The population association of glucokinase gene with type 2 (noninsulin-dependent) diabetes mellitus in Chinese.

abstract：BACKGROUND:Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. In this study, we collected a Han monilethrix family to detect the mutations in patients and investigated the correlation between the genotype and phenotype of monilethrix. METHODS:In this study, ...

journal_title：Chinese medical journal

authors： Ye ZZ,Nan X,Zhao HS,Chen XR,Song QH

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH). The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique. METHODS:The f...

journal_title：Chinese medical journal

authors： Qiu EC,Yu SY,Liu RZ,Wang Y,Ma L,Tian LX

更新日期：2012-02-01 00:00:00

abstract：Background:Betel quid chewing has been a major risk factor for oral cancer (OC) in southern China. This study aimed to analyze the scientific publications on the relationship between betel quid chewing and OC and construct a model to quantitatively and qualitatively evaluate pertinent publications from 1998 to 2017. M...

journal_title：Chinese medical journal

authors： Wang M,Xiao C,Ni P,Yu JJ,Wang XW,Sun H

更新日期：2018-08-20 00:00:00

abstract：: ...

journal_title：Chinese medical journal

authors： Xi SB,Xie YM,Li T,Li YF,Qian MY,Zhang ZW

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are highly conserved small non-coding RNAs of 18 - 25 nucleotides (nt) that mediate post-transcriptional gene regulation. Hepatitis B virus (HBV) can cause either acute or chronic hepatitis B, and is a high risk factor for liver cirrhosis and hepatocellular carcinoma. Some mammalian viruse...

journal_title：Chinese medical journal

authors： Liu Y,Zhao JJ,Wang CM,Li MY,Han P,Wang L,Cheng YQ,Zoulim F,Ma X,Xu DP

更新日期：2009-01-05 00:00:00

abstract：OBJECTIVES:To study the interrelation between nitric oxide (NO) and endothelin-1 (ET1) in experimental acute hypoxic rats, and to evaluate the mechanism of acute hypoxic pulmonary hypertension affected by NO and ET1 and its intervention. METHODS:Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemi...

journal_title：Chinese medical journal

authors： Wang Y,Zhang L,Shen W,Chen L,Fan S

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:The CYP2C19 G681A single polymorphism has been proven to affect clopidogrel responsiveness. However, the effect of coexisting polymorphisms of other genes has not yet been reported in the Chinese population. This study investigated the effect of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel re...

journal_title：Chinese medical journal

authors： Tang XF,Zhang JH,Wang J,Han YL,Xu B,Qiao SB,Wu YJ,Chen J,Wu Y,Chen JL,Gao RL,Yang YJ,Yuan JQ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Previous studies have showed that photooxidative stress can lead to down-modulation of nuclear factor-kappa B (NF-kappaB) activity causing apoptosis of cultured photoreceptor cells. This study aimed at investigating whether NF-kappaB was involved in photoreceptor cells apoptosis induced by N-methyl-N-nitroso...

journal_title：Chinese medical journal

authors： Yang JN,Luo L,Lin SC,Chen JM,Li D,Hu SX

更新日期：2005-07-05 00:00:00

abstract：BACKGROUND:There is a relatively high failure rate of the femoral component in patients with avascular necrosis at the intermediate-term follow-up. Improving the geometrical fit of the femoral stem against the medullary canal may help to provide long-term survivorship of the hip replacement for patients with avascular ...

journal_title：Chinese medical journal

authors： Zhang Q,Cheng CK,Wei HW,Dong X,Chen YT,Lai YS,Wang Y

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:There are relatively few reports focusing on clinical and multi-slice CT (MSCT) imaging findings of mucinous tubular and spindle cell carcinoma (MTSCC). Our study aimed to characterize the clinical and MSCT imaging features of MTSCC. METHODS:The imaging findings in 17 patients with MTSCC by MSCT were retros...

journal_title：Chinese medical journal

authors： Zhu Q,Zhu W,Wang Z,Wu J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In China the ginseng root began to be used in medicine over 2000 years ago. Ginsenosides are the most important component isolated from ginseng. The authors investigated the effect of ginsenoside Rg1 on the spectrum of gene expression in the endothelial cells stimulated by TNF-alpha and further explored the ...

journal_title：Chinese medical journal

authors： Lü JP,Ma ZC,Yang J,Huang J,Wang SR,Wang SQ

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Spinal anesthesia was considered as a reasonable anesthetic option in severe preeclampsia when cesarean delivery is indicated, and there is no indwelling epidural catheter or contraindication to spinal anesthesia. However, the ideal dose of intrathecal bupivacaine has not been quantified for cesarean deliver...

journal_title：Chinese medical journal

authors： Xiao F,Xu WP,Zhang XM,Zhang YF,Wang LZ,Chen XZ

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:Although breast-conserving surgery is one of the standard treatments for breast cancer, few studies have assessed its recent implementation in China. We aimed to clarify the current real-world status of breast-conserving surgery in China. METHODS:This cross-sectional survey relied on data collected by the C...

journal_title：Chinese medical journal

authors： Yu LX,Shi P,Tian XS,Yu ZG,Chinese Society of Breast Surgery.

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated increased functions of osteoblasts on nanophase materials compared to conventional ceramics or composites. Nanophase materials are unique materials that simulate dimensions of constituent components of bone as they possess particle or grain sizes less than 100 nm. However, ...

journal_title：Chinese medical journal

authors： Han P,Ji WP,Zhao CL,Zhang XN,Jiang Y

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To investigate the synergistic antitumor effects of combined use of p14ARF gene and 5-fluorouracil (5-Fu) in pancreatic cancer. METHODS:A human pancreatic cancer cell line PC-3 was transfected with lipofectin-mediated recombinant p14ARF gene, and was then administered with 5-Fu. Cell growth, morphological ch...

journal_title：Chinese medical journal

authors： Zhang Q,Ni Q,Gan J,Shen Z,Luo J,Jin C,Zhang N,Zhang Y

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Nontraumatic spontaneous subarachnoid hemorrhage (SAH) is associated with a high mortality. This study was conducted to investigate the epidemiological features of nontraumatic spontaneous SAH in China. METHODS:From January 2006 to December 2008, the clinical data of patients with nontraumatic SAH from 32 m...

journal_title：Chinese medical journal

authors： Song JP,Ni W,Gu YX,Zhu W,Chen L,Xu B,Leng B,Tian YL,Mao Y

更新日期：2017-04-05 00:00:00

abstract：OBJECTIVE:To evaluate the clinical value of sequential subtraction scintigraphy (SSS) with 99mTc red blood cell (RBC) for the early detection of gastrointestinal (GI) bleeding. METHODS:Ninety patients referred with clinical evidence of GI bleeding underwent 99mTc-RBC scintigraphy with digital gamma camera after labeli...

journal_title：Chinese medical journal

authors： Wu Y,Seto H

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Off-pump coronary artery bypass grafting is fast-becoming a procedure of choice for elective revascularization in high-risk patients with multi-vessel coronary artery disease. However, the role of off-pump coronary artery bypass grafting for patients with acute coronary syndromes requiring emergency revascul...

journal_title：Chinese medical journal

authors： Raja SG,Haider Z,Zaman H

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Evidence has demonstrated that the distal lung, which includes airways of < 2 mm in diameter and lung parenchyma, constitutes an important component of asthma pathology. Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators and bronchoconstrictors involved in the asthmatic process. Guidelines ...

journal_title：Chinese medical journal

authors： Gao JM,Cai F,Peng M,Ma Y,Wang B

更新日期：2013-06-01 00:00:00

abstract：:To understand the mechanism of hemorrhage, coagulation and fibrinolysis in epidemic hemorrhagic fever (EHF), thrombin time (TT), prothrombin time (PT), fibrinogen (FIG), the platelet count (PLAT), plasminogen (PLG), antithrombin-III (AT-III), fibrin-fibrinogen degraded products (FDP) and platelet functions of aggregat...

journal_title：Chinese medical journal

authors： Xiang LB,Zhang ZY,Chen JM,Xiang JM,Cosgriff TM

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To study the interaction between oncogene mdm2 and wp53 in human glandular lung cancer cell line GLC-82. METHODS:By lipofectamine-mediated DNA transfection, wp53 and mdm2 were transfected separately or co-transfected into GLC-82 cells via retrovival vector pDOR-neo, a carrier of wp53 and mdm2. RESULTS:The g...

journal_title：Chinese medical journal

authors： Li P,Rao G,Chen Y,Ding Z,Yu W

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of preoperative transcatheter arterial chemoembolization(TACE) on apoptosis of hepatocellular carcinoma (HCC) cells. METHODS:A total of 136 patients with HCC underwent liver resection. One to five courses of TACE prior to liver resection were performed in 79 patients (TACE group), in w...

journal_title：Chinese medical journal

authors： Xiao E,Li D,Shen S,Zhou S,Tan L,Wang Y,Luo J,Wu Y,Tan C,Liu H,Zhu H

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Activation of N-methyl-D-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors play an important role in the neurons death induced by ischemia. The mitigating effect of intravenous anesthetics on ischemic neuron injury is related to their influence on NMDA ...

journal_title：Chinese medical journal

authors： Zhang YL,Zhang PB,Qiu SD,Liu Y,Tian YF,Wang Y

更新日期：2006-09-20 00:00:00

abstract：:Since February 1982, 23 patients with scoliosis were treated by releasing the soft tissues on the concave side and plaster spinal fusion jacket. Of these patients, 13 had congenital scoliosis and 10 idiopathic scoliosis. Follow-up for 1 to 8.5 years showed that the results of correction were satisfactory. The maximum ...

journal_title：Chinese medical journal

authors： Dong L

更新日期：1992-02-01 00:00:00

abstract：Background:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement is a severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out this ...

journal_title：Chinese medical journal

authors： Song Y,Pei RJ,Wang YN,Zhang J,Wang Z

更新日期：2018-04-05 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of cordocentesis for prenatal diagnosis of various fetal diseases. PATIENTS AND METHODS:Fetal blood sampling was performed in 30 pregnancies from gestational week 19 to 36 for various prenatal diagnoses. We used Aloka SSD-650 real-time ultrasound scanner with 3.5 mHz curvi...

journal_title：Chinese medical journal

authors： Xiang Y,Sun N,Chang X,Bian X,Wang F

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Pancreatic beta-cell apoptosis induced by lipotoxicity, to a large extent, contributes to the progression of type 2 diabetes. To investigate the mechanism of free fatty acid induced apoptosis, we aimed to study the effects of palmitic acid (PA) on the apoptosis and peroxisome proliferator-activated receptor ...

journal_title：Chinese medical journal

authors： He TT,Cao XP,Chen RZ,Zhu XN,Wang XL,Li YB,Xiao HP

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To explore the methods of lens-sparing (without lensectomy), non-silicone oil tamponade and no scleral buckling for treatment of early giant retinal tears. METHODS:Thirteen cases of early retinal detachment of proliferative vitreoretinopathy (PVR) grade C2-D1, with giant tear extending from 135 degrees to 27...

journal_title：Chinese medical journal

authors： Xu X,Zhang X,Wu N,Ho PC

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The primary ovarian sarcoma is a very rare malignancy. The objective of this study was to further investigate the clinicopathologic features and outcome in patients with primary sarcoma of the ovary. METHODS:Between 1988 and 2007, 24 patients with primary ovarian sarcoma who underwent treatment at Peking Un...

journal_title：Chinese medical journal

authors： Dai Y,Shen K,Lang JH,Huang HF,Pan LY,Wu M,Yang JX,Zhong DR

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Fluid dynamic mechanisms attributed to coronary bifurcation lesions remain a subject of study. The present study aimed at investigating the hemodynamic change of wall shear stress (WSS) in patients with coronary bifurcation lesions treated by double kissing (DK) crush or one-stent with final kissing balloon ...

journal_title：Chinese medical journal

authors： Chen SL,Kan J,Zhang JJ,Hu ZY,Xu T

更新日期：2012-05-01 00:00:00