Abstract:
:Damage which occurs following spinal traumas is often irreversible. During recent years free oxygen radicals formed due to the pathological changes following neural tissue ischemia have been identified as being responsible for the ethio-pathogenesis of such damage. In our experimental study, model lesions are formed in spinal cords of rats by standard trauma. Malondialdehyde (MDA), a lipid peroxidation product, was measured in the spinal tissues distal to the trauma in order to examine indirectly the time-quantity relationship of free oxygen radicals in the area. For this study 60 rats in six groups, including one control group, were used to determine the formation of MDA. Under a surgical microscope, the spines of all rats were exposed by C5-Th6 laminectomy, and pressure was applied to the spinal cords of animals, except the members of the control group, at the level of C7 by a Yaşargil aneurysm clip. MDA was measured in spinal cord tissues in order to determine free oxygen radicals at the first and fifteenth minutes and at the first, second, and fourth hours. The statistical evaluation of the findings revealed a significant increase in MDA, starting from the 15th minute after the compression, reaching a maximum at 1 hour, and then decreasing. This observation may provide an important guide for studies on prevention of neural destruction.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Barut S,Canbolat A,Bilge T,Aydin Y,Cokneşeli B,Kaya Udoi
10.1007/BF00308614subject
Has Abstractpub_date
1993-01-01 00:00:00pages
53-9issue
1eissn
0344-5607issn
1437-2320journal_volume
16pub_type
杂志文章abstract::Brachytherapy (BT) for glioblastoma multiforme (GBM) involves the use of radioactive isotopes to deliver ionizing radiation directly into the tumor bed. Its application as a means to prolong survival in GBM patients over the past few decades has come with variable success. The objective of this review is to describe t...
journal_title:Neurosurgical review
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journal_title:Neurosurgical review
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journal_title:Neurosurgical review
pub_type: 临床试验,杂志文章,评审
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journal_title:Neurosurgical review
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journal_title:Neurosurgical review
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journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0279-4
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pub_type: 杂志文章,评审
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journal_title:Neurosurgical review
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