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Testin on Atherosclerosis in Rabbits.

Abstract：

BACKGROUND:The expression of TES, a novel tumor suppressor gene, is found to be down-regulated in the left anterior descending aorta of patients with coronary artery disease (CAD) compared with non-CAD subjects. This study aimed to investigate the expression of TES during the development of atherosclerosis in rabbits. METHODS:Thirty-two New Zealand rabbits were randomly divided into a normal diet (ND) and high-fat diet (HFD) groups. Body weight and serum lipid levels were measured at 0, 4, and 12 weeks after diet treatment. The degree of atherosclerosis in thoracic aortas was analyzed by histological examinations. The expression of Testin in the tissue samples was inspected via immunohistochemical and immunofluorescence confocal microscopy. Real time-polymerase chain reaction and Western blot analysis were performed to evaluate the expression of TES/Testin at mRNA and protein levels in the aortic tissues. RESULTS:After 12 weeks postenrollment, rabbits in HFD group had a higher level of serum lipids and atherosclerotic plaque compared to ND group (P < 0.05). Testin expression was detected at high levels in the endothelium and a weak expression on the subendothelium area. The expression of TES mRNA was markedly reduced by 10-fold in the aortic tissues in the HFD group compared with the ND group (P = 0.015), and the protein level was also significantly decreased in the HFD group (P < 0.05). CONCLUSIONS:Reduced TES/Testin expression is associated with the development of atherosclerosis, implicating a potentially important role in the pathogenesis of atherosclerosis.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Zhang Y,Yuan M,Li HM,Lao M,Xu Z,Li GP

doi

10.4103/0366-6999.158370

subject

Has Abstract

pub_date

2015-06-20 00:00:00

pages

1662-5

issue

12

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2015_128_12_1662_158370

journal_volume

128

pub_type

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