed. The prerequisites for recognition of such an aneurysm are the clinical findings, especially the angiographic control of the course of the aneurysm and, if possible, the results of histological examination. The difficu...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Bingas B,Vogt U

    更新日期:1980-01-01 00:00:00

  • The impact of surgical simulation on patient outcomes: a systematic review and meta-analysis.

    abstract::The use of simulation in surgical training is ever growing. Evidence suggests such training may have beneficial clinically relevant effects. The objective of this research is to investigate the effects of surgical simulation training on clinically relevant patient outcomes by evaluating randomized controlled trials (R...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Meling TR,Meling TR

    更新日期:2020-05-13 00:00:00

  • Flow-diverter in radiation-induced skull base carotid blowout syndrome: do not write it off!

    abstract::Post-radiotherapy carotid blowout syndrome (CBS) of the skull base is a rare but often catastrophic complication of head and neck malignancies. The existing literature on the treatment of this condition with flow-diverting devices (FDD) is extremely limited and disappointing. We present a case of impending CBS in a pa...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Anil G,Zhang J,Ong YK,Hui F

    更新日期:2017-10-01 00:00:00

  • First clinical experience with the new noninvasive transfontanelle ICP monitoring device in management of children with premature IVH.

    abstract::We previously introduced a novel noninvasive technique of intracranial pressure (ICP) monitoring in children with open fontanelles. Within this study, we describe the first clinical implementation and results of this new technique in management of children with hydrocephalus caused by intraventricular hemorrhage (IVH)...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Behmanesh B,Gessler F,Dubinski D,Quick-Weller J,Cattani A,Schubert-Bast S,Seifert V,Konczalla J,Freiman TM

    更新日期:2020-04-01 00:00:00

  • Neuroendoscopic biopsy and the treatment of tumor-associated hydrocephalus of the ventricular and paraventricular region in pediatric patients: a nationwide study in Japan.

    abstract::A neuroendoscopic biopsy is a minimally invasive and useful procedure for the diagnosis and initial management of tumor-associated hydrocephalus. We describe the nationwide investigation of the current status of neuroendoscopic biopsy for intra- and paraventricular tumors in children, as well as the treatment of tumor...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Miwa T,Hayashi N,Endo S,Ohira T

    更新日期:2015-10-01 00:00:00

  • Foramen magnum meningioma presenting as amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative disease of the nervous system. It affects adults in all age groups and leads to death few years after the diagnosis. The etiology is unknown, and there no convincing medical or surgical therapy Some diseases can mimic ALS. If diagnosed early these may ...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Sawaya RA

    更新日期:1998-01-01 00:00:00

  • Endoscopic versus stereotactic biopsies of intracranial lesions involving the ventricles.

    abstract::Stereotactic biopsies of ventricular lesions may be less safe and less accurate than biopsies of superficial lesions. Accordingly, endoscopic biopsies have been increasingly used for these lesions. Except for pineal tumors, the literature lacks clear, reliable comparisons of these two methods. All 1581 adults undergoi...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Birski M,Furtak J,Krystkiewicz K,Birska J,Zielinska K,Sokal P,Rusinek M,Paczkowski D,Szylberg L,Harat M

    更新日期:2020-08-21 00:00:00

  • Local complications of adjunct intrathecal antibiotics for nosocomial meningitis associated with gram-negative pathogens: a meta-analysis.

    abstract::Direct delivery of antibiotics to the ventricular system offers an alternative for the management of nosocomial meningitis. However, the available literature frequently results in controversial findings regarding its safety. The present meta-analysis aimed at summarizing the risk of local complications after the admin...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Brotis AG,Churis I,Karvouniaris M

    更新日期:2019-12-24 00:00:00

  • Neural tissue compatibility of Teflon as an implant material for microvascular decompression.

    abstract::Teflon is utilized in neurosurgery as well as in plastic, vascular and heart surgery. Although the effect of Teflon on different types of cells and tissues has been previously studied, we are not aware of any study in which the effect of Teflon was tested on cells of the central nervous system. We have therefore exami...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Ammar A,Lagenaur C,Jannetta P

    更新日期:1990-01-01 00:00:00

  • Coupling of function, metabolism, and blood flow in the brain.

    abstract::Functional activity, metabolism and blood flow are locally heterogeneous in the brain, but tightly coupled. This adjustment occurs in two different ways: 1. Short-term, dynamic coupling mediated by local vasoactive factors that ensure second-to-second regulation. 2. Long-term, static coupling apparently mediated by ca...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Kuschinsky W

    更新日期:1991-01-01 00:00:00

  • Clinical follow-up after surgery of lumbar disc prolapses. A critical analysis.

    abstract::A retrospective clinical study was made on 987 patients with lumbar disc disease treated by discectomy. All patients had been operated on in the Department of Neurosurgery (University-Hospital Mainz). 545 patients were males, and 442 females (1.2:1). Patients in the 4th decade of life were affected most often (33.5%)....

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Dei-Anang K,Kessel HA,Meinig G

    更新日期:1990-01-01 00:00:00

  • Chemotherapy of malignant gliomas.

    abstract::Chemotherapy of malignant glioma has been discussed in relation to recent advances in experimental and clinical studies. It is now obvious that chemotherapy is of increasing importance in the multidisciplinary treatment of malignant gliomas. Survival time of patients was prolonged by intensive and prolonged chemothera...

    journal_title:Neurosurgical review

    pub_type: 临床试验,杂志文章,评审


    authors: Ushio Y,Hayakawa T,Hasegawa H,Yamada K,Arita N

    更新日期:1984-01-01 00:00:00

  • Diseases of the vertebral arteries.

    abstract::Case reports and postmortem neuropathological findings of a wide spectrum of diseases affecting the vertebral arteries, in particular vasculitis, traumatic lesions, degenerative changes and congenital abnormalities, are discussed. ...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Busch H,Bohl J,Mattern R,Meyermann R

    更新日期:1990-01-01 00:00:00

  • Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced brain and retinal damages.

    abstract::Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 te...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Sezen O,Ertekin MV,Demircan B,Karslioğlu I,Erdoğan F,Koçer I,Calik I,Gepdiremen A

    更新日期:2008-04-01 00:00:00

  • Clinical significance of acute traumatic intracranial pneumocephalus.

    abstract::Among 1142 patients with head injuries hospitalized in the Neurosurgery Department of Gazi University Medical School during the period between 1979 and 1992, 583 had initial CT scans. A retrospective analysis of these initial CT images revealed intracranial air on admission in only 21 cases. These were classified as a...

    journal_title:Neurosurgical review

    pub_type: 临床试验,杂志文章


    authors: Keskil S,Baykaner K,Ceviker N,Işik S,Cengel M,Orbay T

    更新日期:1998-01-01 00:00:00

  • Surgery for posterior fossa meningioma: elevated postoperative cranial nerve morbidity discards aggressive tumor resection policy.

    abstract::Radical excision of meningioma is suggested to provide for the best tumor control rates. However, aggressive surgery for meningiomas located at the posterior cranial fossa may lead to elevated postoperative morbidity of adjacent cranial nerves which in turn worsens patients' postoperative quality of life. Therefore, w...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Schneider M,Schuss P,Güresir Á,Borger V,Vatter H,Güresir E

    更新日期:2020-02-27 00:00:00

  • Magnetic resonance imaging texture analyses in lower-grade gliomas with a commercially available software: correlation of apparent diffusion coefficient and T2 skewness with 1p/19q codeletion.

    abstract::Preoperative prediction of molecular information of lower-grade gliomas (LrGGs) helps to determine the overall treatment strategy as well as the initial surgical strategy. This study aimed to detect magnetic resonance imaging (MRI) texture parameters to predict the molecular signature of LrGGs using a commercially ava...

    journal_title:Neurosurgical review

    pub_type: 杂志文章


    authors: Kanazawa T,Minami Y,Takahashi H,Fujiwara H,Toda M,Jinzaki M,Yoshida K,Sasaki H

    更新日期:2020-08-01 00:00:00

  • Unraveling the riddle of syringomyelia.

    abstract::The pathophysiology of syringomyelia development is not fully understood. Current prevailing theories suggest that increased pulse pressure in the subarachnoid space forces cerebrospinal fluid (CSF) through the spinal cord into the syrinx. It is generally accepted that the syrinx consists of CSF. The here-proposed int...

    journal_title:Neurosurgical review

    pub_type: 杂志文章,评审


    authors: Greitz D

    更新日期:2006-10-01 00:00:00