Abstract：
OBJECTIVES:To study the interrelation between nitric oxide (NO) and endothelin-1 (ET1) in experimental acute hypoxic rats, and to evaluate the mechanism of acute hypoxic pulmonary hypertension affected by NO and ET1 and its intervention. METHODS:Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemical staining method, Griess biochemical assay and radioimmune assay were applied to investigate the changes of nitric oxide syntheses (NOS), NO and ET1 in normal, hypoxic, and L-Arginine (L-Arg) and dexamethasone treated hypoxic rats. RESULTS:In normal rats, the NOS stain was localized in pulmonary vascular endothelium, and in the hypoxic rats, the activity of NOS was significantly lower. The level of plasma NO was significantly lower during acute hypoxia, but L-Arg as well as dexamethasone could prevent the drop of plasma NO. The level of plasma ET1 rose up significantly in the acute hypoxic rats, but after L-Arg therapy, it was significantly reduced, however, dexamethasone could not affect plasma ET1. The level of plasma cyclic guanosine monophosphate (cGMP) was significantly lower in the acute hypoxic rats, and L-Arg could prevent the drop of plasma cGMP, but dexamethasone could not prevent the drop of plasma cGMP. CONCLUSIONS:NO and ET1 may modulate hypoxic pulmonary hypertension and acute hypoxia can result in acute hypoxic pulmonary hypertension. L-Arg can reverse the acute hypoxic pulmonary hypertension. Further study is needed if dexamethasone is beneficial in acute hypoxic diseases. NO may play an important role in physiology of the lung and acute hypoxic diseases.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Wang Y,Zhang L,Shen W,Chen L,Fan Skeywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
363-5issue
4eissn
0366-6999issn
2542-5641journal_volume
112pub_type
杂志文章abstract：BACKGROUND:Coexistent carotid and coronary artery diseases are common and patients with them remain at a high risk for perioperative stroke or myocardial infarction after coronary bypass surgery. The aim of this study was to investigate the effect of combined carotid endarterectomy (CEA) and off-pump coronary artery by...
journal_title：Chinese medical journal
pub_type： 杂志文章
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journal_title：Chinese medical journal
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journal_title：Chinese medical journal
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journal_title：Chinese medical journal
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更新日期：2009-02-05 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
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更新日期：1998-11-01 00:00:00
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更新日期：2001-07-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
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doi：
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更新日期：2000-03-01 00:00:00
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doi：10.4103/0366-6999.176981
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pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
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更新日期：2007-05-05 00:00:00
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更新日期：2001-02-01 00:00:00
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更新日期：2002-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-06-01 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2006-11-20 00:00:00
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
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journal_title：Chinese medical journal
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更新日期：2012-08-01 00:00:00
