Epidemic hemorrhagic fever. The mechanism of coagulation and fibrinolysis.

Abstract:

:To understand the mechanism of hemorrhage, coagulation and fibrinolysis in epidemic hemorrhagic fever (EHF), thrombin time (TT), prothrombin time (PT), fibrinogen (FIG), the platelet count (PLAT), plasminogen (PLG), antithrombin-III (AT-III), fibrin-fibrinogen degraded products (FDP) and platelet functions of aggregation and release were studied dynamically with advanced methods in 134 EHF patients. TT and PT were prolonged, FIG, AT-III and PLG were decreased and FDP was increased. Besides, the decrease of PLAT, the platelet functions of aggregation and release were below the normal level. The results showed that the balance of blood coagulation and fibrinolysis was lost from the early stage of the disease.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Xiang LB,Zhang ZY,Chen JM,Xiang JM,Cosgriff TM

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

391-5

issue

5

eissn

0366-6999

issn

2542-5641

journal_volume

103

pub_type

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