Abstract:
:Overcoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1alpha and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression profiles of the U-251 malignant glioma cell line under normoxic and hypoxic conditions to discover future research targets. U-251 cells were grown to 75% confluence and exposed to either normoxic or hypoxic conditions for 24 h. RNA was extracted, amplified, and hybridized to a cDNA microarray chip containing ~8,800 universal cellular genes. A threefold increase in mRNA expression was used as a threshold value for differential expression. Identified genes were divided into cell cycle control, stress response, and "newly connected" genes. Hybridization identified 11 hypoxia-induced genes: 1 involved with cell cycle control (CCNG2), 6 in stress response (IGFBP3, SLC2A3, GSTT2, FOS, DDIT3, AKR1C3), and 2 newly connected genes (Depp, AKAP4). One stress-related gene (AKR1C3) encodes for an enzyme that synthesizes progesterone. Of newly connected genes, the gene decidual protein induced by progesterone (Depp) showed the highest expression (4.2-fold increase). Possible future targeting for "hypoxic" glioma cells includes the targets for the AP-1 transcription factor complex (FOS), as well as blockade of the enzyme AKR1C3 with nonsteroidal anti-inflammatory drugs. Possible functions of the highly expressed gene Depp include tumor vascularization. Future studies will focus on the hypothesis that Depp is up-regulated in an autocrine fashion by the AKR1C3 enzyme in U-251 glioma cells under hypoxic conditions.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Ragel BT,Couldwell WT,Gillespie DL,Jensen RLdoi
10.1007/s10143-007-0070-zsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
181-7; discussion 187issue
3eissn
0344-5607issn
1437-2320journal_volume
30pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVE:Sylvian fissure arteriovenous malformations (AVMs) are among the most challenging AVMs to manage surgically. The estimates of their risk factors and prediction of their long-term prognosis are crucial for clinical decision-making. The authors conducted a retrospective review to patients with sy...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-013-0470-1
更新日期:2013-10-01 00:00:00
abstract::Although several studies have suggested that aneurysmal wall inflammation and laminar thrombus are associated with the rupture of saccular aneurysms, the mechanisms leading to the rupture remain obscure. We performed full exposure of aneurysms before clip application and attempted to keep the fibrin cap on the rupture...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0628-0
更新日期:2015-07-01 00:00:00
abstract::In the last decade, operative decompression of cord and cauda, internal fixation with rods, bony fusion and early ambulation, have become more popular in the management of thoracolumbar injuries with neurological deficit. Computer-tomography, CT myelography and peroperative ultrasonography provided direct evidence, th...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01743066
更新日期:1986-01-01 00:00:00
abstract::This retrospective study included eight consecutive cases with C2 vertebral body neoplastic lesions. The anterior retropharyngeal approach was used to remove the lesions and decompress the spinal cord. Spinal stabilization with occipitocervical plating in a second-stage operation makes the treatment more tolerable for...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0319-0
更新日期:2004-07-01 00:00:00
abstract::The objective of this study was to ascertain if stereotactic neurosurgical biopsy (SNB) optimizes the therapy of undefined CNS masses. The design was of retrospective treatment and outcome analysis and the setting was a large general hospital. We studied a total of 141 patients with undefined, space-occupying CNS lesi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050043
更新日期:1999-10-01 00:00:00
abstract::Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identi...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析
doi:10.1007/s10143-018-0965-x
更新日期:2020-02-01 00:00:00
abstract::We conducted a systematic review of the literature to evaluate the efficacy of various treatment modalities for intracranial aneurysms (IA) in patients with moyamoya disease (MMD) based on anatomical location of IA. A comprehensive review of studies documenting single cases or series of MMD patients with concomitant I...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01307-1
更新日期:2020-05-08 00:00:00
abstract::Different disorders may produce irreducible atlanto-axial dislocation with compression of the ventral spinal cord. Among the surgical approaches available for a such condition, the transoral resection of the odontoid process is the most often used. The aim of this anatomical study is to demonstrate the possibility of ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0084-6
更新日期:2007-07-01 00:00:00
abstract::Tumor consistency is a critical factor that influences operative strategy and patient counseling. Magnetic resonance imaging (MRI) describes the concentration of water within living tissues and as such, is hypothesized to predict aspects of their biomechanical behavior. In meningiomas, MRI signal intensity has been us...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-016-0801-0
更新日期:2018-07-01 00:00:00
abstract::Solitary brain affection is rare in echinococcosis. We report the case of a 35-year-old woman presenting with symptomatic grand-mal epilepsy due to a right frontal, partially cystic space-occupying lesion. Pre-operative computed tomography and magnetic resonance imaging (MRI) suggested a cystic astrocytoma. However, h...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050011
更新日期:1999-01-01 00:00:00
abstract::We report here on congenital sphenoorbital encephalocele which could not be disclosed by computed tomography including contrast medium application or by orbital sonography. Surgery and histological examination were necessary to establish correct the diagnosis. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01794689
更新日期:1988-01-01 00:00:00
abstract::We evaluate the current literature regarding treatment of intracranial atherosclerotic disease, with particular emphasis on emerging medical, surgical, and endovascular trials. A MEDLINE and PubMed search of the literature related to intracranial atherosclerotic disease was performed. Articles which discussed medical,...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-008-0172-2
更新日期:2009-01-01 00:00:00
abstract::The use of simulation in surgical training is ever growing. Evidence suggests such training may have beneficial clinically relevant effects. The objective of this research is to investigate the effects of surgical simulation training on clinically relevant patient outcomes by evaluating randomized controlled trials (R...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01314-2
更新日期:2020-05-13 00:00:00
abstract::We report the case of a patient with two distinct brain tumors. A meningioma was resected surgically. Nine months later a glioblastoma appeared in the same region, but at a different site. This was not treated, because the patient died. The clinical significance and etiology of these tumors are considered. ...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/BF00306823
更新日期:1994-01-01 00:00:00
abstract::The purpose of this study was to determine the effect of aspirin therapy discontinuation on intraoperative blood loss in spinal surgery. We searched Medline and Google Scholar 1946 to January 2017 inclusive for case-control studies, cohort studies, and controlled trials reporting intraoperative blood loss during spina...
journal_title:Neurosurgical review
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10143-018-0945-1
更新日期:2018-10-01 00:00:00
abstract::Many immune responses are controlled by genes of the major histocompatibility complex (MHC). In humans these include the loci encoding the HLA-A, -B, -C, -DR, -DQ, and -DP antigens, and many diseases have been linked with these. However, little information is available about any connection between malignant tumors and...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00418435
更新日期:1994-01-01 00:00:00
abstract::Surgical resections of meningiomas, the most common intracranial tumor in adults, can only be curative if radical resection is achieved. Potentially, the extent of resection could be improved, especially in complex and/or high-grade meningiomas by fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA), indocy...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-018-01062-4
更新日期:2019-12-01 00:00:00
abstract::Intermediate nerve schwannomas (INS) are extremely rare lesions in literature. They have been described mimicking facial nerve schwannomas, but not vestibular schwannomas (VS). We aimed to review the previously published cases, as well as the evidence to believe that they are far more common, though usually misdiagnos...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-019-01173-6
更新日期:2020-12-01 00:00:00
abstract::5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue. Therefore, the use of 5-ALA in the surgical treatment of intracranial tumors, particularly gliomas, has gained popularity i...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-015-0697-0
更新日期:2016-07-01 00:00:00
abstract::Magnesium has neuroprotective and antivasospastic properties in the presence of subarachnoid hemorrhage (SAH). The present study investigated the effect of intracisternal administration of magnesium on cerebral vasospasm in the experimental SAH rat model. The rat double-SAH model (0.2 mL autologous blood injected twic...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0122-z
更新日期:2008-04-01 00:00:00
abstract::A unique case of suprasellar dermoid cyst and familial hypercholesterolemia in a child is reported. Such an association, which strengthens the congenital hypothesis of dermoid cysts, could be a manifestation of a complex dyslipidemic inherited syndrome, at least in children. Surgical removal of the dermoid cyst which ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00416478
更新日期:1995-01-01 00:00:00
abstract::A case of "sudden infant death" after 15 minutes of successful resuscitation of cardiovascular function is presented. While apnoic cranial nerve areflexia and electrocerebral silence persisted, angiography and transcranial Doppler sonography demonstrated nearly normal cerebral perfusion, which even increased day by da...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00257815
更新日期:1992-01-01 00:00:00
abstract::We report our experience with the anterior subtemporal approach for the posterior communicating artery aneurysm protruding posteriorly. Between 2000 and 2005, seven patients with posterior communicating artery aneurysm were operated on through the anterior subtemporal approach. The approach provided a better view than...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0083-7
更新日期:2007-07-01 00:00:00
abstract::Generally speaking, the term "ophthalmic aneurysms" refers to carotid-ophthalmic aneurysms, which arise from the internal carotid artery (ICA) wall at or around the origin of the ophthalmic artery (OA). In contrast, aneurysms arising from the OA stem or its branches, separate from the ICA are called peripheral OA aneu...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-010-0290-5
更新日期:2011-01-01 00:00:00
abstract::Despite the introduction of new antiepileptic drugs and advances in the surgical treatment of epilepsy, an important group of patients still remains uncontrolled by any of these methods. The relatively recent introduction of vagus nerve stimulation is yet another possible treatment for refractory epilepsy. This safe, ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-014-0555-5
更新日期:2014-10-01 00:00:00
abstract::A hypothalamic hamartoma associated with true precocious puberty in a 7-month-old girl is hereby reported. Hormonal studies disclosed elevated serum levels of luteinizing hormone (LH) and follicle stimulating hormone, both of which responded well to LH-releasing hormone stimulation. Following a subtotal removal of the...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00258250
更新日期:1993-01-01 00:00:00
abstract::Patients infected with the human immunodeficiency virus (HIV) or suffering from acquired immunodeficiency syndrome (AIDS) are now surviving for longer periods of time secondary to improvements in medical management. As the classical causes of morbidity and mortality in this patient population have come under better co...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-004-0371-4
更新日期:2005-04-01 00:00:00
abstract::Case report of traumatic induced tetraplegia due to multiple cranio-cervical abnormalities with cord compression at the level of C4/C5. Diagnostic and operative procedure. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01743105
更新日期:1983-01-01 00:00:00
abstract::Although endovascular or surgical treatment has been performed for preventing the rupture of saccular cerebral aneurysms (sCA), in some patients, the aneurysms may recur and require retreatment. We aimed to investigate the clinical and radiological outcomes of treating recurrent sCA. We retrospectively evaluated the d...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01259-6
更新日期:2020-02-21 00:00:00
abstract::Stroke therapy has been revolutionized in the past two decades with the widespread implementation of chemical thrombolysis for acute stroke. However, chemical thrombolysis continues to be limited in its efficacy secondary to relatively short time windows and a high associated risk of hemorrhage. In an attempt to minim...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-010-0294-1
更新日期:2011-01-01 00:00:00