p14ARF upregulation of p53 and enhanced effects of 5-fluorouracil in pancreatic cancer.

abstract：BACKGROUND:Previous studies have indicated that the cognitive deficits in patients with Alzheimer's disease (AD) may be due to topological deteriorations of the brain network. However, whether the selection of a specific frequency band could impact the topological properties is still not clear. Our hypothesis is that t...

journal_title：Chinese medical journal

authors： Qin YY,Li YP,Zhang S,Xiong Y,Guo LY,Yang SQ,Yao YH,Li W,Zhu WZ

更新日期：2015-03-05 00:00:00

abstract：OBJECTIVES:To get a more comprehensive recognition about carpal tunnel syndrome (CTS), especially the manual housework as its risk factor, and to facilitate early diagnosis and proper treatment. METHODS:262 CTS patients (396 CTS hands) were analyzed retrospectively. A 1:1 matched case-control study of 61 woman pairs i...

journal_title：Chinese medical journal

authors： Tang X,Zhuang L,Lu Z

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is an important issue with significant morbidity and mortality in clinical practice, especially in diabetes mellitus (DM). Studies focusing on S. aureus pneumonia in DM is limited, we sought to make a relatively comprehensive exploration of clinica...

journal_title：Chinese medical journal

authors： Zhang QR,Chen H,Liu B,Zhou M

更新日期：2019-06-20 00:00:00

abstract：:In 123 cases of transient ischemic attacks, 72 were followed up for 22 years. The percentage of complete stroke was 46.5% and the fatality rate 47.9%. Causes of death, survival rate by life table, limitation of indication of neurovascular surgical operation and rehabilitation of survived patients were studied. The cau...

journal_title：Chinese medical journal

authors： Wang XD

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:The development of new adjuvants for human use has been the focus of attention. This study's aim is to explore the possibility of using nanoparticle Ca nanoparticles (CA) as a vaccine adjuvant of anti-idiotypic antibody NP30 against schistosomiasis and its protective mechanisms. METHODS:Nanoparticle CA-NP30...

journal_title：Chinese medical journal

authors： Feng ZQ,Zhong SG,Li YH,Li YQ,Qiu ZN,Wang ZM,Li J,Dong L,Guan XH

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:It is unclear whether a history of paroxysmal atrial fibrillation (PAF) would impact the effect of catheter ablation on persistent atrial fibrillation (AF). This study aimed to compare the effect of catheter ablation on persistent AF with and without a history of PAF. METHODS:One hundred and eighty-three pa...

journal_title：Chinese medical journal

authors： Miao CL,Yin XD,Dong JZ,Liu XP,Yu RH,Long DY,Tang RB,Sang CH,Ma CS

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:This study was to examine the expression of total vascular endothelial growth factor (VEGF) and the anti-angiogenic VEGF 165 b isoform in the vitreous body of retinopathy of prematurity (ROP) patients, and to further study the role of the VEGF splicing in the development of ROP. METHODS:This was a prospecti...

journal_title：Chinese medical journal

authors： Zhao M,Xie WK,Bai YJ,Huang LZ,Wang B,Liang JH,Yin H,Li XX,Shi X

更新日期：2015-09-20 00:00:00

abstract：BACKGROUND:Prostate specific membrane antigen (PSMA) can facilitate the growth, migration, and invasion of the LNCaP prostate cancer cell lines, but the underlying molecular mechanisms have not yet been clearly defined. Here, we investigated whether PSMA serves as a novel regulator of the phosphatidylinositol 3-kinase ...

journal_title：Chinese medical journal

authors： Guo Z,Lai Y,Du T,Zhang Y,Chen J,Bi L,Lin T,Liu H,Wang W,Xu K,Jiang C,Han J,Zhang C,Dong W,Huang J,Huang H

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Carotid stenosis is one of the common reasons for patients with ischemic stroke, and the two invasive options carotid endarterectomy (CEA) and carotid artery stenting (CAS) are the most popular treatments. But the relative efficacy and safety of the methods are not clear. METHODS:About 521 articles related ...

journal_title：Chinese medical journal

authors： Wang L,Liu XZ,Liu ZL,Lan FM,Shi WC,Liu J,Zhang JN

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:At present, revascularization is still one of the most critical technologies in orthotopic liver transplantation (OLT). Hepatic artery (HA) variations occur frequently in both donors and recipients. Moreover, there are always some pathological changes in the recipient hepatic artery. If handled improperly, i...

journal_title：Chinese medical journal

authors： Ma Y,Li Q,Ye ZM,Zhu XF,He XS

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To investigate the effectiveness of using continuous veno venous hemofiltration (CVVH) in the treatment of acute necrotizing pancreatitis (ANP). METHODS:Thirteen ANP patients were involved in this study, including 4 females and 9 males, averaging 50.6 +/- 10.8 years old. CT scans upon admission revealed 33% ...

journal_title：Chinese medical journal

authors： Xie H,Ji D,Gong D,Liu Y,Xu B,Zhou H,Liu Z,Li L,Li W,Quan Z,Li J

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the diagnosis and aggressive surgical approach for brainstem tumors. METHODS:A series of 24 adult patients with brainstem tumors were involved. Magnetic resonance (MR) imaging was performed on all patients. Surgical technique, potential risk and management of complications were described. RESULT...

journal_title：Chinese medical journal

authors： Xu Q,Bao W,Mao R

更新日期：1997-02-01 00:00:00

abstract：:Psoralen (PSO) was found cytotoxic against in vitro cultured human mucoepidermoid carcinoma cells of MEC-1 cell line. Its IC50 value was 8.6 micrograms/ml, and relative antitumor activity (RAA) 15. PSO suppressed DNA synthesis, damaged microvilli and cell membrane, and induced degeneration of mitochondria. It inhibite...

journal_title：Chinese medical journal

authors： Wu JZ,Situ ZQ,Wang W,Chen JY,Liu B

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To review the development of T follicular helper (TFH) cells and their role in systemic lupus erythematosus (SLE) pathogenesis, the effect of dendritic cells (DCs) on TFH cells in SLE, as well as the potential use of TFH cells as a new therapeutic target in clinical practice. DATA SOURCES:The data used in th...

journal_title：Chinese medical journal

authors： Ma H,Wan S,Xia C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Accurate evaluation of coronary artery, aortic valve annulus diameter (AVAD), and cardiac function in patients with aortic valve disease is of great significance for surgical strategy. In this study, we explored the preoperative evaluation of low-dose sequence (MinDose sequence) scan of dual-source CT (DSCT)...

journal_title：Chinese medical journal

authors： Feng J,Wang XM,Ji XP,Li HO,Li Q,Guo WB,Wang ZJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Serum expression of cytokines may provide information about the clinical outcome of advanced non-small cell lung cancer (NSCLC) patients. This study aimed to investigate the relationship between serum cytokine levels and the clinical outcome of erlotinib treatment in a second or third line setting in patient...

journal_title：Chinese medical journal

authors： Wang YS,Miao LY,Liu L,Cai HR,Ding JJ,Ren SX,Zhou CC,Schmid-Bindert G

更新日期：2013-10-01 00:00:00

abstract：:Increasing evidence suggests that long non-coding RNAs (lncRNAs) are of vital importance for various biological processes, and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis. LncRNAs modulate gene expression at the transcriptional, post-transcriptional, and translational leve...

journal_title：Chinese medical journal

authors： Song JK,Yin SY,Li W,Li XD,Luo Y,Luo Y,Xing M,Li B,Kuai L

更新日期：2020-12-14 00:00:00

abstract：:The saliva samples from 13 patients with hepatocellular carcinoma and a control group of 21 random healthy adults were measured for alpha-fetoprotein (AFP), using a highly sensitive sandwich enzyme immunoassay specific for human AFP. In patients with hepatocellular carcinoma, significantly higher levels of saliva AFP ...

journal_title：Chinese medical journal

authors： You XY,Jiang J,Yin FZ

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:In 2008, infants in some areas of China suffered from stones of the urinary system which were caused by melamine-contaminated milk formula. Most of the infants were asymptomatic, and a few suffered from acute renal failure induced by urinary obstruction by stones. This study aimed to assess the significance ...

journal_title：Chinese medical journal

authors： Shen Y,Liu XR,Zhang GJ,Zhou N

更新日期：2009-02-05 00:00:00

abstract：Background::Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor (TGF)-β receptors and platelet-derived growth factor (PDGF) recep...

journal_title：Chinese medical journal

authors： Li LK,Wang N,Wang WD,Du XN,Wen XY,Wang LY,Deng YY,Wang DP,Lin HL

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Vascular endothelial dysfunction is considered a key pathophysiologic process for the development of acute lung injury. In this study, we aimed at investigating the effects of unfractionated heparin (UFH) on the lipopolysaccharide (LPS)-induced changes of vascular endothelial-cadherin (VE-cadherin) and the p...

journal_title：Chinese medical journal

authors： Mu ST,Tang J,Ma JQ,Zhong Y,Liu HZ,Ma XC,Zheng Z

更新日期：2020-08-05 00:00:00

abstract：BACKGROUND:Transgenic overexpression of human prostasin in rats disturbs salt balance and causes hypertension. We investigated whether genetic variations in prostasin were implicated in hypertension or related phenotypes in the Xinjiang Kazakh population. METHODS:We sequenced all exons and the promoter regions of the ...

journal_title：Chinese medical journal

authors： Li NF,Zhang JH,Chang JH,Yang J,Wang HM,Zhou L,Luo WL

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is a Th2 dominant cytokine response. Chloride channel-3 (ClC-3) plays an important role in nasal mucosal edema and inflammatory pathologic changes in AR. Antiallergic herbal agents (AHA) are antiallergic herbal products. In the previous study, we have demonstrated that AHA clearly inhi...

journal_title：Chinese medical journal

authors： Wang LF,Xu LJ,Guo FH,Wang LN,Shen XH

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Epithelial to mesenchymal transition (EMT) is strongly linked with tumor invasion and metastasis, which performs a vital role in carcinogenesis and cancer progression. Emerging evidence suggests that microRNAs (miRNAs) expression are closely associated to EMT by regulating targeted genes. MiR542 has been fou...

journal_title：Chinese medical journal

authors： Li C,Liu HL,Zhou YM,Shi YC,Zhang ZB,Chen L,Feng SY

更新日期：2020-10-20 00:00:00

abstract：:Intraoperative coronary venography was performed in 24 patients before and after portal-azygos disconnection for portal hypertension. Before the procedure the portal vein was found to be communicated with cardial and esophageal veins by two pathways, i,e., from the esophageal and gastric branches of the coronary vein ...

journal_title：Chinese medical journal

authors： Zou ZS,Li JS,Li N,Liu FK

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Trichosporon asahii (T. asahii) is one of the most important pathogenic fungus in the genus of trichosporon. Although the species identification of T. asahii was based upon the complicated results of morphologic, biochemical and biologic examination, the morphology characteristic is still the first clue to t...

journal_title：Chinese medical journal

authors： Wang WL,Yang RY,Ao JH

更新日期：2009-08-05 00:00:00

abstract：BACKGROUND:Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare but potentially life-threatening congenital heart defect. A retrospective analysis was carried out to elucidate the surgical outcomes of ALCAPA in infants and children using follow-up echocardiography. METHODS:From Sep...

journal_title：Chinese medical journal

authors： Gao Y,Zhang J,Huang GY,Liang XC,Jia B,Ma XJ

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:CD4(+)CD25(+) regulatory T cells (Tregs) mediate immune suppression through cell-cell contact with surface molecules, particularly cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR), and transforming growth factor beta (TG...

journal_title：Chinese medical journal

authors： Zhang Q,Qian FH,Liu H,Zhou LF,Huang M,Zhang XL,Yin KS

更新日期：2008-02-05 00:00:00

abstract：BACKGROUND:Despite great reduction of in-stent restenosis, first-generation drug-eluting stents (DESs) have increased the risk of late stent thrombosis due to delayed endothelialization. Arsenic trioxide, a natural substance that could inhibit cell proliferation and induce cell apoptosis, seems to be a promising surrog...

journal_title：Chinese medical journal

authors： Shen L,Yang W,Yin JS,Liu XB,Wu YZ,Sun AJ,Qian JY,Ge JB

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH). The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique. METHODS:The f...

journal_title：Chinese medical journal

authors： Qiu EC,Yu SY,Liu RZ,Wang Y,Ma L,Tian LX

更新日期：2012-02-01 00:00:00