Abstract:
BACKGROUND:Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH). The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique. METHODS:The functional magnetic resonance imaging scans were obtained for 12 male CH patients with spontaneous right-sided headache attacks during "in attack" and "out of attack" periods and 12 age- and sex-matched normal controls. The data were analyzed to detect the altered brain activity by the regional homogeneity method using statistical parametric mapping software. RESULTS:Altered regional homogeneity was detected in the anterior cingulate cortex, the posterior cingulate cortex, the prefrontal cortex, insular cortex, and other brain regions involved in pain processing and modulation among different groups. CONCLUSION:It is referred that these brain regions with altered regional homogeneity might be related to the pain processing and modulation of CH.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Qiu EC,Yu SY,Liu RZ,Wang Y,Ma L,Tian LXsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
705-9issue
4eissn
0366-6999issn
2542-5641journal_volume
125pub_type
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