Changes in serum ammonia concentration in cirrhotic patients with Helicobacter pylori infection.

Abstract:

OBJECTIVE:To study whether liver cirrhosis associated with Helicobacter pylori (H. pylori) infection will induce increased serum ammonia and whether the peripheral serum ammonia reflects the level of portal vein serum ammonia. METHODS:Blood was taken from the portal vein and the cubital vein in cirrhotic patients with and without H. pylori infection and non-cirrhotic patients (splenic rupture) with and without H. pylori infection, and the serum ammonia was measured. RESULTS:The mean levels of serum ammonia in the group of cirrhotic patients with H. pylori infection were 167.82 +/- 8.97 mumol/L (portal vein) and 142.2 +/- 13.35 mumol/L (cubital vein). They were increased significantly as compared with cirrhotic patients without H. pylori infection (47.68 +/- 12.03 mumol/L portal vein and 37.23 +/- 7.04 mumol/L cubital vein), and also compared with the groups of splenic rupture patients with and without H. pylori infection (P < 0.01). There was no significant difference between the serum ammonia level of the cubital vein and portal vein (P > 0.05). CONCLUSIONS:H. pylori infection can induce an increase in serum ammonia in patients with liver dysfunction, and the peripheral serum ammonia measurement may replace the portal vein serum ammonia as a monitoring method. Eradication of H. pylori in cirrhotic patients may prevent hepatic encephalopathy (HE).

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Si J,Cao Q,Gao M,Fang L,Qian G,Wang Y

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1080-1

issue

12

eissn

0366-6999

issn

2542-5641

journal_volume

113

pub_type

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