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Effects of Calcium Sulfate Combined with Platelet-rich Plasma on Restoration of Long Bone Defect in Rabbits.

Abstract：

BACKGROUND:The treatment for long bone defects has been a hot topic in the field of regenerative medicine. This study aimed to evaluate the therapeutic effects of calcium sulfate (CS) combined with platelet-rich plasma (PRP) on long bone defect restoration. METHODS:A radial bone defect model was constructed through an osteotomy using New Zealand rabbits. The rabbits were randomly divided into four groups (n = 10 in each group): a CS combined with PRP (CS-PRP) group, a CS group, a PRP group, and a positive (recombinant human bone morphogenetic protein-2) control group. PRP was prepared from autologous blood using a two-step centrifugation process. CS-PRP was obtained by mixing hemihydrate CS with PRP. Radiographs and histologic micrographs were generated. The percentage of bone regenerated bone area in each rabbit was calculated at 10 weeks. One-way analysis of variance was performed in this study. RESULTS:The radiographs and histologic micrographs showed bone restoration in the CS-PRP and positive control groups, while nonunion was observed in the CS and PRP groups. The percentages of bone regenerated bone area in the CS-PRP (84.60 ± 2.87%) and positive control (52.21 ± 4.53%) groups were significantly greater than those in the CS group (12.34 ± 2.17%) and PRP group (16.52 ± 4.22%) (P < 0.001). In addition, the bone strength of CS-PRP group (43.10 ± 4.10%) was significantly greater than that of the CS group (20.10 ± 3.70%) or PRP group (25.10 ± 2.10%) (P < 0.001). CONCLUSION:CS-PRP functions as an effective treatment for long bone defects through stimulating bone regeneration and enhancing new bone strength.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Chen H,Ji XR,Zhang Q,Tian XZ,Zhang BX,Tang PF

doi

10.4103/0366-6999.176981

subject

Has Abstract

pub_date

2016-03-05 00:00:00

pages

557-61

issue

5

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2016_129_5_557_176981

journal_volume

129

pub_type

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