DNA vaccine pCD-Sj32 and its efficacy of protective immunity against infection of Schistosoma japonicum.

abstract：BACKGROUND:Ischemic disease is one of the leading causes of death in the world. In order to further study gene therapy for ischemic disease, we constructed a recombinant plasmid for co-expression of human angiopoietin-1 and vascular endothelial growth factor 165(VEGF165) gene in adeno-associated virus (AAV) gene delive...

journal_title：Chinese medical journal

authors： Chen DJ,Tan Z,Xie YL,Liu F

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:The present study was undertaken to replicate the associations of representative polymorphisms in three genes (complement factor H (CFH), complement factor B (BF) and HtrA serine peptidase 1 (HTRA1)) with exudative age-related macular degeneration (AMD) in a Han Chinese population, and to test if the modifia...

journal_title：Chinese medical journal

authors： Chu J,Zhou CC,Lu N,Zhang X,Dong FT

更新日期：2008-12-20 00:00:00

abstract：OBJECTIVES:To study the interrelation between nitric oxide (NO) and endothelin-1 (ET1) in experimental acute hypoxic rats, and to evaluate the mechanism of acute hypoxic pulmonary hypertension affected by NO and ET1 and its intervention. METHODS:Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemi...

journal_title：Chinese medical journal

authors： Wang Y,Zhang L,Shen W,Chen L,Fan S

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China. METHODS...

journal_title：Chinese medical journal

authors： Lin HJ,Du LZ,Ma XL,Shi LP,Pan JH,Tong XM,Li QP,Zhou JG,Yi B,Liu L,Chen YB,Wei QF,Wu HQ,Li M,Liu CQ,Gao XR,Xia SW,Li WB,Yan CY,He L,Liang K,Zhou XY,Han SP,Lyu Q,Qiu YP,Li W,Chen DM,Lu HR,Liu XH,Li

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:Genetic factors contribute to the development of coronary artery disease (CAD). Recently, a missense mutation in the low density lipoprotein receptor related protein 6 (LRP6) gene, encoding low density lipoprotein receptor related protein 6, has been implicated in an autosomal dominant form of early-onset CA...

journal_title：Chinese medical journal

authors： Wang H,Liu QJ,Chen MZ,Li L,Zhang K,Cheng GH,Ma L,Gong YQ

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Excessive expression of thymic stromal lymphopoietin (TSLP) has been demonstrated in asthmatic airway epithelia and in nasal epithelia from animal models of allergic rhinitis (AR), but the evidence of expression of TSLP in nasal epithelial cells (NECs) of patients with AR is lacking. We aimed to investigate ...

journal_title：Chinese medical journal

authors： Zhu DD,Zhu XW,Jiang XD,Dong Z

更新日期：2009-10-05 00:00:00

abstract：OBJECTIVE:To determine whether mutation of the coding or junction region of glucokinase gene (GCK) is also the pathogenic cause of the common form of non-insulin-dependent diabetes mellitus (NIDDM) in Chinese. METHODS:Single strand conformation polymorphism (SSCP) analysis was performed after the 12 exons and junction...

journal_title：Chinese medical journal

authors： Xiang K,Wu S,Zheng T,Sun D,Wang Y,Pu L

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is a Th2 dominant cytokine response. Chloride channel-3 (ClC-3) plays an important role in nasal mucosal edema and inflammatory pathologic changes in AR. Antiallergic herbal agents (AHA) are antiallergic herbal products. In the previous study, we have demonstrated that AHA clearly inhi...

journal_title：Chinese medical journal

authors： Wang LF,Xu LJ,Guo FH,Wang LN,Shen XH

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Current treatments for scoliosis have some defects and complications. To study spinal deformities and test novel scoliosis treatments, many animal models of scoliosis have been developed. These models applied a single load to the spine and could not precisely modulate the spinal growth in different dimension...

journal_title：Chinese medical journal

authors： Zhang HY,Li QY,Wu ZH,Zhao Y,Qiu GX

更新日期：2017-11-05 00:00:00

abstract：OBJECTIVE:To study the effects of skeletal muscle satellite cells implanted into infarcted myocardium on the volume of remnant myocytes. METHODS:Thirty-six adult mongrel canines were divided randomly into implantation group and control group. In the implantation group, skeletal muscle satellite cells taken from the gl...

journal_title：Chinese medical journal

authors： Zhong H,Zhu H,Wei H,Zhang Z

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Our previous studies have shown that regulatory factor X5 (RFX5), a classical transcription regulator of MHCII genes, was obviously overexpressed in hepatocellular carcinoma (HCC) tumors. However, the role of RFX5 in the carcinogenesis and progress of HCC remains unknown. This study aimed to reveal its biolo...

journal_title：Chinese medical journal

authors： Chen DB,Zhao YJ,Wang XY,Liao WJ,Chen P,Deng KJ,Cong X,Fei R,Wu X,Shao QX,Wei L,Xie XW,Chen HS

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis, severe burns, and trauma. It is increasingly recognized that atrial natriuretic peptide (ANP) possesses a broad range of biological activities, including ...

journal_title：Chinese medical journal

authors： Zhu YB,Zhang YB,Liu DH,Li XF,Liu AJ,Fan XM,Qiao CH,Ling F,Liu YL

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To study whether liver cirrhosis associated with Helicobacter pylori (H. pylori) infection will induce increased serum ammonia and whether the peripheral serum ammonia reflects the level of portal vein serum ammonia. METHODS:Blood was taken from the portal vein and the cubital vein in cirrhotic patients with...

journal_title：Chinese medical journal

authors： Si J,Cao Q,Gao M,Fang L,Qian G,Wang Y

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Surgical interventions are the main treatment for primary congenital glaucoma (PCG). This study aimed to compare the efficacy and safety between viscocanalostomy and mitomycin C (MMC)-trabeculectomy in patients with PCG. METHODS:A total number of 43 patients with PCG who underwent either viscocanalostomy (g...

journal_title：Chinese medical journal

authors： Chen Q,Yu Y,Sun H,Zong Y,Yuan ZL

更新日期：2013-01-01 00:00:00

abstract：:The results of 31 cases of sutureless esophagogastrostomy by intraluminal elastic circular ligation (IECL) with the biodegradable supporting tube were reported. The fate of the supporting tube could be tracked satisfactorily by X-ray. The tube-dislodge time was 15.03 +/- 2.23 days and unaffected by the size of support...

journal_title：Chinese medical journal

authors： Chen L,Zhang Y,Du X,Wang Q,Zhang Z

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:As a Chinese Traditional Medicine product, Kuntai capsule could improve the peri-menopausal symptoms in postmenopausal women. But it is still not clear whether Kuntai capsule has a good effect on alleviating peri-menopausal symptoms induced by gonadotropin releasing hormone agonist (GnRH-a) treatment. The pu...

journal_title：Chinese medical journal

authors： Chen JM,Gao HY,Ding Y,Yuan X,Wang Q,Li Q,Jiang GH

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:Sericin peptide (SP) has shown a powerful anti-oxidant property in a host of studies. The present study was designed to investigate the possible protective effects of SP against alcohol-induced gastric lesions in mice and to explore the potential mechanisms. METHODS:Animals were randomly divided into 5 grou...

journal_title：Chinese medical journal

authors： Li YG,Ji DF,Lin TB,Zhong S,Hu GY,Chen S

更新日期：2008-10-20 00:00:00

abstract：BACKGROUND:The mitochondrial displacement loop (D-loop) accumulates mutations and single nucleotide polymorphisms (SNPs) at a higher frequency than other regions of mitochondrial DNA (mtDNA). We previously identified disease risk-associated SNPs in the D-loop of chronic kidney disease (CKD) patients; in this study, we ...

journal_title：Chinese medical journal

authors： Bai Y,Guo Z,Xu J,Zhang J,Cui L,Zhang H,Zhang S,Ai X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The importance of polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene for the prediction of the response to fluorouracil-based adjuvant chemotherapy in gastric cancer patients remains unclear. The aim of this study is to assess the predictive value of several polymorphisms of the MTHFR gene...

journal_title：Chinese medical journal

authors： Zhang X,Bai Z,Chen B,Feng J,Yan F,Jiang Z,Zhong Y,Wu J,Cheng L,Lu Z,Tong N,Zhang Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive disease associated with a cellular inflammatory response mostly concerned with cigarette smoking. Chemokine receptors CCR1/5 play an important role in the inflammatory cells recruitment in the lung of COPD patients. The aim of this study was to de...

journal_title：Chinese medical journal

authors： Wang F,He B

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Cardiovascular complications of Kawasaki disease (KD) are a common cause of heart disease in pediatric populations. Previous studies have suggested a role for endothelial progenitor cells (EPCs) in coronary artery lesions associated with KD. However, long-term observations of EPCs during the natural progress...

journal_title：Chinese medical journal

authors： Liu JF,Du ZD,Chen Z,Lu DX,Li L,Guan YQ,Wan SG

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:After total hip arthroplasty (THA), there is a noteworthy inflammatory response. The inflammatory response is associated with postoperative recovery and complications. However, there had been few reports on the relationship between inflammatory response and postoperative complication rate. The aim of the pre...

journal_title：Chinese medical journal

authors： Chen XX,Wang T,Li J,Kang H

更新日期：2016-11-05 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the potential relationship between the dynamic expression of Toll-like receptor 2 and 4 (TLR2/4) in peripheral blood mononuclear cells as well as changes in serum concentration of inflammatory factors and acute lung injury (ALI) in patients after orthotopic liver tran...

journal_title：Chinese medical journal

authors： Chi XJ,Cai J,Luo CF,Cheng N,Hei ZQ,Li SR,Luo GJ

更新日期：2009-04-20 00:00:00

abstract：Background:The increasing frequency of explosive injuries has increased interest in blast-induced traumatic brain injury (bTBI). Various shock tube models have been used to study bTBI. Mild-to-moderate explosions are often overlooked because of the slow onset or mildness of the symptoms. However, heavy gas cylinders an...

journal_title：Chinese medical journal

authors： Zhou Y,Wen LL,Wang HD,Zhou XM,Fang J,Zhu JH,Ding K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is a common pathogen in the lower respiratory tract of infants and children. Recent studies have shown that in adults, especially in the elderly population who have relatively weak immunity, lower respiratory tract infection is not uncommon. RSV was detected in 22% hospitali...

journal_title：Chinese medical journal

authors： Li W,Shen HH

更新日期：2007-01-05 00:00:00

abstract：BACKGROUND:Pancreatic beta-cell apoptosis induced by lipotoxicity, to a large extent, contributes to the progression of type 2 diabetes. To investigate the mechanism of free fatty acid induced apoptosis, we aimed to study the effects of palmitic acid (PA) on the apoptosis and peroxisome proliferator-activated receptor ...

journal_title：Chinese medical journal

authors： He TT,Cao XP,Chen RZ,Zhu XN,Wang XL,Li YB,Xiao HP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Chronic liver disease causes aberrant formation of fibrous tissue that impedes normal liver function, ultimately resulting in liver cirrhosis. Iron uptake can occur within the hepatic parenchyma or within the various nodules that form in a cirrhotic liver, termed siderotic nodules (SN). We aimed to investiga...

journal_title：Chinese medical journal

authors： Tao R,You ZL,Zhang JQ,Dai YM,Zhou DQ,Cai P,Fan Y,Cui JG,Wang J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:A number of studies have demonstrated the rates of overall and aneurysm-related mortality and morbidity in Western populations. The cardiovascular risk factors influencing postoperative outcome have been also reported. Until recently, little has been known about the prognosis in this patient cohort in the Ch...

journal_title：Chinese medical journal

authors： Sun T,Zhang H,Cheng Y,Wang S,Tao Y,Zhang D,Huang J,Zhang J,Li Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Bioactive proteins, such as cytokines and chemokines, have not been systematically evaluated in healthy and preeclamptic pregnancies. We aimed to investigate the difference of these proteins between healthy and preeclamptic pregnancies in order to help clarify their potential roles in the pathogenesis of hyp...

journal_title：Chinese medical journal

authors： Wang T,Wang YY,Zhou R,Song CP,Lin W,Niu XY,Zhang L,Hu HZ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:It is important to modulate the expression of glucocorticoids receptor (GR) in tress and maintain the immunity homeostasis in sepsis process. Rhubarb have been shown to have potential effects on anti-inflammatory and immune modulation. The present study was designed to investigate the effects of rhubarb on t...

journal_title：Chinese medical journal

authors： Liu J,Li G,Chen YZ,Zhang LD,Wang T,Wen ZL,Wang L,Chen DC

更新日期：2019-05-20 00:00:00