Clinical Analysis of Postpartum Hemorrhage Requiring Massive Transfusions at a Tertiary Center.

Abstract:

BACKGROUND:The reports on massive transfusions (MTs) in obstetrics have recently been an increasing trend. We aimed to define the clinical features, risk factors, main causes, and outcomes of MTs due to severe postpartum hemorrhage (PPH) and the frequency trends over the past 10 years. METHODS:We retrospectively analyzed the data of 3552 PPH patients who were at ≥28 weeks of gestation in the Obstetric Department of Peking University First Hospital from January 2006 to February 2015. The clinical records of patients receiving MT with ≥5 units (approximately 1000 ml) of red blood cells within 24 h of giving birth were included. The Pearson's Chi-square and Fisher's exact tests were used to compare the frequency distributions among the categorical variables of the clinical features. RESULTS:One-hundred six women were identified with MT over the 10-year period. The MT percentage was stable between the first 5-year group (2006-2010) and the second 5-year group (2011-2015) (2.5‰ vs. 2.7‰, χ2 = 154.85, P = 0.25). Although uterine atony remained the main cause of MT, there was a rising trend for placental abnormalities (especially placenta accreta) in the second 5-year group compared with the first 5-year group (34% vs. 23%, χ2 = 188.26, P = 0.03). Twenty-four (23%) women underwent hysterectomy, and among all the causes of PPH, placenta accreta had the highest hysterectomy rate of 70% (17/24). No maternal death was observed. CONCLUSIONS:There was a rising trend for placental abnormalities underlying the stable incidence of MT in the PPH cases. Placenta accreta accounted for the highest risk of hysterectomy. It is reasonable to have appropriate blood transfusion backup for high-risk patients, especially those with placenta accreta.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Hu J,Yu ZP,Wang P,Shi CY,Yang HX

doi

10.4103/0366-6999.200545

subject

Has Abstract

pub_date

2017-03-05 00:00:00

pages

581-585

issue

5

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2017_130_5_581_200545

journal_volume

130

pub_type

杂志文章
  • Efficacy of the Dynamic Interspinous Assisted Motion system in clinical treatment of degenerative lumbar disease.

    abstract:BACKGROUND:The Dynamic Interspinous Assisted Motion (DIAM) system was designed to stabilize degenerative spinal segments without fusion surgery, maintain segment motion and prevent adjacent segment degeneration. The aim of this study was to investigate clinical efficacy of the DIAM system in treatment of degenerative l...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhao Y,Wang YP,Qiu GX,Zhao H,Zhang JG,Zhou X

    更新日期:2010-11-01 00:00:00

  • Passive graft perfusion in off-pump coronary artery bypass grafting.

    abstract:BACKGROUND:Myocardial protection during off-pump coronary artery bypass grafting (OPCABG) is a multifactorial problem in which maintaining stable systemic hemodynamics is very important. In this study passive graft perfusion (PGP) was applied to investigate the effect during and after OPCABG as evaluated by cardiac tro...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Lu F,Ji BY,Liu JP,Liu MZ,Wang GY,Hu SS

    更新日期:2007-02-05 00:00:00

  • Impact of multidisciplinary team working on the management of colorectal cancer.

    abstract:BACKGROUND:The continual and rapid development of techniques which are used for diagnosis and treatment makes management of colorectal cancer more difficult depending on single discipline. Colorectal cancer multidisciplinary team (MDT) working model is recommended by UK and other countries, but there is little informat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ye YJ,Shen ZL,Sun XT,Wang ZF,Shen DH,Liu HJ,Zhang WL,Chen YL,Zhou J,Poston GJ,Wang S

    更新日期:2012-01-01 00:00:00

  • Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography.

    abstract:OBJECTIVE:To investigate whether coagulation factor VII (FVII) polymorphisms play a role in the pathogenesis of coronary artery disease (CAD) and/or myocardial infarction (MI) in a series of Hans. METHODS:The Arg(353)Gln and HVR4 polymorphisms of FVII gene were determined in 374 patients undergoing selective coronary ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xu G,Jin G,Fu G,Ma J,Shi Y,Tang O,Shan J

    更新日期:2003-08-01 00:00:00

  • Safety and immunogenicity of live attenuated hepatitis A virus vaccine (H2 strain) in humans.

    abstract::A study was made in Neijiang City, Sichuan Province to observe the safety and immunogenicity of a live attenuated hepatitis A virus (HAV) vaccine (H2 strain). 3,031 children, aged 6 to 9 years, were injected subcutaneously with 10(6.0) TCID50, 10(5.5) TCID50, and 10(5.0) TCID50 of HAV vaccine; the seroconversion rate ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ran LA,Wang DZ,Duan QY,Yan TY,Liu QL,Luo YG,Yang DZ,Yang DF,Xiao Z,Xie QJ

    更新日期:1993-08-01 00:00:00

  • Trocar-site hernia after gynecological laparoscopic surgery: a 20-year, single-center experience.

    abstract:BACKGROUND:Trocar-site hernia (TSH) is a serious complication after laparoscopic procedures. Although it is a rare entity, it can have life-threatening consequences. This study aimed to retrospectively analyze the potential associated factors for TSH following gynecologic laparoscopy and summarize prevention strategies...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000000510

    authors: Zhu YP,Liang S,Zhu L,Sun ZJ,Lang JH

    更新日期:2019-11-20 00:00:00

  • Triggering of toll-like receptors 2 and 4 by Aspergillus fumigatus conidia in immortalized human corneal epithelial cells to induce inflammatory cytokines.

    abstract:BACKGROUND:Cornea epithelial cells play early and crucial roles in the initiation of ocular surface responses to pathogens. Participation of toll-like receptor (TLR) 2 and TLR4, which are major forms of fungi receptors, may be involved in Aspergillus fumigatus induced immune responses. The objective of the present stud...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhao J,Wu XY

    更新日期:2008-03-05 00:00:00

  • Percutaneous balloon mitral valvuloplasty. An observation of 50 patients.

    abstract::Percutaneous balloon mitral valvuloplasty (PBMV) was successfully performed in 50 selected patients with mitral stenosis by using Inoue pillow-shaped balloon and Inoue technique. The average diameter of balloon used was 26.9 +/- 0.9 mm. 90% (45/50) of cases had either double or single mitral commissura split. Of the r...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Fang WY,Yu WX,Lu ZX,Li XM,Bu DX,Xu WL

    更新日期:1994-09-01 00:00:00

  • Blockade of the OX40/OX40L pathway and induction of PD-L1 synergistically protects mouse islet allografts from rejection.

    abstract:BACKGROUND:OX40/OX40 ligand (OX40/OX40L) and programmed death-1/programmed death ligand-1 (PD-1/PD-L1) costimulatory signals play important roles in T cell-induced immune responses. The aim of this study was to investigate the roles of OX40/OX40L and PD-1/PD-L1 costimulatory pathways in mouse islet allograft rejection....

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li T,Ma R,Zhu J,Wang F,Huang L,Leng X

    更新日期:2014-01-01 00:00:00

  • Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis.

    abstract:OBJECTIVE:Sepsis remains a leading cause of death in many Intensive Care Units worldwide. Immunosuppression has been a primary focus of sepsis research as a key pathophysiological mechanism. Given the important role of the negative costimulatory molecules programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.4103/0366-6999.204113

    authors: Liu Q,Li CS

    更新日期:2017-04-20 00:00:00

  • Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid.

    abstract:BACKGROUND:CD4(+)CD25(+) regulatory T cells (Tregs) mediate immune suppression through cell-cell contact with surface molecules, particularly cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR), and transforming growth factor beta (TG...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang Q,Qian FH,Liu H,Zhou LF,Huang M,Zhang XL,Yin KS

    更新日期:2008-02-05 00:00:00

  • Testin on Atherosclerosis in Rabbits.

    abstract:BACKGROUND:The expression of TES, a novel tumor suppressor gene, is found to be down-regulated in the left anterior descending aorta of patients with coronary artery disease (CAD) compared with non-CAD subjects. This study aimed to investigate the expression of TES during the development of atherosclerosis in rabbits. ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.158370

    authors: Zhang Y,Yuan M,Li HM,Lao M,Xu Z,Li GP

    更新日期:2015-06-20 00:00:00

  • Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases.

    abstract:BACKGROUND:Exposure of adult mice to more than 95% O(2) produces a lethal injury by 72 hours. Nitric oxide synthase (NOS) is thought to contribute to the pathophysiology of murine hyperoxia-induced acute lung injury (ALI). Osteopontin (OPN) is a phosphorylated glycoprotein produced principally by macrophages. OPN inhib...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang XF,Liu S,Zhou YJ,Zhu GF,Foda HD

    更新日期:2010-04-05 00:00:00

  • Common variants in PERK, JNK, BIP and XBP1 genes are associated with the risk of prediabetes or diabetes-related phenotypes in a Chinese population.

    abstract:BACKGROUND:Prediabetes is an early stage of β-cell dysfunction presenting as insulin resistance. Evidences suggest that endoplasmic reticulum (ER) stress is involved in the pathogenesis of type 2 diabetes mellitus and prediabetes. In a Chinese population with prediabetes, we investigated single nucleotide polymorphisms...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Feng N,Ma X,Wei X,Zhang J,Dong A,Jin M,Zhang H,Guo X

    更新日期:2014-01-01 00:00:00

  • Effect of preoperative transcatheter arterial chemoembolization on apoptosis of hepatocellular carcinoma cells.

    abstract:OBJECTIVE:To evaluate the effect of preoperative transcatheter arterial chemoembolization(TACE) on apoptosis of hepatocellular carcinoma (HCC) cells. METHODS:A total of 136 patients with HCC underwent liver resection. One to five courses of TACE prior to liver resection were performed in 79 patients (TACE group), in w...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xiao E,Li D,Shen S,Zhou S,Tan L,Wang Y,Luo J,Wu Y,Tan C,Liu H,Zhu H

    更新日期:2003-02-01 00:00:00

  • Surgical outcome and clinical follow-up in patients with symptomatic myocardial bridging.

    abstract:BACKGROUND:Myocardial bridging with systolic compression of the left anterior descending coronary artery (LAD) may be associated with myocardial ischaemia. The clinical outcome in patients with surgical treatment for symptomatic myocardial bridging remains undetermined. This study assessed the middle- and long-term res...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Huang XH,Wang SY,Xu JP,Song YH,Sun HS,Tang Y,Dong C,Yang YJ,Hu SS

    更新日期:2007-09-20 00:00:00

  • Cochlear mitochondrial DNA3867bp deletion in aged mice.

    abstract:OBJECTIVES:To study the status of cochlear mitochondrial DNA (mtDNA) and to determine the location of mtDNA deletion in aged mice. METHODS:We detected cochlear mtDNA in 2, 7 - 10 and 17 - 19 month old mice by nested polymerase chain reaction (PCR) and DNA sequencing. RESULTS:mtDNA3867bp deletions were found in the co...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang X,Han D,Ding D,Dai P,Yang W,Jiang S,Salvi RJ

    更新日期:2002-09-01 00:00:00

  • Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice.

    abstract:BACKGROUND:Respiratory syncytial virus (RSV) is a common pathogen in the lower respiratory tract of infants and children. Recent studies have shown that in adults, especially in the elderly population who have relatively weak immunity, lower respiratory tract infection is not uncommon. RSV was detected in 22% hospitali...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li W,Shen HH

    更新日期:2007-01-05 00:00:00

  • Effect of fixing distal radius fracture with volar locking palmar plates while preserving pronator quadratus.

    abstract:BACKGROUND:L-shaped incision of pronator quadratus (PQ) muscle along its radial and distal borders was always taken for distal radius fractures reduction and internal fixation. Repair of the PQ muscle was always recommended at the end of operation for some instructive reasons. But repair of PQ is not satisfied because ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Fan J,Chen K,Zhu H,Jiang B,Yuan F,Zhu X,Mei J,Yu G

    更新日期:2014-01-01 00:00:00

  • Etiology and prevalence of abnormal serum alanine aminotransferase levels in a general population in Northeast China.

    abstract:BACKGROUND:Chronic liver diseases are a major burden in China. Alanine aminotransferase (ALT) can be used as an indicator of hepatocyte damage. In this study, we determined the prevalence and etiologies of elevated ALT in an adult population in Jilin, China. METHODS:A total of 4072 individuals aged between 18 and 79 y...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang H,Jiang YF,He SM,Sun J,Gu Q,Feng XW,DU B,Wang W,Shi XD,Wang CY,Zhang SQ,Li WY,Niu JQ

    更新日期:2011-09-01 00:00:00

  • Involvement of hydrogen sulfide in the progression of renal fibrosis.

    abstract:OBJECTIVE:Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered endogenous small gas signaling ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/CM9.0000000000000537

    authors: Wang Y,Xing QQ,Tu JK,Tang WB,Yuan XN,Xie YY,Wang W,Peng ZZ,Huang L,Xu H,Qin J,Xiao XC,Tao LJ,Yuan QJ

    更新日期:2019-12-05 00:00:00

  • Efficacy and safety of the treatment: combination of benazepril/lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension.

    abstract:BACKGROUND:Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension. This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension. METHODS:One hundred and eighty-...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Chen T,Chen GH,Yang TS,Zhong ZY,An WS,Zhang XX,Li JD

    更新日期:2013-06-01 00:00:00

  • Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients.

    abstract:BACKGROUND:Programmed cell death 5 (PDCD5) is a novel apoptotic regulatory gene that promotes apoptosis in various tumor cells. Studies have shown that PDCD5 accelerates the apoptosis of synoviocytes in vitro, implying a potential role in rheumatoid arthritis (RA) pathogenesis. This study examined the expression of PDC...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang JF,Guan ZP,Zhang SL,Pei Z,Chen YY,Pan H

    更新日期:2013-01-01 00:00:00

  • Prognostic factors of retroperitoneal soft tissue sarcomas: analysis of 132 cases.

    abstract:BACKGROUND:Retroperitoneal sarcoma is a rare disease with poor prognosis. The aim of this study was to investigate the prognostic factors of the disease. METHODS:Between January 1988 and December 2003, 132 patients with retroperitoneal sarcoma were surgically treated in our hospital, 79 of them were followed up for 1 ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chen CQ,Yin L,Peng CH,Cai Y,Li YF,Zhao R,Zhou HJ,Li HW

    更新日期:2007-06-20 00:00:00

  • Diagnostic value of magnetocardiography in patients with coronary heart disease and in-stent restenosis.

    abstract:BACKGROUND:In-stent restenosis (ISR) has become one of the most challenging problems in patients with coronary heart disease. At present, using non-invasive methods to assess ISR is a hot topic. In this investigation we attempted to explore the potential of magnetocardiography (MCG) in diagnosis of in-stent restenosis....

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Quan WW,Lu GP,Qi WH,Li YM,Shen Y,Yuan R

    更新日期:2008-01-05 00:00:00

  • Outcomes of Adults with Acute Lymphoblastic Leukemia After Autologous Hematopoietic Stem Cell Transplantation and the Significance of Pretransplantation Minimal Residual Disease: Analysis from a Single Center of China.

    abstract:BACKGROUND:The postremission therapies for adult patients generally contain consolidation chemotherapy, allogeneic hematopoietic stem cell transplantation and autologous hematopoietic stem cell transplantation (auto-HSCT). Because of the various results from different centers, the optimal therapy for adult acute lympho...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.161365

    authors: Ding Z,Han MZ,Chen SL,Ma QL,Wei JL,Pang AM,Zhang XY,Liang C,Yao JF,Cao YG,Feng SZ,Jiang EL

    更新日期:2015-08-05 00:00:00

  • Correlation between retinal fluorescein angiography and blood viscosity and other factors in patients with primary open angle glaucoma.

    abstract:OBJECTIVE:To investigate the correlation among retinal fluorescein angiography, blood viscosity, and other factors in patients with open angle glaucoma (POAG). METHODS:Multiple step regression analysis was made to investigate the correlation between each of the following blood vessel filling times: the arm-choroid (A-...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu X,Zhou W,Ye T,Ge J,Cai X,Cheng A,Lin Y,Liang L,Tang H,Chen Z

    更新日期:1997-09-01 00:00:00

  • Lipid signal in evaluation of intracranial meningiomas.

    abstract:BACKGROUND:Using magnetic resonance imaging, diagnosis of malignant meningioma from benign meningioma with atypical features is uncertain. We evaluated the value of lipid signal in differentiating intracranial meningiomas. METHODS:1H-magnetic resonance spectroscopy (MRS) using a point resolved spectroscopy (TR/TE 1000...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Qi ZG,Li YX,Wang Y,Geng DY,Li KC,Shen TZ,Chen XR

    更新日期:2008-12-05 00:00:00

  • A serological study of hepatitis C infection in plasmapheresis donors.

    abstract::An epidemic of parenterally transmitted non-A, non-B hepatitis (PT-NANBH) occurred in plasmapheresis donors in Guan County, Hebei Province, China, in 1985. PT-NANBH was diagnosed by epidemiological studies and serological exclusion of HAV, HBV, CMV and EBV infections. Recently, 163 sera samples of 108 patients with PT...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Meng ZD,Sun YD,Chen XR,Wang SY,Sun DG,Chen Z,Liu CB,Zhuang H,Xu ZY

    更新日期:1991-06-01 00:00:00

  • Telomerase activity in myelodysplastic syndrome.

    abstract:OBJECTIVE:To study telomerase activity (TA) and its variation in bone marrow mononuclear cells from patients with myelodysplastic syndrome (MDS) at different stages in comparison with normal bone marrow cells and leukemic cells. METHODS:The TA was semi-quantitatively determined in mononuclear cells from 20 normal bone...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Fu C,Chen Z

    更新日期:2002-10-01 00:00:00