Could propranolol be beneficial in adult cerebral cavernous malformations?

Abstract:

:Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem CCM, multiple CCM, or those located in functional areas. Propranolol, a non-selective beta-blocker used as first-line treatment for infantile haemangiomas, has proved spectacularly effective in a few cases of adult patients with CCM. We herein review the histological, in vitro data and clinical findings that support the idea of propranolol as a potential treatment for CCM. Since one retrospective study has not been conclusive, we support the idea that prospective trials are necessary.

journal_name

Neurosurg Rev

journal_title

Neurosurgical review

authors

Apra C,Dumot C,Bourdillon P,Pelissou-Guyotat I

doi

10.1007/s10143-018-01074-0

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

403-408

issue

2

eissn

0344-5607

issn

1437-2320

pii

10.1007/s10143-018-01074-0

journal_volume

42

pub_type

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