Coupling of function, metabolism, and blood flow in the brain.

Abstract:

:Functional activity, metabolism and blood flow are locally heterogeneous in the brain, but tightly coupled. This adjustment occurs in two different ways: 1. Short-term, dynamic coupling mediated by local vasoactive factors that ensure second-to-second regulation. 2. Long-term, static coupling apparently mediated by capillary density and developed in response to local functional and metabolic activity. Recognizing these two mechanisms permits one to distinguish apparent from real uncoupling. It allows the conclusion that there is no indication of an uncoupling of metabolism and blood flow during physiological conditions.

journal_name

Neurosurg Rev

journal_title

Neurosurgical review

authors

Kuschinsky W

doi

10.1007/BF00310651

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

163-8

issue

3

eissn

0344-5607

issn

1437-2320

journal_volume

14

pub_type

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