Abstract：
:We carried out an experimental investigation of cartilage endplate vascularity of degenerated intervertebral discs produced by exogenous melatonin (MEL) treatment. Adult Swiss albino rats were divided into three groups: control, operated degeneration, and MEL treatment. There were five rats in each group and, using a posterior approach, cuts were made parallel to the endplates in the posterior annulus fibrosus in five consecutive intervertebral discs between the 5th and 10th vertebral segments of the rats' tails. At 8 weeks, five of these animals were treated with exogenous MEL (s.c. injection of 30 microg/100 g body weight daily for 4 weeks). In each experimental group, one animal was examined using CT scanner to study the density of the cartilage endplate of the disc. To evaluate the bone growth and vascularity of the cartilage endplate region, the animals were killed for subsequent histopathological evaluation. We found that the vascular channel counts and percentage areas from animals treated with MEL were significantly lower than from the operated degeneration animals. Accordingly, the density histogram in the MEL group showed a spike profile for both the vertebral body and the cartilage endplate, indicating an increase in the amount of higher density tissues in these regions. Our results demonstrate that the use of MEL reduces the cartilage endplate vascularity of degenerated intervertebral discs, suggesting that it may have an osteoinductive effect on bone formation. Further studies are needed to characterize fully the relevance of our findings for the treatment of disorders such as postmenopausal osteoporosis.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Turgut M,Uslu S,Uysal A,Yurtseven ME,Ustün Hdoi
10.1007/s10143-003-0259-8keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
133-8issue
2eissn
0344-5607issn
1437-2320journal_volume
26pub_type
杂志文章abstract：:Although abundant in nature, fungi are infrequently pathogenic in humans. CNS fungal infections in non-immunocompromised individuals are uncommon. We discuss here the case of an otherwise healthy black woman with an isolated mass of the cerebellopontine angle identified as Blastomyces dermatitidis, successfully treate...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s101430050053
更新日期：1999-10-01 00:00:00
abstract：:This study aimed to find the factors that may affect the surgical outcomes of congenital tethered cord syndrome (TCS) in adults by evaluating the long-term surgical outcomes of 25 consecutive cases. Medical records of 79 TCS cases which underwent surgery in Bakırköy Research and Training Hospital for Neurology, Neuros...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-017-0842-z
更新日期：2018-01-01 00:00:00
abstract：:Dissecting aneurysms in the anterior cerebral artery (ACA), although rare, can cause ischemic and/or hemorrhagic stroke. Hemorrhagic dissecting aneurysms in the A1 portion of the ACA are often associated with a poor prognosis. We retrospectively investigated three rare cases of hemorrhagic dissecting aneurysms in the ...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-017-0841-0
更新日期：2018-04-01 00:00:00
abstract：:Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-018-01074-0
更新日期：2019-06-01 00:00:00
abstract：:We present 78 patients with spinal cord injuries. Operation is not indicated in cord contusion, extended bleeding into the spinal canal or severe fracture dislocation. However, it would seem advisable to operate on patients with vertebral fractures, particularly at the lower thoracic and lumbar levels, if intraspinal ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01790702
更新日期：1989-01-01 00:00:00
abstract：:The aim of this study was to analyze the long-term clinical and radiological outcomes of craniocervical decompression for patients affected by Chiari I-related syringomyelia. We performed a retrospective analysis of a group of patients affected by Chiari I-associated syringomyelia treated by craniocervical decompressi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-010-0260-y
更新日期：2010-07-01 00:00:00
abstract：:Fifteen cases of chronic vegetative state (CVS), following severe head injury and lasting for two years or more, are reported. Vegetative state, in most instances after a period of coma, consists of a return of wakefulness accompanied by an apparent total lack of higher mental activity. A protracted period of vegetati...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01790694
更新日期：1989-01-01 00:00:00
abstract：:Human malignant gliomas arise from neural progenitor cells and/or dedifferentiated astrocytes. By now, they are genetically so well characterized that several murine glioma models have emerged that faithfully reiterate the typical histological features of the disease. In experimental animals, only one or two elements ...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-003-0267-8
更新日期：2003-07-01 00:00:00
abstract：:Magnesium has neuroprotective and antivasospastic properties in the presence of subarachnoid hemorrhage (SAH). The present study investigated the effect of intracisternal administration of magnesium on cerebral vasospasm in the experimental SAH rat model. The rat double-SAH model (0.2 mL autologous blood injected twic...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-008-0122-z
更新日期：2008-04-01 00:00:00
abstract：:A hypothalamic hamartoma associated with true precocious puberty in a 7-month-old girl is hereby reported. Hormonal studies disclosed elevated serum levels of luteinizing hormone (LH) and follicle stimulating hormone, both of which responded well to LH-releasing hormone stimulation. Following a subtotal removal of the...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00258250
更新日期：1993-01-01 00:00:00
abstract：:Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- an...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-017-0880-6
更新日期：2018-04-01 00:00:00
abstract：:We conducted a systematic review of the literature to evaluate the efficacy of various treatment modalities for intracranial aneurysms (IA) in patients with moyamoya disease (MMD) based on anatomical location of IA. A comprehensive review of studies documenting single cases or series of MMD patients with concomitant I...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-020-01307-1
更新日期：2020-05-08 00:00:00
abstract：:A large variety of vertebral tumours undergoes transarterial embolisation (TAE) prior to surgery. However, the subsequent intra-operative blood loss is unpredictable. This retrospective analysis, aims to determine the impact of various factors that may potentially influence the estimated intra-operative blood loss (EB...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-1003-8
更新日期：2019-12-01 00:00:00
abstract：:Intracranial aneurysms usually occur at arterial bifurcations. However, in middle cerebral artery (MCA) aneurysms, we often find that the aneurysmal neck does not necessarily exist just on the arterial bifurcation. In this study, we have evaluated the relation among aneurysmal neck, parent artery, and daughter arterie...
journal_title：Neurosurgical review
pub_type： 临床试验,杂志文章
doi：10.1007/s10143-005-0379-4
更新日期：2005-07-01 00:00:00
abstract：:Multilevel discectomy and inter-vertebral body fusion combined with anterior plate-screw fixation is the common procedure in cervical spine surgery. The correct placement of the screws is an important factor for the outcome of these operations. Yet no systematic approach has been undertaken to optimize the geometry of...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-005-0386-5
更新日期：2005-10-01 00:00:00
abstract：:It is well known that radiation can induce meningiomas. These tumors usually arise in patients with a history of low-dose radiation to the scalp for treatment of tinea capitis or high-dose radiation for a previous brain tumor. Radiation-associated meningiomas (RAMs) morphologically resemble their spontaneously arising...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-004-0366-1
更新日期：2005-04-01 00:00:00
abstract：:Esthesioneuroblastoma is an uncommon malignant neoplasm that arises from olfactory mucosa, often with intracranial extension. A case report of the youngest victim in the literature (2-year-old boy) is presented. ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01390528
更新日期：1997-01-01 00:00:00
abstract：:The purpose of this study is to compare intervertebral bone fusion and clinical outcomes in L4-5 posterior lumbar interbody fusion (PLIF) using the same posterior instrumentation with four combinations of one of three types of interbody cage with one of two bone grafts, iliac and local or only local. In 67 patients wh...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-015-0610-x
更新日期：2015-07-01 00:00:00
abstract：:Residual and recurrent intracranial aneurysms after surgical clipping present a persistent risk of bleeding. Secondary coiling after incomplete clipping represents a strategy to occlude the residual sac: feasibility, bleeding risk and outcome were evaluated through a systematic review of literature along with the seri...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-0950-4
更新日期：2019-06-01 00:00:00
abstract：:This study was carried out to evaluate the early results and the prognostic factors affecting the outcome during the in-hospital stay of 110 patients with civilian gunshot wounds to the head admitted at the Hospital of Restauração, Recife, Brazil. Penetrating injury (66%) was the most prevalent type of wound encounter...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-012-0377-2
更新日期：2012-07-01 00:00:00
abstract：:Proximally located posterior communicating artery (PCoA) aneurysms, projecting postero-laterally in proximity to the tentorium, may pose a technical challenge for microsurgical clipping due to obscuration of the proximal aneurysmal neck by the anterior petroclinoid fold. We describe an efficacious technique utilizing ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-014-0554-6
更新日期：2014-10-01 00:00:00
abstract：:Overcoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1alpha and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression profiles of the U-2...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-007-0070-z
更新日期：2007-07-01 00:00:00
abstract：:Magnetic resonance angiography (MRA) is increasingly used as a noninvasive means to assess internal carotid artery (ICA) stenosis. When used alone, however, MRA may not be sufficiently accurate in certain settings to determine whether ICA disease meets surgical criteria. Although MRA has been recognized to overestimat...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/s10143-004-0354-5
更新日期：2005-04-01 00:00:00
abstract：:The introduction of computed tomography (CT) and magnetic resonance (MR) imaging has resulted in the detection of increasing numbers of asymptomatic intraventricular tumors. Establishing the correct preoperative diagnosis is important to prevent unnecessary surgical intervention. Our study includes nine cases of benig...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-004-0353-6
更新日期：2005-04-01 00:00:00
abstract：:This short paper summarizes the basic concept and the technology of a new computed radiographic system which uses an energy-storage phosphorus panel called "Imaging Plate" as an image sensor. The "Imaging Plate" can be used to obtain radiographs in exactly the same way as the screen-film combination is used in convent...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF01744878
更新日期：1985-01-01 00:00:00
abstract：:The authors describe 3 cases of cerebral pleomorphic xanthoastrocytoma, one of which has an unusual neuroradiological appearance, and review the clinical and prognostic features of the 96 cases reported in the literature. Pleomorphic xanthoastrocytoma is a neuroectodermal tumor that affects young patients, in a superf...
journal_title：Neurosurgical review
pub_type： 杂志文章,评审
doi：10.1007/BF00346603
更新日期：1996-01-01 00:00:00
abstract：:Vasospasm is a major contributor to morbidity and mortality in aneurysmal subarachnoid hemorrhage (SAH), with inflammation playing a key role in its pathophysiology. Myeloperoxidase (MPO), an inflammatory marker, was examined as a potential marker of vasospasm in patients with SAH. Daily serum samples from patients wi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-012-0375-4
更新日期：2012-07-01 00:00:00
abstract：:Microvascular decompression represents an effective treatment for hemifacial spasm. The use of lateral spread response (LSR) monitoring remains a useful intraoperative tool to ensure adequate decompression of the facial nerve. The aim of this study was to assess the value of LSRs intraoperative monitoring as a prognos...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-016-0708-9
更新日期：2016-07-01 00:00:00
abstract：:This aimed to evaluate the effect of surgery for overall survival (OS) and progression-free survival (PFS) in intracranial primary CNS lymphoma (PCNSL) of all patients diagnosed at a single center. A prospective database at Oslo University Hospital of PCNSL was reviewed over a 12-year period (2003-2014). Seventy-nine ...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/s10143-018-0946-0
更新日期：2018-10-01 00:00:00
abstract：:80-90% of individuals suffering from aneurysmal bone cyst (ABC) are children or adolescents. Primary ABC is a non-neoplastic lesion. Diagnostic assessment and detection of recurrence demands repeated plain x-rays or CT scans. These repeated radiographic examinations expose these young patients to large doses of ionizi...
journal_title：Neurosurgical review
pub_type： 杂志文章
doi：10.1007/BF00383659
更新日期：1990-01-01 00:00:00
