Abstract:
:Although several studies have suggested that aneurysmal wall inflammation and laminar thrombus are associated with the rupture of saccular aneurysms, the mechanisms leading to the rupture remain obscure. We performed full exposure of aneurysms before clip application and attempted to keep the fibrin cap on the rupture point. Using these specimens in a nearly original state before surgery, we conducted a pathological analysis and studied the differences between ruptured and unruptured aneurysms to clarify the mechanism of aneurysmal wall degeneration. This study included ruptured (n = 28) and unruptured (n = 12) saccular aneurysms resected after clipping. All of the ruptured aneurysms were obtained within 24 h of onset. Immunostainings for markers of inflammatory cells (CD68) and classical histological staining techniques were performed. Clinical variables and pathological findings from ruptured and unruptured aneurysms were compared. Patients with ruptured or unruptured aneurysms did not differ by age, gender, size, location, and risk factors, such as hypertension, smoking, and hyperlipidemia. The absence or fragmentation of the internal elastica lamina, the myointimal hyperplasia, and the thinning of the aneurysmal wall were generally observed in both aneurysms. The existence of subintimal fibrin deposition, organized laminar thrombus, intramural hemorrhage, neovascularization, and monocyte infiltration are more frequently observed in ruptured aneurysms. Multivariate logistic regression analysis showed that ruptured aneurysm was associated with presence of subintimal fibrin deposition and monocyte infiltration. These findings suggest that subintimal fibrin deposition and chronic inflammation have a strong impact on degeneration of the aneurysmal wall leading to their rupture, and this finding may be caused by endothelial dysfunction.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Hokari M,Nakayama N,Nishihara H,Houkin Kdoi
10.1007/s10143-015-0628-0subject
Has Abstractpub_date
2015-07-01 00:00:00pages
531-40; discussion 540issue
3eissn
0344-5607issn
1437-2320journal_volume
38pub_type
杂志文章abstract::The early identification and optimized treatment of wound dehiscence are a complex issue, with implications on the patient's clinical and psychological postoperative recovery and on healthcare system costs. The most widely accepted treatment is surgical debridement (also called "wash out"), performed in theater under ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-018-1022-5
更新日期:2020-02-01 00:00:00
abstract::Otogenic brain abscesses are a significant cause of mortality and morbidity in developing countries. Usually they occur either by distant thrombophlebitis of cerebral veins or by direct extension in an unsafe type of chronic suppurative otitis media. This case of cerebellar abscess was prepared for surgical excision, ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01111489
更新日期:1998-01-01 00:00:00
abstract::The purpose of the present study is to analyze the impact of intraoperative resection control modalities on overall survival (OS) and progression-free survival (PFS) following gross total resection (GTR) of glioblastoma. We analyzed data of 76 glioblastoma patients (30f, mean age 57.4 ± 11.6 years) operated at our ins...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0698-z
更新日期:2016-07-01 00:00:00
abstract::Structural and functional neuroimaging studies are essential in the evaluation of individuals with partial epilepsy syndromes. Magnetic resonance imaging (MRI) is important to delineate structural abnormalities underlying seizure disorders, commonly including hippocampal sclerosis or cortical dysplasias. Identificatio...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-003-0293-6
更新日期:2003-10-01 00:00:00
abstract::The use of simulation in surgical training is ever growing. Evidence suggests such training may have beneficial clinically relevant effects. The objective of this research is to investigate the effects of surgical simulation training on clinically relevant patient outcomes by evaluating randomized controlled trials (R...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01314-2
更新日期:2020-05-13 00:00:00
abstract::Despite the introduction of new antiepileptic drugs and advances in the surgical treatment of epilepsy, an important group of patients still remains uncontrolled by any of these methods. The relatively recent introduction of vagus nerve stimulation is yet another possible treatment for refractory epilepsy. This safe, ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0555-5
更新日期:2014-10-01 00:00:00
abstract::5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue. Therefore, the use of 5-ALA in the surgical treatment of intracranial tumors, particularly gliomas, has gained popularity i...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0697-0
更新日期:2016-07-01 00:00:00
abstract::A technique to reconstruct the posterior elements of the spinal canal in osteoplastic laminotomy is described. The use of titanium microplates allows a stable fixation of the laminar arch with optimal realignment of the lamina cut ends. The titanium implants are fully compatible with magnetic resonance imaging. The au...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF02389311
更新日期:1998-01-01 00:00:00
abstract::Supplemental education is desirable for neurosurgical training, and the use of human cadaver specimen and virtual reality models is routine. An in vivo porcine training model for cranial neurosurgery was introduced in 2005, and our recent experience with this unique model is outlined here. For the first time, porcine ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0572-4
更新日期:2015-01-01 00:00:00
abstract::Preoperative prediction of molecular information of lower-grade gliomas (LrGGs) helps to determine the overall treatment strategy as well as the initial surgical strategy. This study aimed to detect magnetic resonance imaging (MRI) texture parameters to predict the molecular signature of LrGGs using a commercially ava...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01157-6
更新日期:2020-08-01 00:00:00
abstract::Traumatic bifrontal contusions (TBC) form a recognised clinical entity among patients with traumatic brain injury (TBI). This study aims to systematically review current literature on demographics, management, and predictors of outcomes of patients with TBC. A multi-database literature search (PubMed, Cochrane, OVID M...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-019-01098-0
更新日期:2020-06-01 00:00:00
abstract::The pathophysiology of syringomyelia development is not fully understood. Current prevailing theories suggest that increased pulse pressure in the subarachnoid space forces cerebrospinal fluid (CSF) through the spinal cord into the syrinx. It is generally accepted that the syrinx consists of CSF. The here-proposed int...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-006-0029-5
更新日期:2006-10-01 00:00:00
abstract::Acute hydrocephalus is a well-documented complication of subarachnoid hemorrhage. The insertion of external ventricular drainage (EVD) has been the standard of care in the management of this complication, aiming primarily at immediate improvement of the clinical condition of these patients, making them more suitable c...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-005-0423-4
更新日期:2006-01-01 00:00:00
abstract::In order to study the clinical characteristics of intraventricular meningiomas, we analyzed retrospectively 25 patients and reviewed the literature with regard to incidence, clinical manifestation, imaging features, preoperative diagnosis, surgical findings, and histopathological results. Intraventricular meningiomas ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-005-0418-1
更新日期:2006-01-01 00:00:00
abstract::Arteriovenous malformation (AVM) may change the cerebral hemodynamics. The purpose of this study was to detect the effects of ionizing radiation (IR) on tissues surrounding AVM in a rat caroticojugular fistula model. Forty rats were divided into four groups. Eight weeks after caroticojugular fistulas and chronic hypop...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0316-3
更新日期:2004-04-01 00:00:00
abstract::Eosinophilic granuloma is an uncommon lesion, often self-limiting. A location in the spine is rare; until now, only 35 cases have been reported. MRI is the most effective diagnostic technique, although conventional X-ray can also be useful as a first approach. Therapy consists of immobilization of the patients, surger...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF00383729
更新日期:1995-01-01 00:00:00
abstract::Surgery of the infratemporal fossa (ITF) and parapharyngeal area presents a formidable challenge to the surgeon due to its anatomical complexity and limited access. Conventional surgical approaches to these regions were often too invasive and necessitate sacrifice of normal function and anatomy. To describe a less inv...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0655-x
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to determine the efficacy and safety of intrathecal baclofen therapy delivered by a programmable pump for the chronic treatment of spinal spasticity. Twelve patients with intractable spasticity caused by spinal cord injuries underwent implantation of a programmable continuous infusion pump af...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-002-0221-1
更新日期:2002-08-01 00:00:00
abstract::A remote cerebellar hemorrhage (RCH) is a spontaneous bleeding in the posterior fossa, which can be rarely observed as a complication of spine surgery. As well as for RCH reported after supratentorial procedures, it shows a characteristic bleeding pattern defined "zebra sign". Nowadays, RCH pathophysiology still remai...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-015-0673-8
更新日期:2016-07-01 00:00:00
abstract::The purpose of this study was to investigate and to compare the effects of microsuturing to that of tissue adhesives (Tisseel) on the healing of anastomosing peripheral nerve incisions. Forty-five Wistar-Albino rats were placed in special cages and separated into three groups (n = 15). In the control group, biliteral ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01105896
更新日期:1997-01-01 00:00:00
abstract::We report our experience with the anterior subtemporal approach for the posterior communicating artery aneurysm protruding posteriorly. Between 2000 and 2005, seven patients with posterior communicating artery aneurysm were operated on through the anterior subtemporal approach. The approach provided a better view than...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0083-7
更新日期:2007-07-01 00:00:00
abstract::A rare case of fourth ventricle meningioma with a combined intraventricular-intracerebellar localization, successfully removed by surgical treatment, is reported. The features of this type of meningioma as compared to the purely intra-ventricular variety are discussed. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00313514
更新日期:1992-01-01 00:00:00
abstract::Polyostotic fibrous dysplasia affects many bones of the skeleton and usually on one side only. In monostotic variety only one bone is affected. The condition which usually starts in early childhood is at first active, gradually becomes quiescent and finally with termination of skeletal growth becomes inactive and ceas...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01837749
更新日期:1981-01-01 00:00:00
abstract::Direct delivery of antibiotics to the ventricular system offers an alternative for the management of nosocomial meningitis. However, the available literature frequently results in controversial findings regarding its safety. The present meta-analysis aimed at summarizing the risk of local complications after the admin...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-019-01226-w
更新日期:2019-12-24 00:00:00
abstract::Intradiploic epidermoid tumor of the occipital bone was presented. There were neither intracranial extensions nor neurologic deficits. The lesion started as a painless mass under the scalp. The total removal of the tumor was associated with a good prognosis. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00418080
更新日期:1996-01-01 00:00:00
abstract::Massive hemorrhage is a very uncommon event among hemangioblastomas. Forty-four cases have been reported before this review. Thorough analysis of all reported cases on literature was accomplished. The majority presented as parenchymatous or subarachnoid bleedings. Subarachnoid hemorrhage was only associated with spina...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-009-0217-1
更新日期:2010-01-01 00:00:00
abstract::A hypothalamic hamartoma associated with true precocious puberty in a 7-month-old girl is hereby reported. Hormonal studies disclosed elevated serum levels of luteinizing hormone (LH) and follicle stimulating hormone, both of which responded well to LH-releasing hormone stimulation. Following a subtotal removal of the...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00258250
更新日期:1993-01-01 00:00:00
abstract::The purpose of this paper is to provide a comprehensive review encompassing the syndromes associated with the lower cranial nerves (LCNs). We will discuss the anatomy of some of these syndromes and the historical contributors after whom they were named. The LCNs can be affected individually or in combination, since th...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01344-w
更新日期:2020-07-08 00:00:00
abstract::CSF hydrocele as a complication of migration or extrusion of the peritoneal end of the V-P shunt has rarely been reported. Here the case of a 6 month old infant, born at 28 weeks gestational age, is reported. The baby was noted to have scrotal swelling, exacerbated by crying, two months after insertion of ventriculope...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00313040
更新日期:1991-01-01 00:00:00
abstract::A case of "sudden infant death" after 15 minutes of successful resuscitation of cardiovascular function is presented. While apnoic cranial nerve areflexia and electrocerebral silence persisted, angiography and transcranial Doppler sonography demonstrated nearly normal cerebral perfusion, which even increased day by da...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00257815
更新日期:1992-01-01 00:00:00