Altered regional homogeneity in spontaneous cluster headache attacks: a resting-state functional magnetic resonance imaging study.

Abstract:

BACKGROUND:Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH). The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique. METHODS:The functional magnetic resonance imaging scans were obtained for 12 male CH patients with spontaneous right-sided headache attacks during "in attack" and "out of attack" periods and 12 age- and sex-matched normal controls. The data were analyzed to detect the altered brain activity by the regional homogeneity method using statistical parametric mapping software. RESULTS:Altered regional homogeneity was detected in the anterior cingulate cortex, the posterior cingulate cortex, the prefrontal cortex, insular cortex, and other brain regions involved in pain processing and modulation among different groups. CONCLUSION:It is referred that these brain regions with altered regional homogeneity might be related to the pain processing and modulation of CH.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Qiu EC,Yu SY,Liu RZ,Wang Y,Ma L,Tian LX

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

705-9

issue

4

eissn

0366-6999

issn

2542-5641

journal_volume

125

pub_type

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